Fasting Blood Glucose Profile among Secondary School Adolescents in Ado-Ekiti, Nigeria

Background.Over the past two decades there has been an increase in type 2 diabetes mellitus (T2DM) in children. Baseline data is needed to assess the impact of changing lifestyles on Ado-Ekiti, a previously semiurban community in Southwest Nigeria. This study was therefore conducted to assess the fasting blood glucose (FBG) of adolescents in Ado-Ekiti, Nigeria.Methodology.This was a cross-sectional study involving 628 adolescents from three different secondary schools in Ado-Ekiti, Nigeria. With parental consent, volunteers completed a structured questionnaire, and an overnight FBG was measured.Results.There were 346 males and 282 females (male : female ratio = 1.2 : 1). Their ages ranged from 10 to 19 years (mean age:14.2±1.7years). Four hundred and forty-four (70.7%) had normal FBG, while 180 (28.7%) and 4 (0.6%) had FBG in the prediabetic and diabetic range, respectively. Female gender, age group 10–14 years, and family history of obesity were significantly associated with impaired FBG (Pvalue <0.001, <0.001, and 0.045, resp.).Conclusion.Impaired FBG is common among secondary school adolescents and it is more prevalent among younger female adolescents (10–14 years) with positive family history of obesity.

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The Early Prelinguistic Skills in Iranian Infants and Toddlers

Iranian Rehabilitation Journal ◽

10.32598/irj.19.4.1605.1 ◽

2021 ◽

Vol 19 (4) ◽

pp. 441-454

Author(s):

Narges Bayat ◽

◽

Atieh Ashtari ◽

Mohsen Vahedi ◽

◽

...

Keyword(s):

Family History ◽

Speech Therapy ◽

Positive Family History ◽

Age Groups ◽

Language Disorders ◽

Cross Sectional ◽

History Of ◽

The Impact ◽

Children's Development ◽

Children’S Development

Objectives: The prelinguistic skills which pave the way for language development have always been an area of research in the Speech Therapy field. Although studying these skills is important, there is a study gap among Persian children. Therefore, this study explored prelinguistic skills among a sample of Persian-speaking children aged 6 to 24 months and made a comparison between different age groups. We also studied the effects of gender and family history of speech-language disorders on children’s prelinguistic abilities. Methods: In the present study, 277 mothers of Iranian Persian-speaking children aged 6 to 24 months were asked to fill a research-made checklist that evaluated the prelinguistic skills of their children. This study was cross-sectional and was conducted in Tehran City, Iran, in 2021. Children’s abilities in different age groups were compared using the analysis of variance (ANOVA), Scheffe test, the Kruskal-Wallis test, and the post-hoc test. The differences between the total scores of the two genders were also determined using the Mann-Whitney U test. Results: Comparing the prelinguistic skills in different age groups indicated a statistically significant increase in the scores as children grow up. Children with a positive family history of speech-language disorders scored lower on the checklist than the others (91.03±17.37). Furthermore, there were statistically significant differences between the two genders in developing gesture, vocalization, first words, social interaction, imitation, and play; girls had higher scores. Conclusion: Based on the studies conducted in different countries, prelinguistic skills develop as children grow up; these skills facilitate language acquisition and other social skills. The present study also demonstrated the development of these skills alongside children’s development. This similarity between Persian-speaking children and other children from different cultures and languages, as well as better performance in children with a negative family history of speech-language impairments, confirm the role of genetic factors in children’s development. Moreover, the differences in the development of some prelinguistic skills between girls and boys reveal the impact of various factors, such as social factors, on prelinguistic skills development.

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The Impact of Metabolic Syndrome on Increased Risk of Thyroid Nodules and Size

Health Services Research and Managerial Epidemiology ◽

10.1177/2333392818775517 ◽

2018 ◽

Vol 5 ◽

pp. 233339281877551 ◽

Cited By ~ 1

Author(s):

Abdulbari Bener ◽

Yaşar Özdenkaya ◽

Cem Cahit Barışık ◽

Mustafa Öztürk

Keyword(s):

Metabolic Syndrome ◽

Blood Glucose ◽

Family History ◽

Thyroid Nodules ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Family History Of Diabetes ◽

Increased Risk ◽

History Of ◽

The Impact

Aim: The present research aimed to determine the relation between metabolic syndrome (MetS) and thyroid volume and nodule prevalence among Turkish population patients. Methods: This retrospective cohort study was carried on 850 patients between the ages of 20 and 65 who visited the diabetic, endocrinology, and general surgery outpatient clinics in the Mega Medipol and Medipol Hospital between January 2014 and December 2017. This study included sociodemographic information, body mass index (BMI), diabetes mellitus (DM), systolic (SBP) and diastolic (DBP) blood pressures, and clinical biochemistry results such as serum triglyceride, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL) cholesterol, hemoglobin A1c (HbA1c), fasting blood glucose levels, thyroid-stimulating hormone (TSH), T3, T4, and other MetS parameters. Thyroid fine needle aspiration biopsy was suggested to patients whose thyroid nodules were greater than 1.00 cm. The definition and diagnostic of MetS used as proposed by the National Cholesterol Education Program—Third Adult Treatment Panel. Results: There were statistically significant differences between patients with thyroid nodules and those without regarding age, gender, BMI, physical activity, cigarette smoking, shisha smoking, family history of diabetes, hypertension, and thyroid. Meanwhile, statistically significant differences were found between with and without MetS for calcium ( P = .028), magnesium ( P < .001), potassium ( P < .001), fasting blood glucose ( P = .047), HbA1c ( P < .001), HDL ( P < .001), LDL ( P < .001), albumin ( P = .008), bilirubin ( P = .002), triglyceride ( P = .011), SBP ( P = .001) and DBP ( P = .011), TSH ( P = .005), T3 ( P < .001), and T4 ( P < .001). Furthermore, there were statistically significant differences between participants with and without thyroid nodules for calcium ( P < .001), magnesium ( P < .001), potassium ( P < .001), fasting blood glucose ( P = .010), HbA1c ( P = .019), HDL ( P < .001), LDL ( P = .012), albumin ( P = .002), bilirubin ( P < .001), triglyceride ( P < .001), SBP ( P < .001) and DBP ( P = .004), TSH ( P = .015), T3 ( P < .001), and T4 ( P < .001). Multivariate stepwise logistic regression analysis used for independent predictors for the presence of thyroid nodules which TSH ( P < .001), family history of thyroid and DM ( P < .001), age in years ( P = .025), DBP and SBP ( P < .001), BMI ( P = .014), HDL-C ( P = .034), and waist circumference (in cm; P = .044) were considered at higher risk as a predictors of thyroid with patients with MetS. Conclusion: The results of the current study confirm a strong positive association between MetS and thyroid nodules risk among patients with MetS. This study suggest that the patients with MetS can be considered as a marker to have moderately increased risk of future thyroid nodules and cancer. Meanwhile, MetS, obesity, and hyperglycemia could be a qualifiable and modifiable risk factor for thyroid nodules. The regularly glycemic control may be the most important treatment for the reduction of incidence or the prevention of thyroid.

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Obesity Among Secondary School Students in Bahrain

Nutrition and Health ◽

10.1177/026010609300900103 ◽

1993 ◽

Vol 9 (1) ◽

pp. 25-32 ◽

Cited By ~ 19

Author(s):

Abdulrahman O. Musaiger ◽

Ahmed M. Matter ◽

Sadiq A. Alekri ◽

Abdul-Rassol E. Mahdi

Keyword(s):

Family History ◽

Secondary School ◽

Secondary School Students ◽

Cross Sectional Study ◽

School Students ◽

Cross Sectional ◽

Prevalence Of Obesity ◽

History Of ◽

History Of Obesity ◽

And Control

The aim of this study is to estimate the prevalence of obesity and factors associated with it in Bahraini secondary school students. A cross-sectional study involving a sample of 825 students (417 boys and 408 girls) aged 15 to 21 years was obtained from secondary schools. Obesity was determined using body mass index (BMI = Wt/Ht2). The findings revealed that 15.6% of boys and 17.4% of girls were either overweight or obese (BMI ≥25). Family size, parents education, and family history of obesity were significantly associated with obesity among boys, while family history was the only socio-economic factors statistically associated with obesity among girls. Meal patterns such as eating between meals, number of meals per day, and method of eating were not associated with obesity in students. Boys who ate alone were 3 times more likely to be obese than those who ate with family members (odd ratio = 3.4). Measures to prevent and control obesity among children are suggested.

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Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

BMC Research Notes ◽

10.1186/s13104-021-05703-8 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Uzair Abbas ◽

Bushra Imdad ◽

Sikander Adil Mughal ◽

Israr Ahmed Baloch ◽

Afshan Mehboob Khan ◽

...

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Positive Family History ◽

Cross Sectional Study ◽

Vital Role ◽

Micro Rna ◽

Cross Sectional ◽

Family History Of Diabetes ◽

History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

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What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

Tanzania Medical Journal ◽

10.4314/tmj.v31i2.363 ◽

2020 ◽

Vol 31 (2) ◽

pp. 33-44

Author(s):

Simon Francis ◽

Obadia V. Nyongole

Keyword(s):

Prostate Cancer ◽

Family History ◽

Positive Family History ◽

Negative Attitude ◽

Cross Sectional Study ◽

Cross Sectional ◽

Adult Men ◽

History Of ◽

One Year ◽

High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

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Prevalence and Risk Factors for Glucose Intolerance among Saudi Women with Gestational Diabetes

Journal of Diabetes Research ◽

10.1155/2018/4282347 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Hayfaa Wahabi

Keyword(s):

Risk Factors ◽

Family History ◽

Gestational Diabetes ◽

Glucose Intolerance ◽

Fasting Blood Glucose ◽

Positive Family History ◽

Family History Of Diabetes ◽

Saudi Women ◽

History Of ◽

One Year

Objectives. The objective of this study was to determine the incidence and risk factors of glucose intolerance one year after delivery in women with gestational diabetes (GDM). Methods. All women who had GDM and completed one year since delivery at King Khalid University Hospital were contacted to participate in the study. Based on to the American Diabetes Association criteria and the results of fasting blood glucose (FPG) and HbA1c, participants were classified into three groups: diabetic, impaired glucose tolerance (IGT), and normal. The incidence of diabetes and IGT was calculated. Clinical, biochemical, and sociodemographic predictors of glucose intolerance were compared between the three groups. Odds ratio (OR) for risk factors with P value less than 0.05 was calculated. Results. From a total 316 eligible women, 133 fulfilled the inclusion criteria and agreed to participate in the study. From the study participants, 58 (44%) women were normoglycemic, 60 (45%) women had IGT, and 15 (11%) women were diabetic. The odds of developing IGT or diabetes increased to nearly fourfold when women needed insulin for the control of GDM during pregnancy (OR 3.8, 95% CI 0.81–18.3, P=0.08) and to nearly one-and-a-half-fold when they have positive family history of T2DM (OR 1.2, 95% CI 0.74–2.09, P=0.40). Nevertheless, none of the odds ratios was statistically significant. Conclusion. The incidence of postpartum hyperglycemia (diabetes and IGT) is very high in Saudi women with GDM. Family history of diabetes and insulin treatment of GDM may be predictors of postpartum hyperglycemia.

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Clinical and Demographic Profiles of Patients Diagnosed as Cough Variant Asthma attended at Tertiary Referral Hospital

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v2i1.32960 ◽

2017 ◽

Vol 2 (1) ◽

pp. 30-33

Author(s):

SK Shahinur Hossain ◽

Md Safiul Islam ◽

Md Mustafizur Rahman ◽

Shubhashish Dey ◽

Khurshid Mahmud

Keyword(s):

Family History ◽

Positive Family History ◽

Challenge Test ◽

Young Male ◽

Tertiary Referral Hospital ◽

Cross Sectional ◽

Cough Variant Asthma ◽

Demographic Profiles ◽

History Of ◽

Study Population

Background: Cough variant asthma is presented with different clinical and demographic characteristics.Objectives: The purpose of the present study was to see the clinico-demographic profiles of cough variant asthma patients.Methodology: This descriptive type of cross-sectional study was carried out in theDepartment of Respiratory Medicine at National Institute of Diseases of the Chest and Hospital (NIDCH), Dhaka, Bangladesh from September 2014 to August 2015 for a period of one year. Patients presented with cough variant asthma attending in NIDCH were selected as study population. Methacholine challenge test was performed to diagnosis of Cough Variant Asthma. Result: A total number of 50 patients were recruited for this study. The mean age±SD was found 19.1±7.6 years. Male was predominant than female with a ratio of 1.4.:1. Among the study population positive family history of asthma was found in 39.0% cases and associated allergic rhinitis was reported in 58.0% cases. Eczema was associated with 16.0% patients;however, only 4% patients had associate conjunctivitis. Conclusion: In conclusion young male is more commonly affected by cough variant asthma of which majority have family history of asthma. Journal of National Institute of Neurosciences Bangladesh, 2016;2(1):30-33

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Sociodemographic and Clinical Variables of Depression among Patients with Epilepsy in a Neuropsychiatric Hospital in Nigeria

Depression Research and Treatment ◽

10.1155/2020/2953074 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Nasir Olamide Madandola ◽

Shehu Sale ◽

Adebayo Sunday Adebisi ◽

Ayodele Obembe ◽

Auwal S. Salihu ◽

...

Keyword(s):

Family History ◽

Depressive Disorder ◽

General Health Questionnaire ◽

Positive Family History ◽

Composite International Diagnostic Interview ◽

Minority Ethnic Group ◽

Cross Sectional ◽

History Of ◽

Patients With Epilepsy ◽

Minority Ethnic

Background. Depression is a major contributor to the global burden of disease. Its occurrence in patients living with epilepsy is not just common but also a serious comorbidity. Patients tend to suffer if the depressive disorder is undetected and thus untreated. The aim of this study is to estimate the prevalence of depressive disorder in patients with epilepsy. Also, the sociodemographic and clinical factors that are associated with the development of depression in people living with epilepsy were examined. Materials and Method. This was a descriptive cross-sectional study of participants living with epilepsy and receiving care at the Federal Neuropsychiatric Hospital, Sokoto, Nigeria. Participants were recruited consecutively as they come for follow-up care. A sociodemographic/clinical questionnaire and General Health Questionnaire version 28 (GHQ-28) were first administered to participants followed by the Composite International Diagnostic Interview (CIDI). The descriptive statistics were generated and analyzed. Logistic regression was also done to determine the predictors of depression in the study participants. All test of probability was set at p<0.05. Results. A total of 400 participants with epilepsy were examined with GHQ-28 and CIDI. Out of the GHQ-28 examined individuals, 71 people (17.8%) met criteria for caseness while 35 participants (8.8%) were depressed when assessed with CIDI. The predictors of depressive illness in participants living with epilepsy were GHQ caseness (p≤0.001), minority ethnic group (p=0.006), and a positive family history of mental illness (p=0.021). Conclusion. Depression is common in people with epilepsy. Physicians should actively assess individuals with epilepsy for symptoms of depression. Special attention should be paid to patients with a family history of epilepsy and those from minority ethnic groups.

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The Effect of Ranitidine on Olanzapine-Induced Weight Gain

BioMed Research International ◽

10.1155/2013/639391 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Fatemeh Ranjbar ◽

Alireza Ghanepour ◽

Homayoun Sadeghi-Bazargani ◽

Mahbob Asadlo ◽

Amineh Alizadeh

Keyword(s):

Weight Gain ◽

Family History ◽

Positive Family History ◽

First Episode ◽

Long Run ◽

Combined Use ◽

History Of ◽

History Of Obesity ◽

Baseline Bmi ◽

First Time

Induced weight gain is a disturbing side effect of Olanzapine that affects the quality of life in psychotic patients. The aim of this study was to assess the efficacy of Ranitidine in attenuating or preventing Olanzapine-induced weight gain. A parallel 2-arm clinical trial was done on 52 patients with schizophrenia, schizoaffective and schizophreniform disorders who received Olanzapine for the first time. All these were first-episode admitted patients. They were randomly allocated to receive either Ranitidine or placebo. The trend of body mass index (BMI) was compared between groups over 16-week course of treatment. Mean weight was 62.3 (SD: 9.6) kg at baseline. Thirty-three subjects (63.5%) had positive family history of obesity. The average BMI increment was 1.1 for Ranitidine group and 2.4 for the placebo group. The multivariate analysis showed this effect to be independent of sex, family history of obesity, and baseline BMI value. The longitudinal modeling after controlling for baseline values failed to show the whole trend slope to be different. Although the slight change in trend’s slope puts forward a hypothesis that combined use of Ranitidine and Olanzapine may attenuate the weight gain long run, this needs to be retested in future larger scale long-term studies. This trial is registered with IRCT.ir201009112181N5.

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Clinical Asssessment of Sensorineural Hearing Loss among Diabetes Mellitus Patients

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2020.v28i2.297 ◽

2020 ◽

Vol 28 (2) ◽

pp. 112-119

Author(s):

Raveendra P Gadag ◽

Puneeth S Nayak ◽

Tejaswini J

Keyword(s):

Hearing Loss ◽

Blood Glucose ◽

Family History ◽

Hearing Impairment ◽

Fasting Blood Glucose ◽

Bone Conduction ◽

Pure Tone Audiometry ◽

Chi Square ◽

History Of ◽

And Gender

Background: Hearing impairment is known to hamper the quality of life among patients, especially among diabetics due to the association of neuropathy with diabetes. However, the prevalence and degree of the SNHL depends upon different factors, such as age, gender, disease duration of DM, family history and glycemic status of the patients. Therefore, this study aimed to assess the association of SNHL with DM duration and familial DM and gender preponderance among SNHL–DM patients. Methods: Total 140 patients with DM were assessed for hearing impairment using Rinne, Weber and Absolute Bone Conduction Tests along with pure tone audiometry. Patients’ glycaemic status was determined by estimating fasting blood glucose (FBG) and post prandial blood glucose (PPBG) levels. Independent t-test, chi-square, ANOVA and Pearson’s correlation tests along with linear regression model were used to find association and correlation using R software. Results: Out of 140 patients, 60 were suffering from SNHL and majority were suffering from bilateral minimal hearing loss. SNHL was significantly associated with family history, age, duration of DM, FBG and PPBG levels were(Pvalues:1.79E08, 4.41E-06 and 0.02), however, significant correlated with duration of DM, FBS and PPBG level (r value:0.14–0.41).Furthermore, significant SNHL at 500 and 8000Hz was observed in the present study (Pvalue:0.002). Conclusion: A conclusive proof was drawn that family history of DM serve as a valuable variable in assessing the SNHL among DM patients.

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