Are Plasma Thyroid-Stimulating Hormone Levels Associated with Degree of Obesity and Metabolic Syndrome in Euthyroid Obese Patients? A Turkish Cohort Study

We aimed to observe the association between degree of obesity and metabolic syndrome and plasma thyrotropin levels in obese, euthyroid Turkish patients. 947 obese and overweight patients who admitted to our outpatient clinic were assessed retrospectively. 150 healthy euthyroid cases were also recruited as the control group. Cases with metabolic syndrome were determined. Patients were divided into various subgroups as overweight, obese, morbid obese, men, and women. No statistical significance was determined when all the patients’ and subgroups’ plasma thyrotropin levels were compared to normal weight control group. No association was shown between the presence of metabolic syndrome and plasma thyrotropin levels for both all patients and subgroups. Also there was not any association between each component of metabolic syndrome and plasma thyrotropin levels. In conclusion, we did not found any significant association between plasma thyrotropin levels and obesity and metabolic syndrome in our euthyroid subjects.

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Sequence Analysis of theUCP1Gene in a Severe Obese Population from Southern Italy

Journal of Obesity ◽

10.1155/2011/269043 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 10

Author(s):

Giuseppe Labruna ◽

Fabrizio Pasanisi ◽

Giuliana Fortunato ◽

Carmela Nardelli ◽

Carmine Finelli ◽

...

Keyword(s):

Sequence Analysis ◽

Weight Control ◽

Southern Italy ◽

Uncoupling Protein ◽

Normal Weight ◽

Obese Patients ◽

Uncoupling Protein 1 ◽

Obese Adults ◽

Brown Adipose ◽

Normal Weight Control

Brown adipose tissue, where Uncoupling Protein 1 (UCP1) activity uncouples mitochondrial respiration, is an important site of facultative energy expenditure. This tissue may normally function to prevent obesity. Our aim was to investigate by sequence analysis the presence ofUCP1gene variations that may be associated with obesity. We studied 100 severe obese adults (BMI > 40 kg/m2) and 100 normal-weight control subjects (BMI range = 19–24.9 kg/m2). We identified 7 variations in the promoter region, 4 in the intronic region and 4 in the exonic region. Globally, 72% of obese patients boreUCP1polymorphisms. AmongUCP1variants, g.IVS4−208T>G SNP was associated with obesity (OR: 1.77; 95% CI = 1.26–2.50;P=.001). Further, obese patients bearing the g.−451C>T (CT+TT) or the g.940G>A (GA+AA) genotypes showed a higher BMI than not polymorphic obese patients (P=.008andP=.043, resp.). In conclusion,UCP1SNPs could represent “thrifty” factors that promote energy storage in prone subjects.

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Weight loss normalizes the inhibitory effect of N6-(phenylisopropyl)adenosine on lipolysis in fat cells of massively obese human subjects

Clinical Science ◽

10.1042/cs0830589 ◽

1992 ◽

Vol 83 (5) ◽

pp. 589-592 ◽

Cited By ~ 9

Author(s):

Jorma J. Ohisalo ◽

Johanna M. Kaartinen ◽

Susanna Ranta ◽

Pertti Mustajoki ◽

Stanely P. Hreniuk ◽

...

Keyword(s):

Gastric Bypass ◽

Body Weight ◽

Weight Control ◽

Normal Weight ◽

Fat Cells ◽

Obese Patients ◽

Control Subjects ◽

Phenylisopropyl Adenosine ◽

Normal Weight Control ◽

In Cells

1. Fat cells were isolated from massively obese patients at or before gastric bypass, from other patients after normalization of body weight after gastric bypass or gastroplasty (post-bypass patients) and from control subjects of a stable normal body weight. 2. The inhibition of isoprenaline-stimulated lipolysis by N6-(phenylisopropyl)adenosine in the presence of adenosine deaminase was much attenuated in cells from the massively obese patients as compared with those from normal-weight control subjects, but was normal in cells from post-bypass patients. 3. Isolated fat cells of the massively obese patients were larger (913 ± 197 pl, mean ± sem) than those of the normal-weight group (437 ± 95 pl). The volume of cells from the post-bypass patients was only 125 ± 49 pl, although the body mass index of this group was almost exactly the same as that of the normal-weight control subjects. 4. Although epidemiological studies have suggested that genetic factors are important in the development and maintenance of obesity, these results demonstrate that the changes observed in the inhibitory regulation of lipolysis in obesity are secondary.

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The effects of weight fluctuation on the components of metabolic syndrome: a 16-year prospective cohort study in South Korea

Archives of Public Health ◽

10.1186/s13690-021-00539-x ◽

2021 ◽

Vol 79 (1) ◽

Author(s):

Young Ran Chin ◽

Eun Sun So

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Prospective Cohort Study ◽

Abdominal Obesity ◽

Prospective Cohort ◽

Weight Control ◽

Normal Weight ◽

Health Concern ◽

Care Providers ◽

Weight Fluctuation

Abstract Background Weight fluctuation (WF) is highly prevalent in parallel with the high prevalence of intentional or unintentional dieting. The health risks of frequent WF for metabolic syndrome (MS) have become a public health concern, especially for health care providers who supervise dieting as an intervention to prevent obesity-related morbidity or to improve health, as well as for the general population for whom dieting is of interest. The aim of this study was to investigate the long-term effect of WF on the risk of MS in Koreans. Methods This study analyzed secondary data from the Korean Genome and Epidemiology Study, a 16-year prospective cohort study, on 8150 individuals using time-dependent Cox regression. Results WF did not increase the risk of MS in either normal-weight or obese subjects. In an analysis of the components of MS, greater WF significantly increased the risk of abdominal obesity (HR = 1.05, 95% CI = 1.02–1.07, p < 0.001) in normal-weight individuals. However, WF did not increase the risk of hyperglycemia, low high-density lipoprotein cholesterol levels, elevated blood pressure, or raised fasting glucose in normal-weight individuals, and it did not influence any of the components of MS in obese individuals. Conclusion Since WF was found to be a risk factor for abdominal obesity, which is the most reliable predictor of MS, it should be considered when addressing weight control. Further studies on cut-off points for the degree of weight loss in a certain period need to be conducted to help clinicians provide guidance on appropriate weight control.

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Plasma Nesfatin-1 Level in Obese Patients after Acupuncture: A Randomised Controlled Trial

Acupuncture in Medicine ◽

10.1136/acupmed-2014-010530 ◽

2014 ◽

Vol 32 (4) ◽

pp. 313-317 ◽

Cited By ~ 11

Author(s):

Yongfang Guo ◽

Mingqing Xing ◽

Wenjuan Sun ◽

Xiaoyan Yuan ◽

Hongyan Dai ◽

...

Keyword(s):

Weight Control ◽

Serum Insulin ◽

Controlled Trial ◽

Diet Group ◽

Normal Weight ◽

Obese Patients ◽

Obese Adults ◽

The Difference ◽

Randomised Controlled ◽

The Relationship

Background Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity. Objective To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment. Methods 64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days. Results Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05. Conclusions Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.

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Abstract 3698: Decreased Circulating Endothelial Progenitor Cells and Endothelial Dysfunction: a Novel Mechanism of Atherogenesis in Obesity.

Circulation ◽

10.1161/circ.116.suppl_16.ii_839-c ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Paulo F Leite ◽

Claudia R Andrade ◽

Santa Poppe ◽

Luiz A Cesar ◽

Silmara Coimbra ◽

...

Keyword(s):

Metabolic Syndrome ◽

Multivariate Analysis ◽

Endothelial Dysfunction ◽

Endothelial Function ◽

Progenitor Cells ◽

Endothelial Progenitor Cells ◽

Obese Patients ◽

Endothelial Progenitor ◽

Circulating Endothelial Progenitor Cells ◽

Morbid Obese

Underlying mechanisms of endothelial dysfunction in obesity are not fully understood. Circulating Endothelial Progenitor Cells (EPCs) are known to promote endothelial repair. Our aim was to assess the number/function of EPCs in morbid obese individuals and its correlation with endothelial function and inflammatory markers. EPCs were isolated from 33 morbid obese patients (age 47±1.8 y; men=34%; BMI=49±2.1 kg/m 2 , metabolic syndrome=84%) and 20 lean controls. Peripheral blood EPC number was significantly reduced in obese patients both with flow cytometry (KDR + /CD34 + ; 0.041±0.04 vs 0.074±0.05 %events, p<0.001) and fluorescence analysis after short-term culture (49±4 vs 28±2 cells/field, p<0.001). The plasma number of primitive CD 133 + cells, and concentrations of VEGF (Elisa) and nitrogen oxides (which potentially recruit EPCs), were similar to control, suggesting that reduction of EPCs occurs distally to early cell differentiation. Importantly, C-Reactive Protein (CRP), robustly increased in obese patients (0.15±0.04 vs 1.3±0.3; p=0.003), was a strong predictor of reduced EPC number at multivariate analysis (r=0.623; p < 0.001). Likewise, the migratory response of EPCs to VEGF in vitro was significantly impaired in obese vs controls, despite similar VEGF receptor numbers. Multivariate analysis suggested potential roles of metabolic syndrome and leptin in such effect. Endothelial function at flow-mediated brachial artery reactivity was markedly reduced (by 60%) in obese patients, and had a significant inverse correlation with EPC number (r= 0.678; p< 0.001). Carotid intimal thickness was also increased in obese patients (0.68±0.02 vs 0.58±0.08; p=0.001). On the other hand, the number of circulating endothelial cells (CD31 + /CD106 + ) was similar in both groups, suggesting that apoptosis was not enhanced in the obese. These results suggest for the first time that reduced number and migratory capacity of EPCs correlate with endothelial dysfunction or increased CRP and may be a key underlying mechanism of vascular complications and atherosclerosis in obesity.

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Influence of duration of menopause, anthropometric and hormonal parameters on metabolic syndrome

Medicinski pregled ◽

10.2298/mpns1002033s ◽

2010 ◽

Vol 63 (1-2) ◽

pp. 33-39 ◽

Cited By ~ 1

Author(s):

Aleksandra Simoncig-Netjasov ◽

Svetlana Vujovic ◽

Miomira Ivovic ◽

Milina Tancic-Gajic ◽

Milka Drezgic

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Diastolic Blood Pressure ◽

Fasting Glucose ◽

Fat Distribution ◽

Normal Weight ◽

Sex Hormone Binding Globulin ◽

Control Group ◽

Obese Women ◽

Waist Hip Ratio

Introduction. Hypoestrogenic status in the menopausal women shows a shift to a central android fat distribution and metabolic syndrome (MS). Related metabolic changes and hypertension increase the risk for cardiovascular (CV) diseases. The aim of this study was to investigate the influence of duration of menopause, anthropometric and hormonal parameters on metabolic syndrome. Material and methods. 50 obese women were examined with BMI=31.92?5.83 kg/m2, age 54.40?3.64, time since menopause 5.90?5.46 years. Control group consisted of 37 normal weight women with BMI=23.50?2.13 kg/m2, age 53.92?3.95, time since menopause 5.96?4.92 years. Anthropometric characteristics and blood pressure were measured. Blood was taken at 8 am for: fasting glucose, triglycerides, cholesterol, HDL, LDL, apolipoprotein A (ApoA), apolipoprotein B (ApoB), lipoprotein(a) (Lp(a)), C-reactive protein (CRP), fibrinogen, FSH, LH, prolactin, estradiol, progesterone, testosterone and sex hormone binding globulin (SHBG). Results. In obese women significant negative correlations were found for: BMI and HDL (p<0,05), waist and HDL (p<0,05), FSH and systolic blood pressure (p<0.01), FSH and fasting glucose (p<0,05), LH and waist (p<0.05), SHBG and fasting glucose (p<0.05). A positive correlation was found for lime since meno?pause and waist/hip ratio (p<0.05). In controls positive correlations were found for: waist/hip ratio and systolic and diastolic blood pressure (p<0,05), LH and HDL (p<0.05), estradiol and diastolic blood pressure (p<0,05). Negative correlations were detected for estradiol and waist (p<0,05), time since menopause and HDL (p<0,05). Conclusion. Gaining weight together with menopausal endocrine changes cause metabolic and hemodynamic imbalances, which contribute to risk for cardiovascular diseases.

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Severe Obesity: Effects on Foot Mechanics During Walking

Foot & Ankle International ◽

10.1177/107110079401500106 ◽

1994 ◽

Vol 15 (1) ◽

pp. 29-34 ◽

Cited By ~ 51

Author(s):

Stephen P. Messier ◽

Angela B. Davies ◽

Dominic T. Moore ◽

Shala E. Davis ◽

Robert J. Pack ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Weight Control ◽

Severe Obesity ◽

Normal Weight ◽

Control Group ◽

Posterior Aspect ◽

Adult Females ◽

Q Angle ◽

Severely Obese

The purpose of our study was to determine the effects of severe obesity on the foot mechanics of adult females. Twenty-nine adult females between the ages of 20 and 48 years volunteered as subjects for this investigation. The subjects were separated into a severely obese (O) group (body mass index = 41.14 ± 2.61; N = 16) and a normal weight control group (body mass index = 20.84 ± 0.47; N = 13). A Locam camera (100 Hz) positioned perpendicular to the subjects’ posterior aspect was used to film the rearfoot movement of the subjects during the final 15 sec of a 10 min treadmill walk. The O group had a significantly greater touchdown angle ( P = .05), more total eversion range of motion ( P = .001), and a faster maximum eversion velocity ( P < .001). Moreover, analysis of dynamic foot angles indicated that the O group had significantly ( P = .003) more forefoot abduction. Finally, anthropometric data revealed statistically different ( P < .001) Q angle measurements between the O and control groups. The results of this study suggest that severely obese females have significantly greater rearfoot motion, foot angle, and Q angle values than normal weight females.

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Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms

10.21203/rs.3.rs-15825/v1 ◽

2020 ◽

Author(s):

Juan Wang ◽

Yulong Zhang ◽

Zhiwei Liu ◽

Yating Yang ◽

Yi Zhong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Negative Symptoms ◽

Psychiatric Symptoms ◽

Normal Weight ◽

Control Group ◽

Strongly Correlated ◽

Clinical Trial Registration ◽

Negative Factor ◽

Syndrome Scale ◽

Mental Symptoms

Abstract Background: Schizophrenia patients with a metabolically abnormal obese (MAO) phenotype have been shown poor cardiovascular outcomes, but the characteristics of their current mental symptoms have not been characterized. This study mainly explored the psychiatric symptoms of schizophrenia patients with the MAO phenotype.Methods: A total of 329 patients with schizophrenia and 175 sex- and age-matched people without schizophrenia from Anhui Province in China were enrolled. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of the schizophrenia patients. The MAO phenotype was defined as meeting 1-4 metabolic syndrome criteria (excluding waist circumference) and having a body mass index (BMI) ≥ 28 kg/m 2 . And, metabolically healthy normal-weight (MHNW) phenotype was defined as meeting 0 criteria for metabolic syndrome and 18.5 ≤ BMI < 24 kg/m 2.Results: Overall, 15.8% of the schizophrenia patients and 9.1% of the control group were consistent with the MAO phenotype, and the prevalence of MAO in the schizophrenia group was higher than that in the control group. Among the patients with schizophrenia, the MAO group had lower negative factor, cognitive factor and total PANSS scores than the MHNW group. However, when confounding factors were controlled, only the negative factor remained lower. The correlation analysis showed that the MAO phenotype was strongly correlated with C-peptide and insulin levels.Conclusion: we found that schizophrenia patients with the MAO phenotype had reduced negative symptoms, which may indicate an internal mechanism linking metabolic disorders and negative symptoms.Trial registration: This study was registered in the China Clinical Trial Registration Center (No. chiCTR 1800017044)

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Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms

10.21203/rs.3.rs-15825/v2 ◽

2020 ◽

Author(s):

Juan Wang ◽

Yulong Zhang ◽

Zhiwei Liu ◽

Yating Yang ◽

Yi Zhong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Negative Symptoms ◽

Psychiatric Symptoms ◽

Normal Weight ◽

Trial Registration ◽

Control Group ◽

Clinical Trial Registration ◽

Negative Factor ◽

Syndrome Scale ◽

Mental Symptoms

Abstract Background: Schizophrenia patients with a metabolically abnormal obese (MAO) phenotype have been shown poor cardiovascular outcomes, but the characteristics of their current psychiatric symptoms have not been characterized. This study mainly explored the psychiatric symptoms of schizophrenia patients with the MAO phenotype. Methods: A total of 329 patients with schizophrenia and 175 sex- and age-matched people without schizophrenia from Anhui Province in China were enrolled. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of the schizophrenia patients. The MAO phenotype was defined as meeting 1-4 metabolic syndrome criteria (excluding waist circumference) and having a body mass index (BMI) ≥ 28 kg/m2. And, metabolically healthy normal-weight (MHNW) phenotype was defined as meeting 0 criteria for metabolic syndrome and 18.5 ≤ BMI < 24 kg/m2. Results: Overall, 15.8% of the schizophrenia patients and 9.1% of the control group were consistent with the MAO phenotype, and the prevalence of MAO in the schizophrenia group was higher than that in the control group. Among the patients with schizophrenia, the MAO group had lower negative factor, cognitive factor and total PANSS scores than the MHNW group. However, when confounding factors were controlled, only the negative factor remained lower. The correlation analysis showed that the MAO phenotype was strongly correlated with C-peptide and insulin levels.Conclusion: we found that schizophrenia patients with the MAO phenotype had reduced negative symptoms, which may indicate an internal mechanism linking metabolic disorders and negative symptoms.Trial registration: This study was registered in the China Clinical Trial Registration Center (No. chiCTR 1800017044)

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Obesity indices as a risk factor of skin diseases: A Case-control study conducted in Cairo, Egypt

South East Asia Journal of Public Health ◽

10.3329/seajph.v5i2.28309 ◽

2016 ◽

Vol 5 (2) ◽

pp. 23-29 ◽

Cited By ~ 1

Author(s):

Raed M Alazab ◽

Abdel Raouf M Almohsen

Keyword(s):

Risk Factor ◽

Skin Diseases ◽

Statistical Significance ◽

Case Control ◽

Normal Weight ◽

Overweight And Obesity ◽

University Hospital ◽

Obese Patients ◽

Dermatology Clinic ◽

Obesity Indices

Overweight and obesity are two major health problems that have been recognized worldwide which affect all ages and have many negative health effects. WHO in year 2010 reported that in Egypt the prevalence of overweight among women is 76% compared to 64.5% for male while the prevalence of obesity among women is 48% compared to 22% for male. The aim of the study was to determine the most prevalent skin diseases among the studied over-weight and obese patients and to examine if overweight and obesity are risk factors for skin diseases. A case-control was carried out on 250 overweight and obese patients compared with another 250 normal weight patients as controls. The participants were selected from the outpatient dermatology clinic of Al Hussein University hospital, Faculty of medicine, Alazhar University, Egypt. All patients were subjected to medical history, clinical dermatological examination and measurement of obesity indices. The most prevalent skin diseases among the studied cases were: striae (68.4%), planter hyperkeratosis (61.6%), skin tags (61.2%), acanthosis nigricans (53.6%), intertrigo (53.6%), tinea pedis (41.2%) with statistical significance difference compared to controls. As a result, overweight and obesity might be a risk factor for some skin diseases. Dermatologists must work with primary health care physicians and nutritional specialists to reduce incidence of obesity or reduce the effects of obesity on the skin.South East Asia Journal of Public Health Vol.5(2) 2015: 23-29

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