Prevalence of Skin Sensitization to Pollen of Date Palm in Marrakesh, Morocco

Background. Date palm’s pollen has been identified as a source of allergy; the rate of sensitization of this pollen is between 6 and 29%. Objective. To determine the prevalence of sensitization to date palm in Marrakesh and to identify the clinical profile. Patients and Methods. This study is based on a questionnaire and the prick test on 7 allergens, in population aged 5 years and above with clinical symptoms suggesting allergic diseases, from November 2012 to February 2013 in Marrakech. Results. We included 468 patients (women: 79.5%). The prick tests were considered interpretable in 467 cases. The prevalence of skin sensitization to pollen of date palm was 6.6%. The 31 cases of sensitization to date palm involved 7 men and 24 women with an average age of 37.5 years. Cutaneous monosensitization to date palm’s pollen was observed in 2 cases. Asthma, rhinitis, and conjunctivitis were recorded, respectively, in 48.4%, 93.5%, and 67.7%. Conclusion. Skin sensitization to pollen of date palm does not seem unusual among allergic patients in Marrakech and is comparable to that found in Casablanca (7%), Barcelona (6.6%), and Cartagena (6.1%).

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Clinical profile and skin prick test analysis in children with allergic rhinitis of North Kerala, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20180436 ◽

2018 ◽

Vol 5 (2) ◽

pp. 372

Author(s):

Shyna K. P. ◽

Veena Kumari M. ◽

Divya Krishnan K. ◽

Abdul Azeez V. K.

Keyword(s):

Allergic Rhinitis ◽

Skin Prick Test ◽

House Dust ◽

House Dust Mite ◽

Cost Effective ◽

Allergic Diseases ◽

Clinical Profile ◽

Prick Test ◽

Dust Mite ◽

Ige Mediated

Background: Allergic rhinitis (AR) is increasing in prevalence among children globally and in India. Allergens are factors which trigger allergic rhinitis. Skin prick test (SPT) is a rapid, sensitive and cost effective test to detect IgE- mediated allergic diseases. Identification of common aeroallergens in an area is necessary, in order to educate the patient on what allergens to avoid and also help find the best formulation of allergen immunotherapy for effective AR treatment. This study was done to find the clinical profile and skin sensitivity to common allergens by skin prick test in children with allergic rhinitis between six and fifteen years.Methods: This cross-sectional study was conducted for a period of one year from January 2016 to December 2016. All children between 6 to 15 years with allergic rhinitis were included in the study. Skin prick test was done with seven most common allergens.Results: A total of 60 children with allergic rhinitis were studied and 42 patients (70%) tested positive for SPT. The major symptoms were persistent sneezing (68%), nasal itching (33%), rhinorrhea (85%) and nasal congestion (42%). The proportion of sneezers-runners was higher than blockers (64% versus 36). We tested seven common allergens and house dust mite allergen yielded the highest number of positive responses (33%) followed by cockroach (25%), alternaria (16.66%), parthenium (10%), cat dander (8.35%), sorghum (5%) and dog dander (5%). Among patients with SPT positivity; eight were positive to one allergen, thirteen were positive to two allergens, sixteen to three allergens and five to four allergens.Conclusions: Allergic Rhinitis with a number of allergic co morbidities has a significant impact on the quality of life and scholastic performance in children. Skin prick test which is a standardized, most rapid, sensitive and cost-effective test to detect IgE-mediated allergic diseases is helpful in identifying the common allergens. House dust mite is the commonest allergen tested positive in our study in children.

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Sensitization to cat and dog components and prediction of symptoms in cat-sensitized children.

10.21203/rs.3.rs-25143/v1 ◽

2020 ◽

Author(s):

Katarzyna Smejda ◽

Joanna Jerzyńska ◽

Daniela Podlecka ◽

Agnieszka Brzozowska

Keyword(s):

Respiratory Symptoms ◽

Clinical Symptoms ◽

Allergic Diseases ◽

Prick Test ◽

Allergen Components ◽

Cat Allergy ◽

Fel D 1 ◽

Eye Symptoms ◽

Cat Allergen ◽

Can F 1

Abstract Background: Sensitization to cat and/or dog allergens during childhood represents a risk factor for the development of allergic diseases later in life.Material and Methods: The study investigated the association of patterns of sensitization to cat and dog allergen components with clinical symptoms of allergy to these furry animals among cat-sensitized children. It included 50 children aged 5-17 years who showed sensitization to cat in the skin prick test. They were considered to have cat allergy if they suffered from one or more allergy symptoms when being exposed to contact with a cat. The children were evaluated for the presence of bronchial asthma, atopic dermatitis and allergic rhinitis. Their mothers completed a questionnaire on pet exposure at home. Levels of serum IgE cat epitopes Fel d (1, 2, 4), as well as dog components Can f (1, 2, 3, 5) were measured in all the studied children.Results: Respiratory symptoms following exposure to the cat allergen were most common in children with Fel d 2 epitope (p = 0.041). After contact with a dog, respiratory symptoms were most common in children with Can f 1 epitope (p = 0.042), eczema in children with sensitization to both Can f 1 (p = 0.009) and Can f 2 (p = 0.002), whereas eye symptoms occurred mostly in children with Can f 3 (p = 0.039).Conclusions: Molecular diagnosis in patients with pet allergy may help clinicians to predict clinical symptoms and their severity.

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Immunotherapy in Allergic Rhinitis: It’s Effect on the Immune System and Clinical Symptoms

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.264 ◽

2018 ◽

Vol 6 (7) ◽

pp. 1248-1252 ◽

Cited By ~ 2

Author(s):

Samaneh Kouzegaran ◽

Mohammad Ali Zamani ◽

Reza Faridhosseini ◽

Houshang Rafatpanah ◽

Abdolrahim Rezaee ◽

...

Keyword(s):

Allergic Rhinitis ◽

Clinical Symptoms ◽

Nasal Congestion ◽

Subcutaneous Immunotherapy ◽

Positive Skin Prick Test ◽

Tgf Beta ◽

Positive Skin ◽

Ifn Gamma ◽

Clinical Criteria ◽

Prick Test

BACKGROUND: Allergic rhinitis is one of the most common allergic diseases and characterised by sneezing, rhinorrhea, nasal congestion and nasopharyngeal itching. Subcutaneous immunotherapy (SCIT) for specific allergens is an effective treatment and induces the inhibitory effect of T regulatory lymphocytes and decreases clinical symptoms in allergic rhinitis.AIM: In this study effect of subcutaneous immunotherapy with specific allergens on clinical symptoms and T regulatory and T Helper cells cytokines, in patients with allergic rhinitis are evaluated.METHODS: In this study, 30 patients with moderate to severe allergic rhinitis according to clinical criteria and positive skin prick test for aeroallergens were selected and treated by SCIT. Clinical symptoms and T cells cytokines IL4, IL17, IFN gamma, TGF beta, GITR, FOXP3 and IL-10 (by RT-PCR) were evaluated before and one year after initiation of treatment.RESULTS: Thirty (30) patients with allergic rhinitis at age range 15-45 years old were treated by SCIT, and 23 (14 female, 9 male) patients continued the study, and 7 patients did not continue treatment. After immunotherapy, clinical symptoms decreased significantly. The specific cytokines TGF beta and IL10 levels increased and changes were statistically significant. (Respectively P = 0.013 and P = 0.05) The IL17 level was also increased, but not statistically significant. (P = 0.8) IFN gamma, IL4, GITR, FOXP3, all decreased, but the changes were not statistically significant (P > 0.05).CONCLUSION: Subcutaneous Immunotherapy for specific allergens decreases clinical symptoms in patients with allergic rhinitis and induces tolerance in T lymphocytes, especially by increasing T regulatory cells cytokines, TGF beta and IL10.

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Analysis of clinical profile of women presenting with pyrexia in pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20181325 ◽

2018 ◽

Vol 7 (4) ◽

pp. 1406

Author(s):

Surabhi Porwal ◽

Amita Sharma

Keyword(s):

Clinical Symptoms ◽

Public Health Problem ◽

Clinical Profile ◽

Major Public Health Problem ◽

Abdominal Wall Defects ◽

Chi Square ◽

Medical College ◽

Central Nervous System Defects ◽

High Risk Situation ◽

In Pregnancy

Background: Pyrexia in pregnancy is major public health problem in India. Pyrexia in pregnancy is associated with resorption of the embryo, foetal deaths and potentially lethal malformations such as central nervous system defects, abdominal-wall defects, and cardiovascular malformations. This study was carried out to analyse clinical profile of women presenting with pyrexia during pregnancy.Methods: After approval by institutional ethical committee the prospective case control study was conducted in the department of obstetrics and gynecology, NSCB Medical College, Jabalpur (M.P.) from 1st June 2012 to 31st October 2013. Total 100 antenatal women with pyrexia taken as cases and 50 antenatal women without pyrexia taken as control were included and analyzed in this study. In women fulfilling inclusion criteria detailed history was taken and documented in proforma. Required investigations were sent to the department of pathology and virology laboratory of Indian Council of Medical Research, Jabalpur. Results were analyzed statistically by using t test and chi square test.Results: On analysis of clinical symptoms pyrexia, cough, malaise, rash, headache, nausea and vomiting, joint pain, anorexia, breathlessness and burning and frequency of micturition were significantly higher in cases as compare to control. Viral pathogens were responsible for most of the cases of pyrexia in pregnancy.Conclusions: Pyrexia in pregnancy is a high-risk situation, early identification and prompt treatment will reduce maternal and perinatal morbidity and mortality associated with pyrexia in pregnancy.

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Mosquito hypersensitivity may be associated with atopic background in children

Allergologia et Immunopathologia ◽

10.15586/aei.v49i6.448 ◽

2021 ◽

Vol 49 (6) ◽

pp. 67-72

Author(s):

Süleyman Tolga Yavuz ◽

Onur Akin ◽

Ozan Koc ◽

Ali Gungor ◽

Ahmet Bolat ◽

...

Keyword(s):

Grass Pollen ◽

Matched Control ◽

Allergic Diseases ◽

Atopic Disease ◽

Duration Of Symptoms ◽

Prick Test ◽

Pediatric Allergy ◽

Systemic Reactions ◽

Dust Mite ◽

Children With Asthma

Background: Many children encounter unusual or “exaggerated” reactions such as large local, atypical or systemic reactions after mosquito bites.Objective: The aim of this study was to document the clinical features of children with mos-quito allergy and investigate the possible associations between demographic features and type of reactions in this population.Methods: Children with large local or unusual reactions after mosquito bites who attended to our outpatient pediatric allergy department were enrolled in the study along with control subjects.Results: A total of 180 children (94 with mosquito allergy and 86 age and sex-matched control subjects) with a median age of 6.8 years (IQR 5.5–9.3) were enrolled. Atopy (35.1% vs. 11.6%, p < 0.001) and grass pollen sensitization (28.7% vs. 8.1%, p < 0.001) were significantly more frequent in children with mosquito allergy. Skin prick test with mosquito allergen was positive in only 6 children (6,4%). Grass pollen sensitization was most common in children (28.7%) followed by sensitization to house dust mite (9.6%). 30 children (31.9%) had an accompanying atopic disease such as allergic rhinitis, asthma or atopic dermatitis. Bullae were significantly more frequent in children with asthma (41.7% vs.15.9, p = 0.034). The median duration of symptoms after onset were significantly longer in patients with ecchymosis, with immediate wheals and in children whose symptoms start in 20 min to 4 hours after mosquito bites.Conclusion: There is an association between unusual, large local or exaggerated reactions after mosquito bites and allergic diseases in children. The severity of reactions increases with age and particularly in children with atopic background.

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INVOLVEMENT OF SOME ALLERGENS OF PLANT AND ANIMAL ORIGIN IN ALLERGIC REACTIONS RELATED TO RESPIRATORY SYSTEM

Journal of medical pharmaceutical and allied sciences ◽

10.22270/jmpas.v10i6.1947 ◽

2021 ◽

Vol 11 (6) ◽

pp. 76-74

Author(s):

Hemalata V. Dange

Keyword(s):

Pollen Grains ◽

Allergic Diseases ◽

Health Concern ◽

Animal Origin ◽

Chronic Obstructive ◽

Allergic Reactions ◽

Obstructive Pulmonary Disease ◽

Prick Test ◽

Bird Droppings ◽

Animal Dander

In India, the prevalence of allergic responses and bronchial asthma is on the rise, which is a major public health concern. Increased exposure to an allergen, a substance that causes a reaction, can cause allergy sensitization in genetically vulnerable people. Continued exposure to allergens can raise the risk of allergic diseases which can further progress into life threating respiratory diseases. Allergic reactions to a variety of indoor and outdoor allergens play a key role in severe breathing disorders such as asthma and chronic obstructive pulmonary disease (COPD). There are distinctive kinds of allergens like animal proteins and animal dander, pollen, food, fungi, mould, Insects, Bird droppings and many others. The common allergens that cause respiratory difficulties have been identified after an honest effort. A modest retrospective analysis of 160 patients was done. Their medical history was gathered in order to determine whether or not they had been exposed to allergies in the past. All of the study participants were given a Skin prick test (SPT) with a variety of allergens, and their allergy status was evaluated based on the results. Most allergens, such as dust mites, pollen grains, and pigeon droppings, have been discovered to cause severe respiratory allergies, which can lead to life-threatening respiratory complications.

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Food Hypersensitivity as a Cause of Atopic Dermatitis

Paediatrica Indonesiana ◽

10.14238/pi34.5-6.1994.129-35 ◽

2018 ◽

Vol 34 (5-6) ◽

pp. 129-35

Author(s):

Hendra Santoso

Keyword(s):

Atopic Dermatitis ◽

Skin Prick Test ◽

Allergic Diseases ◽

Food Hypersensitivity ◽

Prick Test ◽

Skin Symptoms ◽

History Of ◽

Nineteen 6 ◽

Allergic Manifestations ◽

Positive Results

Thirty children from infancy to 12 years suffering from atopic dermatitis were evaluated for food hypersensitivity by means of history, skin prick test, total eosinophils count, and elimination of suspected food. Sixteen (53%) patients had history of allergy to suspected food, the other 16 (53%) had ether allergic diseases. Of the 30 patients, 15 (50%) had one of the parents with allergic diseases, and in 3 patients both parents suffered from a1Iergic diseases. Nineteen (6:3-1.) children had atopic dermatitis triggered by food; egg accounted for 400/o, fish for 53-lo and shrimp for 40% for the allergic manifestations. Skin prick test consisted of 20 food allergens was done to all children above 2 years of age, 12 (40%) of the pa1ients showed positive results. This study demonstrated that food hypersensitivity may play a pathogenic role in some children with atopic dermatitis. Appropriate diagnosis and restriction of diet can improve their skin symptoms.

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Prevalence of aeroallergens and food allergens in allergic patients in Tehran, Iran

International Journal of Medical Laboratory ◽

10.18502/ijml.v5i4.160 ◽

2018 ◽

Author(s):

Nasrin Pazoki ◽

Ali Ahmadi ◽

Fatemeh Onsori ◽

Mohsen Mosavi Khorshidi ◽

Mahboubeh Mansori ◽

...

Keyword(s):

Skin Prick Test ◽

Egg Yolk ◽

Allergic Diseases ◽

Cross Sectional Study ◽

Food Allergens ◽

Sectional Study ◽

Cross Sectional ◽

Prick Test ◽

Allergy And Immunology ◽

Allergen Extracts

Background and Aims: Identification of different allergens is a major challenge in allergic diseases. Avoiding these allergens is known as one of the best types of treatment. The aim of this study is to determine the prevalence of aeroallergens and food allergens in patients with allergy by Skin Prick Test. Materials and Methods: A cross-sectional study was conducted on 255 patients with allergic diseases who had referred to the Khorshid Allergy and Immunology Clinic. Skin Prick Test was performed using 82 allergen extracts to determine the patients' sensitivity to food and aeroallergens. Results: One hundred percent of the patients were sensitive to at least one allergen. Allergy to food allergens and aeroallergens was 49% and 51 %, respectively. Most sensitivity to food allergens included hazelnut (26.27%), bananas (21.96%), egg yolk (21.56%) and wheat (20.39%). Among the aeroallergens, grass with a frequency of 87% and fungi with a frequency of 34% had the highest and lowest frequencies. Conclusion: Depending on the nutrition, cultural habits, environmental conditions, and life style, prevalence of the allergens in each area may be different. Therefore, early identification and avoidance from these allergens can be suggested.

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Hallucinations without delusions in patients with first-episode psychosis: Clinical correlates and implications for pathophysiological models

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.859 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S32-S32

Author(s):

I. Melle

Keyword(s):

Negative Symptoms ◽

Clinical Symptoms ◽

Age At Onset ◽

Diagnostic Interview ◽

Clinical Profile ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

Competing Interest

IntroductionThe symptomatic distribution in schizophrenia spectrum disorder is heterogeneous. Patients may experience hallucinations, delusions and combinations thereof, in addition to disorganized and negative symptoms. We have previously found that patients with monosymptomatic hallucinations exhibited a different clinical profile than patients with monosymptomatic delusions or combinations of the two; with an earlier age at onset and more suicidal symptoms.AimsTo replicate findings in a new group of patients with schizophrenia spectrum disorders.MethodsA total of 421 consecutive patients with schizophrenia spectrum disorders were included into the study. They were comprehensively assessed by specifically trained psychiatrists or clinical psychologists; using the SCID for DSM-IV for diagnostic purposes, the PANSS to assess current clinical symptoms and CDSS to assess current depression. Lifetime presence of different symptom types was ascertained during the diagnostic interview.ResultsA total of 346 (82%) had experienced both hallucinations and delusion, 63 (15%) had experienced delusions without hallucinations, 10 (2.5%) had experienced hallucinations without delusions and 2 patients (0.5%) had neither but experienced negative and severely disorganized symptoms. Contrary to hypothesis, we did not find any statistically significant differences in age at onset and in clinical symptoms (including suicidality) between these groups. We also did not find any differences in the type of hallucinatory experiences between hallucinating groups.ConclusionsIn a new sample of patients, we did not replicate previous findings of a different clinical profile in patients with monosymptomatic hallucinations. This type of psychotic disorder is relatively rare, which might pose a problem concerning statistical strength.Disclosure of interestThe author has not supplied his declaration of competing interest.

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