scholarly journals Antimicrobial, Antioxidant, Anti-Inflammatory, and Cytotoxic Activities of Propolis from the Stingless BeeTetragonisca fiebrigi(Jataí)

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Jaqueline Ferreira Campos ◽  
Uilson Pereira dos Santos ◽  
Paola dos Santos da Rocha ◽  
Marcio José Damião ◽  
José Benedito Perrella Balestieri ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Biological Fluids ◽  
Folk Medicine ◽  
Ethanol Extract ◽  
K562 Cells ◽  
Biological Properties ◽  
Cytotoxic Activities ◽  
Therapeutic Properties ◽  
Anti Inflammatory ◽  
Therapeutic Activities

Propolis from stingless beesTetragonisca fiebrigifound in Brazil is used in folk medicine by their nutritional and therapeutic properties. However, there are no scientific records evidencing such properties. The present study was designed to investigate the chemical composition and the biological properties of propolis fromT. fiebrigi. For this, the chemical composition of the ethanol extract of propolis (EEP) was determined by GC-MS and presented phenolic compounds, alcohol, and terpenes as its major class compounds. The antimicrobial activity was accessed in gram-positive and gram-negative bacteria and in fungi, isolated from different biological fluids and reference strains. The EEP was active against all microorganisms and showed antioxidant activity by scavenging free radicals, inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. The anti-inflammatory potential of the EEP was confirmed by inhibition of the hyaluronidase enzyme. The cytotoxic activity was concentration-dependent against K562 cells, with a predominance of death by necrosis. Taken together, these results show that propolis fromT. fiebrigihas important therapeutic activities, which suggest its potential application in the pharmaceutical industry, as well as in health foods, beverages, and nutritional supplements.

scholarly journals Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss.

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3486
Author(s):  
Aleksandra Pieczykolan ◽  
Wioleta Pietrzak ◽  
Urszula Gawlik-Dziki ◽  
Renata Nowak
Keyword(s):  
Chemical Composition ◽  
Bound States ◽  
Folk Medicine ◽  
Biological Properties ◽  
Scientific Data ◽  
High Concentration ◽  
Methanolic Extracts ◽  
Anti Inflammatory ◽  
Inhibitory Potential ◽  
Aerva Lanata

Many plants that are commonly used in folk medicine have multidirectional biological properties confirmed by scientific research. One of them is Aerva lanata (L.) Juss. (F. Amaranthaceae). It is widely used, but there are very few scientific data about its chemical composition and pharmacological activity. The aim of the present study was to investigate the chemical composition of phenolic acid (PA)-rich fractions isolated from methanolic extracts of A. lanata (L.) Juss. herb using the liquid/liquid extraction method and their potential antioxidant, anti-inflammatory, and anti-diabetic properties. The free PA fraction (FA), the PA fraction (FB) released after acid hydrolysis, and the PA fraction (FC) obtained after alkaline hydrolysis were analysed using liquid chromatography/electrospray ionization triple quadrupole mass spectrometry (LC-ESI-MS/MS). The phenolic profile of each sample showed a high concentration of PAs and their presence in A. lanata (L.) Juss. herb mainly in bound states. Thirteen compounds were detected and quantified in all samples, including some PAs that had not been previously detected in this plant species. Bioactivity assays of all fractions revealed high 2,2-diphenyl-1-picrylhydrazyl (DPPH•) (2.85 mM Trolox equivalents (TE)/g) and 2,2-azino-bis-3(ethylbenzthiazoline-6-sulphonic acid) (ABTS•+) (2.88 mM TE/g) scavenging activity. Fraction FB definitely exhibited not only the highest antiradical activity but also the strongest xanthine oxidase (XO) (EC50 = 1.77 mg/mL) and lipoxygenase (LOX)(EC50 = 1.88 mg/mL) inhibitory potential. The fraction had the best anti-diabetic properties, i.e., mild inhibition of α-amylase (EC50 = 7.46 mg/mL) and strong inhibition of α-glucosidase (EC50 = 0.30 mg/mL). The activities of all analysed samples were strongly related to the presence of PA compounds and the total PA content.

scholarly journals Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory

2016 ◽  
Vol 88 (3) ◽  
pp. 1471-1484
Author(s):  
GLAUCIEMAR DEL-VECHIO-VIEIRA ◽  
BRUNA C.S. SANTOS ◽  
MARIA SILVANA ALVES ◽  
AÍLSON L.A. ARAÚJO ◽  
CÉLIA H. YAMAMOTO ◽  
...  
Keyword(s):  
Antinociceptive Effect ◽  
Folk Medicine ◽  
Reducing Power ◽  
Ethanol Extract ◽  
Immersion Test ◽  
Significant Inhibition ◽  
Paw Edema ◽  
Hot Plate ◽  
Tail Immersion ◽  
Anti Inflammatory

ABSTRACT The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenan-induced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of total phenols and flavonoids and a promising antioxidant effect were quantified. At the doses of 50, 100 and 200 mg/kg, the extract inhibited the writhing, reduced both phases of paw licking time and increased the reaction time on the hot plate. In the tail immersion test, the extract (50, 100 and 200 mg/kg) caused a significant inhibition of pain. In these doses, the paw edema, exudate volume and leucocyte mobilization were significantly reduced. These results suggest that A. fastigiatum can be an active source of substances with antioxidant, antinociceptive and anti-inflammatory activities, adding scientific support to the appropriate use in the Brazilian folk medicine.

scholarly journals Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Nabil Albaser ◽  
Najeeb Ghanem ◽  
Mohanad Shehab ◽  
Adnan Al-Adhal ◽  
Mohammed Amood AL-Kamarany
Keyword(s):  
Chronic Inflammation ◽  
Guinea Pigs ◽  
Therapeutic Potential ◽  
Histological Study ◽  
Folk Medicine ◽  
Ethanol Extract ◽  
Optimum Dose ◽  
Repeated Doses ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Caralluma is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely, Caralluma penicillata (C. penicillata) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of C. penicillata against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with/without indomethacin were performed. The results showed that a 400 mg/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10 mg/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.

scholarly journals Chemical composition, antioxidant, anti-inflammatory and antinociceptive activities of the ethanol extract of ripe fruits of Solanum lycocarpum St. Hil. (Solanaceae)

2020 ◽  
Vol 262 ◽  
pp. 113125
Author(s):  
Melissa Grazielle Morais ◽  
Aline Aparecida Saldanha ◽  
João Paulo Costa Rodrigues ◽  
Iara Cotta Mendes ◽  
Letícia Marcelle Ferreira ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Ethanol Extract ◽  
Anti Inflammatory

scholarly journals Lichens as a source of chemical compounds with anti-inflammatory activity

2018 ◽  
Vol 64 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Elżbieta Studzińska-Sroka ◽  
Adrianna Dubino
Keyword(s):  
Animal Studies ◽  
Inflammatory Process ◽  
Folk Medicine ◽  
Chemical Compounds ◽  
Biological Properties ◽  
Inflammatory Activity ◽  
Medicinal Substances ◽  
Anti Inflammatory ◽  
Biological Actions

SummarySymptoms of inflammation accompany a number of diseases. In order to mitigate them, folk medicine has used a variety of medicinal substances, including herbs and mushrooms. Lichens are less known organisms, containing specific secondary metabolites with interesting biological properties. One of their biological actions is the anti-inflammatory activity that has been confirmed byin vitroand animal studies. It has been proven that compounds and extracts from lichens inhibit the enzymes involved in the inflammatory process. The following paper is a review of research on the little-known anti-inflammatory properties of lichens.

scholarly journals HPTLC analysis and anti-inflammatory activity of Plectranthus amboinicus (Lour.) leaves

2021 ◽  
Vol 12 (3) ◽  
pp. 2077-2082
Author(s):  
Ananthi T ◽  
Ramya V
Keyword(s):  
Antiinflammatory Activity ◽  
Protein Denaturation ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Metabolite Profile ◽  
Solvent Mixture ◽  
Phytochemical Analysis ◽  
Anti Inflammatory ◽  
Plectranthus Amboinicus

Plectranthus amboinicus (Lour.) Spreng. are generally used in Chinese folk medicine for treating fever, cough, mumps, sore throats, and mosquito bite. The current study was therefore carried out to provide vital pharmacological details about the leaf. This study investigated the anti-inflammatory properties of ethanolic extract from Plectranthus amboinicus. The leaves of Plectranthus amboinicus were rinsed, air dried and then powdered using machine. The ethanol extract of the plant was used for phytochemical analysis to identify the constituents present in the plants. HPTLC analysis was carried out to investigate its secondary metabolite profile by using the solvent mixture. The anti-inflammatory effect was analysed by inhibition of protein denaturation assay. The hypotonicity induced haemolysis was observed from 100µg/ml to 500µg/ml of extract concentration. The results proved that the ethanolic leaf extract of P.amboinicus has antiinflammatory activity. The presence of flavonoid, quercetin in plant extract was confirmed by HPTLC analysis and these flavonoids may be responsible for the antiinflammatory activity. Further studies are needed to the development of potential drug that may be used for various pharmacological activities.

scholarly journals ECLIPTA ALBA (BHRINGRAJ): A PROMISING HEPATOPROTECTIVE AND HAIR GROWTH STIMULATING HERB.

2021 ◽  
pp. 16-23
Author(s):  
ISHA KUMARI ◽  
HEMLATA KAURAV ◽  
GITIKA CHAUDHARY
Keyword(s):  
Medicinal Plant ◽  
Folk Medicine ◽  
Primary Source ◽  
Biological Properties ◽  
Vital Role ◽  
Eclipta Alba ◽  
Cosmetic Industry ◽  
Ancient Times ◽  
Therapeutic Properties ◽  
Phytochemical Constituents

Plants are the primary source of food, shelter, and various remedial approaches. They are being in use for treating various kinds of human ailments across the world since the ancient times. One of such important plants is Eclipta alba hassk (Asteraceae) which is commonly known as Bhringraj and false daisy. This plant is known for its extra-ordinary therapeutic properties. It is one of most widely used plant in traditional systems of medicines such as Ayurvedic, Unani, Sidha, homeopathy, Chinese, and folk. Each part of this medicinal plant contains many important phytochemical constituents such as coumestans, triterpenes, flavonoids, steroids, polypeptides, and saponins. It is majorly used for enhancing the growth, strength, and blackening of hair. It is used as the main ingredient in many hair oils. It significantly treats problems related to hair such as hair fall, dandruff, premature greying, and baldness. E. alba exhibits many other important biological properties such as anticancer, anti-bacterial, anti-viral, anti-stress, and immunomodulatory. Thus, this medicinal plant is playing a vital role in the medical field and cosmetic industry. The present review is a summary of phytomedicinal importance of E. alba in Ayurveda as well as folk medicine system.

Helenalin - A Sesquiterpene Lactone with Multidirectional Activity

2019 ◽  
Vol 20 (4) ◽  
pp. 444-452 ◽  
Author(s):  
Joanna Drogosz ◽  
Anna Janecka
Keyword(s):  
Sesquiterpene Lactone ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Folk Medicine ◽  
Biological Properties ◽  
Pathological Conditions ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Minor Injuries

Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the Asteracea family, are used in the traditional medicine of many countries for the treatment of various pathological conditions. They exert a broad range of activities, including antiinflammatory, anti-bacterial and anti-cancer properties. The best-known sesquiterpene lactones which are already used as drugs or are used in clinical trials are artemisinin, thapsigargin and parthenolide. Yet another sesquiterpene lactone, helenalin, an active component of Arnica montana, known for its strong anti-inflammatory activity, has been used for centuries in folk medicine to treat minor injuries. Unfortunately, helenalin’s ability to cause allergic reactions and its toxicity to healthy tissues prevented so far the development of this sesquiterpene lactone as an anticancer or anti-inflammatory drug. Recently, the new interest in the biological properties, as well as in the synthesis of helenalin analogs has been observed. This review describes helenalin's major biological activities, molecular mechanisms of action, its toxicity and potential for further research.

scholarly journals Review: Marsh rosemary (Rhododendron tomentosum Harmaja (ex Ledum palustre Linn) growing in Lithuania) essential oils and their properties

Chemija ◽  
2020 ◽  
Vol 31 (4) ◽  
Author(s):  
Asta Judžentienė
Keyword(s):  
Essential Oils ◽  
Folk Medicine ◽  
Modified Electrodes ◽  
Biological Properties ◽  
Diffusion Method ◽  
Published Data ◽  
Toxic Activity ◽  
Ledum Palustre ◽  
Anti Inflammatory ◽  
Rhododendron Tomentosum

The paper reviews already (in the past fifteen years) published data from research articles on essential oils (EOs) and their biological properties (such as antioxidant, antifungal, anti-inflammatory and toxic activity) of marsh rosemary (Rhododendron tomentosum (Stokes) Harmaja (ex Ledum palustre Linnaeus, Ericaceae Juss.) growing wild in Lithuania. Rh. tomentosum is a perennial woody shrub (up to 1 m in height) with evergreen leaves and small white or white-pink sticky flowers grouped in racemes. The plant emits a strong specific smell that affects the central nervous system, and may cause nausea, headache or aggressive behaviour to some people. Only one species of the plant (ex L. palustre var. palustre) grows in Lithuania, mainly forming colonies in limited areas over all the territory. Marsh rosemary are widely used in folk medicine and homeopathy for treatment of various sickness, externally and internally as well. Most applications of Rh. tomentosum and pharmacological properties have been validated by scientific researches. In Lithuania, the plant is used for healing rheumatism, different pains, insect bites, eczema and other skin problems, infections, bronchitis, asthma, cold, tuberculosis, to block bleeding, etc. Rhododendron tomentosum H. (ex Ledum palustre L.) plants, the essential oils (EOs) of which are already investigated, were collected mostly in the Eastern part of the country (Rokiškis, Utena, Vilnius and Šalčininkai districts). Monoterpene hydrocarbons, p-cymene, myrcene and limonene, bicyclic monoterpenoid ascaridole and oxygenated sesquiterpenes, ledol, palustrol and cyclocolorenone isomers, were found to be principal compounds in the investigated EOs. Some oils contained appreciable quantities of heterocyclic compound lepalol. Most of the oils could be attributed to the ledol+palustrol or ledol+palustrol+ascaridole chemotype. Antifungal activity of Rh. tomentosum EOs was evaluated by several different techniques: against Penicillium cyclopium Westling, Trichoderma harzianum Rifai and Candida parapsilosis using an agar diffusion method; and amperometricaly, using Saccharomyces cerevisiae yeast-modified electrodes. Anti-inflammatory activity of Lithuanian marsh rosemary EOs has been revealed by subcutaneous carrageenan injection-induced hind paw oedema tests. However, antioxidant activity (tests using ABTS˙+, DPPH˙ and TROLOX) and toxic properties (against brine shrimp (Artemia sera) larvae) of Rh. tomentosum EOs were summarized.

scholarly journals Boswellia serrata ROXB. EX COLEBR. (Salai): An Ayurvedic Herb with Anti-inflammatory Potential

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Gitika Chaudhary ◽  
Isha Kumari
Keyword(s):  
Folk Medicine ◽  
Complex Mixture ◽  
Boswellia Serrata ◽  
Indian States ◽  
Medicinal Tree ◽  
Stomach Pain ◽  
Cosmetic Industry ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Therapeutic Activities

Medicinal plants hold a very significant place in the pharmaceutical, cosmetic, and nutraceutical industries. Boswellia serrata is one of such plants which is used in the pharmaceutical as well as cosmetic industry for so many purposes. This medicinal tree belongs to the family Burseraceae and called Indian Olibanum in English and Salai in Hindi. It is found in many Indian states including Madhya Pradesh, Jharkhand, and Andhra Pradesh etc. It is a well-recognized plant in Ayurvedic pharmacopeia. It is used in folk medicine practices to treat many human ailments such as inflammation, joint pain, cough, diarrhoea, dysentery, stomach pain, edema, hydrocoele, toothache and headache etc. The characteristic feature of the plant is its oleo-gum-resin which is a complex mixture of many therapeutically important phytochemical constituents such as boswellic acids. The main therapeutic activities associated with this plant are anti-inflammatory, anti-diabetic, anti-bacterial, anti-oxidant, hepatoprotective, nephroprotective, diuretic, anti-obesity, analgesic and anti-cancer. The present study has summarized the therapeutic and pharmacological value of Boswellia serrata along with its utilization in the Folklore medicinal system.

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