scholarly journals Raman Microimaging Using a Novel Multifiber-Based Device: A Feasibility Study on Pharmaceutical Tablets

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Sana Tfaili ◽  
Cyril Gobinet ◽  
Jean-François Angiboust ◽  
Michel Manfait ◽  
Olivier Piot
Keyword(s):  
Real Time ◽  
Spatial Resolution ◽  
Biomedical Applications ◽  
Biological Tissues ◽  
Imaging Device ◽  
Analytical Technique ◽  
Pharmaceutical Tablets ◽  
Pharmaceutical Applications ◽  
Health Field ◽  
Portable Raman

Raman microimaging is a potential analytical technique in health field and presents many possible pharmaceutical applications. In this study, we tested a micrometer spatial resolution probe coupled to a portable Raman imager via an indexed multifiber bundle. At the level of the probe, the fibers were arranged in a circular geometry in order to fit to the pupil of an objective. The imaging potential of this Raman system was assessed on pharmaceutical-like pellets. We showed that this setup permits to record, nearly in real time, Raman images with a micrometer resolution. The collected images revealed a marked heterogeneity in chemicals distribution. Further investigations will be led on cells and biological tissues to evaluate the potential of this Raman imaging device for biomedical applications.

scholarly journals UV/Vis absorption spectroelectrochemistry of folic acid

2021 ◽  
Author(s):  
F. Olmo ◽  
A. Rodriguez ◽  
A. Colina ◽  
A. Heras
Keyword(s):  
Folic Acid ◽  
Optical Signal ◽  
Oxidation Products ◽  
Basic Medium ◽  
Analytical Technique ◽  
Pharmaceutical Tablets ◽  
Solution Interface ◽  
Vitamin B9 ◽  
Analytical Protocol ◽  
Parallel Configuration

AbstractUV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry.

scholarly journals Unsupervised Sub-Pixel Water Body Mapping with Sentinel-3 OLCI Image

2019 ◽  
Vol 11 (3) ◽  
pp. 327 ◽  
Author(s):  
Xia Wang ◽  
Feng Ling ◽  
Huaiying Yao ◽  
Yaolin Liu ◽  
Shuna Xu
Keyword(s):  
Surface Water ◽  
Real Time ◽  
Spatial Resolution ◽  
Water Body ◽  
Land Surface ◽  
Clustering Algorithm ◽  
Body Mapping ◽  
Water Index ◽  
Land Surface Water ◽  
Body Map

Mapping land surface water bodies from satellite images is superior to conventional in situ measurements. With the mission of long-term and high-frequency water quality monitoring, the launch of the Ocean and Land Colour Instrument (OLCI) onboard Sentinel-3A and Sentinel-3B provides the best possible approach for near real-time land surface water body mapping. Sentinel-3 OLCI contains 21 bands ranging from visible to near-infrared, but the spatial resolution is limited to 300 m, which may include lots of mixed pixels around the boundaries. Sub-pixel mapping (SPM) provides a good solution for the mixed pixel problem in water body mapping. In this paper, an unsupervised sub-pixel water body mapping (USWBM) method was proposed particularly for the Sentinel-3 OLCI image, and it aims to produce a finer spatial resolution (e.g., 30 m) water body map from the multispectral image. Instead of using the fraction maps of water/non-water or multispectral images combined with endmembers of water/non-water classes as input, USWBM directly uses the spectral water index images of the Normalized Difference Water Index (NDWI) extracted from the Sentinel-3 OLCI image as input and produces a water body map at the target finer spatial resolution. Without the collection of endmembers, USWBM accomplished the unsupervised process by developing a multi-scale spatial dependence based on an unsupervised sub-pixel Fuzzy C-means (FCM) clustering algorithm. In both validations in the Tibet Plate lake and Poyang lake, USWBM produced more accurate water body maps than the other pixel and sub-pixel based water body mapping methods. The proposed USWBM, therefore, has great potential to support near real-time sub-pixel water body mapping with the Sentinel-3 OLCI image.

scholarly journals Pharmaceutical applications of citric acid

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sopan Nangare ◽  
Yogini Vispute ◽  
Rahul Tade ◽  
Shailesh Dugam ◽  
Pravin Patil
Keyword(s):  
Citric Acid ◽  
Biomedical Applications ◽  
Antioxidant Systems ◽  
Coating Agent ◽  
Branched Polymer ◽  
Pharmaceutical Applications ◽  
Buffering Agent ◽  
Animal Metabolism ◽  
Polymer Capping ◽  
Flavoring Agent

Abstract Background Citric acid (CA) is a universal plant and animal-metabolism intermediate. It is a commodity chemical processed and widely used around the world as an excellent pharmaceutical excipient. Notably, CA is offering assorted significant properties viz. biodegradability, biocompatibility, hydrophilicity, safety, etc. Therefore, CA is broadly employed in many sectors including foodstuffs, beverages, pharmaceuticals, nutraceuticals, and cosmetics as a flavoring agent, sequestering agent, buffering agent, etc. From the beginning, CA is a regular ingredient for cosmetic pH-adjustment and as a metallic ion chelator in antioxidant systems. In addition, it is used to improve the taste of pharmaceuticals such as syrups, solutions, elixirs, etc. Furthermore, free CA is also employed as an acidulant in mild astringent preparations. Main text In essence, it is estimated that the functionality present in CA provides excellent assets in pharmaceutical applications such as cross-linking, release-modifying capacity, interaction with molecules, capping and coating agent, branched polymer nanoconjugates, gas generating agent, etc. Mainly, the center of attention of the review is to deliver an impression of the CA-based pharmaceutical applications. Conclusion In conclusion, CA is reconnoitered for multiple novels pharmaceutical and biomedical/applications including as a green crosslinker, release modifier, monomer/branched polymer, capping and coating agent, novel disintegrant, absorption enhancer, etc. In the future, CA can be utilized as an excellent substitute for pharmaceutical and biomedical applications. Graphical abstract

scholarly journals Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1972
Author(s):  
Agnieszka Gierej ◽  
Thomas Geernaert ◽  
Sandra Van Vlierberghe ◽  
Peter Dubruel ◽  
Hugo Thienpont ◽  
...  
Keyword(s):  
Systematic Review ◽  
Optical Fibers ◽  
Optical Waveguides ◽  
Biomedical Applications ◽  
State Of The Art ◽  
Chemical Properties ◽  
Biological Tissues ◽  
Biodegradable Materials ◽  
Essential Properties ◽  
Optically Transparent

The limited penetration depth of visible light in biological tissues has encouraged researchers to develop novel implantable light-guiding devices. Optical fibers and waveguides that are made from biocompatible and biodegradable materials offer a straightforward but effective approach to overcome this issue. In the last decade, various optically transparent biomaterials, as well as different fabrication techniques, have been investigated for this purpose, and in view of obtaining fully fledged optical fibers. This article reviews the state-of-the-art in the development of biocompatible and biodegradable optical fibers. Whilst several reviews that focus on the chemical properties of the biomaterials from which these optical waveguides can be made have been published, a systematic review about the actual optical fibers made from these materials and the different fabrication processes is not available yet. This prompted us to investigate the essential properties of these biomaterials, in view of fabricating optical fibers, and in particular to look into the issues related to fabrication techniques, and also to discuss the challenges in the use and operation of these optical fibers. We close our review with a summary and an outline of the applications that may benefit from these novel optical waveguides.

scholarly journals Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1876
Author(s):  
Lorenzo Marsili ◽  
Michele Dal Bo ◽  
Federico Berti ◽  
Giuseppe Toffoli
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Biological Tissues ◽  
Special Focus ◽  
Thermoresponsive Polymers ◽  
Basic Principles ◽  
Natural Polysaccharide ◽  
Non Covalent Interactions ◽  
Covalent Interactions ◽  
Or Applications

Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent times, chitosan has been used for the preparation of graft copolymers with thermoresponsive polymers such as poly-N-vinylcaprolactam (PNVCL) and poly-N-isopropylamide (PNIPAM), allowing the combination of the biodegradability of the natural polymer with the ability to respond to changes in temperature. Due to the growing interest in the utilization of thermoresponsive polymers in the biological context, it is necessary to increase the knowledge of the key principles of thermoresponsivity in order to obtain comparable results between different studies or applications. In the present review, we provide an overview of the basic principles of thermoresponsivity, as well as a description of the main polysaccharides and thermoresponsive materials, with a special focus on chitosan and poly-N-Vinyl caprolactam (PNVCL) and their biomedical applications.

scholarly journals Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7185
Author(s):  
Oliver Gould ◽  
Natalia Drabińska ◽  
Norman Ratcliffe ◽  
Ben de Lacy Costello
Keyword(s):  
Mass Spectrometry ◽  
Volatile Compounds ◽  
Real Time ◽  
Qualitative Data ◽  
Method Development ◽  
Complex Matrices ◽  
Analytical Technique ◽  
Monitoring Drug ◽  
Highly Sensitive ◽  
Insight Into

Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has resulted in numerous variations of the technique being developed over the years, which can be divided into hyphenated and real-time MS techniques. Hyphenated chromatographic techniques coupled with MS offer unparalleled qualitative analysis and high accuracy and sensitivity, even when analysing complex matrices (breath, urine, stool, etc.). However, these benefits are traded for a significantly longer analysis time and a greater need for sample preparation and method development. On the other hand, real-time MS techniques offer highly sensitive quantitative data. Additionally, real-time techniques can provide results in a matter of minutes or even seconds, without altering the sample in any way. However, real-time MS can only offer tentative qualitative data and suffers from molecular weight overlap in complex matrices. This review compares hyphenated and real-time MS methods and provides examples of applications for each technique for the detection of VCs from humans.

scholarly journals A Simulation of a Novel High Quantum Efficiency Scintillating Fiber Detector with Anti-scatter Properties for Megavoltage X-Ray Imaging

2021 ◽  
Author(s):  
James Day
Keyword(s):  
Spatial Resolution ◽  
Detection Efficiency ◽  
Original Design ◽  
High Quantum Efficiency ◽  
Imaging Device ◽  
X Ray ◽  
Image Guided Radiation Therapy ◽  
X Ray Imaging ◽  
High Detection Efficiency ◽  
Square Array

To further develop a MV x-ray portal imaging device with high detection efficiency and adequate spatial resolution for image guided radiation therapy, the experimental results for a prototype detector were matched using Monte-Carlo software to then improve upon the design. The simulation and experiment were carried out using a 6 MV beam from a linear accelerator machine. An adequate match was obtained with the spatial resolution matching up to a MTF value of 0.2 and then diverging and the total signal registered in the central fiber was matched for field sizes ranging from 3 cm by 3 cm to 20 cm by 20 cm for 5 cm, 15 cm and 25 cm air gaps within 3%. The design was altered from a hexagonal array of round double cladded fibers to a square array of single cladded square fibers. The spatial resolution was improved from 0.242 lp mm-1 to 0.359 lp mm-1 at an MTF value of 0.5 from the original design to a square array of square fibers 0.5 mm wide separated by 0.25 mm of lead foil. With further optimization of the detector design it may be possible to increase spatial resolution for MV x-ray imaging while maintaining an adequate detection efficiency.

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