A computer model of human thermoregulation for a wide range of environmental conditions: the passive system

1999 ◽  
Vol 87 (5) ◽  
pp. 1957-1972 ◽  
Author(s):  
Dusan Fiala ◽  
Kevin J. Lomas ◽  
Martin Stohrer

A dynamic model predicting human thermal responses in cold, cool, neutral, warm, and hot environments is presented in a two-part study. This, the first paper, is concerned with aspects of the passive system: 1) modeling the human body, 2) modeling heat-transport mechanisms within the body and at its periphery, and 3) the numerical procedure. A paper in preparation will describe the active system and compare the model predictions with experimental data and the predictions by other models. Here, emphasis is given to a detailed modeling of the heat exchange with the environment: local variations of surface convection, directional radiation exchange, evaporation and moisture collection at the skin, and the nonuniformity of clothing ensembles. Other thermal effects are also modeled: the impact of activity level on work efficacy and the change of the effective radiant body area with posture. A stable and accurate hybrid numerical scheme was used to solve the set of differential equations. Predictions of the passive system model are compared with available analytic solutions for cylinders and spheres and show good agreement and stable numerical behavior even for large time steps.

2021 ◽  
Vol 22 (13) ◽  
pp. 6845
Author(s):  
Rebecca L. Pratt

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body’s fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.


2018 ◽  
Vol 860 ◽  
pp. 739-766 ◽  
Author(s):  
Rémi Bourguet

The flow-induced vibrations of an elastically mounted circular cylinder, free to oscillate in an arbitrary direction and forced to rotate about its axis, are examined via two- and three-dimensional simulations, at a Reynolds number equal to 100, based on the body diameter and inflow velocity. The behaviour of the flow–structure system is investigated over the entire range of vibration directions, defined by the angle $\unicode[STIX]{x1D703}$ between the direction of the current and the direction of motion, a wide range of values of the reduced velocity $U^{\star }$ (inverse of the oscillator natural frequency) and three values of the rotation rate (ratio between the cylinder surface and inflow velocities), $\unicode[STIX]{x1D6FC}\in \{0,1,3\}$, in order to cover the reference non-rotating cylinder case, as well as typical slow and fast rotation cases. The oscillations of the non-rotating cylinder ($\unicode[STIX]{x1D6FC}=0$) develop under wake-body synchronization or lock-in, and their amplitude exhibits a bell-shaped evolution, typical of vortex-induced vibrations (VIV), as a function of $U^{\star }$. When $\unicode[STIX]{x1D703}$ is increased from $0^{\circ }$ to $90^{\circ }$ (or decreased from $180^{\circ }$ to $90^{\circ }$), the bell-shaped curve tends to monotonically increase in width and magnitude. For all angles, the flow past the non-rotating body is two-dimensional with formation of two counter-rotating spanwise vortices per cycle. The behaviour of the system remains globally the same for $\unicode[STIX]{x1D6FC}=1$. The principal effects of the slow rotation are a slight amplification of the VIV-like responses and widening of the vibration windows, as well as a limited asymmetry of the responses and forces about the symmetrical configuration $\unicode[STIX]{x1D703}=90^{\circ }$. The impact of the fast rotation ($\unicode[STIX]{x1D6FC}=3$) is more pronounced: VIV-like responses persist over a range of $\unicode[STIX]{x1D703}$ but, outside this range, the system is found to undergo a transition towards galloping-like oscillations characterised by amplitudes growing unboundedly with $U^{\star }$. A quasi-steady modelling of fluid forcing predicts the emergence of galloping-like responses as $\unicode[STIX]{x1D703}$ is varied, which suggests that they could be mainly driven by the mean flow. It, however, appears that flow unsteadiness and body motion remain synchronised in this vibration regime where a variety of multi-vortex wake patterns are uncovered. The interaction with flow dynamics results in deviations from the quasi-steady prediction. The successive steps in the evolution of the vibration amplitude versus $U^{\star }$, linked to wake pattern switch, are not captured by the quasi-steady approach. The flow past the rapidly-rotating, vibrating cylinder becomes three-dimensional over an interval of $\unicode[STIX]{x1D703}$ including the in-line oscillation configuration, with only a minor effect on the system behaviour.


2010 ◽  
Vol 69 (4) ◽  
pp. 511-517 ◽  
Author(s):  
Robert F. Grimble

The objective of the present review is to provide an overview of the metabolic effects of pro-inflammatory cytokine production during infection and injury; to highlight the disadvantages of pro-inflammatory cytokine production and inflammatory stress on morbidity and mortality of patients; to identify the influence of genetics and adiposity on inflammatory stress in patients and to indicate how nutrients may modulate the inflammatory response in patients. Recent research has shown clearly that adipose tissue actively secretes a wide range of pro- and anti-inflammatory cytokines. Paradoxically, although inflammation is an essential part of the response of the body to infection, surgery and trauma, it can adversely affect patient outcome. The metabolic effects of inflammation are mediated by pro-inflammatory cytokines. Metabolic effects include insulin insensitivity, hyperlipidaemia, muscle protein loss and oxidant stress. These effects, as well as being present during infective disease, are also present in diseases with a covert inflammatory basis. These latter diseases include obesity and type 2 diabetes mellitus. Inflammatory stress also increases during aging. The level of cytokine production, within individuals, is influenced by single nucleotide polymorphisms (SNP) in cytokine genes. The combination of SNP controls the relative level of inflammatory stress in both overt and covert inflammatory diseases. The impact of cytokine genotype on the intensity of inflammatory stress derived from an obese state is unknown. While studies remain to be done in the latter context, evidence shows that these genomic characteristics influence morbidity and mortality in infectious disease and diseases with an underlying inflammatory basis and thereby influence the cost of in-patient obesity. Antioxidants andn-3 PUFA alter the intensity of the inflammatory process. Recent studies show that genotypic factors influence the effectiveness of immunonutrients. A better understanding of this aspect of nutrient–gene interactions and of the genomic factors that influence the intensity of inflammation during disease will help in the more effective targeting of nutritional therapy.


2016 ◽  
Vol 17 (3-4) ◽  
pp. 107-111
Author(s):  
T. A. Zamesova

Heavy metals, especially their large concentration, is toxic for all living creatures because they are accumulating in the living things tissues. Theirs excessive levels evoke coagulation of proteins that cause immediate death of cells. Heavy metals get into the ground by different ways: directly because of using, precipitation, industrial pollution. Their impacts may be either time limited and have low toxicity or, alternatively, it may be long-termed and expressing the pollutants' ability to accumulate them in the body and supply chains. In the edaphotop block of land biogeocenosis most of the transformation processes begin with soil degradation ones. This leads to disruption of soil-forming process cycle of matter and biological productivity of systems. Optimization of a particular system or a block is possible only by acting on their biological relations, which is responsible for managing the system. Distortion or optimization of relations occurs with the animals environmental-forming, the component of which is animals burrow activity. As a result of it, water and chemicals are being reallocated in soil depths, thermal and aeration modes are changed, formed typical zoogenous micro relief with specific physical and chemical properties of the soil. This improves the living conditions of soil micro-organisms. Last ones are involved in soil enzyme activity forming. Enzymes involved in important biochemical processes: synthesis and humus decomposition, hydrolysis of organic compounds, the schedule remains of plants and microorganisms and converted them available to fixation, fix loose items, are actively involved in the cycling of essential elements for plants, in oxidation renewable reactions, etc. It is possible to determine the extent of microorganism’s activity by means of indexes of soil proteolytic activity. Conducted studies of the impact for animals burrow activity on the soils proteolytic activity for artificial forest under conditions of heavy metal pollution. Control plots were contaminated by lead with concentrations of 32; 160; 320 mg/kg of soil, which correspond to the maximum permissible concentration of 1; 5; 10 MAC. Samples were taken at 1st, 3rd and 15th months after contamination; proteolytic activity was determined by the Mishustin application method. Current proteolytic activity of soil is determined in vivo. It is the result of microorganism’s vital functions. And in turn can be an indicator of microbial activity. Contamination of lead depressing vital functions for soil microorganisms. This effect is more noticeable in the first month after contamination. The characteristic dependence of the soil proteolytic activity on metal concentration was observed also, the higher the MPC, the lower proteolytic activity level. The characteristics' dependence of soil proteolytic activity on metal concentration were also observed: the higher MPC, the lower the activity level. It was shown that on the mole rats burrows-dug with lead contaminated the medium proteolytic activity level exceeded control 1.9; 1.76 and 1.53 times respectively, at 1st; 3rd and 15th months after contamination. Based on this we can say that burrowing activity of animals inhibits inhibitory effect of heavy metals and plays an important role in the self-cleaning environment.


Energies ◽  
2022 ◽  
Vol 15 (1) ◽  
pp. 354
Author(s):  
Ludovica Maria Campagna ◽  
Francesco Fiorito

The body of literature on climate change impacts on building energy consumption is rising, driven by the urgency to implement adaptation measures. Nevertheless, the multitude of prediction methodologies, future scenarios, as well as climate zones investigated, results in a wide range of expected changes. For these reasons, the present review aims to map climate change impacts on building energy consumption from a quantitative perspective and to identify potential relationships between energy variation and a series of variables that could affect them, including heating and cooling degree-days (HDDs and CDDs), reference period, future time slices and IPCC emission scenarios, by means of statistical techniques. In addition, an overview of the main characteristics of the studies related to locations investigated, building types and methodological approaches are given. To sum up, global warming leads to: (i) decrease in heating consumptions; (ii) increase in cooling consumption; (iii) growth in total consumptions, with notable differences between climate zones. No strong correlation between the parameters was found, although a moderate linear correlation was identified between heating variation and HDDs, and total variation and HDDs. The great variability of the collected data demonstrates the importance of increasing specific impact studies, required to identify appropriate adaptation strategies.


2019 ◽  
Vol 121 (1) ◽  
pp. 218-239 ◽  
Author(s):  
Saman Sheikhesmaeili ◽  
Sana Hazbavi

Purpose The purpose of this paper is to determine the impact of food-related lifestyle (FRL) and food-related personality traits (FRPTs) on customer satisfaction and loyalty so that sufficient evidence for forming a new pattern of predictors of customer satisfaction and loyalty can be explored. Design/methodology/approach The research method in this study was the descriptive type and was based on the goal of the applied research methods. Data were collected from 384 sample group consumers of chain stores in the city of Tehran. The hypothesized relationships were tested using structural equation modeling (SEM). Findings Final results of study showed the significant effects of FRL and FRPT on satisfaction and loyalty of consumers. This indicates that aforementioned variables can create customer satisfaction and loyalty toward food. The research conceptual model was confirmed with goodness of fit. Research limitations/implications First, the sample consisted of customers who use a wide range of food despite diverse motives and interests. While knowing that costumers’ specific traits about food would have provided a more detailed and comprehensive understanding, conducting research in a set of general food consumer without considering special foods category could be a limitation. Second, and more importantly, since the customer behavior in consumption choices is an unconscious and cognitive process, other factors and domain that are linked to customer satisfaction and loyalty would have been missed. Practical implications This study shows that understanding the behavioral aspects of food consumption can help food producing companies to adjust their production and specially to foresee changes. Marketers are advised to investigate customer traits to promote customer satisfaction and loyalty effectively. This paper contributes to the body of knowledge in food marketing. Originality/value The present study offers a unique and valuable insight into a customer’s behavior and deepens customer satisfaction and loyalty by incorporating FRL, food neophobia scale and food involvement scale as independent variables to contribute knowledge in the context of food marketing, and throws some light upon the predictive power of mentioned variables on customer behaviors.


Author(s):  
Joseph F. Haley ◽  
Chris Swan ◽  
Richard Gibson

This paper concerns the difficulties arising in the prediction of the impact loads associated with an extreme wave event. A new set of experimental observations are presented. These concern the impact loads arising on a slender horizontal cylinder located at varying elevations above the still water level. The experimental observations incorporate a wide range of wave forms. In each case, data is provided describing (i) the incident water surface profiles, (ii) the incident fluid velocities and (iii) the load components acting on the cylinder. Comparisons between the measured data and the classical impact load solutions confirm a number of important departures. In particular, it is shown that as the wave becomes very steep (approaching the breaking limit) the vector sum of the horizontal and vertical velocity components at the water surface may deviate significantly from the normal to the local water surface. In such cases it becomes unclear exactly what direction the impact force acts. The present data suggests that this is, in part, dependent on the rate of inundation of the body. Furthermore, the present results also show that if the direction of the force is correct modelled, the variations in the predicted loading (or slamming) coefficient are much reduced.


Author(s):  
Mariya S. Pravdivtseva ◽  
Oleg B. Shevelev ◽  
Vadim V. Yanshole ◽  
Mikhail P. Moshkin ◽  
Igor V. Koptyug ◽  
...  

AbstractThe impact of alcohol on the body can be investigated with NMR spectroscopy in vitro, which can detect a wide range of metabolites but preparing samples includes tissue biopsy. Blood sampling is less invasive, but blood metabolic content might not reflect the changes occurring in other tissues. Thus, this study aimed to investigate the liver, brain, and serum metabolism and evaluate the link between tissues and serum metabolic content. Two experimental groups with ten outbred rats each were provided intragastrically with water (control group) and 50% ethanol solution (alcohol group) for 28 days. 1H NMR spectroscopy in vitro was performed on the brain cortex, liver, and serum samples. Student’s t test with Holm–Bonferroni correction was used to investigate significant differences between groups. Partial least-squares discriminant analysis (PLS-DA) and two-way ANOVA were performed to compare liver and serum, brain and serum. In all, 38, 37, and 21 metabolites were identified in the liver, brain, and serum samples, respectively. Significant differences for three metabolites were found in the liver (alanine, proline, and glutathione, p < 0.002) and four in serum (lactate, betaine, acetate, and formic acid, p < 0.002) were detected between the control and alcohol groups. The contents of glucose, betaine, and isoleucine were correlated (r > 0.65) between serum and liver samples. PLS-DA determined separation between all tissues (p < 0.001) and between control and alcohol groups only for liver and serum (p < 0.001). Alcohol had a more substantial effect on liver and serum metabolism than on the brain.


Author(s):  
Mervyl McPherson

The demographic diversity of local and global work forces and markers is increasing within what is still generally a context of tight labour market conditions, especially or skilled labour. This paper reviews a wide range of literature on the impact of workforce diversity on business oil/comes and how that diversity can he best managed for business success. The review considers various types of diversity, different methodological approaches from quasi-experimental to case studies, and a range of positive business outcomes including improved staff recruitment and retention; improved creativity, innovation and problem solving, improved marketing strategies and outcomes, productivity and net financial returns. Although there are some specific studies or instances that appear to prove the exception to the rule, the consensus from the body of evidence existing to date is that diverse workforces are the reality of the future and that, in general, they have the potential to result in positive/enhanced business outcomes. The exceptions are generally explained away as being due to lack of best practice implementation of diversity and equality policies, and management of diverse teams and workforces. This paper, therefore, also investigates the key workplace, management and implementation factors associated with positive versus negative outcomes. We found lack of research into the links between diversity, workplace practices and business outcomes in the New Zealand context with its large number of small businesses, a unique range of ethnic groups and its own cultural norms, signaling the potential for further research.


2019 ◽  
Vol 5 (2) ◽  
pp. 16-20
Author(s):  
Sayed Muhammad Yadain ◽  
Aftab Alam Tanoli ◽  
Riffat Masood ◽  
Shagufta Shafi ◽  
Rizwan Zafar Ansari ◽  
...  

OBJECTIVES:The aim of the study was to determine (a) most common sites of torture, nature of injuries and their complications and (b) psychological and physical effects of torture on the prisoner’s mental and physical health. METHODOLOGY: It was a cross-sectional descriptive study. The study was conducted on 193 prisoners admitted at District Police Hospital Peshawar over a period of one year. These prisoners were the victims of torture under police captivity. Majority of the victims were prisoners. The data was collected on a Performa mentioning age, duration of captivity; nature of injuries (simple, grievous), weapon used for physical torture (blunt, sharp) and prisoners were interviewed and examined by the medical officers and co-authors. SPSS 20 was used for data analysis. RESULTS: One hundred and eighty (93.2%) of the 193 subjects were male. Average age was 27.4 ±4 years. Hundred (51.8%) prisoners were physically tortured and 92 cases (47.6%) were due to physical assault among prisoners. Out of 92 cases 12 (13.04%) prisoners showed injuries due to strenuous physical work, mostly on palms and soles in the form of blisters. These injuries were carefully examined and correlated with history. Torture methods observed in this study were beating with hands on face (35.6%), whipping with rod (61.6%), kicking on buttock and abdomen (16.4%), forceful dragging (16.4%), burning with cigarettes (12.3%), hanging with hand cuffs (13.7%) and whipping on palms and sole (6.9%). Majority of the cases (74%) were tortured in custody, (12.3%) in prisons, (9.6%) on the street and (4.1%) at home. The impact of physical and psychological torture was variable depending upon the duration of captivity and nature of torture. Patients kept for a longer period 42 (42%) had developed post captivity psychosocial stress syndrome. Physical torture has taken 07 (3%) lives and 24 (12.4%) victims were permanently disabled in this year. CONCLUSION: A wide range of different types of injuries were observed on various parts of the body. Blunt trauma was most frequent. Violation of Istanbul Protocol for violence against torture under police custody was also clear.


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