Association betweenHelicobacter pyloriInfection and Chronic Urticaria: A Meta-Analysis

Background. Some studies have shown the possible involvement ofHelicobacter pylori(H. pylori) infection in chronic urticaria, but the relationship remains controversial. The aim of this meta-analysis was to quantitatively assess the association betweenH. pyloriinfection and chronic urticaria.Methods. Observational studies comparing the prevalence ofH. pyloriinfection in patients with chronic urticaria and control subjects were identified through a systematic search in MEDLINE and EMBASE up to July 2014.H. pyloriinfection was confirmed by serological or nonserological tests. For subgroup analyses, studies were separated by region, publication year, andH. pyloridetection method to screen the potential factors resulting in heterogeneity.Results. 16 studies involving 965 CU cases and 1235 controls were included. Overall, the prevalence ofH. pyloriinfection was higher in urticarial patients than in controls (OR = 1.66; 95% CI: 1.12–2.45;P=0.01). This result persisted in subanalysis of nine high-quality studies (OR = 1.36; 95% CI: 1.03–1.80;P=0.03). Subgroup analysis showed that detection method ofH. pyloriis also a potential influential factor for the overall results.Conclusions. Our present meta-analysis suggests thatH. pyloriinfection is significantly, though weakly, associated with an increased risk of chronic urticaria.

Download Full-text

Association between gout and atrial fibrillation: A meta-analysis of observational studies

F1000Research ◽

10.12688/f1000research.17104.1 ◽

2018 ◽

Vol 7 ◽

pp. 1924 ◽

Cited By ~ 1

Author(s):

Keith Sai Kit Leung ◽

Mengqi Gong ◽

Yingzhi Liu ◽

Rachel Wing Chuen Lai ◽

Chengsheng Ju ◽

...

Keyword(s):

Atrial Fibrillation ◽

Observational Studies ◽

Case Control Study ◽

Meta Analysis ◽

Search Term ◽

Monosodium Urate ◽

Increased Risk ◽

The Relationship ◽

Control Study ◽

Urate Crystals

Background: Gout is a systemic inflammatory arthritis characterized by the deposition of monosodium urate crystals due to hyperuricemia. Previous studies have explored the link between gout and atrial fibrillation (AF). Given the increasing prevalence and incidence of gout, there is a need to quantify the relationship between gout and the risk of AF. Therefore, we conducted a systematic review and meta-analysis on this topic. Methods: PubMed and Embase were searched for studies that reported the association between gout and AF using the following search term: (‘Gout’ and ‘Arrhythmia’). The search period was from the start of the database to 3rd August 2018 with no language restrictions. Results: A total of 75 and 22 articles were retrieved from PubMed and Embase, respectively. Of these, four observational studies (three cohort studies, one case-control study) including 659,094 patients were included. Our meta-analysis demonstrated that gout was significantly associated with increased risk of AF (adjusted hazard ratio: 1.31; 95% confidence interval: 1.00-1.70; P = 0.05; I2 = 99%) after adjusting for significant comorbidities and confounders. Conclusions: Our meta-analysis confirms the significant relationship between gout and AF. More data are needed to determine whether this risk can be adequately reduced by urate-lowering therapy.

Download Full-text

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

10.21203/rs.2.16520/v2 ◽

2020 ◽

Author(s):

Xiao-ce Dai ◽

Xin-xin Yang ◽

Lan Ma ◽

Guan-min Tang ◽

Yan-yun Pan ◽

...

Keyword(s):

Observational Studies ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Aortic Diseases ◽

Inverse Variance ◽

Increased Risk ◽

Statistical Heterogeneity ◽

First Occurrence ◽

The Relationship

Abstract Background. Our aim was to determine the relationship between the use of fluoroquinolones and the risk of aortic diseases. Methods. PubMed, EMBASE and the Web of Science were searched from inception to July 6, 2019, to identify observational studies that evaluated the risk of aortic diseases associated in users of fluoroquinolones compared with nonusers or users of other antibiotics. The primary outcome was the first occurrence of aortic diseases. We used the GRADE approach to rate the strength of evidence. We used the inverse variance method random-effect model to estimate the odds ratios (ORs) with 95% CIs, and statistical heterogeneity was assessed by the I 2 statistic. Results. This meta-analysis enrolled 2,829,385 patients reported the relationship between fluoroquinolones and the risk of aortic diseases. Compared with nonusers or users of other antibiotics, users of fluoroquinolone had a significantly increased risk of aortic diseases (adjusted OR, 2.10; 95% CI, 1.65-2.68; P =.000, I 2 =16.4%). The quality of evidence was moderate, and the number needed to harm (NNH) for aortic diseases among patients was estimated to be 1301. Conclusions. The fluoroquinolone use in patients significantly increases the risk of new-onset aortic diseases. Clinicians need to pay attention to these severe adverse events when considering fluoroquinolone use. Key Words: Fluoroquinolones; aortic aneurysm; aortic dissection; meta-analysis

Download Full-text

The Evolving Epidemiology ofHelicobacter pyloriInfection and Gastric Cancer

Canadian Journal of Gastroenterology ◽

10.1155/2003/692808 ◽

2003 ◽

Vol 17 (suppl b) ◽

pp. 18B-20B ◽

Cited By ~ 20

Author(s):

Jia-Qing Huang ◽

Richard H Hunt

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Epidemiological Studies ◽

Increased Risk ◽

H Pylori ◽

The Relationship

The relationship betweenHelicobacter pyloriinfection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role ofcagAstrains ofH pyloriin relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection withcagA-positive strains ofH pyloriand the risk of gastric cancer, and found that patients who are seropositive forcagAstrains ofH pyloriare at an increased risk for developing noncardia gastric cancer compared with those withH pyloriinfection alone. Therefore, searching forcagA-positive strains ofH pylorimay help identify populations at a greater risk for developing gastric cancer.

Download Full-text

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

10.21203/rs.2.16520/v3 ◽

2020 ◽

Author(s):

Xiao-ce Dai ◽

Xin-xin Yang ◽

Lan Ma ◽

Guan-min Tang ◽

Yan-yun Pan ◽

...

Keyword(s):

Observational Studies ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Aortic Diseases ◽

Inverse Variance ◽

Increased Risk ◽

Statistical Heterogeneity ◽

First Occurrence ◽

The Relationship

Abstract Background. Our aim was to determine the relationship between the use of fluoroquinolones and the risk of aortic diseases.Methods. PubMed, EMBASE and the Web of Science were searched from inception to July 6, 2019, to identify observational studies that evaluated the risk of aortic diseases associated in users of fluoroquinolones compared with nonusers or users of other antibiotics. The primary outcome was the first occurrence of aortic diseases. We used the GRADE approach to rate the strength of evidence. We used the inverse variance method random-effect model to estimate the odds ratios (ORs) with 95% CIs, and statistical heterogeneity was assessed by the I2 statistic.Results. This meta-analysis enrolled 2,829,385 patients reported the relationship between fluoroquinolones and the risk of aortic diseases. Compared with nonusers or users of other antibiotics, users of fluoroquinolone had a significantly increased risk of aortic diseases (adjusted OR, 2.10; 95% CI, 1.65-2.68; P=.000, I2=16.4%). The quality of evidence was moderate, and the number needed to harm (NNH) for aortic diseases among patients was estimated to be 1301.Conclusions. The fluoroquinolone use in patients significantly increases the risk of new-onset aortic diseases. Clinicians need to pay attention to these severe adverse events when considering fluoroquinolone use.

Download Full-text

The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2021/8886085 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Liang Wang ◽

Junyin Chen ◽

Wenxi Jiang ◽

Li Cen ◽

Jiaqi Pan ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Subgroup Analysis ◽

Meta Analysis ◽

Chronic Cholecystitis ◽

Cochrane Library ◽

Positive Correlation ◽

Increased Risk ◽

H Pylori ◽

The Relationship

Helicobacter pylori (H. pylori) is proved to be the main pathogenic agent of various diseases, including chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. In addition, chronic cholecystitis and cholelithiasis are common worldwide, which are supposed to increase the total mortality of patients. Epidemiologic evidence on the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis still remains unclear. We conducted a systematic review and meta-analysis of overall studies to investigate the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis. Two researchers searched PubMed, Embase, and Cochrane Library databases to obtain all related and eligible studies published before July 2020. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by the random-effects model. Subgroup analysis, heterogeneity, publication bias, and sensitivity analysis were also conducted. Twenty studies were included in the meta-analysis, involving 1735 participants and 1197 patients with chronic cholecystitis/cholelithiasis. Helicobacter species infection of the gallbladder was positively correlated with increased risk of chronic cholecystitis and cholelithiasis, especially H. pylori (OR = 3.05; 95% CI, 1.81–5.14; I2 = 23.5%). Besides, country-based subgroup analysis also showed a positive correlation between the gallbladder H. pylori positivity and chronic cholecystitis/cholelithiasis risk. For Asian and non-Asian country studies, the ORs were 4.30 (95% CI, 1.76–10.50; I2 = 37.4%) and 2.13 (95% CI, 1.23–3.70; I2 = 0.0%), respectively. The association was more obvious using the bile sample and urease gene primer. In conclusion, this meta-analysis provided evidence that there is a positive correlation between H. pylori infection in the gallbladder and increased risk of chronic cholecystitis and cholelithiasis.

Download Full-text

cagA-Seropositive Strains ofHelicobacter pyloriIncrease the Risk for Gastric Cancer more than the Presence ofH pyloriAlone

Canadian Journal of Gastroenterology ◽

10.1155/2004/424018 ◽

2004 ◽

Vol 18 (5) ◽

pp. 341-343

Author(s):

Naoki Chiba

Keyword(s):

Gastric Cancer ◽

Odds Ratio ◽

Meta Analysis ◽

Review Of The Literature ◽

Chain Reaction ◽

Positive Strain ◽

Increased Risk ◽

Polymerase Chain ◽

H Pylori ◽

The Relationship

Huang et al have performed a meta-analysis to determine the relationship betweencagA seropositivity (by serology and polymerase chain reaction) and the risk of gastric cancer. An extensive review of the literature identified no previous systematic overviews. The authors identified 16 studies involving 2284 cases and 2770 controls. The overall prevalence of Helicobacter pylori was 77.7% in cases and 63.1% in controls. Tests forcagA were positive in 62.8% of cases and 37.5% of controls. Thus,H pyloriandcagA seropositivity significantly increased the risk for gastric cancer, by 2.28 (95% CI 1.71 to 3.05) and 2.87 (95% CI 1.95 to 4.22), respectively. In patients withH pylori, those who were infected by acagA-positive strain had a slightly higher risk of gastric cancer, with an odds ratio of 1.64 (95% CI 1.21 to 2.24). The authors also found that patients infected withH pyloriwith or withoutcagA seropositivity had an increased risk of noncardia gastric cancer, but not of cancer of the gastric cardia. They concluded thatcagA-positive strains confer a greater risk of gastric cancer than does H pylori infection alone.

Download Full-text

Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

Gastroenterology Research and Practice ◽

10.1155/2015/278905 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13 ◽

Cited By ~ 12

Author(s):

Lin Li ◽

Lingling Li ◽

Xiaoying Zhou ◽

Shuping Xiao ◽

Huiyuan Gu ◽

...

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Pregnant Women ◽

Web Of Science ◽

Hyperemesis Gravidarum ◽

Meta Analysis ◽

Control Group ◽

Increased Risk ◽

H Pylori ◽

The Relationship

Background. Several studies have shown a possible involvement ofHelicobacter pylori(H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG andH. pyloriinfection.Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence ofH. pyloriinfection between pregnant women with HG and the normal pregnant control subjects.Results. Of the HG cases, 1289 (69.6%) wereH. pylori-positive; however, 1045 (46.2%) wereH. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate ofH. pyloriwas significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81,P<0.001). Subgroup analysis indicated thatH. pyloriinfection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54,P<0.001).Conclusions.H. pylorishould be considered one of the risk factors of HG, especially in the developing countries.H. pylorieradication could be considered to relieve the symptoms of HG in some intractable cases.

Download Full-text

Association of Helicobacter Pylori babA2 gene and Gastric Cancer Risk: A Meta-analysis

10.21203/rs.2.17506/v2 ◽

2020 ◽

Author(s):

Marce-Amara Kpoghomou ◽

jinchen Wang ◽

Tianpei Wang ◽

Guangfu Jin

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Asian Population ◽

South American ◽

Case Control Studies ◽

South American Population ◽

Increased Risk ◽

H Pylori ◽

The Relationship

Abstract Background: The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk.Methods: Case-control studies involving the association between H. pylori babA2 gene and GC risk were systematically identified from PubMed databases. A meta-analysis was used to pool studies and to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of H. pylori babA2 gene associated with GC risk.Results: Twenty studies were identified with a total of 1289 GC cases and 1081 controls. H. pylori babA2 gene was associated with an increased risk of GC by 2.05 fold (95% CI: 1.30-3.24, P=0.002). In subgroup analysis, we found that H. pylori babA2 gene was significantly associated with GC risk in Asian population (OR=2.63, 95% CI: 1.36-5.09 P=0.004) but not in South American population (OR=1.35, 95% CI: 0.69-2.64, P=0.379).Conclusions: This meta-analysis indicates that H. pylori babA2 gene may be associated with increased risk of GC, especially in Asian population.

Download Full-text

Breakfast skipping and the risk of type 2 diabetes: a meta-analysis of observational studies

Public Health Nutrition ◽

10.1017/s1368980015000257 ◽

2015 ◽

Vol 18 (16) ◽

pp. 3013-3019 ◽

Cited By ~ 71

Author(s):

Huashan Bi ◽

Yong Gan ◽

Chen Yang ◽

Yawen Chen ◽

Xinyue Tong ◽

...

Keyword(s):

Type 2 Diabetes ◽

Observational Studies ◽

Meta Analysis ◽

Adjusted Relative Risk ◽

China National Knowledge Infrastructure ◽

Cross Sectional ◽

Breakfast Skipping ◽

Risk Estimates ◽

Increased Risk

AbstractObjectiveBreakfast skipping has been reported to be associated with type 2 diabetes (T2D), but the results are inconsistent. No meta-analyses have applied quantitative techniques to compute summary risk estimates. The present study aimed to conduct a meta-analysis of observational studies summarizing the evidence on the association between breakfast skipping and the risk of T2D.DesignSystematic review and meta-analysis.SettingRelevant studies were identified by a search of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI) and SINOMED up to 9 August 2014. We also reviewed reference lists from retrieved articles. We included studies that reported risk estimates (including relative risks, odds ratios and hazard ratios) with 95 % confidence intervals for the association between breakfast skipping and the risk of T2D.SubjectsEight studies involving 106 935 participants and 7419 patients with T2D were included in the meta-analysis.ResultsA pooled adjusted relative risk for the association between exposure to breakfast skipping and T2D risk was 1·21 (95 % CI 1·12, 1·31; P=0·984; I2=0·0 %) in cohort studies and the pooled OR was 1·15 (95 % CI, 1·05, 1·24; P=0·770; I2=0·0 %) in cross-sectional studies. Visual inspection of a funnel plot and Begg’s test indicated no evidence of publication bias.ConclusionsBreakfast skipping is associated with a significantly increased risk of T2D. Regular breakfast consumption is potentially important for the prevention of T2D.

Download Full-text

Serum uric acid levels and risk of prehypertension: a meta-analysis

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2016-0339 ◽

2017 ◽

Vol 55 (3) ◽

Cited By ~ 8

Author(s):

Menglin Jiang ◽

Dandan Gong ◽

Yu Fan

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Meta Analysis ◽

Elevated Serum ◽

China National Knowledge Infrastructure ◽

Cross Sectional ◽

Knowledge Infrastructure ◽

Increased Risk ◽

Cross Sectional Studies ◽

The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

Download Full-text