Interleukin-22 in kidney injury and regeneration

2015 ◽  
Vol 308 (10) ◽  
pp. F1041-F1046 ◽  
Author(s):  
Marc Weidenbusch ◽  
Severin Rodler ◽  
Hans-Joachim Anders
Keyword(s):  
Functional Role ◽  
Immune Cell ◽  
Kidney Injury ◽  
Kidney Regeneration ◽  
Innate And Adaptive Immunity ◽  
Functional Roles ◽  
Interleukin 22 ◽  
Immune Cell Subsets ◽  
Key Features

Interleukins have become well-known regulators of innate and adaptive immunity-related tissue inflammation. Recently, IL-22 has gained a lot of interest for its unique functions in maintaining and regaining epithelial integrity. IL-22 is exclusively secreted by different immune cell subsets, while IL-22 receptors are mainly expressed by epithelial cells. As the kidney is largely an epithelial organ, the functional role of IL-22 in the kidney deserves to be explored in detail. Here, we briefly summarize the key features of IL-22 biology and review the available data on its expression and functional roles in kidney injury and kidney regeneration. Furthermore, we provide suggestions on how to explore this evolving field in the future.

Abstract 175: The Role of Axl in Accumulation of Immune Cells in Kidney and the Onset of Hypertension

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Sri Nagarjun Batchu ◽  
Angie Hughson ◽  
Janice Gerloff ◽  
Deborah J Fowell ◽  
Vyacheslav A Korshunov
Keyword(s):  
Blood Pressure ◽  
Immune Cells ◽  
Immune Cell ◽  
Kidney Injury ◽  
Wild Type ◽  
Protein Levels ◽  
Immune Cell Subsets ◽  
Early Increase ◽  
Salt Hypertension

Introduction: Gas6/Axl pathway contributes to elevation of blood pressure. Immune cells are implicated in initiation and maintenance of hypertension. In this study we aimed to investigate the role of Axl in immune cells on kidney injury and initiation of hypertension. Methods and Results: Deoxycorticosterone-acetate (DOCA; 75mg, 60days release) and salt hypertension was induced for 1wk or 6wks in four groups of Axl chimeras (n=4-5) that were generated by bone marrow (BM) transplant. Multi parameter flow cytometry was used to quantify five major immune cell subsets in digested kidneys from Axl chimeras. Systolic blood pressure (SBP) increased by 30mmHg in Axl+/+ →Axl+/+, Axl-/- →Axl-/- and Axl+/+ →Axl-/- mice after 1wk of DOCA-salt. However, chimeras that lack Axl in the BM cells (Axl-/- →Axl+/+) showed reduction in early increase in SBP (16+2mmHg). We observed a significant decrease in urine protein levels in Axl-/- →Axl+/+ (0.3+0.1μg/μl) compared to other Axl chimeras (∼0.7μg/μl) after 1wk of DOCA-salt. Kidney glomeruli areas were reduced in Axl-/- →Axl+/+ (4,143+229μm 2 ) compared to other Axl chimeras (∼6,000μm 2 ) after 6wks of DOCA-salt. Kidneys from Axl-/- →Axl-/- showed an increase in total leukocytes (8 vs. 4%), B cells (29 vs. 12%) and decrease in monocytes/macrophages (16 vs. 22%) and dendritic cells (5 vs. 10%) compared to Axl+/+ →Axl+/+. Moreover, Axl-/- →Axl+/+ showed further increase in leukocytes (17%), B (39%) and dendritic (13%) cells in kidneys compared to other Axl chimeras. In addition a small percentage of wild type T cells was increased in the kidneys from Axl-/- →Axl+/+ chimeras. Conclusions: These findings suggest that Axl expression in BM-derived cells is critical for kidney injury in DOCA-salt hypertension. Axl-dependent pathways regulate immune cell populations in the kidneys during initiation of hypertension. This study was supported by HL105623 grant (VAK)

scholarly journals Tuning cancer fate: the unremitting role of host immunity

Open Biology ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. 170006 ◽  
Author(s):  
B. Calì ◽  
B. Molon ◽  
A. Viola
Keyword(s):  
Immune Cells ◽  
Immune Cell ◽  
Tumour Progression ◽  
Host Immunity ◽  
Adaptive Immune ◽  
Adaptive Immune Cells ◽  
Immune Mediated ◽  
Immune Cell Subsets ◽  
Therapeutic Protocols

Host immunity plays a central and complex role in dictating tumour progression. Solid tumours are commonly infiltrated by a large number of immune cells that dynamically interact with the surrounding microenvironment. At first, innate and adaptive immune cells successfully cooperate to eradicate microcolonies of transformed cells. Concomitantly, surviving tumour clones start to proliferate and harness immune responses by specifically hijacking anti-tumour effector mechanisms and fostering the accumulation of immunosuppressive immune cell subsets at the tumour site. This pliable interplay between immune and malignant cells is a relentless process that has been concisely organized in three different phases: elimination, equilibrium and escape. In this review, we aim to depict the distinct immune cell subsets and immune-mediated responses characterizing the tumour landscape throughout the three interconnected phases. Importantly, the identification of key immune players and molecules involved in the dynamic crosstalk between tumour and immune system has been crucial for the introduction of reliable prognostic factors and effective therapeutic protocols against cancers.

Semantics, conceptual role

2018 ◽  
Author(s):  
Ned Block
Keyword(s):  
Decision Making ◽  
Social Interaction ◽  
Cognitive Science ◽  
Functional Role ◽  
Good Health ◽  
Procedural Semantics ◽  
Functional Roles ◽  
Conceptual Role Semantics ◽  
Conceptual Role

According to conceptual role semantics (CRS), the meaning of a representation is the role of that representation in the cognitive life of the agent, for example, in perception, thought and decision-making. It is an extension of the well-known ‘use’ theory of meaning, according to which the meaning of a word is its use in communication and, more generally, in social interaction. CRS supplements external use by including the role of a symbol inside a computer or a brain. The uses appealed to are not just actual, but also counterfactual: not only what effects a thought does have, but what effects it would have had if stimuli or other states had differed. Of course, so defined, the functional role of a thought includes all sorts of causes and effects that are non-semantic, for example, perhaps happy thoughts can bolster one’s immunity, promoting good health. Conceptual roles are functional roles minus such non-semantic causes and effects. The view has arisen separately in philosophy (where it is sometimes called ‘inferential’ or ‘functional’ role semantics) and in cognitive science (where it is sometimes called ‘procedural semantics’).

scholarly journals The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Xueyi Zhu ◽  
Jie Cui ◽  
La Yi ◽  
Jingjing Qin ◽  
Wuniqiemu Tulake ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Activation ◽  
Immune Cell ◽  
Immune Microenvironment ◽  
Innate And Adaptive Immunity ◽  
Immune Cell Activation ◽  
Inflammatory Signals ◽  
Macrophage Dysfunction ◽  
New Perspective

Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.

Telomere shortening in immune cell subsets of women with a history of child maltreatment: The role of cortisol and oxytocin

2016 ◽  
Vol 71 ◽  
pp. 53 ◽  
Author(s):  
Christina Boeck ◽  
Sabrina Krause ◽  
Alexander Karabatsiakis ◽  
Katharina Schury ◽  
Christiane Waller ◽  
...  
Keyword(s):  
Child Maltreatment ◽  
Immune Cell ◽  
Telomere Shortening ◽  
Immune Cell Subsets ◽  
History Of

Role of Feedback Connections in Central Visual Processing

2020 ◽  
Vol 6 (1) ◽  
pp. 313-334
Author(s):  
Farran Briggs
Keyword(s):  
Visual Processing ◽  
Physiological Response ◽  
Functional Role ◽  
Functional Roles ◽  
Vision Science ◽  
The Core ◽  
Feedback Circuits ◽  
Corticothalamic Feedback ◽  
Feedback Connections

The physiological response properties of neurons in the visual system are inherited mainly from feedforward inputs. Interestingly, feedback inputs often outnumber feedforward inputs. Although they are numerous, feedback connections are weaker, slower, and considered to be modulatory, in contrast to fast, high-efficacy feedforward connections. Accordingly, the functional role of feedback in visual processing has remained a fundamental mystery in vision science. At the core of this mystery are questions about whether feedback circuits regulate spatial receptive field properties versus temporal responses among target neurons, or whether feedback serves a more global role in arousal or attention. These proposed functions are not mutually exclusive, and there is compelling evidence to support multiple functional roles for feedback. In this review, the role of feedback in vision will be explored mainly from the perspective of corticothalamic feedback. Further generalized principles of feedback applicable to corticocortical connections will also be considered.

scholarly journals Transcriptome Analysis of Circulating Immune Cell Subsets Highlight the Role of Monocytes in Zaire Ebola Virus Makona Pathogenesis

2017 ◽  
Vol 8 ◽  
Author(s):  
Andrea R. Menicucci ◽  
Krista Versteeg ◽  
Courtney Woolsey ◽  
Chad E. Mire ◽  
Joan B. Geisbert ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Ebola Virus ◽  
Immune Cell ◽  
Immune Cell Subsets

The Functional Significance of Endocrine-immune Interactions in Health and Disease

2020 ◽  
Vol 21 (1) ◽  
pp. 52-65
Author(s):  
Sridhar Muthusami ◽  
Balasubramanian Vidya ◽  
Esaki M Shankar ◽  
Jamuna Vadivelu ◽  
Ilangovan Ramachandran ◽  
...  
Keyword(s):  
Immune System ◽  
Cell Differentiation ◽  
Amino Acid ◽  
Functional Role ◽  
Immune Cell ◽  
Amino Acid Derivatives ◽  
Endocrine Glands ◽  
Immune Systems ◽  
Health And Disease

Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.

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