scholarly journals Effects of Oral L-Carnitine on Liver Functions after Transarterial Chemoembolization in Intermediate-Stage HCC Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Abeer Hassan ◽  
Yasuhiro Tsuda ◽  
Akira Asai ◽  
Keisuke Yokohama ◽  
Ken Nakamura ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Transarterial Chemoembolization ◽  
Intermediate Stage ◽  
Control Group ◽  
Control Groups ◽  
Medical College ◽  
Impaired Liver ◽  
Liver Functions ◽  
Branched Chain ◽  
And Control

Transarterial chemoembolization (TACE) is usually followed by hepatic dysfunction. We evaluated the effects of L-carnitine on post-TACE impaired liver functions.Methods. 53 cirrhotic hepatocellular carcinoma patients at Osaka Medical College were enrolled in this study and assigned into either L-carnitine group receiving 600 mg oral L-carnitine daily or control group. Liver functions were evaluated at pre-TACE and 1, 4, and 12 weeks after TACE.Results. The L-carnitine group maintained Child-Pugh (CP) score at 1 week after TACE and exhibited significant improvement at 4 weeks after TACE (P<0.01). Conversely, the control group reported a significant CP score deterioration at 1 week (P<0.05) and 12 weeks after TACE (P<0.05). L-carnitine suppressed serum albumin deterioration at 1 week after TACE. There were significant differences between L-carnitine and control groups regarding mean serum albumin changes from baseline to 1 week (P<0.05) and 4 weeks after TACE (P<0.05). L-carnitine caused prothrombin time improvement from baseline to 1, 4 (P<0.05), and 12 weeks after TACE. Total bilirubin mean changes from baseline to 1 week after TACE exhibited significant differences between L-carnitine and control groups (P<0.05). The hepatoprotective effects of L-carnitine were enhanced by branched chain amino acids combination.Conclusion. L-carnitine maintained and improved liver functions after TACE.

scholarly journals Outcome of Training on “Doctor-Patient Communication Skill” for the Pre-intern Physicians

2019 ◽  
Vol 21 (1) ◽  
pp. 3-7
Author(s):  
Mehrunnissa Khanom ◽  
Shahena Akter ◽  
ASM Zahed ◽  
Maliha Ata ◽  
Rummana Khair ◽  
...  
Keyword(s):  
Communication Skill ◽  
Skills Training ◽  
Control Group ◽  
Communication Skill Training ◽  
Control Groups ◽  
P Values ◽  
Medical College ◽  
Post Test ◽  
And Control ◽  
Experimental Group

Background: Communication is the way how a physician interacts with the patient; it should have nonverbal, verbal and para-verbal components. This study was designed for communication skill training on newly graduated medical and dental physicians and to compare the outcomes of training in terms of pretest and post-test results among experimental group and control groups. Materials & methods: It was a randomized, prospective, interventional study performed on newly graduated medical and dental physicians, recruited from four participating centres: Chittagong Medical College, Chattagram Maa-O-Shishu Hospital Medical College, Southern Medical College & Hospital and Chattagram International Dental College. Duration of study was from 1st January 2017 to 30th August 2017. After selecting 60 participants (experimental group: 50; control group: 10) by lottery method, informed consent was taken and all the participants of both groups appeared at a pre-test. Only experimental group attended the training program and both the groups appeared at post-test. Results: When pre-test and post-test values of experimental group was compared by t-test, the p values for proper introduction, verbal, non-verbal, para-verbal and total scores were 0.00, 0.00, 0.00, 0.00 and 0.00 respectively. During comparison post-test scores in experimental and control groups by ANCOVA, the p values for proper introduction, verbal, non-verbal, para-verbal and total scores were 0.00, 0.00, 0.00, 0.00 and 0.00 respectively. Conclusions: There was significant improvement in communication skill of physicians after receiving the training with no possibility of occurring those changes by chance. If appropriate, the results can be utilized to approach for formal introduction of communication skills training for pre-intern physicians. J MEDICINE JAN 2020; 21 (1) : 3-7

PHENOBARBITONE ENHANCEMENT OF BROMSULPHALEIN CLEARANCE IN NEONATAL HYPERBILIRUBINEMIA

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 556-561
Author(s):  
C. Y. Yeung ◽  
Victor Y. H. Yu
Keyword(s):  
Drug Therapy ◽  
Serum Bilirubin ◽  
Newborn Infants ◽  
Hepatic Uptake ◽  
Control Group ◽  
Control Groups ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
Before And After ◽  
And Control

Forty jaundiced Chinese newborn infants were randomly assigned to treatment and control groups. Twenty infants in the former group were given phenobarbitone 5 mg 8-hourly; those in the control group received no drug. BSP tests were performed in all infants on admission and repeated 24 hours afterwards. The percentage disappearance of the dye at designated intervals up to 135 minutes of each test before and after drug therapy was compared with that of the controls. Rate constants for the hepatic uptake phase (K1) and the biliary excretory phase (K2) in BSP removal were calculated from the plasma dye disappearance graph. Following phenobarbitone therapy, a significant increase in BSP clearance was observed, with increases in K1 and K2 values, suggesting the corresponding enhanced hepatic uptake and excretion of the dye. These results are consistent with the hypothesis that several mechanisms together are responsible for the phenobarbitone effect on the impaired liver function of newborn infants. It is suggested that the observed reduction of serum bilirubin levels with phenobarbitone therapy results both from enhanced uptake and from increased excretion of bilirubin by the liver.

scholarly journals TO COMPARE THE NEED FOR INTRAVENOUS VASOPRESSOR (RESCUE) THERAPY FOR TREATING SPINAL ANAESTHESIA INDUCED HYPOTENSION AMONG PHENYLEPHRINE, EPHEDRINE AND CONTROL GROUPS.

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Utsav Sharma ◽  
Kunwar Singh Thakur ◽  
Preeti Goyal ◽  
Bhanu Choudhary
Keyword(s):  
Caesarean Section ◽  
Spinal Anaesthesia ◽  
Rescue Therapy ◽  
Elective Caesarean Section ◽  
Control Group ◽  
Control Groups ◽  
Induced Hypotension ◽  
Medical College ◽  
And Control

The study was undertaken in the Department of Anaesthesiology, Gajra Raja Medical College, Gwalior. The study included 90 patients (age 20-35 years) undergoing elective caesarean section under spinal anaesthesia. Maximum hypotension was observed in control group. As compared to the control group, incidence of hypotension was significantly less in phenylephrine group as well as ephedrine group. Also comparing ephedrine and phenylephrine groups, although incidence of hypotension was low in phenylephrine group but it was not found to be significant. The incidence of hypotension was significantly low in phenylephrine group (p=0.000) and ephedrine group (p=0.005). But when phenylephrine and ephedrine groups were compared, although incidence of hypotension was low in phenylephrine group but it was not found to be significant (p=0.869). Keywords: Intravenous Vasopressor, Spinal Anaesthesia, Hypotension & Phenylephrine.

scholarly journals The association between serum betahuman Chorionic gonadotropin and Preeclampsia

2015 ◽  
Vol 23 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Zinat Begum ◽  
Iffat Ara ◽  
Shaorin Tanira ◽  
Kashfia Ahmed Keya
Keyword(s):  
Pregnant Women ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Medical College ◽  
Significant Difference ◽  
Blood Pressures ◽  
The Mean ◽  
And Control

Background: Exact aetiology of this potentially fatal disorder remains poorly understood. A number of theories have been put forward where different biochemical markers have been implicated in the causal association of preeclampsia. This study was intended to find the association between serum b-hCG level and preclampsia Methods: This cross-sectional, case-control study was conducted on 74 pregnant women with preeclampsia (cases) who were admitted in the Eclampsia ward of Dhaka Medical College Hospital, Dhaka between January and July of 2013. A total of 76 normotensive pregnant women were also taken from the Obstetrics & Gynaecology Out-patient Department of the same hospital as control. The study subjects were selected on the basis of predefined eligibility criteria. The serum levels of b-hCG were compared between case and control groups as well as between mild and severe preeclampsia. Result: The case and control groups were almost similar in terms of all the baseline demographic and obstetric characteristics except past history of PET which was significantly higher in the former group than that in the latter group. Majority (97.1%) of the cases had severe hypertension (74.3%) with mean systolic and diastolic blood pressures being 162.6 and 110.8 mmHg respectively. The mean serum ?-hCG was much higher in the case group than that in the control group (p<0.001). The mean serum ?-hCG was the highest in severe preeclampsia and the lowest in the control group, while that in mild preeclampsia lie in between the two (p<0.001). The serum ?-hCG exhibits a significantly linear correlation with systolic and diastolic blood pressures (p<0.001 respectively). Conclusion: There was a significant difference between the ?-hCG level in the preeclamptic women compared to the normotensive pregnant women and the severity of preeclamsia increases with further rise of ?-hCG level. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22701 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 89-93

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

Sri Lankan Cleft Lip and Palate Study Model Analysis: Clefts of the Secondary Palate

1993 ◽  
Vol 30 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Andrew Mccance ◽  
David Roberts-Harry ◽  
Martyn Sherriff ◽  
Michael Mars ◽  
William J.B. Houston
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Model Analysis ◽  
Control Group ◽  
Tooth Size ◽  
Sri Lankan ◽  
Control Groups ◽  
Secondary Palate ◽  
Comparable Control ◽  
And Control

The study models of a group of adult Sri Lankan patients with clefts of the secondary palate were investigated. Tooth-size and arch-dimension comparisons were made with a comparable control group. Significant differences were found between the cleft and control groups in tooth sizes, chord lengths, and arch widths. The cleft group dimensions were generally smaller than those of the control group. Overjets were larger in the cleft group.

THE EFFECT OF APPLYING ANIMAL CARTOON PICTURES ON STUDENTS’ ACHIEVEMENT IN WRITING NARRATIVE TEXT

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Hasanul Arifin Zul And Masitowarni Siregar
Keyword(s):  
T Test ◽  
Narrative Text ◽  
Control Group ◽  
First Year ◽  
Writing Achievement ◽  
Control Groups ◽  
Post Test ◽  
Written Test ◽  
And Control ◽  
Experimental Group

This thesis is focused on the investigation of the effect of applying animal cartoon pictures on students’ achievement in writing narrative text. This study aims to find whether applying animal cartoon pictures significantly affect the students’ writing achievement or not. The data in this study were obtained by administering a written test. The population was the 2015/2016 first year (grade XI) of SMA Swasta Nusantara Lubuk Pakam and 66 students were taken as the sample by using random sampling. The sample was divided into two groups, experimental and control groups. The experimental group was taught by applying animal cartoon pictures while the control group without animal cartoon pictures (x = lecturing). The data were taken the scores from the pre-test and post-test to both experimental and control groups. These data were analyzed by using t-test. The result of computing the t-test obviously showed that t-observed is higher than t-table (5.21 >1,67) with the degree of freedom 64 (df =N-2) at the level significance 0,05 one tail test. It showed that the application of animal cartoon pictures significantly affected the students of SMA Swasta Nusantara Lubuk Pakam achievement in writing narrative text.

THE EFFECT OF APPLYING DEMONSTRATION METHOD ON STUDENTS’ ACHIEVEMENT IN SPEAKING SKILL AT THE THIRD GRADE OF SMK PAB 3 MEDAN ESTATE

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Meryanti Napitupulu And Anni Holila Pulungan
Keyword(s):  
High School ◽  
Control Group ◽  
Vocational High School ◽  
Control Groups ◽  
Speaking Test ◽  
The Third ◽  
Speaking Skill ◽  
The Subject ◽  
And Control ◽  
Experimental Group

This study was conducted as an attempt to discover the effect of applying Demonstration Method on students’ achievement in speaking skill. It was an experimental research. The subject was students of Grade XII, Vocational High School (Sekolah Menengah Kejuruan: SMK), which consisted of 79 students. The research was divided into two groups: experimental and control groups. The instrument used to collect the data was speaking test. To obtain the reliability of the test, the writer applied Kuder Richardson 21 formula. The result of the reliability was 0.7, and it was found that the test was reliable. The data were analyzed by using t-test formula. The analysis showed that the scores of the students in the experimental group were significantly higher than the scores of the students in the control group at the level of significant m = 0.05 with the degree of freedom (df) 77, t-observed value 8.9 > t-table value 1.99. The findings indicate that using Demonstration Method significantly affected the students’ achievement in speaking skill. So, English teachers are suggested to use Demonstration Method in order to improve students’ achievement in speaking skill.

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Effects of Time and Perceptual Orientation on Actors' and Observers' Attributions

1984 ◽  
Vol 58 (1) ◽  
pp. 23-30
Author(s):  
Donald S. Martin ◽  
Ming-Shiunn Huang
Keyword(s):  
Video Recording ◽  
Control Group ◽  
Control Groups ◽  
Video Recordings ◽  
Before And After ◽  
Perceptual Orientation ◽  
Initial Difference ◽  
Variety Show ◽  
And Control ◽  
Unrelated Variety

The actor/observer effect was examined by Storms in a 1973 study which manipulated perceptual orientation using video recordings. Storms' study was complex and some of his results equivocal. The present study attempted to recreate the perceptual reorientation effect using a simplified experimental design and an initial difference between actors and observers which was the reverse of the original effect. Female undergraduates performed a motor co-ordination task as actors while watched by observers. Each person made attributions for the actor's behaviour before and after watching a video recording of the performance. For a control group the video recording was of an unrelated variety show excerpt. Actors' initial attributions were less situational than observers'. Both actors and observers became more situational after the video replay but this effect occurred in both experimental and control groups. It was suggested the passage of time between first and second recording of attributions could account for the findings and care should be taken when interpreting Storms' (1973) study and others which did not adequately control for temporal effects.

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