scholarly journals Changes in Serum Lipids and Blood Glucose in Non Diabetic Patients with Metabolic Syndrome after Mixed Meals of Different Composition

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Adriana Branchi ◽  
Adriana Torri ◽  
Cristina Berra ◽  
Emanuela Colombo ◽  
Domenico Sommariva
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Serum Lipids ◽  
Hdl Cholesterol ◽  
Nutrient Composition ◽  
Diabetic Patients ◽  
Serum Triglycerides ◽  
Different Response ◽  
Design And Methods ◽  
Usual Diet

Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS−) metabolic syndrome.Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS− consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal.Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS− (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (−4% and −5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS−) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 μU/mL, 2 and 4:30 hours after the meal) than in MetS− (46.7 and 21.6 μU/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group.Conclusions. As compared with MetS−, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.

scholarly journals Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat

2009 ◽  
Vol 296 (1) ◽  
pp. E203-E210 ◽  
Author(s):  
Michele La Merrill ◽  
David S. Baston ◽  
Michael S. Denison ◽  
Linda S. Birnbaum ◽  
Daniel Pomp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Blood Glucose ◽  
Estrogenic Activity ◽  
Fasting Blood Glucose ◽  
Growth Spurt ◽  
Cancer Model ◽  
Serum Triglycerides ◽  
Cancer Models

Diets high in fat are associated with increased susceptibility to obesity and metabolic syndrome. Increased adipose tissue that is caused by high-fat diets (HFD) results in altered storage of lipophilic toxicants like 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), which may further increase susceptibility to metabolic syndrome. Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz[a]anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background. Pregnant mice dosed with 1 μg/kg of TCDD or vehicle on gestational day 12.5 were placed on a HFD or low-fat diet (LFD) at parturition. Body weights, percent body fat, and fasting blood glucose were measured longitudinally, and triglycerides were measured at study termination. On HFD, all cancer models reached the pubertal growth spurt ahead of FVB controls. Among mice fed HFD, the HER2 model had a greater increase in body weight and adipose tissue from puberty through adulthood compared with the PyMT and DMBA models. However, the DMBA model consistently had higher fasting blood glucose levels than the PyMT and HER2 models. TCDD only impacted serum triglycerides in the PyMT model maintained on HFD. Because the estrogenic activity of the HFD was three times lower than that of the LFD, differential dietary estrogenic activities did not drive the observed phenotypic differences. Rather, the HFD-dependent changes were cancer model dependent. These results show that cancer models can have differential effects on metabolic syndrome-associated phenotypes even before cancers arise.

scholarly journals Metabolic characteristics and nutrition intake on women with normal body mass index

Food Research ◽  
2020 ◽  
Vol 4 (S3) ◽  
pp. 6-12
Author(s):  
D.Y. Fitranti ◽  
F.F. Dieny ◽  
D.M. Kurniawati ◽  
R. Purwanti ◽  
B. Kusumaningnastiti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Normal Body Mass Index ◽  
Metabolic Characteristics ◽  
Low Hdl ◽  
Nutrition Intake

Metabolic syndrome can be found on an individual with normal weight (Metabolically Obese Normal Weight/MONW). Eating habits and lifestyle changing in early adulthood can be the risk of metabolic syndrome in person with a normal body mass index (BMI). The purpose of this study was to identify metabolic characteristics in women with normal BMI and to analyze the correlation of nutrition intake with metabolic syndrome on women with normal BMI. This is an observational study with a cross-sectional design at five offices in Semarang. The sample in this study was 64 subjects. Inclusion criteria of study subject were women aged 25-40 years and BMI <25 kg/m2 . Study subject was chosen by using a consecutive sampling method. The data of nutrition intake was obtained by using the Food Frequency Questionnaire. HDL cholesterol, fasting blood glucose and triglyceride were analyzed. Analysis data was conducted by using Pearson correlation and Rank Spearman. MONW was present in 10.9% and more than 50% had pre metabolic syndrome. A total of 51.6% of the subjects had central obese and 26.6% had low HDL cholesterol. About 14.1% of the subjects have hypertension. There was a positive correlation between energy, fat intake and waist circumference. Carbohydrate intake was positively correlated with fasting blood glucose and triglyceride. The higher protein intake, the higher HDL cholesterol. The most common indicator of metabolic syndrome on women with normal BMI was central obesity and low HDL cholesterol. The factors related to the prevalence of metabolic syndrome on women with normal BMI was macronutrient intake.

scholarly journals Heritability of the risk factors characteristic for the metabolic syndrome: a twin study

2011 ◽  
Vol 152 (32) ◽  
pp. 1265-1271 ◽  
Author(s):  
György Jermendy ◽  
Levente Littvay ◽  
Rita Steinbach ◽  
Ádám Jermendy ◽  
Ádám Tárnoki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Environmental Factors ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Anthropometric Parameters ◽  
Serum Triglycerides ◽  
The Metabolic Syndrome ◽  
Genetic And Environmental Factors

Both genetic and environmental factors play role in the pathogenesis of the metabolic syndrome. The magnitude of genetic and environmental influences on the components of metabolic syndrome may vary in different populations. Aims: The present study was aimed to determine the effects of genetic and environmental factors on risk factors characteristic for the metabolic syndrome. Methods: A total of 101 (63 monozygotic and 38 dizygotic) adult twin pairs (n = 202; mean age: 43.3±15.8 years) were investigated. Medical history was recorded and physical examination was carried out for each subject. Fasting venous blood samples were used for measuring laboratory parameters. The presented estimates include the heritability structural equation (A-C-E) model results. In Model-1, all presented parameters are age- and gender- corrected. In Model-2, parameters were corrected for age, gender, body mass index and waist circumference. Results: Heritability in waist circumference (as well as in other anthropometric parameters such as weight and height) was high (Model-1: 71.0–88.1%). Similarly, genetic factors had the highest proportion of total phenotypic variance in systolic and diastolic blood pressure (Model-2: 57.1% and 57.7%, respectively). Based on the results of Model-2, unique environmental factors dominate alterations in serum triglycerides values (55.9%) while shared environmental factors proved to be substantial in alterations of HDL-cholesterol and fasting blood glucose values (58.1% and 57.1%, respectively). Comparing the results of Model-1 and Model-2, the difference in A-C-E model varied from 0.0% to 17.1%, indicating that only a minor proportion of genetic and environmental influences can be explained by the effects of anthropometric parameters. Conclusions: Among adult Hungarian healthy people, genetic factors have substantial influence on waist circumference and blood pressure values while environmental factors dominate alterations in serum triglycerides, HDL-cholesterol and fasting blood glucose values. The different heritability of individual risk factors challenges the original unifying concept of the metabolic syndrome. The results may be useful for establishing and implementing primary cardiovascular prevention both at individual and population levels. Orv. Hetil., 2011, 152, 1265–1271.

scholarly journals Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity

2018 ◽  
Vol 2018 ◽  
pp. 1-12
Author(s):  
Diego Ortega-Pacheco ◽  
María Marcela Jiménez-Pérez ◽  
Jeanet Serafín-López ◽  
Juan Gabriel Juárez-Rojas ◽  
Arturo Ruiz-García ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Blood Glucose ◽  
Preventive Treatment ◽  
Normal Diet ◽  
Vanadyl Sulfate ◽  
Metabolic Effects ◽  
Diabetic Patients ◽  
Insulin Mimetic ◽  
Obese Rats

Background. Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hypoglycemic compound in animal and human studies showing effective insulin-mimetic properties. This characteristic encompasses several molecules that have beneficial pleiotropic effects. The aim was to determine the antiobesity, hypoglycemic, and hypolipidemic effects of VS on fructose-induced metabolic syndrome in aged rats. Material and Methods. Five groups of male Wistar rats were made, each with six rats: two groups with normal diet (ND) and three with high-fructose diet (HFD). The first ND group was treated with saline solution (SS), the second with VS; treatment for HFD groups was in the first group with SS, second with VS, and third with metformin. Weight, body mass index (BMI), blood glucose, and lipidic profile were measured; water, food, fructose and energy consumption were also determined. All parameters were compared among groups. Results and Discussion. Although obese rats treated with VS presented anorexia, oligodipsia, and a marked weight loss in the first two weeks. They recovered food and water intake in the third week with a slow recovery of some weight weeks later. VS normalized blood glucose level and decreased triglyceride and insulin levels in obese rats. These results suggest that vanadyl sulfate shows antiobesity, hypoglycemic, and hypolipidemic properties in old obese rats and could be useful as an alternative, additional, and potent preventive treatment for obesity and T2DM control in elderly obese and poorly controlled diabetic patients. Conclusion. VS could play an important role in the treatment of metabolic syndrome, contributing to a decrease in obesity and T2DM, through different ways, such as euglycemia, satiety, weight loss, and lipid profile optimization, among others. However, more research is needed to confirm this suggestion.

scholarly journals Lipid Abnormalities in the Natural History of Diabetes

2015 ◽  
Vol 16 (2) ◽  
pp. 83-88
Author(s):  
Muhammad Hafizur Rahman ◽  
Liaquat Ali
Keyword(s):  
Metabolic Syndrome ◽  
Natural History ◽  
Total Cholesterol ◽  
Fasting Glucose ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Family History Of Diabetes ◽  
History Of ◽  
Lipid Abnormalities ◽  
Design And Methods

Objective: To explore lipid abnormalities in normoglycemic first-degree diabetic relatives (FDRs) and prediabetic and diabetic subjects in the natural history of diabetes.Research design and methods: Thirty six impaired fasting glucose (IFG), 61 isolated impaired glucose tolerance (I-IGT), 64 combined IFG-IGT, 73 diabetic, and 32 FDRs along with 57 normoglycemic healthy controls without family history of diabetes in 1st degree relatives, were selected purposively following 2003 ADA cut-off values and 2006 WHO/IDF grouping. Anthropometry and blood pressure of the subjects were taken. Fasting and 2-h plasma glucose and HbA1C were measured. Fasting plasma triglyceride, total cholesterol and HDL cholesterol were measured by enzymatic colorimetric method.Results: Serum triglyceride was higher in IFG, I-IGT, IFG-IGT, diabetic and FDRs compared to Control [145 (59- 307), 128 (66-584), 166 (68-764), 161 (69-750) and 130 (81-281) vs. 108 (47-219) mg/dl, P<0.01, P<0.01, P<0.001, P<0.001 and P<0.05]. Total cholesterol was raised in IFG-IGT and diabetes compared to Control [185 (105-310), 185 (123-326) vs. 171 (101-235) mg/dl, P<0.05] and FDRs. But HDL did not differ among the groups. Prevalence of metabolic syndrome was higher in IFG, I-IGT, IFG-IGT and diabetes and FDRs than Control [55%, 38%, 57%, 58% and 36% vs. 15%, P<0.001, P<0.01, P<0.001, P<0.001 and P<0.05] and also in IFGIGT and diabetic compared to I-IGT and FDRs (P<0.05).Conclusions: Higher prevalence of metabolic syndrome and raised serum triglyceride is seen among diabetic, prediabetic and 1st degree diabetic-relatives. Total cholesterol and non-HDL cholesterol is raised only in IFG-IGT and diabetes, the more decompensated glycemic states.J MEDICINE July 2015; 16 (2) : 83-88

scholarly journals Daidzein-metabolising phenotypes in relation to serum lipids and uric acid in adults in Guangzhou, China

2010 ◽  
Vol 104 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Kaiping Guo ◽  
Bo Zhang ◽  
Chaogang Chen ◽  
Shigeto Uchiyama ◽  
Tomomi Ueno ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Lipids ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Present Cross Sectional Study ◽  
Usual Diet

Previous studies have suggested that daidzein's metabolites, equol andO-desmethylangolensin (O-DMA), rather than daidzein itself may contribute to the beneficial effects of soya foods in the prevention of CVD. The present study aims to assess the proportion of equol andO-DMA producers, and to compare differences in anthropometric factors, serum lipids, glucose and uric acid between producers and non-producers in Chinese adults aged 20–69 years. For the present cross-sectional study, 202 subjects (100 women and 102 men) were recruited. Twenty-four-hour urinary daidzein and its metabolites were determined in these subjects while on their usual diet and again after a 3-d isoflavone challenge. Fasting serum lipids, glucose and uric acid were examined on their usual diet. Three days of 24 h dietary recalls were used to assess dietary intakes. Of the 202 subjects, 27 (13·4 %) and 27 (13·4 %) excreted equol andO-DMA on their usual diet, and 101 (50 %) and 94 (46·5 %) produced equol andO-DMA after a load of 80 mg/d isoflavones. Equol producers showed lower serum uric acid ( − 10·2 %,P = 0·001), TAG ( − 29·5 %,P = 0·007) and waist:hip ratio ( − 2·6 %,P = 0·032), and tended to have higher HDL cholesterol (6·3 %,P = 0·069) compared with equol non-producers. There were no significant differences in serum lipids, glucose and uric acid betweenO-DMA producers and non-producers. In conclusion, equol phenotypes might influence cardiovascular risk.

scholarly journals HUBUNGAN KUALITAS TIDUR DENGAN 5 INDIKATOR SINDROMA METABOLIK PADA PERAWAT DI RUMAH SAKIT UMUM PUSAT HAJI ADAM MALIK MEDAN

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Simon Simon
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Sleep Quality ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
T Test ◽  
Human Beings ◽  
Glucose Content ◽  
Significant Difference

 ABSTRACTHigh death rate caused by non-transmitted diseases in the world is begun with metabolic syndrome in human beings such the increase in IMT (Body Mass Index) to be obesity, the increase in blood pressure to be hypertension, the increase in blood glucose to be diabetes mellitus, and abnormality of triglycerides, and  HDL cholesterol. Many factors which trigger the indicator abnormality, and of them is bad sleep quality. The research used cross sectional design by analyzing the correlation between sleep quality and 5 metabolic syndrome indicator in female nurses in the operation room of Adam Malik Medan hospital. Sleep quality was measured by using questionnaire of Pittsburg Sleep Quality Index (PSQI), body height and weight were measured to get IMT value, blood pressure was measured by using tensimeter, blood glucose and blood lipid were measured by getting the respondent’s vena blood samples. The data were processed and analysis with independent t-test.The result with independent t-test showed that there was significant difference in IMT (sig=0,003), systolic blood pressure (sig=0,028), and fasting blood glucose content (sig=0,00). However, there was no significant difference in trigliyceride content (sig=0,519), HDL cholesterol content (sig=0,300),). The conclusion was that sleep quality was correlated with three metabolic syndrome indicators: IMT, blood pressure, and blood glucose content, but there was no correlation with trigliyceride and HDL cholesterol.Keywords: Sleep Quality, Metabolic Syndrome , T-Test, 

scholarly journals No Association between Visfatin (NAMPT) Gene Variants and Metabolic Traits in the Newfoundland Population

2010 ◽  
Vol 3 ◽  
pp. GEG.S5337
Author(s):  
Jennifer L Shea ◽  
JC Loredo-Osti ◽  
Guang Sun
Keyword(s):  
Insulin Resistance ◽  
Serum Lipids ◽  
Additive Model ◽  
Hdl Cholesterol ◽  
Serum Glucose ◽  
Fat Percentage ◽  
Current Time ◽  
Insulin Mimetic ◽  
And Gender ◽  
Design And Methods

Objective Visfatin is a novel adipokine initially reported to exhibit insulin-mimetic effects that increase insulin sensitivity. Further studies indicate it may also be associated with obesity, serum lipids, and systemic inflammation. At the current time, the role of genetic variation in the visfatin gene (NAMPT) on these parameters is not clear. In the present study, we examined the association between 10 SNPs in NAMPT and insulin resistance, obesity, serum lipids and hsCRP levels. Research design and methods A total of 1838 subjects (413 men, 1425 women) were recruited from the ongoing CODING Study. All subjects were from the genetically homogenous population of Newfoundland and Labrador, Canada. BMI, waist circumference, waist-to-hip ratio, and body fat percentage (determined using DXA) were measured for all subjects. Serum glucose, insulin, HOMAIR, HOMAβ, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and hsCRP were also determined after a 12-hour fast. Ten SNPs in NAMPT were genotyped using TaqMan validated or functionally tested SNP genotyping assays including rs7789066 (A > G 5′ flanking region), rs3801266 (A > G intron), rs6963243 (G > C intron), rs2058539 (A > C intron), rs6947766 (C > T intron), rs4730153 (G > A intron), rs10808150 (G > A intron), rs2098291 (C > T intron), rs10953502 (T > C intron), and rs10953501 (A > G 3′ UTR). Results We observed no significant associations between any of the variants sites and any parameter of insulin resistance, body composition, serum lipids or hsCRP under an additive model with age and gender included as covariates. This was also true when both dominant and recessive models were applied. Conclusions Our results do not support a significant role for variations in NAMPT with differences in the measured variables in the Newfoundland population.

The Oslo Health Study: Soft drink intake is associated with the metabolic syndrome

2010 ◽  
Vol 35 (5) ◽  
pp. 635-642 ◽  
Author(s):  
Arne Torbjørn Høstmark
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Soft Drink ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Soft Drinks ◽  
Health Study ◽  
Regression Analyses ◽  
Serum Triglycerides ◽  
The Metabolic Syndrome

It has been reported that the frequency of cola intake (COLA) is positively associated with serum triglycerides and negatively associated with high-density-lioprotein (HDL) cholesterol, both components of the metabolic syndrome (MetS). The question now is whether noncola soft drink intake (NCOLA) is associated with MetS. Among the 18 770 participants in the Oslo Health Study, 5373 men and 6181 women had data on COLA and NCOLA and risk factors for MetS (except fasting glucose). Main MetS requirements are central obesity and 2 of the following: increased triglycerides, low HDL cholesterol, increased systolic or diastolic blood pressure, and elevated fasting blood glucose. The MetSRisk index was calculated to estimate many MetS components. Using regression analyses, the association between COLA (NCOLA) and MetS (MetSRisk) was studied. In young (aged 30 years), middle-aged (aged 40 and 45 years), and senior (aged 59 and 60 years) men and women, there was, in general, a positive correlation between COLA and MetSRisk, and between COLA and single MetS risk factors, except HDL cholesterol, which was negatively correlated. A less consistent picture was found for NCOLA. By regression analyses, after adjustment for sex, age, time since last meal, and use of sugar-sweetened soft drinks, a positive association between COLA (NCOLA) and MetSRisk (MetS) was still found. However, when also controlling for cheese, fatty fish, coffee, alcohol, smoking, physical activity, education, and birthplace, only the association with COLA remained significant, irrespective of the presence or absence of sugar. In conclusion, the self-reported intake frequency of soft drinks can be positively associated with MetS.

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