The Relationship betweenH. pyloriInfection and Osteoporosis in Japan

Background and Objective.H. pyloriinfection causes a chronic inflammation in the gastric mucosa. However, this local inflammation may result in extra-digestive conditions. Our aim is to investigate the relationship betweenH. pyloriinfection and osteoporosis in Japan.Methods. This cross-sectional study was conducted among outpatients at the Juntendo University Hospital between 2008 and 2014. Participants for patient profile,H. pyloriinfection status, comorbidity, internal medical therapies, lumbar dual-energy X-ray absorptiometry (DXA), and bone turnover marker were collected and upper gastrointestinal endoscopy for reflux esophagitis, hiatal hernia, peptic ulcer disease (PUD), and endoscopic gastric mucosal atrophy (EGA) was performed. The diagnosis of osteoporosis was performed in accordance with the Japanese criteria. We investigated risk factors of osteoporosis.Results. Of the eligible 200 study subjects, 41 cases were of osteoporosis. Bivariate analysis showed that age, being female, BMI, alcohol, smoking,H. pylori, bone-specific ALP, PUD, and EGA were related to osteoporosis. Multivariate analysis showed that age (OR 1.13; 95%CI 1.07–1.20), being female (OR 4.77; 95%CI 1.78–12.77), BMI (OR 0.79; 95%CI 0.68–0.92),H. pylori(OR 5.33; 95%CI 1.73–16.42), and PUD (OR 4.98; 95%CI 1.51–16.45) were related to osteoporosis.Conclusions.H. pyloriinfection may be a risk factor of osteoporosis in Japan.

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Could gastric histology be a useful marker for making decision on Helicobacter pylori eradication therapy in patients with dyspepsia?

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032009000300013 ◽

2009 ◽

Vol 46 (3) ◽

pp. 209-213 ◽

Cited By ~ 2

Author(s):

Severino Marcos Borba de Arruda ◽

Nora Manoukian Forones ◽

Norma Thomé Jucá ◽

Kátia Simone Cezário de Barros

Keyword(s):

Helicobacter Pylori ◽

Functional Dyspepsia ◽

Eradication Therapy ◽

Cross Sectional Study ◽

University Hospital ◽

Upper Gastrointestinal Endoscopy ◽

Serological Tests ◽

Cross Sectional ◽

Helicobacter Pylori Eradication ◽

H Pylori

CONTEXT: It still remains an open debate whether Helicobacter pylori eradication is beneficial or not for the improvement of symptoms in functional dyspepsia. Differences in geographic distribution, the worldwide H. pylori genetic variability and the fact that the outcome of infection is strongly related to the virulence of the infecting strain are factors that might be driving ongoing controversies. OBJECTIVE: To study the correlation between gastric histology and H. pylori serology status in patients with dyspepsia. METHODS: This is a cross-sectional study where 40 consecutive dyspeptic patients (28 women and 12 men, mean age 48.5 years) with endoscopically normal stomachs were selected from the endoscopy unit at a university hospital in Recife, PE, Northeast of Brazil, between March 1998 and July 1999. Patients underwent gastric mucosal biopsy and serological tests (anti-Hp and anti-CagA antibodies). Gastric biopsies were examined using H-E and Giemsa stains and gastritis was classified and graded (mild, moderate or severe) according to "the updated Sydney System - Houston, 1994". RESULTS: Among 40 patients with dyspepsia the gastric histology revealed that about ¼ had moderate (25%) or severe (2.5%) gastritis. This subgroup of patients also had a greater positive frequency of anti-Hp (100% vs 41%; P = 0.0005) and anti-CagA (91% vs 58%; P = 0.09) antibodies when compared with those with normal histology (27.5%) or mild gastritis (45%). CONCLUSION: Since upper gastrointestinal endoscopy is part of the functional dyspepsia investigation and serology for anti-CagA antibody is not available in daily clinical practice, by biopsying gastric mucosa we would only be able to selectively apply H. pylori eradication therapy for those with histology that best correlate with virulent infecting strains (moderate or severe gastritis) - around ¼ of our study patients with dyspepsia.

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The number of household members as a risk factor for peptic ulcer disease

Scientific Reports ◽

10.1038/s41598-021-84892-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mi Hong Yim ◽

Keun Ho Kim ◽

Bum Ju Lee

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Living Alone ◽

Cross Sectional ◽

Ulcer Disease ◽

Logistic Regression Models ◽

Household Members ◽

H Pylori

AbstractPeptic ulcer disease (PUD) is caused by many sociodemographic and economic risk factors other than H. pylori infection. However, no studies reported an association between PUD and the number of household members. We showed the number of family members affected by PUD based on sex in a Korean population. This cross-sectional study used 1998–2009 data from the Korea National Health and Nutrition Examination Survey of the Korea Centers for Disease Control and Prevention. Multiple binary logistic regression models adjusted for confounders were constructed to analyze the association of PUD with the number of household members. The number of household members was associated with PUD, age, body mass index (BMI), waist circumference, systolic blood pressure, hemoglobin, glucose, location (urban/rural), income, education level, stress, current drinking, and smoking in both sexes. Men with other household members had a higher PUD risk compared to men or women living alone (reference), and the opposite was observed for women. Men with 4 household members had a higher PUD risk than men living alone in the model adjusted for age, BMI, income, location, education, and stress (OR = 2.04 [95% CI 1.28–3.27], p value = .003). Women with more than 6 household members had a lower PUD risk than women living alone in the adjusted model (OR = 0.50 [0.33–0.75], p value = .001). Women with more household members had a lower PUD risk. However, more men had PUD than women regardless of the number of household members.

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Psychopathological Factors Associated With Burnout in Intensive Care Nurses: A Cross-Sectional Study

Journal of the American Psychiatric Nurses Association ◽

10.1177/1078390321999725 ◽

2021 ◽

pp. 107839032199972

Author(s):

Erman Yıldız

Keyword(s):

Intensive Care ◽

Emotional Exhaustion ◽

Cross Sectional Study ◽

Personal Accomplishment ◽

University Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

Anxiety Depression ◽

The Relationship

BACKGROUND: Although previous studies have separately revealed that parameters such as anxiety, depression, and secondary traumatic stress (STS) are associated with burnout, there is still a limited understanding of the relationship between anxiety, depression, and STS and burnout in intensive care unit (ICU) nurses. AIMS: To investigate the relationship between levels of burnout, anxiety, depression, and STS in ICU nurses. METHOD: A cross-sectional study was conducted with ICU nurses ( N = 164) from a university hospital in eastern Turkey. The participants completed the anxiety, depression, STS, and burnout scales along with the descriptive characteristics form. The data were analyzed using descriptive statistics, correlation, and logistic regression analysis. RESULTS: The mean scores for STS, anxiety, depression, and burnout were 40.60 ± 13.77, 17.14 ± 12.90, 13.28 ± 9.75 and 41.39 ± 14.87, respectively. The results showed that, in the ICU nurses, anxiety, depression, and STS components explained 61% of emotional exhaustion, 38% of depersonalization, and 13% of personal accomplishment. CONCLUSIONS: While the present findings supported the paradigm that burnout in ICU nurses is associated with STS, anxiety, and depression, they also revealed some details about the psychopathological factors associated with burnout. These details were as follows: (1) individuals who resorted to avoidance as a component of STS on a high level were more likely to experience emotional exhaustion and depersonalization, (2) individuals with severe depressive symptoms were more likely to experience a decrease in their personal accomplishment, and (3) individuals with anxiety symptoms were more likely to experience both emotional exhaustion and personal accomplishment.

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Relationship between Number and Order of Children with Exclusive Breastfeeding Practices in Surakarta

Smart Society Empowerment Journal ◽

10.20961/ssej.v1i1.48533 ◽

2021 ◽

Vol 1 (1) ◽

pp. 7

Author(s):

Vivienne Tjung ◽

Husnia Auliyatul Umma ◽

Jarot Subandono

Keyword(s):

Exclusive Breastfeeding ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Chi Square ◽

Cross Sectional ◽

Number Of Children ◽

Breastfeeding Practices ◽

Analysis Technique ◽

The Relationship ◽

Breastfeeding Practice

Introduction: Exclusive breast milk is breastfeeding for six months to babies, without providing other foods and drinks. Breastfeeding for up to 6 months is recommended by various health organizations, including the Ministry of Health. In Indonesia, exclusive breastfeeding is still low, even though the benefits of breastfeeding are numerous. Various studies that have been conducted have shown different results regarding the relationship between the number and sequence of children with breastfeeding practices. This study aimed to determine the relationship between the number of children and the order of the children with the practice of exclusive breastfeeding in SurakartaMethods: This study was an analytic observational study with a cross-sectional study design. The research sample was determined by random sampling of mothers registered at the Penumping Health Center. The research sample consisted of 50 people who have children aged 1-5 years. Assessment of completeness of breastfeeding was measured using a questionnaire. Data were analyzed using bivariate analysis techniques using chi-square and multivariate logistic regression.Results and discussions: From 47 subjects studied with the bivariate analysis technique using the chi square between the number of children and the order of children with exclusive breastfeeding practice, the results were less significant, p = 0.724 and p = 0.401.Conclusion: There was no significant relationship between the number of children and the order of children with the practice of exclusive breastfeeding in Surakarta.Keywords: Exclusive breastfeeding, number of children, order of children.

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Obesity in Pregnant Adolescents: Clinical Correlates, Maternal and Fetal Outcomes

Global Journal of Medical Research ◽

10.34257/gjmrevol20is4pg17 ◽

2020 ◽

pp. 17-25

Author(s):

Cecília Ogando Alfama ◽

Amanda Vilaverde Perez ◽

Mariana Sbaraini ◽

Marianna Sperb ◽

Rafaela da Silveira Corrêa ◽

...

Keyword(s):

Gestational Hypertension ◽

Cross Sectional Study ◽

University Hospital ◽

Sectional Study ◽

Pregnant Adolescents ◽

Fetal Outcomes ◽

Cross Sectional ◽

The Relationship ◽

Weight Excess ◽

Lower Adherence

Objective: To evaluate the relationship between pregestational obesity and maternal and fetal outcomes in pregnant adolescents. Methods: Cross-sectional study conducted among puerperal teenagers of a university hospital in Southern Brazil. Structured questionnaires on sociodemographic and obstetric data were applied. Results: We evaluated 500 puerperal adolescents with a mean age of 17.77± 1.36. Of these, 31.2% (n=156) had pregestational weight excess. Pregestational weight excess was significantly associated with gestational hypertension (p=0.037) and diabetes (p=0.045), cesarean delivery (p=0.040),and lower adherence to prenatal care (24.7%, p=0.007).

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Lactate dehydrogenase level as an early predictor of transient tachypnea of the newborn duration and complications

10.21203/rs.3.rs-119294/v1 ◽

2020 ◽

Author(s):

Mada Osefori ◽

Leen Jamel Doya ◽

Bana Nezha ◽

Adnan Dayoub

Keyword(s):

Intensive Care ◽

Lactate Dehydrogenase ◽

Neonatal Intensive Care ◽

Lactate Dehydrogenase Level ◽

Cross Sectional Study ◽

Postnatal Period ◽

University Hospital ◽

Cross Sectional ◽

Duration Of Hospitalization ◽

The Relationship

Abstract Background: Transient tachypnea of the newborn(TTNB) is a common cause of respiratory distress in the postnatal period. It is rarely associated with serious complications that need intensive care. Prediction of the complications during the first hours of hospitalization is very difficult, so the purpose of the current study is to investigate the relationship between lactate dehydrogenase (LDH) level in blood and the course of Transient tachypnea of the newborn (the duration of hospitalization, and the incidence of complications).Material and methods: In a cross-sectional study design included 120 neonates with Transient tachypnea of the newborn who had referred to the Neonatal Intensive Care Unit (NICU) at Tishreen University Hospital over 1 year period from January 2018 to January 2019. The neonates were classified according to Lactate dehydrogenase measurement as normal or high lactate dehydrogenase level in blood.Results: The results showed that there was a significant relationship between the level of lactate dehydrogenase and the duration of hospitalization, the incidence of complications, and the frequency of complications.Conclusions: lactate dehydrogenase might be useful for clinicians to predict the duration of hospitalization and the incidence of complications in neonates with TTNB.

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Perbedaan Prevalensi Infeksi Helicobacter pylori antara Etnis Tionghoa dan Dayak dengan Sindrom Dispepsia

Jurnal Penyakit Dalam Indonesia ◽

10.7454/jpdi.v3i1.5 ◽

2017 ◽

Vol 3 (1) ◽

pp. 29

Author(s):

Willy Brodus Uwan ◽

Ari Fahrial Syam ◽

C Rinaldi A. Lesmana ◽

Cleopas Martin Rumende

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

Native People ◽

Bivariate Analysis ◽

Infection Prevalence ◽

Chi Square ◽

Cross Sectional ◽

Endoscopic Findings ◽

H Pylori ◽

Epidemiological Characteristics

Pendahuluan. Risiko infeksi Helicobacter pylori (H. pylori) dikaitkan dengan banyak faktor yang terkait dengan pejamuagen-lingkungan. Etnis adalah salah satu faktor dari pejamu yang banyak diteliti di luar negeri. Prevalensi infeksi H. pylori didapatkan lebih tinggi pada etnis tertentu seperti misalnya di Cina. Berdasarkan teori migrasi dan teori transmisi, diduga infeksi H. pylori akan dibawa oleh penduduk yang bermigrasi dari daerah dengan prevalensi tinggi ke tempat tujuan migrasi. Etnis Tionghoa di Kalimantan Barat berasal dari daerah Cina Selatan dengan prevalensi infeksi H.pylori tinggi. Diperkirakan ada perbedaan angka prevalensi infeksi H. pylori pada etnis Tionghoa dibandingkan pada etnis asli Kalimantan Barat, yaitu etnis Dayak. Penelitian ini dilakukan untuk mengetahui perbedaan angka prevalensi, karakteristik epidemiologis dan gambaran hasil pemeriksaan endoskopi pada subjek etnis Tionghoa dan Dayak dengan sindrom dispepsia.Metode. Penelitian ini menggunakan studi potong lintang untuk mengetahui perbedaan angka prevalensi infeksi H.pylori. Penelitian dilakukan di RSU Santo Antonius Pontianak dari bulan Desember 2014 sampai Juni 2015 dengan metode pengambilan sampel secara consecutive sampling. Angka prevalensi infeksi H. pylori disajikan dalam angka persentase, sedangkan perbedaan karakteristik epidemiologis dan perbedaan gambaran hasil pemeriksaan endoskopi pada etnis Tionghoa dan Dayak dianalisis dengan analisis bivariat menggunakan chi-square dengan tingkat kemaknaan (p)=0,05.Hasil. Dari 203 subjek yang diteliti, terdiri dari 102 subjek etnis Tionghoa dan 101 subjek etnis Dayak, didapatkan angkaprevalensi H. pylori sebesar 40,8%. Prevalensi pada etnis Tionghoa didapatkan lebih tinggi dibanding etnis Dayak,berturut-turut sebesar 48,0% dan 33,7%. Tidak ditemukan adanya perbedaan karakteristik epidemiologis dan temuan hasil pemeriksaan endoskopi yang bermakna pada kedua kelompok etnis.Simpulan. Terdapat perbedaan angka prevalensi infeksi H. pylori pada etnis Tionghoa (48,0%) dibanding etnis Dayak (33,7%). Namun, tidak ada perbedaan karakteristik epidemiologis dan gambaran hasil pemeriksaan endoskopi pada kedua kelompok etnis tersebut.Kata kunci: Dayak, etnis, Helicobacter pylori, sindrom dispepsia, Tionghoa The Difference in Prevalence of Helicobacter pylori Infection between Chinese and Dayak Ethnics with Dyspepsia SyndromeIntroduction. Helicobacter pylori (H. pylori) infection risk is associated with many factors related to host-agent-environment. Ethnicity is one of the host factors which was the most studied factor overseas. The prevalence of H. pylori infection was found higher in certain ethnic such among Chinese. Based on migration and transmission theory, it was suspected that H. pylori infection was transmitted by people migrating from areas with a high prevalence of infection to the destination area. Chinese in West Borneo are originated from South China region where the prevalence of H. pylori infection is high. It is estimated that there are differences in the prevalence of H. pylori infection among Chinese compared to the native people of West Borneo, the Dayaknese. Methods. This was a cross-sectional study to determine the differences in the prevalence of H. pylori infection. The study was conducted at St. Antonius General Hospital Pontianak from December 2014 to June 2015 with consecutive samplingmethod. H. pylori infection prevalence is presented in percentage numbers, while the epidemiological characteristics and endoscopic finding differences among Chinese and Dayaknese were analyzed by bivariate analysis using the chi-square with significance value (p) = 0.05.Results. From a total of 203 subjects in this study, consisted of 102 Chinese subjects and 101 Dayaknese subjects, the prevalence of H. pylori infection was 40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0% and 33.7%, respectively. There is no difference in the epidemiological characteristics and endoscopic findings in both ethnic groups.Conclusions. The prevalence of H. pylori infection among the Chinese (48.0%) is higher than among Dayaknese (33.7%). There is no difference in the epidemiological characteristics and endoscopic findings among both ethnic groups.Keywords: Chinese, Dayak, Dyspeptic syndrome, Ethnic, Helicobacter pylori

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The Correlation Between Arterial Lactate and Venous Lactate in Patients With Sepsis and Septic Shock

Journal of Intensive Care Medicine ◽

10.1177/0885066616663169 ◽

2016 ◽

Vol 33 (2) ◽

pp. 116-120 ◽

Cited By ~ 14

Author(s):

Pongdhep Theerawit ◽

Chalermpon Na Petvicharn ◽

Viratch Tangsujaritvijit ◽

Yuda Sutherasan

Keyword(s):

Characteristic Curve ◽

Cross Sectional Study ◽

University Hospital ◽

Strongly Correlated ◽

Cross Sectional ◽

Arterial Lactate ◽

Paired Samples ◽

The Mean ◽

Sepsis And Septic Shock ◽

The Relationship

Background: Applying peripheral venous lactate instead of arterial lactate in clinical practice is questionable because of deviation between both values. We aimed to find the relationship between the arterial lactate and the peripheral venous lactate before reasoned that the venous lactate could be used in substitution to the arterial lactate in sepsis. Methods: We conducted a prospective, cross-sectional study at a university hospital. The patients with sepsis in ICU who required lactate level monitoring were enrolled in this research. The correlation and agreement between arterial lactate (A-LACT) and peripheral venous lactate (V-LACT) were the primary outcomes. Results: A total of 63 paired samples were collected. The A-LACT and V-LACT were strongly correlated ( r = .934, P < .0001, r2 = .873). The regression equation was A-LACT = (0.934 × V-LACT) − 0.236. The mean difference between V-LACT and A-LACT was 0.66 ± 1.53 mmol/L. The 95% limits of agreement were between −3.66 and 2.33 mmol/L. The V-LACT ≥ 4 mmol/L can predict A-LACT level ≥ 4 mmol/L with 87.5% sensitivity and 91.5% specificity, and the area under receiver operating characteristic curve was 0.948. Conclusion: The present study demonstrated a strong correlation between A-LACT and V-LACT, but an agreement between both parameters was poor. We suggest not to use the V-LACT in substitution to the A-LACT in sepsis regarding the absolute value and clearance rate, but the V-LACT ≥ 4.5 mmol/L may be used for predicting the A-LACT ≥ 4 mmol/L.

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Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis

The Indonesian Biomedical Journal ◽

10.18585/inabj.v6i3.29 ◽

2014 ◽

Vol 6 (3) ◽

pp. 163 ◽

Cited By ~ 1

Author(s):

Gontar Alamsyah Siregar ◽

Sahat Salim ◽

Ricky Rivalino Sitepu

Keyword(s):

Helicobacter Pylori ◽

Serum Levels ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Rapid Urease Test ◽

Serum Samples ◽

Cross Sectional ◽

Non Invasive ◽

Urease Test ◽

H Pylori

BACKGROUND: Helicobacter pylori is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. The gastric mucosal levels of the proinflammatory cytokines Interleukin 6 (IL-6) and IL-8 have been reported to be increased in H. pylori infection, but the serum levels in H. pylori infection is still controversial. The purpose of this study was to investigate the serum levels of IL-6 and IL-8 in H. pylori infection.METHODS: A cross sectional study was done on eighty consecutive gastritis patients admitted to endoscopy units at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia from May-October 2014. Histopathology was performed for the diagnosis of gastritis. Rapid urease test for diagnosis of H. pylori infection. Serum samples were obtained to determine circulating IL-6 and IL-8. Univariate and bivariate analysis (independent t test) were done.RESULTS: There were 41.25% patients infected with H. pylori. Circulatory IL-6 levels were significantly higher in H. pylori-infected patients compared to H. pylori negative, but there were no differences between serum levels of IL-8 in H. pylori positive and negative patients.CONCLUSION: The immune response to H. pylori promotes systemic inflammation, which was reflected in an increased level of serum IL-6. Serum levels of IL-8 were not significantly different between H. pylori positive and negative.KEYWORDS: Helicobacter pylori, gastritis, IL-6, IL-8, cytokine

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GENDER, AGE, ENDOSCOPIC FINDINGS, UREASE AND HELICOBACTER PYLORI: ALL UNCORRELATED WITHIN A SAMPLE OF A HIGH GASTRIC CANCER PREVALENCE POPULATION IN AMAZON

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201900000-50 ◽

2019 ◽

Vol 56 (3) ◽

pp. 264-269

Author(s):

Ariney Costa de MIRANDA ◽

Cássio CALDATO ◽

Mira Nabil SAID ◽

Caio de Souza LEVY ◽

Claudio Eduardo Corrêa TEIXEIRA ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Cross Sectional Study ◽

Upper Gastrointestinal Endoscopy ◽

Histopathological Analysis ◽

Rapid Urease Test ◽

Cross Sectional ◽

Cancer Prevalence ◽

Urease Test ◽

H Pylori

ABSTRACT BACKGROUND: It is widely assumed that gender, age, gastritis and Helicobacter pylori , all have some degree of correlation and, therefore, can synergistically lead to the development of gastric cancer. OBJECTIVE: In this cross-sectional study, we expected to observe the above mentioned correlation in the analysis of medical records of 67 patients of both sexes (female, n=44), mean age ± standard deviation: 41±12 years old, all from Belém (capital of Pará State, Brazilian Amazon), a city historically known as one with the highest gastric cancer prevalence in this country. METHODS: All patients were submitted to upper gastrointestinal endoscopy for gastric biopsy histopathological analysis and rapid urease test. All diagnoses of gastritis were recorded considering its topography, category and the degree of inflammatory activity, being associated or not associated with H. pylori infection. RESULTS: The results show that no statistically relevant associations were found among the prevalences of the observed variables. CONCLUSION: The authors hypothesize that observed risk factors associated to gastric cancer might be lesser synergistic than is usually expected.

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