scholarly journals The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Gerry K. Schwalfenberg
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Back Pain ◽  
Chronic Diseases ◽  
Bone Health ◽  
Medical Literature ◽  
Muscle Growth ◽  
Morbidity And Mortality ◽  
Alkaline Ph

This review looks at the role of an alkaline diet in health. Pubmed was searched looking for articles on pH, potential renal acid loads, bone health, muscle, growth hormone, back pain, vitamin D and chemotherapy. Many books written in the lay literature on the alkaline diet were also reviewed and evaluated in light of the published medical literature. There may be some value in considering an alkaline diet in reducing morbidity and mortality from chronic diseases and further studies are warranted in this area of medicine.

Role of Dietary Calcium and Vitamin D in Alveolar Bone Health

1985 ◽  
pp. 591-595
Author(s):  
Gary S. Rogoff ◽  
Roger B. Galburt ◽  
Abraham E. Nizel
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Alveolar Bone ◽  
Dietary Calcium

scholarly journals Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 579 ◽  
Author(s):  
Mirian de la Puente Yagüe ◽  
Luis Collado Yurrita ◽  
Maria J. Ciudad Cabañas ◽  
Marioa A. Cuadrado Cenzual
Keyword(s):  
Vitamin D ◽  
Athletic Performance ◽  
Muscle Growth ◽  
Positive Influence ◽  
Sports Performance ◽  
Musculoskeletal Health ◽  
Wide Range ◽  
Low Levels ◽  
Injury Recovery

We are currently experiencing a vitamin D (VITD) deficiency pandemic across the world. Athletes have the same predisposition to low levels of vitamin D, the majority of its concentrations being below 20 ng/mL in a wide range of sports, especially in the winter months. Vitamin D is important in bone health, but recent research also points out its essential role in extraskeletal functions, including skeletal muscle growth, immune and cardiopulmonary functions and inflammatory modulation, which influence athletic performance. Vitamin D can also interact with extraskeletal tissues to modulate injury recovery and also influence the risk of infection. The data presented in this paper has triggered investigations in relation to the importance of maintaining adequate levels of vitamin D and to the possible positive influence supplementation has on immune and musculoskeletal functions in athletes, benefiting their performance and preventing future injuries. The objective of this review is to describe the latest research conducted on the epidemiology of vitamin D deficiency and its effects on sports performance and musculoskeletal health.

Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

2021 ◽  
Vol 15 (6) ◽  
pp. 1231-1233
Author(s):  
A. W. Khan ◽  
H. T. Hussain ◽  
Z.U. Mustafa ◽  
M. A. Qamar ◽  
M. A. Qamar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Morbidity And Mortality ◽  
P Value ◽  
Mortality And Morbidity ◽  
Severe Vitamin ◽  
Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

scholarly journals Vitamin D Supplementation in Sarcoidosis: A Double-Edged Sword

2021 ◽  
Author(s):  
Rishikesh Chandran ◽  
Lakshmi Nagendra ◽  
Shrikrishna Acharya ◽  
Giridhar Belur Hosmane ◽  
Vijith Shetty ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Bone Health ◽  
Calcium Metabolism ◽  
Vitamin D Supplementation ◽  
Osteoporosis Prevention ◽  
Hydroxyvitamin D ◽  
Severe Hypercalcemia ◽  
25 Hydroxyvitamin D

AbstractSarcoidosis is complicated by disordered vitamin D and calcium metabolism, which has important implications on disease activity and bone health. Although the majority of the patients with sarcoidosis are typically deficient in 25-hydroxyvitamin D, repletion of vitamin D is controversial in light of the hypercalcemia risk. Presently, there are no clear guidelines regarding vitamin D supplementation as a part of osteoporosis prevention in patients with vitamin D deficiency and sarcoidosis. We report a patient with sarcoidosis who presented with severe hypercalcemia following vitamin D supplementation and review the debated role of vitamin D supplementation in vitamin D-deficient sarcoid patients.

scholarly journals Minerals and vitamins in bone health: the potential value of dietary enhancement

2009 ◽  
Vol 101 (11) ◽  
pp. 1581-1596 ◽  
Author(s):  
Jean-Philippe Bonjour ◽  
Léon Guéguen ◽  
Cristina Palacios ◽  
Martin J. Shearer ◽  
Connie M. Weaver
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Dietary Supplementation ◽  
Fragility Fractures ◽  
Bone Diseases ◽  
Community Studies ◽  
Populations At Risk ◽  
Average Intake ◽  
Hard Evidence

Nutrition is important to bone health, and a number of minerals and vitamins have been identified as playing a potential role in the prevention of bone diseases, particularly osteoporosis. Despite this, there is currently no consensus on maximum levels to allow in food or as dietary supplements. The benefits of supplementation of populations at risk of osteoporosis with Ca and vitamin D are well established. Prolonged supplementation of Ca and vitamin D in elderly has been shown to prevent bone loss, and in some intervention studies to prevent fragility fractures. Although P is essential to bone health, the average intake is considered to be more than sufficient and supplementation could raise intake to adverse levels. The role of vitamin K in bone health is less well defined, though it may enhance the actions of Ca and vitamin D. Sr administered in pharmacological doses as the ranelate salt was shown to prevent fragility fractures in postmenopausal osteoporosis. However, there is no hard evidence that supplementation with Sr salts would be beneficial in the general population. Mg is a nutrient implicated in bone quality, but the benefit of supplementation via foodstuffs remains to be established. A consensus on dietary supplementation for bone health should balance the risks, for example, exposure of vulnerable populations to values close to maximal tolerated doses, against evidence for benefits from randomised clinical trials, such as those for Ca and vitamin D. Feedback from community studies should direct further investigations and help formulate a consensus on dietary supplementation for bone health.

scholarly journals Vitamin D: current status and perspectives

2009 ◽  
Vol 47 (2) ◽  
Author(s):  
Etienne Cavalier ◽  
Pierre Delanaye ◽  
Jean-Paul Chapelle ◽  
Jean-Claude Souberbielle
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bone Health ◽  
Active Metabolite ◽  
Current Status ◽  
25 Oh Vitamin D

AbstractThe role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH)Clin Chem Lab Med 2009;47:120–7.

scholarly journals Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health?

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 628 ◽  
Author(s):  
Patrizia D’Amelio ◽  
Luca Quacquarelli
Keyword(s):  
Vitamin D ◽  
Chronic Diseases ◽  
Older Adult ◽  
Adult Population ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Brain Health ◽  
Old Patients ◽  
Older Adult Population

The older-adult population is constantly increasing, hence aging and mechanisms leading to aging are a topic raising increasing interest. Hypovitaminosis D is common amongst old patients and has been proposed as causative of several chronic diseases. Here we review the role of hypovitaminosis D and vitamin D supplementation in sarcopenia and dementia, from bench to bedside.

scholarly journals Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

2018 ◽  
Vol 54 (03) ◽  
pp. 153-159
Author(s):  
Bushra Parveen ◽  
Manjari Tripathi ◽  
Divya Vohora
Keyword(s):  
Vitamin D ◽  
Sodium Valproate ◽  
Bone Health ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Indian Women ◽  
25 Hydroxy Vitamin D ◽  
Wnt Inhibitors ◽  
Dickkopf 1

ABSTRACT Background: Antiepileptic drug (AED) therapy has been claimed to deteriorate bone health. Majority of the research was inclined towards vitamin-D deficiency as the patho-mechanism. However, after the role of Wnt in bone metabolism was discovered, it has paved way for investigating the role of Wnt inhibitors in mediating effects on bone accrual. Recently, we have reported the modulation of two Wnt inhibitors, sclerostin and dickkopf-1 (DKK-1), following AED therapy in Indian women with epilepsy, however, the subgroup analysis for individual drug is elucidated in this report. Methods: Individual analysis for our earlier cross-sectional study on three AEDs, carbamazepine (CBZ), sodium valproate (SVP) and levetiracetam (LTM), on sclerostin and dickkopf-1, and their correlation with receptor activator of nuclear factor kappaB ligand (RANKL) and serum 25-hydroxy vitamin D (25OHD) was assessed in Indian women with epilepsy. Results: We observed enhanced sclerostin and 25OHD levels with all three AEDs while serum RANKL was higher with SVP and LTM only. Further, serum DKK-1 levels were lowered with CBZ and LTM. Sclerostin showed a positive correlation with RANKL in CBZ group, while DKK-1 presented no such relationship. Conclusion: As sclerostin is more specific than DKK-1, we may conclude that these drugs may compromise bone health through disturbance in Wnt signaling mechanisms.

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