scholarly journals Quantitative Gait Analysis Detects Significant Differences in Movement between Osteoarthritic and Nonosteoarthritic Guinea Pig Strains before and after Treatment with Flunixin Meglumine

Arthritis ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
K. S. Santangelo ◽  
A. C. Kaeding ◽  
S. A. Baker ◽  
A. L. Bertone
Keyword(s):  
Body Weight ◽  
Guinea Pig ◽  
Gait Analysis ◽  
Walking Speed ◽  
Gait Pattern ◽  
Rapid Screening ◽  
Flunixin Meglumine ◽  
Gait Parameters ◽  
Before And After ◽  
Species Specific

A computer-aided gait analysis system was used to contrast two guinea pig strains with differing propensity for osteoarthritis (OA), with/without administration of a nonsteroidal anti-inflammatory drug. Walking speed and static/dynamic gait parameters were determined at baseline. Flunixin meglumine was given and animals were evaluated 4, 24, and 72 hours after treatment. Body weight was compared using unpaired t-tests. Knee joints were histologically evaluated using species-specific criteria; indices were analyzed using one-way ANOVA, Kruskal-Wallis test, followed by Dunn’s multiple comparisons. A generalized linear model followed by Tukey’s posttests juxtaposed gait parameters; walking speed was a covariate for other outcome measures. Body weight was not different between strains; OA-prone animals demonstrated more progressive chondropathy. At baseline, OA-prone animals had slower walking speeds, narrower hind limb bases of support, shorter stride lengths, and slower limb swing speeds relative to OA-resistant animals. These differences were not detected 4 or 24 hours after treatment. By 72 hours, OA-prone animals had returned to baseline values. These findings indicate a distinct voluntary gait pattern in a rodent model of bilateral primary OA, modification of which may allow rapid screening of novel therapies. Flunixin meglumine temporarily permitted OA-prone animals to move in a manner that was analogous to OA-resistant animals.

Gait worsening and the microlesion effect following deep brain stimulation for essential tremor

2019 ◽  
Vol 90 (8) ◽  
pp. 913-919 ◽  
Author(s):  
Ryan Roemmich ◽  
Jaimie A Roper ◽  
Robert S Eisinger ◽  
Jackson N Cagle ◽  
Lauren Maine ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Repeated Measures ◽  
Walking Speed ◽  
Stimulation Parameters ◽  
Gait Parameters ◽  
Before And After ◽  
Walking Speeds ◽  
Deep Brain

ObjectiveTo investigate the effects of unilateral thalamic deep brain stimulation (DBS) on walking in persons with medication-refractory essential tremor (ET).MethodsWe performed laboratory-based gait analyses on 24 persons with medication-refractory ET before and after unilateral thalamic DBS implantation. Normal and tandem walking parameters were analysed across sessions (PRE-DBS/DBS OFF/DBS ON) by repeated measures analyses of variance. Pearson’s correlations assessed whether changes in walking after DBS were global (ie, related across gait parameters). Baseline characteristics, lead locations and stimulation parameters were analysed as possible contributors to gait effects.ResultsDBS minimally affected gait at the cohort level. However, 25% of participants experienced clinically meaningful gait worsening. Walking speed decreased by >30% in two participants and by >10% in four others. Decreased walking speed correlated with increased gait variability, indicating global gait worsening in affected participants. The worsening persisted even after the stimulation was turned off. Participants with worse baseline tandem walking performance may be more likely to experience post-DBS gait worsening; the percentage of tandem missteps at baseline was nearly three times higher and tandem walking speeds were approximately 30% slower in participants who experienced gait worsening. However, these differences in tandem walking in persons with gait worsening as compared with those without worsening were not statistically significant. Lead locations and stimulation parameters were similar in participants with and without gait worsening.ConclusionGlobal gait worsening occurred in 25% of participants with unilateral DBS for medication-refractory ET. The effect was present on and off stimulation, likely indicating a microlesion effect.

scholarly journals Gait Parameters Associated With Responsiveness to Treadmill Training With Body-Weight Support After Stroke: An Exploratory Study

2010 ◽  
Vol 90 (2) ◽  
pp. 209-223 ◽  
Author(s):  
Sara J. Mulroy ◽  
Tara Klassen ◽  
JoAnne K. Gronley ◽  
Valerie J. Eberly ◽  
David A. Brown ◽  
...  
Keyword(s):  
Body Weight ◽  
Lower Extremity ◽  
Muscle Activation ◽  
Walking Speed ◽  
Treadmill Training ◽  
High Response ◽  
Emg Activity ◽  
Locomotor Training ◽  
Gait Parameters ◽  
Response Group

Background Task-specific training programs after stroke improve walking function, but it is not clear which biomechanical parameters of gait are most associated with improved walking speed. Objective The purpose of this study was to identify gait parameters associated with improved walking speed after a locomotor training program that included body-weight–supported treadmill training (BWSTT). Design A prospective, between-subjects design was used. Methods Fifteen people, ranging from approximately 9 months to 5 years after stroke, completed 1 of 3 different 6-week training regimens. These regimens consisted of 12 sessions of BWSTT alternated with 12 sessions of: lower-extremity resistive cycling; lower-extremity progressive, resistive strengthening; or a sham condition of arm ergometry. Gait analysis was conducted before and after the 6-week intervention program. Kinematics, kinetics, and electromyographic (EMG) activity were recorded from the hemiparetic lower extremity while participants walked at a self-selected pace. Changes in gait parameters were compared in participants who showed an increase in self-selected walking speed of greater than 0.08 m/s (high-response group) and in those with less improvement (low-response group). Results Compared with participants in the low-response group, those in the high-response group displayed greater increases in terminal stance hip extension angle and hip flexion power (product of net joint moment and angular velocity) after the intervention. The intensity of soleus muscle EMG activity during walking also was significantly higher in participants in the high-response group after the intervention. Limitations Only sagittal-plane parameters were assessed, and the sample size was small. Conclusions Task-specific locomotor training alternated with strength training resulted in kinematic, kinetic, and muscle activation adaptations that were strongly associated with improved walking speed. Changes in both hip and ankle biomechanics during late stance were associated with greater increases in gait speed.

Differences in gait parameters at a preferred walking speed in healthy subjects due to age, height and body weight

2001 ◽  
Vol 13 (1) ◽  
pp. 16-21 ◽  
Author(s):  
M. M. Samson ◽  
A. Crowe ◽  
P. L. de Vreede ◽  
J. A. G. Dessens ◽  
S. A. Duursma ◽  
...  
Keyword(s):  
Body Weight ◽  
Healthy Subjects ◽  
Walking Speed ◽  
Gait Parameters

The influence of trunk extension in using advanced reciprocating gait orthosis on walking in spinal cord injury patients: A pilot study

2014 ◽  
Vol 39 (4) ◽  
pp. 286-292 ◽  
Author(s):  
Mokhtar Arazpour ◽  
Masoud Gharib ◽  
Stephen William Hutchins ◽  
Monireh Ahmadi Bani ◽  
Sarah Curran ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Walking Speed ◽  
Step Length ◽  
Trunk Flexion ◽  
Gait Parameters ◽  
Cord Injury ◽  
Before And After ◽  
Spatial Parameters ◽  
Trunk Extension

Background:Spinal cord injury patients walk with a flexed trunk when using reciprocating gait orthoses. Reduction of trunk flexion during ambulation may produce an improvement in gait parameters for reciprocating gait orthosis users.Objectives:To investigate the effect on kinematics and temporal–spatial parameters when spinal cord injury patients ambulate with an advanced reciprocating gait orthosis while wearing a thoracolumbosacral orthosis to provide trunk extension.Study design:Comparative study between before and after use o thoracolumbosacral orthosis with the advanced reciprocating gait orthoses.Methods:Four patients with spinal cord injury were fitted with an advanced reciprocating gait orthosis and also wore a thoracolumbosacral orthosis. Patients walked along a flat walkway either with or without the thoracolumbosacral orthosis at their self-selected walking speed. Temporal–spatial parameters and lower limb kinematics were analyzed.Results:Mean walking speed, step length, and cadence all improved when walking with the thoracolumbosacral orthosis donned compared to the trunk support offered by the advanced reciprocating gait orthosis. Hip and ankle joint ranges of motion were significantly increased when wearing the thoracolumbosacral orthosis during ambulation.Conclusion:Using an advanced reciprocating gait orthosis when wearing a thoracolumbosacral orthosis can improve walking speed and the step length of walking as compared with walking with an advanced reciprocating gait orthosis, probably due to the extended position of the trunk.Clinical relevanceDonning the thoracolumbosacral orthosis produced a relatively extended trunk position in the advanced reciprocating gait orthosis for all the patients included in the study, which resulted in improved gait parameters.

scholarly journals Gait analysis of healthy rhesus monkeys using a pressure-sensing walkway system

2020 ◽  
Author(s):  
Jinyoung Won ◽  
Keonwoo Kim ◽  
Hyeon-Gu Yeo ◽  
Junghyung Park ◽  
Jincheol Seo ◽  
...  
Keyword(s):  
Kinetic Parameter ◽  
Gait Analysis ◽  
Kinetic Parameters ◽  
Rhesus Monkeys ◽  
Gait Pattern ◽  
Vertical Force ◽  
Pressure Sensing ◽  
Quadrupedal Locomotion ◽  
Species Specific ◽  
Parameter Values

AbstractGait analysis in non-human primate models has been performed to elucidate the neural systems involved in controlling quadrupedal locomotor behavior. This study aimed to use a pressure-sensing walkway to identify characteristics of species-specific quadrupedal locomotion in rhesus monkeys. A total of nine healthy adult female rhesus monkeys (Macaca mulatta) were used for gait analysis. We measured the temporo-spatial and kinetic parameters of quadrupedal gait using a custom-built pressure-sensing walkway and compared the left- and right-side parameters to assess the symmetry of the gait pattern. All temporo-spatial and kinetic parameter values showed no significant differences among the nine rhesus monkeys for both the forelimbs and hindlimbs. However, significant differences were observed between forelimb and hindlimb kinetic parameters such as peak vertical force, vertical impulse, and the percentage of body weight distribution. All kinetic parameter values were higher for the forelimbs than for the hindlimbs. These data indicated that the center of gravity in healthy rhesus monkeys is located at the forelimbs rather than at the hindlimbs while walking. Furthermore, the symmetry indices considered for symmetric gait pattern showed a low variability. Most median symmetry index values were nearly zero, indicating no difference between the right and left sides. This study described valid methods for assessing gait parameters and demonstrated rhesus-specific characteristics of quadrupedal locomotion, providing a basis for the assessment of gait normality in rhesus monkeys.

Gait Analysis before and after Osteotomy for Hallux Valgus

Foot & Ankle ◽  
1987 ◽  
Vol 8 (3) ◽  
pp. 134-136 ◽  
Author(s):  
Dimitrios Vittas ◽  
Erik C. Jansen ◽  
Tommy K. Larsen
Keyword(s):  
Gait Analysis ◽  
Hallux Valgus ◽  
Large Series ◽  
Female Patients ◽  
Gait Parameters ◽  
Before And After ◽  
Gait Function

Twenty-one female patients with bunions were treated by Mitchell osteotomy. Nineteen had clinically excellent or good results. This included no pain on walking, normal ambulation, and improved appearance. Two patients were dissatisfied. By using an instrumented treadmill the gait function was tested before and a median of 6 ½ months after operation. No significant improvements or losses were found in a large series of gait parameters. The benefits of operation were not due to an improved gait function and other factors must have influenced the final result.

scholarly journals Relationship between Gait Parameters and Postural Stability in Early and Late Parkinson's Disease and Visual Feedback-Based Balance Training Effects

2017 ◽  
Vol 5 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Mohieldin M. Ahmed ◽  
Douaa M. Mosalem ◽  
Aziz K. Alfeeli ◽  
Ayyoub B. Baqer ◽  
Doaa Youssry Soliman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gait Analysis ◽  
Postural Stability ◽  
Walking Speed ◽  
Balance Training ◽  
Assessment Tools ◽  
Dynamic Posturography ◽  
Gait Parameters ◽  
Group B

BACKGROUND: Gait disorders or postural instability has been done before. However, lack of reviews has addressed the relation between gait and postural stability in Parkinson's disease (PD).AIM: The aim was to evaluate the relation between gait parameters and postural stability in early and late stages of PD.MATERIALS AND METHODS: The forty-one idiopathic PD patients were divided into two groups into a group (A) considered as early PD and group (B) considered as late ambulant PD. They were evaluated for postural stability by computerised dynamic posturography (CDP) device and gait analysis using an 8 m-camera Vicon 612 data capturing system set.RESULTS: There was a statistically significant improvement of composite equilibrium score, the composite latency of motor response, walking speed and cadence after treatment as compared to before training (p < 0.05) in early PD. However, in the late PD, there was a non-significant change of previous parameters after treatment as compared to before training (p > 0.05).There was a significant correlation between UPDRS motor part score, walking speed and composite equilibrium score after training in early PD (p > 0.05).CONCLUSIONS: Both gait analysis and CDP are important quantitative assessment tools of gait and posture instability.

Immediate Effects of Silicone Insoles on Gait Pattern in Patients with Flexible Flatfoot

2007 ◽  
Vol 28 (10) ◽  
pp. 1053-1056 ◽  
Author(s):  
Duygu Geler Kulcu ◽  
Gunes Yavuzer ◽  
Sercan Sarmer ◽  
Sureyya Ergin
Keyword(s):  
Gait Analysis ◽  
Sagittal Plane ◽  
Three Dimensional ◽  
Gait Pattern ◽  
Over The Counter ◽  
Video Recordings ◽  
Relieve Pain ◽  
Gait Parameters ◽  
Flexible Flatfoot ◽  
Analysis System

Background: Flatfoot in which a normal arch fails to develop is a common deformity in both children and adults. A frequently-used treatment is an over-the-counter insole to normalize foot mechanics and relieve pain. This study was designed to evaluate the effects of over-the-counter silicone insoles on the gait patterns of patients with flexible flatfoot. Methods: Thirty-four adults (24 women and nine men, average age 43.7 ± 9.7 years) with bilateral symptomatic flatfoot deformities were included in the study. Flatfoot was diagnosed by a lateral talometatarsal angle of more than 4 degrees and a talocalcaneal angle of more than 30 degrees. Three-dimensional gait analysis and video recordings were done at a single session. All patients walked at self-selected speeds over a 10-meter walkway with and without insoles. Time-distance parameters and kinematic and kinetic characteristics of gait in the sagittal plane were evaluated by a quantitative gait analysis system. Results: Mean lateral talometatarsal and talocalcaneal angles were 6.3 ± 2.5 degrees and 56.1 ± 8.6 degrees, respectively. There was no difference in gait parameters with or without the insoles. Conclusions: Over-the-counter insoles have no beneficial effect in normalizing forces acting on the foot and on the entire lower extremity in adults with flexible flatfoot.

scholarly journals Effect of the Hybrid Assistive Limb on the Gait Pattern for Cerebral Palsy

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 673
Author(s):  
Yuki Mataki ◽  
Hirotaka Mutsuzaki ◽  
Hiroshi Kamada ◽  
Ryoko Takeuchi ◽  
Shogo Nakagawa ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Gait Analysis ◽  
Sagittal Plane ◽  
Gait Training ◽  
Gait Pattern ◽  
Walking Ability ◽  
Gait Symmetry ◽  
Motor Disability ◽  
Before And After ◽  
Hybrid Assistive Limb

Background and objectives: Cerebral palsy (CP) is the most frequent childhood motor disability. Achieving ambulation or standing in children with CP has been a major goal of physical therapy. Recently, robot-assisted gait training using the Hybrid Assistive Limb® (HAL) has been effective in improving walking ability in patients with CP. However, previous studies have not examined in detail the changes in gait pattern after HAL training for patients with spastic CP, including gait symmetry. This study aimed to evaluate the immediate effect of HAL training on the walking ability and the changes in gait pattern and gait symmetry in patients with spastic CP. Materials and Methods: We recruited 19 patients with spastic CP (13 male and six female; mean age, 15.7 years). Functional ambulation was assessed using the 10-Meter Walk Test and gait analysis in the sagittal plane before and after a single 20-min HAL intervention session. Results: The walking speed and stride length significantly increased after HAL intervention compared to the pre-intervention values. Two-dimensional gait analysis showed improvement in equinus gait, increase in the flexion angle of the swing phase in the knee and hip joints, and improvement in gait symmetry. Immediate improvements in the walking ability and gait pattern were noted after HAL training in patients with spastic CP. Conclusions: The symmetry of the joint angle of the lower limb, including the trunk, accounts for the improvement in walking ability after HAL therapy.

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