Circulating Vitamin D and Risk of Epithelial Ovarian Cancer

We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59–2.01). In addition, there was no evidence of an interaction effect betweenVDRSNP genotype or haplotype and circulating 25(OH)D levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.

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Evidence of Differential Effects of Vitamin D Receptor Variants on Epithelial Ovarian Cancer Risk by Predicted Vitamin D Status

Frontiers in Oncology ◽

10.3389/fonc.2014.00286 ◽

2014 ◽

Vol 4 ◽

Cited By ~ 6

Author(s):

Jennifer Prescott ◽

Kimberly A. Bertrand ◽

Brett M. Reid ◽

Jennifer Permuth-Wey ◽

Immaculata De Vivo ◽

...

Keyword(s):

Ovarian Cancer ◽

Vitamin D ◽

Cancer Risk ◽

Epithelial Ovarian Cancer ◽

Vitamin D Receptor ◽

Ovarian Cancer Risk ◽

Vitamin D Status ◽

Differential Effects

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Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study

International Journal of Cancer ◽

10.1002/ijc.31062 ◽

2017 ◽

Vol 142 (3) ◽

pp. 534-539 ◽

Cited By ~ 1

Author(s):

Megan S. Rice ◽

Pamela M. Rist ◽

Anke C. Winter ◽

Tobias Kurth ◽

Shelley S. Tworoger

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Epithelial Ovarian Cancer ◽

Women’S Health ◽

Women's Health ◽

Health Study ◽

Ovarian Cancer Risk ◽

Invasive Epithelial Ovarian Cancer

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Anthropometric measures and epithelial ovarian cancer risk among Chinese women: results from the Shanghai Women’s Health Study

British Journal of Cancer ◽

10.1038/bjc.2013.384 ◽

2013 ◽

Vol 109 (3) ◽

pp. 751-755 ◽

Cited By ~ 23

Author(s):

X Ma ◽

A Beeghly-Fadiel ◽

X-O Shu ◽

H Li ◽

G Yang ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Epithelial Ovarian Cancer ◽

Women’S Health ◽

Women's Health ◽

Chinese Women ◽

Health Study ◽

Ovarian Cancer Risk ◽

Anthropometric Measures

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Vitamin D Receptor Gene Polymorphisms and Epithelial Ovarian Cancer Risk

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-07-0753 ◽

2007 ◽

Vol 16 (12) ◽

pp. 2566-2571 ◽

Cited By ~ 61

Author(s):

G. Lurie ◽

L. R. Wilkens ◽

P. J. Thompson ◽

K. E. McDuffie ◽

M. E. Carney ◽

...

Keyword(s):

Ovarian Cancer ◽

Vitamin D ◽

Cancer Risk ◽

Epithelial Ovarian Cancer ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Ovarian Cancer Risk ◽

Vitamin D Receptor Gene ◽

Receptor Gene Polymorphisms

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Does Time-to-Chemotherapy after Primary Complete Macroscopic Cytoreductive Surgery Influence Prognosis for Patients with Epithelial Ovarian Cancer? A Study of the FRANCOGYN Group

Journal of Clinical Medicine ◽

10.3390/jcm10051058 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1058

Author(s):

Grégoire Rocher ◽

Thomas Gaillard ◽

Catherine Uzan ◽

Pierre Collinet ◽

Pierre-Adrien Bolze ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Cytoreductive Surgery ◽

Retrospective Cohort ◽

Early Stage ◽

Cohort Analysis ◽

Recurrence Free Survival ◽

Advanced Stage ◽

Free Survival ◽

Retrospective Cohort Analysis

To determine if the time-to-chemotherapy (TTC) after primary macroscopic complete cytoreductive surgery (CRS) influences recurrence-free survival (RFS) and overall survival (OS) in patients with epithelial ovarian cancer (EOC). We conducted an observational multicenter retrospective cohort analysis of women with EOC treated from September 2006 to November 2016 in nine institutions in France (FRANCOGYN research group) with maintained EOC databases. We included women with EOC (all FIGO stages) who underwent primary complete macroscopic CRS prior to platinum-based adjuvant chemotherapy. Two hundred thirty-three patients were included: 73 (31.3%) in the early-stage group (ESG) (FIGO I-II), and 160 (68.7%) in the advanced-stage group (ASG) (FIGO III-IV). Median TTC was 43 days (36–56). The median OS was 77.2 months (65.9–106.6). OS was lower in the ASG when TTC exceeded 8 weeks (70.5 vs. 59.3 months, p = 0.04). No impact on OS was found when TTC was below or above 6 weeks (78.5 and 66.8 months, respectively, p = 0.25). In the whole population, TTC had no impact on RFS or OS. None of the factors studied were associated with an increase in TTC. Chemotherapy should be initiated as soon as possible after CRS. A TTC greater than 8 weeks is associated with poorer OS in patients with advanced stage EOC.

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Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer

Cancer Letters ◽

10.1016/j.canlet.2007.11.002 ◽

2008 ◽

Vol 260 (1-2) ◽

pp. 209-215 ◽

Cited By ~ 35

Author(s):

Tess V. Clendenen ◽

Alan A. Arslan ◽

Karen L. Koenig ◽

Kerstin Enquist ◽

Isaac Wirgin ◽

...

Keyword(s):

Ovarian Cancer ◽

Vitamin D ◽

Epithelial Ovarian Cancer ◽

Vitamin D Receptor

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Intake of specific carotenoids and the risk of epithelial ovarian cancer

British Journal Of Nutrition ◽

10.1017/s0007114507690011 ◽

2007 ◽

Vol 98 (1) ◽

pp. 187-193 ◽

Cited By ~ 19

Author(s):

Min Zhang ◽

C. D'Arcy J. Holman ◽

Colin W. Binns

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Contraceptive Use ◽

Hormone Replacement ◽

Menopausal Status ◽

Ovarian Cancer Risk ◽

Total Carotenoids ◽

Oral Contraceptive Use ◽

Tea Drinking ◽

Β Carotene

There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, few studies have examined the association between intake of specific carotenoids and the risk of epithelial ovarian cancer and the results for carotenoids have been inconclusive. To investigate whether the intake of α-carotene, β-carotene, β-cryptoxanthin, lutein and zeaxanthin, and lycopene is inversely associated with ovarian cancer risk, a case–control study was conducted in China during 1999–2000. The cases were 254 patients with histologically confirmed epithelial ovarian cancer and 652 age-matched controls were randomly recruited during the same period. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable FFQ. The US Department of Agriculture nutrient composition database was used to calculate the intake of specific carotenoids. Unconditional logistic regression analyses were used to estimate OR and 95 % CI, accounting for age, locality, education, BMI, smoking, tea drinking, parity, oral contraceptive use, hormone replacement therapy, menopausal status, family history of ovarian cancer, physical activity and energy intake. Compared with the highest v. the lowest quartile of intake, the adjusted OR were 0·39 (95 % CI 0·23, 0·66) for α-carotene, 0·51 (95 % CI 0·31, 0·84) for β-carotene, 0·51 (95 % CI 0·31, 0·83) for β-cryptoxanthin, 0·45 (0·27, 0·76) for lutein and zeaxanthin, and 0·33 (95 % CI 0·20, 0·56) for total carotenoids, with statistically significant tests for trend. It is concluded that a higher intake of carotenoids can reduce the risk of epithelial ovarian cancer.

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