Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials

The objective of this study was to evaluate the influence of calorie restriction (CR) on free-living physical activity levels among humans. Data were from three CALERIE phase I site-specific protocols. Participants were nonobese (body mass index = 23.5–29.9 kg/m2) adults randomly assigned to 25% CR, low-calorie diet (LCD, 890 kcal/day supplement diet until 15% weight loss, then weight maintenance), or control at Pennington Biomedical Research Center (PBRC); 30% or 10% CR at Tufts University; and 20% CR or control at Washington University School of Medicine (WUSM). Activity was measured at months 0, 3, and 6 (PBRC) and at months 0, 3, 6, 9, and 12 (WUSM and Tufts). Total daily energy expenditure (TEE) by doubly labeled water and resting metabolic rate (RMR) were used to compute activity energy expenditure: AEE = TEE − RMR − 0.1 * TEE. Accelerometry and 7-day recall categorized activities by intensity. At Tufts, the 10% and 30% CR groups experienced significant decreases in AEE at months 6, 9, and 12. At month 6, a larger decrease in AEE was observed in the CR than the control group at WUSM. At months 3 and 6, larger decreases in AEE were observed in the CR and LCD groups than the control group at PBRC. Accelerometry and 7-day PAR did not consistently detect changes in activity categories. CR-associated changes in AEE were variable but, generally, reduced the energy deficit, which would reduce the expected rate of weight loss. Accelerometry and recall did not consistently explain reduced AEE, suggesting that increased muscle efficiency and/or decreased fidgeting accounted for decreased AEE. Inaccuracy of accelerometry and recall also likely negatively affected sensitivity.

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Physical Activity for Weight Loss in Children: Is There Any Compensatory Mechanism?

Pediatric Exercise Science ◽

10.1123/pes.2013-0154 ◽

2014 ◽

Vol 26 (2) ◽

pp. 121-123 ◽

Cited By ~ 3

Author(s):

David Thivel ◽

Pascale Duché

Keyword(s):

Physical Activity ◽

Weight Loss ◽

Energy Expenditure ◽

Overweight And Obesity ◽

Compensatory Mechanism ◽

Activity Levels ◽

Compensatory Responses ◽

Physical Activity Levels ◽

Prevention And Treatment ◽

And Control

Although physical activity is primarily considered for its effects on energy expenditure for prevention and treatment of both overweight and obesity, its role in the regulation and control of energy balance seems more complex. Not only does physical activity affect energy expenditure, it also leads to modifications in energy intake and appetite that have been identified in children and that should be considered for weight loss. It also appears that it may not systematically favor increased energy expenditure due to individual differences in compensatory responses. This brief paper summarizes the pediatric evidence regarding those potential compensatory responses to physical activity and suggests that these compensatory responses of increasing physical activity levels may depend on children’s adiposity status.

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Nonresponders of Physical Activity on Prescription (PAP) Can Increase Their Exercise Capacity with Enhanced Physiotherapist Support

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094795 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4795

Author(s):

Tom Martinsson Ngouali ◽

Mats Börjesson ◽

Åsa Cider ◽

Stefan Lundqvist

Keyword(s):

Physical Activity ◽

Oxygen Uptake ◽

Exercise Capacity ◽

Cardiorespiratory Fitness ◽

Medium Effect ◽

Control Group ◽

Activity Levels ◽

The Metabolic Syndrome ◽

Physical Activity Levels ◽

Insufficient Physical Activity

Swedish physical activity on prescription (PAP) is an evidence-based method to promote physical activity. However, few studies have investigated the effect of Swedish PAP on physical fitness, in which better cardiorespiratory fitness is associated with lower risks of all-cause mortality and diagnose-specific mortality. Direct measures of cardiorespiratory fitness, usually expressed as maximal oxygen uptake, are difficult to obtain. Hence, exercise capacity can be assessed from a submaximal cycle ergometer test, taking the linear relationship between heart rate, work rate, and oxygen uptake into account. The aim of this study was to evaluate exercise capacity in the long term, following PAP treatment with enhanced physiotherapist support in a nonresponding patient cohort. In total, 98 patients (48 women) with insufficient physical activity levels, with at least one component of the metabolic syndrome and nonresponding to a previous six-month PAP treatment, were randomized to PAP treatment with enhanced support from a physiotherapist and additional exercise capacity tests during a two-year period. A significant increase in exercise capacity was observed for the whole cohort at two-year follow-up (7.6 W, p ≤ 0.001), with a medium effect size (r = 0.34). Females (7.3 W, p = 0.025), males (8.0 W, p = 0.018) and patients ≥58 years old (7.7 W, p = 0.002) improved significantly, whereas a nonsignificant increase was observed for patients <58 years old (7.6 W, p = 0.085). Patients with insufficient physical activity levels who did not respond to a previous six-month PAP treatment can improve their exercise capacity following PAP treatment with enhanced support from a physiotherapist during a two-year period. Future studies should include larger cohorts with a control group to ensure valid estimations of exercise capacity and PAP.

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Session 3 (Joint with the British Dietetic Association): Management of obesity Weight-loss interventions in the treatment of obesity

Proceedings of The Nutrition Society ◽

10.1017/s0029665109991844 ◽

2009 ◽

Vol 69 (1) ◽

pp. 34-38 ◽

Cited By ~ 11

Author(s):

C. R. Hankey

Keyword(s):

Physical Activity ◽

Weight Loss ◽

Energy Expenditure ◽

Energy Intake ◽

Weight Maintenance ◽

Dietary Advice ◽

Excess Body Weight ◽

Lifestyle Interventions ◽

Post Intervention ◽

Weight Losses

Treatments to induce weight loss for the obese patient centre on the achievement of negative energy balance. This objective can theoretically be attained by interventions designed to achieve a reduction in energy intake and/or an increase in energy expenditure. Such ‘lifestyle interventions’ usually comprise one or more of the following strategies: dietary modification; behaviour change; increases in physical activity. These interventions are advocated as first treatment steps in algorithms recommended by current clinical obesity guidelines. Medication and surgical treatments are potentially available to those unable to implement ‘lifestyle interventions’ effectively by achieving losses of between 5 kg and 10 kg. It is accepted that the minimum of 5% weight loss is required to achieve clinically-meaningful benefits. Dietary treatments differ widely. Successful weight loss is most often associated with quantification of energy intake rather than macronutrient composition. Most dietary intervention studies secure a weight loss of between 5 kg and 10 kg after intervention for 6 months, with gradual weight regain at 1 year where weight changes are 3–4 kg below the starting weight. Some dietary interventions when evaluated at 2 and 4 years post intervention report the effects of weight maintenance rather than weight loss. Specific anti-obesity medications are effective adjuncts to weight loss, in most cases doubling the weight loss of those given dietary advice only. Greater physical activity alone increases energy expenditure by insufficient amounts to facilitate clinically-important weight losses, but is useful for weight maintenance. Weight losses of between half and three-quarters of excess body weight are seen at 10 years post intervention with bariatric surgery, making this arguably the most effective weight-loss treatment.

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Una unidad didáctica intermitente de acondicionamiento físico solo mejora los niveles de capacidad cardiorrespiratoria de los estudiantes con un perfil no saludable de condición física (An intermittent physical fitness teaching unit only improves cardior

Retos ◽

10.47197/retos.v38i38.73605 ◽

2019 ◽

pp. 8-15

Author(s):

Santiago Guijarro-Romero ◽

Daniel Mayorga-Vega ◽

Carolina Casado-Robles ◽

Jesús Viciana

Keyword(s):

Physical Activity ◽

Physical Education ◽

Physical Fitness ◽

Cardiorespiratory Fitness ◽

Control Group ◽

Activity Levels ◽

Physical Activity Levels ◽

Before And After ◽

Teaching Unit ◽

Experimental Group

El objetivo del presente estudio fue comparar el efecto de una unidad didáctica intermitente de acondicionamiento físico en Educación Física sobre los niveles de actividad física y capacidad cardiorrespiratoria entre estudiantes con un perfil saludable/no saludable de capacidad cardiorrespiratoria. Ochenta estudiantes de 2º-3º curso de Educación Secundaria fueron asignados aleatoriamente al grupo control y grupo experimental. El grupo experimental, dividido en perfiles saludable/no saludable, realizó una unidad didáctica intermitente de acondicionamiento físico para mejorar la capacidad cardiorrespiratoria. El grupo control trabajó un contenido diferente durante el mismo tiempo y con la misma frecuencia, pero sin hacer hincapié en la mejora de la capacidad cardiorrespiratoria. Antes y después de la intervención, la capacidad cardiorrespiratoria se evaluó objetivamente mediante el test de ida y vuelta de 20 metros. Los niveles de actividad física fueron medidos objetivamente a través de un pulsómetro durante las clases de Educación Física. Ambos perfiles tuvieron mayores niveles de actividad física durante las clases de Educación Física que el grupo control (p < .001). Sin embargo, solo los estudiantes con un perfil no saludable mejoraron significativamente sus niveles de capacidad cardiorrespiratoria tras la unidad didáctica (p < .01). Aunque una unidad didáctica intermitente de acondicionamiento físico parece tener un efecto similar en los niveles de actividad física de todos los perfiles de capacidad cardiorrespiratoria de los estudiantes, solo mejora la capacidad cardiorrespiratoria de los estudiantes con un perfil no saludable. Abstract. The purpose of the present study was to compare the effect of a Physical Education-based physical fitness intermittent teaching unit on physical activity levels and cardiorespiratory fitness among students with healthy/unhealthy cardiorespiratory fitness profile. Eighty students from 2º-3º grades of Secondary Education were randomly assigned to the control group and experimental group. The experimental group, divided into healthy/unhealthy profiles, performed a physical fitness intermittent teaching unit to improve the cardiorespiratory fitness. The control group worked a different content during the same time and with the same frequency, but without emphasizing cardiorespiratory fitness improvement. Before and after the teaching unit, students’ cardiorespiratory fitness was objectively measured by the 20-meter shuttle run test. Participants’ physical activity levels were measured objectively using a heart rate monitor during Physical Education lessons. Students from both profiles had higher physical activity levels during Physical Education lessons than the control group (p < .001). However, only students with an unhealthy cardiorespiratory fitness profile statistically improved their cardiorespiratory fitness levels after the teaching unit (p < .01). Although an intermittent physical fitness teaching unit seems to have similar effect on physical activity levels of students from all cardiorespiratory fitness profiles, it only improves the cardiorespiratory fitness of those with an unhealthy one.

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Caloric Intake and Energy Expenditures in India

The World Bank Economic Review ◽

10.1093/wber/lhaa018 ◽

2020 ◽

Author(s):

Shari Eli ◽

Nicholas Li

Keyword(s):

Physical Activity ◽

Energy Expenditure ◽

Total Energy ◽

Caloric Intake ◽

Total Energy Expenditure ◽

Activity Levels ◽

Significant Drop ◽

Energy Expenditures ◽

Food And Nutrition ◽

Physical Activity Levels

Abstract Total energy expenditures for the Indian population between 1983 and 2012 are estimated to shed light on the debate concerning falling measured caloric intake during the period (A. Deaton and J. Drèze. 2009. “Food and Nutrition in India: Facts and Interpretations.” Economic and Political Weekly 44(7): 42–65). Anthropometric, time-use, and detailed employment surveys are used to estimate the separate components of total energy expenditure related to metabolism and physical activity levels. Despite a significant drop in adult physical activity levels, total energy expenditures are flat overall between 1983 and 2012. Rising metabolic requirements due to increases in weight dampened the effect of falling activity levels on total energy expenditure. In addition, the 10 percent decline in the population share of children in the period raised average total energy expenditures considerably as children have much lower metabolic requirements and activity levels than adults.

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Quantifying Physical Activity Levels of Survivors of Intensive Care: A Prospective Observational Study

Physical Therapy ◽

10.2522/ptj.20110411 ◽

2012 ◽

Vol 92 (12) ◽

pp. 1507-1517 ◽

Cited By ~ 17

Author(s):

Linda Denehy ◽

Sue Berney ◽

Laura Whitburn ◽

Lara Edbrooke

Keyword(s):

Physical Activity ◽

Intensive Care ◽

Interquartile Range ◽

Apache Ii Score ◽

Activity Levels ◽

Free Living ◽

Factors Associated ◽

Icu Admission ◽

Icu Discharge ◽

Physical Activity Levels

Background Promotion of increased physical activity is advocated for survivors of an intensive care unit (ICU) admission to improve physical function and health-related quality of life. Objective The primary aims of this study were: (1) to measure free-living physical activity levels and (2) to correlate the measurements with scores on a self-reported activity questionnaire. A secondary aim was to explore factors associated with physical activity levels. Design This was a prospective cohort study. Methods Nested within a larger randomized controlled trial, participants were block randomized to measure free-living physical activity levels. Included participants wore an accelerometer for 7 days during waking hours at 2 months after ICU discharge. At completion of the 7 days of monitoring, participants were interviewed using the Physical Activity Scale for the Elderly (PASE) questionnaire. Factors associated with physical activity were explored using regression analysis. Results The ICU survivors (median age=59 years, interquartile range=49–66; mean Acute Physiologic Chronic Health Evaluation [APACHE II] score=18, interquartile range=16–21) were inactive when quantitatively measured at 2 months after hospital discharge. Participants spent an average of 90% of the time inactive and only 3% of the time walking. Only 37% of the sample spent 30 minutes or more per day in the locomotion category (more than 20 steps in a row). Activity reported using the PASE questionnaire was lower than that reported in adults who were healthy. The PASE scores correlated only fairly with activity measured by steps per day. The presence of comorbidities explained one third of the variance in physical activity levels. Limitations Accelerometer overreading, patient heterogeneity, selection bias, and sample size not reached were limitations of the study. Conclusions Survivors of an ICU admission greater than 5 days demonstrated high levels of inactivity for prolonged periods at 2 months after ICU discharge, and the majority did not meet international recommendations regarding physical activity. Comorbidity appears to be a promising factor associated with activity levels.

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Impact of a one-year lifestyle modification program on cholesterol efflux capacities in men with abdominal obesity and dyslipidemia

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00127.2018 ◽

2018 ◽

Vol 315 (4) ◽

pp. E460-E468 ◽

Cited By ~ 6

Author(s):

Marjorie Boyer ◽

Patricia L. Mitchell ◽

Paul Poirier ◽

Natalie Alméras ◽

Angelo Tremblay ◽

...

Keyword(s):

Physical Activity ◽

Abdominal Obesity ◽

Cholesterol Efflux ◽

Lifestyle Modification ◽

Hdl Cholesterol ◽

Control Group ◽

Activity Levels ◽

Apolipoprotein A ◽

Physical Activity Levels ◽

Lifestyle Modification Program

Cholesterol efflux capacities (CECs) are negatively associated with cardiovascular disease risk, irrespective of plasma high-density lipoprotein (HDL) cholesterol levels. Whether interventions targeting lifestyle improve HDL-CECs is unknown. Our objective was to determine whether improving dietary quality and increasing physical activity levels improves HDL-CECs in men with abdominal obesity and dyslipidemia. Our study sample included men (48 ± 8.5 yr) with an elevated waist circumference (≥90 cm) associated with dyslipidemia (triglycerides ≥1.69 and/or HDL cholesterol <1.03 mmol/l); 113 men completed a 1-yr intervention, consisting of a healthy eating and physical activity/exercise program, and 32 were included in a control group. An oral lipid tolerance test (OLTT) was performed in a subsample of 28 men who completed the intervention, and blood was collected every 2 h for 8 h. HDL-CECs were measured using [3H]cholesterol-labeled J774 macrophages and HepG2 hepatocytes. The lifestyle modification program led to an overall improvement in the cardiometabolic risk profile, increases in J774-HDL-CEC by 14.1% (+0.88 ± 1.09%, P < 0.0001), HepG2-HDL-CEC by 3.4% (+0.17 ± 0.75%, P = 0.01), and HDL cholesterol and apolipoprotein A-1 levels (13.5%, P < 0.0001 and 14.9%, P < 0.0001, respectively). J774-HDL-CECs and HepG2-HDL-CECs did not change in the control group. The best predictor for changes in HDL-CEC was apolipoprotein A-1 level. The lifestyle modification program also improved HDL-CEC response in postprandial lipemia during an OLTT. HDL-CEC did not change during the OLTT. Our results suggest that increasing physical activity levels and improving diet quality can have a positive impact on both HDL quantity and quality in men with abdominal obesity and dyslipidemia.

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Energy balance and obesity: a UK perspective on the gluttonyv.sloth debate

Nutrition Research Reviews ◽

10.1017/s095442241300005x ◽

2013 ◽

Vol 26 (2) ◽

pp. 89-109 ◽

Cited By ~ 17

Author(s):

D. Joe Millward

Keyword(s):

Physical Activity ◽

Energy Consumption ◽

Energy Expenditure ◽

Energy Supply ◽

Activity Levels ◽

Food Energy ◽

Household Food ◽

Diet And Exercise ◽

Physical Activity Levels ◽

The Uk

Obesity in the UK was assumed to have developed against a population decline in physical activity, with health messages focused on diet and exercise prevention strategies. Doubly-labelled water (DLW) studies of energy expenditure have indicated the alternative scenario that the increased obesity prevalence reflects excessive food energy intake with physical activity levels unchanged. This analysis is questionable, deriving in part from a weakness of the DLW methodology in identifying changing physical activity levels within populations of increasing body weight. This has resulted in an underestimation of the reduction in physical activity in the overweight and obese, as revealed by direct studies of such behaviour. Furthermore, a close examination of food energy supply, household food purchases and individual food energy consumption since 1955, in relation to likely estimates of current intakes indicated by simple modelling of predicted energy expenditure, identifies: (a) food energy supply as markedly overestimating energy intakes; (b) individual food energy consumption as markedly underestimating energy intakes; and (c) household food purchase data as the closest match to predicted current food energy intakes. Energy intakes indicated by this latter method have fallen by between 20 to 30 %, suggesting comparable falls in physical activity. Although unequivocal evidence for a matching UK trend in falling physical activity is limited, as is evidence that obesity follows reductions in physical activity, such a link has been recently suggested in a large prospective study in adolescents. Thus, for the UK, obesity has developed within a ‘move less–eat somewhat less but still too much’ scenario. A focus on both diet and exercise should remain the appropriate public health policy.

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PO-224 Effect of high-fat diet on body weight and spontaneous physical activity of SD rats

Exercise Biochemistry Review ◽

10.14428/ebr.v1i5.9553 ◽

2018 ◽

Vol 1 (5) ◽

Author(s):

Shanshan Cao ◽

Wei Chen ◽

Juan Li ◽

Yuxiu He

Keyword(s):

Physical Activity ◽

Body Weight ◽

High Fat Diet ◽

Activity Level ◽

Control Group ◽

Activity Levels ◽

High Fat ◽

Exercise Time ◽

Sd Rats ◽

Physical Activity Levels

Objective Excessive intake of high-energy foods and insufficient levels of physical activity are important causes of obesity. In addition, inadequate physical activity is also a major cause of cardiovascular disease and type 2 diabetes. Relevant data suggests that most adults fail to achieve the level of physical activity needed to improve their health. Therefore, understanding the reasons for the lack of physical activity levels is essential for developing a reduction in sedentary and thus preventing chronic acute illnesses. It is well known that physical activity is good for health, but little is known about the genetic and biological factors that may affect this complex behavior. Some studies have shown that diet-induced obesity may alter dopaminergic activity and thus reduce physical activity levels, suggesting that obesity and diet may be inversely related to dopamine signaling. Therefore, it is necessary to further study the correlation between obesity, dopamine and physical activity levels, and to explore the relationship between high-fat diet and body weight changes and physical activity levels. Methods Sixteen male Sprague-Dawley rats were randomly divided into two groups. The control group (n=8) was fed with basal diet for 8 weeks, and the high-fat group (n=8) was fed with high-fat diet for 8 weeks. To compare the difference in body weight and physical activity between SD rats fed with high-fat diet and normal diet, and the relationship between body weight and body activity level; in order to study the effect of obesity on exercise behavior, use the open field experimental recorder for each The movements of the rats in the group were recorded (autonomic activity for 30 min), and the correlation between the effects of high-fat diet on body weight and spontaneous activities of SD rats was analyzed. Results High-fat diet and normal-fed rats were in energy intake (high-fat group 4583.94±349.85; control group 3201±298.58), body weight (high-fat group 406.23±29.35; control group 306.66±31.44) and Lee's index (high-fat group 26.17 ± 0.57; control group 24.35 ± 0.97) were significantly different. There was a high correlation between energy intake and body weight in rats, correlation coefficient r=0.911 (p<0.01); correlation coefficient between body weight and physical activity level r = 0.576 (p < 0.05). In addition, by comparing the exercise time and average speed of rats in each group, the difference in exercise time between the two groups was not significant, and the average speed difference was significant (p<0.05); exercise time was significantly correlated with physical activity level, r= 0.734 (p<0.01); and the mean speed was also positively correlated with physical activity level, and the correlation coefficient was 0.660 (P<0.01). Conclusions Obesity is greatly affected by dietary factors, and long-term high-fat diets lead to a decline in physical activity, which in turn promotes further deterioration of obesity. This interaction can create a vicious circle between obesity and physical activity. Further research on the mechanisms of obesity, lack of physical activity and their interaction may provide a theoretical basis for increasing the level of physical activity in obese people.

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Validation of Static and Dynamic Activity Detection Using a Tri-Axial Accelerometer and Video

ASME 2012 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2012-80488 ◽

2012 ◽

Author(s):

Vipul Lugade ◽

Emma Fortune ◽

Melissa Morrow ◽

Kenton Kaufman

Keyword(s):

Physical Activity ◽

Energy Expenditure ◽

Postural Sway ◽

Activity Monitoring ◽

Metabolic Energy ◽

Activity Levels ◽

Activity Detection ◽

Dynamic Activity ◽

Physical Activity Levels ◽

Metabolic Energy Expenditure

Recording body accelerations has been investigated previously to monitor health, metabolic energy expenditure, postural sway and falls [1]. Activity monitoring and the subsequent analysis of the accelerometry data have also proven useful in detecting physical activity levels among Parkinson’s [2] and osteoarthritis patients [3].

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