scholarly journals Endobronchial Mimics of Primary Endobronchial Carcinoma: A Clinical Study of 25 Cases

2005 ◽  
Vol 12 (3) ◽  
pp. 123-127 ◽  
Author(s):  
Cynthia M Magro ◽  
Patrick Ross
Keyword(s):  
Clinical Study ◽  
Fungal Infection ◽  
Head And Neck ◽  
Bronchogenic Carcinoma ◽  
Present Report ◽  
Critical Role ◽  
Signs And Symptoms ◽  
Definitive Diagnosis ◽  
Pathological Assessment

While endobronchial lesions that present with symptoms of obstruction may be reflective of primary bronchogenic malignancy, there have been a number of reports of bronchial lesions other than primary bronchogenic carcinoma simulating primary endobronchial epithelial malignancy clinically. Twenty-five cases of symptomatic endobronchial disease were encountered with pathological assessment demonstrating an endobronchial process other than carcinoma, representing metastatic disease (breast, colon, renal, head and neck origin), fungal infection, Hodgkin's lymphoma, primary bronchogenic melanoma, lipoma, broncholith and inflammatory pseudopolyp. The present report underscores the potential pathogenetic heterogeneity encountered in lesions presenting with signs and symptoms of endobronchial obstruction, emphasizing the critical role of biopsy for establishing a definitive diagnosis.

scholarly journals A Critical Role of c-Cbl-Interacting Protein of 85 kDa in the Development and Progression of Head and Neck Squamous Cell Carcinomas through the Ras-ERK Pathway

Neoplasia ◽  
2010 ◽  
Vol 12 (10) ◽  
pp. 789-IN4 ◽  
Author(s):  
Takahiro Wakasaki ◽  
Muneyuki Masuda ◽  
Hiroaki Niiro ◽  
Siamak Jabbarzadeh-Tabrizi ◽  
Kumiko Noda ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Critical Role ◽  
Squamous Cell Carcinomas ◽  
Erk Pathway ◽  
Interacting Protein

scholarly journals CONTROLLED RANDOMIZED CLINICAL TRIAL ON USING TALISADI TAILAM FOR TREATING PATIENTS OF TINEA PEDIS W.S.R TO ALASA

AYUSHDHARA ◽  
2021 ◽  
pp. 3104-3108
Author(s):  
Gupta Sudesh ◽  
Manhas Raman, Prasher Aarushi, Sharma Sakshi, Sharma Arun
Keyword(s):  
Clinical Trial ◽  
Clinical Study ◽  
Fungal Infection ◽  
Tinea Pedis ◽  
External Surface ◽  
Signs And Symptoms ◽  
The Body ◽  
Skin Disorders ◽  
Before And After ◽  
Athlete’S Foot

Skin is the general covering of the entire external surface of the body. Because of a large number of its functions, the skin is regarded as an important organ of the body. There are so many skin disorders of which Tenia pedis is a very common fungal infection that affects a significantly large number of people globally. This fungal infection is called Athlete’s foot because it is commonly seen in athletes. In Ayurveda, various skin disorders are described under the heading of kshudraroga. A brief description about Kshudraroga has been given in many Ayurvedic classics. Alasa is a variety of Kshudraroga occurring in between the skin of toes manifesting with Kleda, Kandu, Daha and Ruja. Talisadi tailam mentioned in Sushruta Samhita is an excellent formulation prepared of drugs which are effective against this disease. Current study includes 30 patients from OPD Department of Shalya Tantra, Jammu Institute of Ayurveda and Research, Jammu and Sri Sain Charitable Hospital, Janipur, Jammu diagnosed to have Tenia pedis based on signs and symptoms. Therapeutic effect was evaluated before and after treatment. The present clinical study has shown symptoms of Kandu, Daha, Ruja, Kleda significantly reduced after application of Talisadi tailam.

scholarly journals ERK1/2-EGR1-SRSF10 Axis Mediated Alternative Splicing Plays a Critical Role in Head and Neck Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Sandhya Yadav ◽  
Deepak Pant ◽  
Atul Samaiya ◽  
Neetu Kalra ◽  
Sanjay Gupta ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Alternative Splicing ◽  
Head And Neck ◽  
Neck Cancer ◽  
Splice Variants ◽  
Critical Role ◽  
Splicing Factor ◽  
Binding Motif ◽  
Cancer Pathogenesis

Aberrant alternative splicing is recognized to promote cancer pathogenesis, but the underlying mechanism is yet to be clear. Here, in this study, we report the frequent upregulation of SRSF10 (serine and arginine-rich splicing factor 10), a member of an expanded family of SR splicing factors, in the head and neck cancer (HNC) patients sample in comparison to paired normal tissues. We observed that SRSF10 plays a crucial role in HNC tumorigenesis by affecting the pro-death, pro-survical splice variants of BCL2L1 (BCL2 Like 1: BCLx: Apoptosis Regulator) and the two splice variants of PKM (Pyruvate kinase M), PKM1 normal isoform to PKM2 cancer-specific isoform. SRSF10 is a unique splicing factor with a similar domain organization to that of SR proteins but functions differently as it acts as a sequence-specific splicing activator in its phosphorylated form. Although a body of research studied the role of SRSF10 in the splicing process, the regulatory mechanisms underlying SRSF10 upregulation in the tumor are not very clear. In this study, we aim to dissect the pathway that regulates the SRSF10 upregulation in HNC. Our results uncover the role of transcription factor EGR1 (Early Growth Response1) in elevating the SRSF10 expression; EGR1 binds to the promoter of SRSF10 and promotes TET1 binding leading to the CpG demethylation (hydroxymethylation) in the adjacent position of the EGR1 binding motif, which thereby instigate SRSF10 expression in HNC. Interestingly we also observed that the EGR1 level is in the sink with the ERK1/2 pathway, and therefore, inhibition of the ERK1/2 pathway leads to the decreased EGR1 and SRSF10 expression level. Together, this is the first report to the best of our knowledge where we characterize the ERK 1/2-EGR1-SRSF10 axis regulating the cancer-specific splicing, which plays a critical role in HNC and could be a therapeutic target for better management of HNC patients.

scholarly journals The role of melatonin in ENT cancers: clinical study

2015 ◽  
Vol 10 (4) ◽  
pp. 388-393
Author(s):  
A. ZAMFIR-CHIRU-ANTON ◽  
◽  
C.R. POPESCU ◽  
D.C. GHEORGHE ◽  
◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Clinical Study ◽  
Adjuvant Therapy ◽  
Head And Neck ◽  
Serum Levels ◽  
Head And Neck Cancers ◽  
Normal Individuals

The objective of this study was to determine the serum levels of melatonine in patients presenting different head and neck cancers. We also studied the variations of hormone serum levels in comparison with normal individuals. By statistical analysis of the results, we hypothesized a possible adjuvant therapy for head and neck cancers.

scholarly journals An Updated Review on Head and Neck Cancer Treatment with Radiation Therapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4912
Author(s):  
Garrett Anderson ◽  
Maryam Ebadi ◽  
Kim Vo ◽  
Jennifer Novak ◽  
Ameish Govindarajan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Side Effects ◽  
Oral Cavity ◽  
Head And Neck ◽  
Multidisciplinary Approach ◽  
Critical Role ◽  
Optimal Management ◽  
Sinus Cavity

The complexity of head and neck cancers (HNC) mandates a multidisciplinary approach and radiation therapy (RT) plays a critical role in the optimal management of patients with HNC, either as frontline or adjuvant treatment postoperatively. The advent of both definitive and post-operative RT has significantly improved the outcomes of patients with HNC. Herein, we discuss the role of postoperative RT in different subtypes of HNC, its side effects, and the importance of surveillance. The treatment regions discussed in this paper are the oral cavity, nasopharynx, paranasal sinus cavity, oropharynx, larynx and hypopharynx. Multiple studies that demonstrate the importance of definitive and/or postoperative RT, which led to an improved outlook of survival for HNC patients will be discussed.

scholarly journals A COMPARATIVE CLINICAL STUDY ON THE ROLE OF KOISHORE GUGGULU WITH OR WITHOUT NITYA VIRECHANA IN THE MANAGEMENT OF VATARAK-TA W.S.R TO GOUT

2020 ◽  
Vol 08 (11) ◽  
pp. 4955-4959
Author(s):  
Alpana Majumder ◽  
P. B. Kar Mahapatra
Keyword(s):  
Clinical Study ◽  
Severe Pain ◽  
Signs And Symptoms ◽  
Medical System ◽  
The World ◽  
Comparative Clinical Study ◽  
Long Time ◽  
Group A ◽  
Group B

Objectives: Nowadays, so many diseases are found all over the world related to lifestyle disorder; Gout is one of them. According to different Ayurvedic books, Gout has been compared with ‘Vatarakta’, which is characterized by severe pain, redness, and tenderness in the joints. In other medical system, the medicine for this very disease is to be continued for a long time with so many side effects. Method: Total 40 patients of Gout with the evidence of Hyper Uricemia were selected for this trial and randomly categorized into two groups, Group A and Group B. Group A patients were treated with Koishore Guggul-500mg twice daily and Group B patients were treated with Koishore Guggul- 500mg twice daily along with Nitya Vrechan by Trivritavaleha 10gm daily at night. Trial was continued for 3 weeks. Result: Both groups showed highly significant result but the relief in signs and symptoms in group B was more significant than group A.

scholarly journals Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Liwei Lang ◽  
Fang Wang ◽  
Zhichun Ding ◽  
Xiangdong Zhao ◽  
Reid Loveless ◽  
...  
Keyword(s):  
Cell Survival ◽  
Head And Neck ◽  
Cancer Metabolism ◽  
Tricarboxylic Acid Cycle ◽  
Critical Role ◽  
Lactate Production ◽  
3D Scaffold ◽  
Culture Dish ◽  
Therapeutic Benefits

Abstract Background Alterations in metabolism are one of the emerging hallmarks of cancer cells and targeting dysregulated cancer metabolism provides a new approach to developing more selective therapeutics. However, insufficient blockade critical metabolic dependencies of cancer allows the development of metabolic bypasses, thus limiting therapeutic benefits. Methods A series of head and neck squamous cell carcinoma (HNSCC) cell lines and animal models were used to determine the efficacy of CPI-613 and CB-839 when given alone or in combination. Glutaminase 1 (GLS1) depletion was achieved by lentiviral shRNAs. Cell viability and apoptosis were determined in HNSCC cells cultured in 2D culture dish and SeedEZ™ 3D scaffold. Molecular alterations were examined by Western blotting and immunohistochemistry. Metabolic changes were assessed by glucose uptake, lactate production, glutathione levels, and oxygen consumption rate. Results We show here that HNSCC cells display strong addiction to glutamine. CPI-613, a novel lipoate analog, redirects cellular activity towards tumor-promoting glutaminolysis, leading to low anticancer efficacy in HNSCC cells. Mechanistically, CPI-613 inhibits the tricarboxylic acid cycle by blocking the enzyme activities of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, which upregulates GLS1 and eventually promotes the compensatory role of glutaminolysis in cancer cell survival. Most importantly, the addition of a GLS1 inhibitor CB-839 to CPI-613 treatment abrogates the metabolic dependency of HNSCC cells on glutamine, achieving a synergistic anticancer effect in glutamine-addicted HNSCC. Conclusions These findings uncover the critical role of GLS1-mediated glutaminolysis in CPI-613 treatment and suggest that the CB-839 and CPI-613 combination may potentiate synergistic anticancer activity for HNSCC therapeutic gain.

Autism - A Comprehensive Array of Prominent Signs and Symptoms

2021 ◽  
Vol 27 ◽  
Author(s):  
Muhammad Shahid Nadeem ◽  
Bibi Nazia Murtaza ◽  
Mariam A. Al-Ghamdi ◽  
Akbar Ali ◽  
Mazin A. Zamzami ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Present Report ◽  
Critical Role ◽  
Signs And Symptoms ◽  
Autism Spectrum ◽  
Psychological Therapies ◽  
Gastrointestinal Problems ◽  
Wide Range ◽  
Poor Cognitive Function ◽  
High Level

Background: Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition characterized by multiple psychological and physiological impairments in young children. According to the recent reports 1 out of every 58 newly born children is suffering from autism. The aetiology of disorder is complex and poorly understood, hindering the adaptation of targeted and effective therapies. There are no well-established diagnostic biomarkers for autism, hence the analysis of symptoms by the pediatricians play a critical role in the early intervention. Methods: In the present report we have emphasized on 24 behavioral, psychological and clinical symptoms of autism. Results: Impaired social interaction, restrictive and narrow interests, anxiety, depression; aggressive, repetitive, rigid and self-injurious behavior, lack of consistency, short attention span, fear, shyness and phobias, hypersensitivity and rapid mood alterations, high level of food and toy selectivity; inability to establish friendships or follow the instructions; fascination by round spinning objects and eating non-food materials are common psychological characteristics of autism. Speech or hearing impairments, poor cognitive function, gastrointestinal problems, weak immunity, disturbed sleep and circadian rhythms, weak motor neuromuscular interaction, lower level of serotonin and neurotransmitters, headache and body pain include common physiological symptoms. Conclusion: A variable qualitative and quantitative impact of these wide range of symptoms is perceived in each autistic individual making him/her distinct, incomparable and exceptional. Selection and application of highly personalized medical and psychological therapies are therefore recommended for the management and treatment of autism.

The Role of Mitochondria in the Genesis of Neuroaxonal Dystrophy in the Brains of Aging Mice

1975 ◽  
Vol 33 ◽  
pp. 372-373
Author(s):  
J.E. Johnson
Keyword(s):  
Electron Microscopy ◽  
Present Report ◽  
Light And Electron Microscopy ◽  
Dorsal Column ◽  
Neuroaxonal Dystrophy ◽  
Nucleus Gracilis ◽  
Dystrophic Axons ◽  
The Brain ◽  
Nucleus Cuneatus

Although neuroaxonal dystrophy (NAD) has been examined by light and electron microscopy for years, the nature of the components in the dystrophic axons is not well understood. The present report examines nucleus gracilis and cuneatus (the dorsal column nuclei) in the brain stem of aging mice.Mice (C57BL/6J) were sacrificed by aldehyde perfusion at ages ranging from 3 months to 23 months. Several brain areas and parts of other organs were processed for electron microscopy.At 3 months of age, very little evidence of NAD can be discerned by light microscopy. At the EM level, a few axons are found to contain dystrophic material. By 23 months of age, the entire nucleus gracilis is filled with dystrophic axons. Much less NAD is seen in nucleus cuneatus by comparison. The most recurrent pattern of NAD is an enlarged profile, in the center of which is a mass of reticulated material (reticulated portion; or RP).

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

2008 ◽  
Vol 15 (2) ◽  
pp. 50-59 ◽  
Author(s):  
Amy Philofsky
Keyword(s):  
Language Development ◽  
Critical Role ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Prevalence Estimates ◽  
Notable Increase ◽  
Screening Assessment ◽  
Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

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