scholarly journals Molecular Epidemiology and Genotyping ofMycobacterium tuberculosisIsolated in Baghdad

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Ruqaya Mustafa Ali ◽  
Alberto Trovato ◽  
David Couvin ◽  
Amina N. Al-Thwani ◽  
Emanuele Borroni ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Epidemiology ◽  
Health Problem ◽  
Respiratory Diseases ◽  
Evolutionary Analysis ◽  
Major Health Problem ◽  
Major Health ◽  
Recent Transmission ◽  
Transmission Index

Tuberculosis (TB) remains a major health problem in Iraq but the strains responsible for the epidemic have been poorly characterized. Our aim was to characterize the TB strains circulating in Bagdad (Iraq). A total of 270Mycobacterium tuberculosiscomplex (MTBC) strains isolated between 2010 and 2011 from TB patients attending the Center of Chest and Respiratory diseases in Baghdad were analyzed by Spoligotyping. The analysis indicated that 94.1% of the isolates belong to known genotype clades: CAS 39.6%, ill-defined T clade 29.6%, Manu 7.4%, Haarlem 7%, Ural 4.1%, LAM 3.3%, X 0.7%, LAM7-TUR 0.7%, EAI 0.7%, S 0.7%, and unknown 5.9%. Comparison with the international multimarker database SITVIT2 showed that SIT 309 (CAS1-Delhi) and SIT1144 (T1) were the most common types. In addition, 44 strains were included in SITVIT2 database under 16 new Spoligotype International Types (SITs); of these, 6 SITs (SIT3346, SIT3497, SIT3708, SIT3790, SIT3791, and SIT3800) (n= 32 strains) were created within the present study and 10 were created after a match with an orphan in the database. By using 24-loci MIRU-VNTR-typing on a subset of 110 samples we found a high recent transmission index (RTI) of 33.6%. In conclusion, we present the first unifying framework for both epidemiology and evolutionary analysis ofM. tuberculosisin Iraq.

scholarly journals A CRITICAL REVIEW: TAMAKA SHWASA (BRONCHIAL ASTHMA)

2019 ◽  
Vol 7 (8) ◽  
pp. 258-264
Author(s):  
Vaishnavi Narhari Saka
Keyword(s):  
Bronchial Asthma ◽  
Health Problem ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Climatic Changes ◽  
Chronic Inflammatory Disease ◽  
Age Group ◽  
Major Health Problem ◽  
Major Health ◽  
Recurrent Respiratory Infections

Out of most morbid disorders, the disease shwas is also becoming a major health problem of the society. Difficulties in breathing, cough are common health complains which everyone experiences throughout their life with different magnitude. Such complains are found in every age group. Dyspnea due to respiratory diseases comes under ShwasaRoga. Maha- Urdhva-Chinna-Tamaka and Kshudra are the types of ShwasaRoga. Bronchial asthma is a chronic inflammatory disease of airways characterized by cough, difficulty in breathing and wheeze. Exposure to dust, smoke, recurrent respiratory infections and climatic changes are chief triggering factors of this disease. Bronchial asthma and its associated features clinically correspond to the Tamaka Shwasa described in Ayurveda.

scholarly journals The Role of N-Acetyl Sistein in Pulmonary Tuberculosis

2020 ◽  
Vol 6 (1) ◽  
pp. 27
Author(s):  
Resti Yudhawati ◽  
Nitya Prasanta
Keyword(s):  
Oxidative Stress ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Respiratory Diseases ◽  
Antimicrobial Effect ◽  
Mycobacterium Tuberculosis Infection ◽  
Major Health Problem ◽  
Major Health ◽  
Mucolytic Agent

Pulmonary Tuberculosis is a chronic infection that caused by Mycobacterium tuberculosis (M.tb) infection and it is still the major health problem worldwide. Mycobacterium tuberculosis infection can induce oxidative stress. Some studies has proved that active TB patients have an association with excessive oxidative stress which causes glutathione (GSH) level decrease and free radicals increase. Glutathione (GSH) facilitates the control of M.TB intracellular bacterial growth in macrophages and has direct antimicrobial activity.  N-acetylcysteine (NAC) is thiol, a precursor of L-cysteine and glutathione synthesis (GSH) that has been used for decades as a mucolytic agent in the treatment of respiratory diseases. Some studies report beneficial role of NAC as immunomodulator, besides NAC also has anti-inflammatory and antimicrobial effect in TB management.

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

Prevention and Treatment of Early Childhood Caries (ECC)

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Jeffrey .
Keyword(s):  
Early Childhood ◽  
Health Problem ◽  
Early Childhood Caries ◽  
Health Providers ◽  
Missing Teeth ◽  
Optimal Basis ◽  
Major Health Problem ◽  
Major Health ◽  
Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

scholarly journals Acute Cholecystitis Caused by Ceftriaxone Stones in an Adult

2009 ◽  
Vol 2009 ◽  
pp. 1-2 ◽  
Author(s):  
Christian D. Becker ◽  
Robert A. Fischer
Keyword(s):  
Adult Patient ◽  
Acute Cholecystitis ◽  
Health Problem ◽  
Medical Literature ◽  
Early Recognition ◽  
Gallstone Formation ◽  
Sludge Formation ◽  
Major Health Problem ◽  
Major Health ◽  
First Case

Acute cholecystitis is a major health problem. There are multiple etiologies to be considered and early recognition of the condition is important to optimize management and outcome. We report the first case in the medical literature of symptomatic acute cholecystitis triggered by ceftriaxone-associated gallbladder sludge formation and, importantly, solid ceftriaxone gallstone formation in an adult patient with underlying mineral and pigment cholecystolithiasis, necessitating cholecystectomy. This case serves as a reminder for physicians to keep this uncommon cause of cholecystolithiasis and cholecystitis in mind in patients who receive prolonged ceftriaxone therapy. These patients should be cautioned to promptly report to their physicians any signs or symptoms of cholecystitis in order to ensure timely and appropriate evaluation.

scholarly journals New Drugs for Acute Heart Failure

2012 ◽  
Vol 7 (1) ◽  
pp. 35-38
Author(s):  
Mohammad Salman ◽  
Syed Allahsan ◽  
Manzoor Mahmood ◽  
Md Khairul Anam ◽  
Shahed Mohammad Anwar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Acute Heart Failure ◽  
Health Problem ◽  
Standard Therapy ◽  
New Drugs ◽  
European Medicines Agency ◽  
Major Health Problem ◽  
Major Health ◽  
Long Time

Acute heart failure is a major health problem responsible for several million hospitalizations worldwide each year. Standard therapy has not changed for long time and includes diuretics and variable use of vasodilators or inotropes. Recently Nesiritide and Levosimendan are two drugs for the treatment of acute heart failure which have been approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMEA), respectively. There was little concern that Nesiritide can worsen the renal failure but recent trials had abolished this concern. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10208 UHJ 2011; 7(1): 35-38

scholarly journals A Review on Lepa Kalpana in Dadru W.R.T. to Brihatrayi and Laghutrayi

2021 ◽  
Vol 11 (4) ◽  
pp. 102-105
Author(s):  
Lalita Sharma ◽  
Sudama Singh Yadav
Keyword(s):  
Fungal Infection ◽  
Health Problem ◽  
Skin Diseases ◽  
Modern Science ◽  
Treatment Modalities ◽  
Major Health Problem ◽  
Psychological Burden ◽  
Major Health ◽  
Almost All ◽  
Topical Absorption

Skin is the outermost covering of body and the largest organ of the integumentary system. Skin diseases are major health problem with emotional and psychological burden on patients. In Ayurvedic classics, almost all the skin diseases come under the broad heading of Kushtha. Dadru is a type of Kushtha which can be correlated with Tinea infection (fungal infection) in modern science. Three genera of dermatophytes infect skin i.e. Trichophyton spp, Epidermophyton spp and Microsporum spp. Ayurveda describes a multitude of treatment modalities for skin diseases in relation with various types of kushtha. One of them is the topical use of medicaments over the skin for topical absorption which allows faster absorption and better management of skin diseases. Lepa kalpana is a herbal or herbo-mineral drug for topical use. Although lepa is an important therapy in various diseases but it is highly useful specifically in dermatological diseases. This review describes different lepas which are especially mentioned for Dadru in doctrines of Ayurveda. Key words: Dadru, Kushtha, Lepa kalpana , Skin diseases.

scholarly journals Cancer in Africa: Is It a Genetic or Environmental Health Problem?

2020 ◽  
Vol 10 ◽  
Author(s):  
Abeer A. Bahnassy ◽  
Mona S. Abdellateif ◽  
Abdel-Rahman N. Zekri
Keyword(s):  
Health Problem ◽  
African Ancestry ◽  
Survival Rates ◽  
Mortality Rates ◽  
Sociocultural Factors ◽  
Major Health Problem ◽  
Major Health ◽  
Incidence And Mortality ◽  
Environmental Health Problem ◽  
African Patients

Patients of African ancestry have the poorest outcome and the shortest survival rates from cancer globally. This could be attributed to many variables including racial, biological, socioeconomic and sociocultural factors (either single, multiple or combined), which may be responsible for this major health problem. We sought to assess the most common types of cancer that endanger the health of the African people, and tried to investigate the real differences between African and other Non-African patients regarding incidence, prevalence and mortality rates of different cancers. Therefore, identifying the underlying aetiological causes responsible for the increased incidence and mortality rates of African patients will allow for changing the current plans, to make optimized modalities for proper screening, diagnosis and treatment for those African patients, in order to improve their survival and outcomes.

scholarly journals Protein S Deficiency - An Uncommon Cause with Common Presentation

2016 ◽  
Vol 35 (2) ◽  
pp. 192-194
Author(s):  
Nabanita Kora ◽  
Rajib Das ◽  
Sabyasachi Som ◽  
Sumanta Laha ◽  
Nayan Bannerji ◽  
...  
Keyword(s):  
Health Problem ◽  
Rare Case ◽  
Protein S ◽  
Protein S Deficiency ◽  
Major Health Problem ◽  
Major Health ◽  
Young Stroke ◽  
Common Presentation ◽  
S Deficiency

Correction: The correct PDF for this article was loaded on 9th March 2017. We offer our sincere apologies for having the wrong PDF loaded for this article.Stroke in child poses a major health problem. Thrombophilic factors have been implicated in 4-8% of young stroke worldwide. Protein S deficiency is a very rare cause of stroke. A few cases have been reported in literature. We are reporting a rare case of protein S deficiency causing stroke in a two year old child.J Nepal Paediatr Soc 2015;35(2):192-194

scholarly journals Editorial: Nutrition Management for Chronic Kidney Disease

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3852
Author(s):  
Vassilios Liakopoulos ◽  
Evangelia Dounousi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Health Problem ◽  
Major Health Problem ◽  
Major Health ◽  
Nutrition Management

Chronic kidney disease (CKD) constitutes a major health problem worldwide [...]

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