scholarly journals Analysis of clinical profile of women presenting with pyrexia in pregnancy

2018 ◽  
Vol 7 (4) ◽  
pp. 1406
Author(s):  
Surabhi Porwal ◽  
Amita Sharma
Keyword(s):  
Clinical Symptoms ◽  
Public Health Problem ◽  
Clinical Profile ◽  
Major Public Health Problem ◽  
Abdominal Wall Defects ◽  
Chi Square ◽  
Medical College ◽  
Central Nervous System Defects ◽  
High Risk Situation ◽  
In Pregnancy

Background: Pyrexia in pregnancy is major public health problem in India. Pyrexia in pregnancy is associated with resorption of the embryo, foetal deaths and potentially lethal malformations such as central nervous system defects, abdominal-wall defects, and cardiovascular malformations. This study was carried out to analyse clinical profile of women presenting with pyrexia during pregnancy.Methods: After approval by institutional ethical committee the prospective case control study was conducted in the department of obstetrics and gynecology, NSCB Medical College, Jabalpur (M.P.) from 1st June 2012 to 31st October 2013. Total 100 antenatal women with pyrexia taken as cases and 50 antenatal women without pyrexia taken as control were included and analyzed in this study. In women fulfilling inclusion criteria detailed history was taken and documented in proforma. Required investigations were sent to the department of pathology and virology laboratory of Indian Council of Medical Research, Jabalpur. Results were analyzed statistically by using t test and chi square test.Results: On analysis of clinical symptoms pyrexia, cough, malaise, rash, headache, nausea and vomiting, joint pain, anorexia, breathlessness and burning and frequency of micturition were significantly higher in cases as compare to control. Viral pathogens were responsible for most of the cases of pyrexia in pregnancy.Conclusions: Pyrexia in pregnancy is a high-risk situation, early identification and prompt treatment will reduce maternal and perinatal morbidity and mortality associated with pyrexia in pregnancy.

scholarly journals Haematological profile of children with malaria in Sorong, West Papua, Indonesia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Syilvia Jiero ◽  
Ayodhia Pitaloka Pasaribu
Keyword(s):  
Malaria Infection ◽  
Clinical Symptoms ◽  
Public Health Problem ◽  
Malaria Diagnosis ◽  
White Blood Count ◽  
P Value ◽  
Major Public Health Problem ◽  
Age Group ◽  
Haematological Profile ◽  
West Papua

Abstract Background Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Haematological changes, such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the haematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria. Methods A retrospective study was performed by collecting data from the medical records of malaria patients at Sorong Regional General Hospital, Sorong, West Papua, Indonesia, both from outpatient and inpatient clinics, from January 2014 until December 2017. The laboratory profile of children suffering from malaria was evaluated. Results One hundred and eighty-two children aged 1 month to 18 years old were enrolled. The subjects were mostly male (112, 61.5%) with a mean age of 6.45 years (SD = 4.3 years). Children below 5 years of age suffered the most from malaria in this study (77, 42.3%). One hundred two subjects (56%) were infected with Plasmodium falciparum. Half of the enrolled subjects (50%) had haemoglobin level (Hb) between 5.1 and 10 gr/dL. A total of 41 children (53.2%) less than 5 years old suffered from P. falciparum infection. In the age group of 5–10 years, there were 34 children (57.6%) who suffered from P. falciparum, and in the age group > 10 years, 27 children (58.7%) suffered from P. falciparum infection. Only 4 subjects (5.2%) in the less than 5 years old age group had mixed malaria infection. Among eight predictors of the haematological profile, there were five predictors that were significantly associated with the diagnostic criteria, namely haemoglobin, haematocrit, leukocytes, platelets and monocytes (p < 0.05). Generally, clinical symptoms are not significantly associated with a malaria diagnosis, and only one variable showed a significant relationship, pale, with a P value of 0.001. Conclusions Children with malaria had changes in some haematological markers, with anaemia, low platelet count, white blood count, and lymphocyte count being the most important predictors of malaria infection in the study area. These markers could be used to raise suspicion of malaria in children living in high endemic areas, such as West Papua.

scholarly journals Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Le-Le Ma ◽  
Hui-Min Liu ◽  
Chuan-Hong Luo ◽  
Ya-Nan He ◽  
Fang Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Symptoms ◽  
Signal Transmission ◽  
Public Health Problem ◽  
Pharmacological Action ◽  
Major Public Health Problem ◽  
Neural Pathways ◽  
The World ◽  
In Series

The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, including pyrogenic cytokines and a variety of the mediators of fever. Then the humoral and neural pathways of fever signal transmission will be described. The scattered evidences about fever recorded in recent years are connected in series. On this basis, the understanding of fever is further deepened from the aspects of pathology and physiology. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19.

scholarly journals Knowledge, attitude and practice regarding various tobacco products and their effects on health and COTPA act among ≥15 years age group persons in urban field practice area of a medical college in Telangana

2020 ◽  
Vol 7 (6) ◽  
pp. 2180
Author(s):  
Jyothi Veleshala ◽  
Varun Malhotra
Keyword(s):  
Tobacco Use ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Community Based ◽  
Cross Sectional ◽  
Tobacco Products ◽  
Medical College ◽  
Attitudes And Practices ◽  
Supply And Distribution ◽  
Almost All

Background: Tobacco use is a major public health problem. The prevalence of tobacco use among men has been reported to be high (generally exceeding 50%) from almost all parts of India. “The Cigarettes and Other Tobacco Products (Prohibition of Advertisement and Regulation of Trade and Commerce, Production, Supply, and Distribution) Act 2003”, which came into effect since 1st May 2004. Information on knowledge, attitudes, and practices of population regarding COTPA is necessary to effectively implement the legislation. Hence the present study was undertaken.Methods: The present study was a cross-sectional community-based survey carried out in urban slums of Nalgonda town. Data was collected using a structured schedule by interviewing 300 participants, aged above 15 years.Results: The current use of any tobacco was reported by 45.7% of the participants. Overall awareness of COTPA was 58.2%. Marital status, type of family, unemployment, Illiterates, lower SES, and age had a significant influence on tobacco use. Television (77.05%) was the major source of awareness regarding COTPA. The majority of smokers were aware of various sections of COTPA (>50%). About 34.8% of the participants had a favorable attitude towards COTPA. The positive attitude was more (53.7%) towards the display of health warnings on tobacco products among smokers. 11.2% had paid penalty for violation of the act and 32.4% have noticed a reduction in their habit to some extent.Conclusions: A concerted effort has to be made to increase the awareness of the act amongst the vulnerable population.

Prevalence and Risk Factors Associated with First-Line Anti-Tuberculosis Induced Hepatotoxicity in Suratthani Hospital, Thailand

2021 ◽  
Vol 104 (2) ◽  
pp. 233-239
Keyword(s):  
Risk Factors ◽  
Serum Albumin ◽  
Clinical Symptoms ◽  
Significant Risk ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
First Line ◽  
Drug Induced ◽  
Factors Associated ◽  
Drug Risk

ackground: Tuberculosis (TB) is a major public health problem, including Thailand. Anti-TB drugs are very effective treatment, but they can cause hepatotoxicity. Data on the prevalence of anti-TB drug-induced hepatotoxicity (DIH), as well as the contributing risk factors, are scarce in Thailand. Objective: To measure the prevalence and identify risk factors associated with first-line drugs (FLD) induced hepatoxicity in TB patients. Materials and Methods: The present study was a retrospective study design in TB clinic of Suratthani Hospital, in Southern Thailand. All patients diagnosed with TB and received FLD between January and December 2017, were eligible for the study. Hepatoxicity defined as the following criteria: serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) levels >5x upper limit of normal (ULN) without symptoms, or AST or ALT >3x ULN with clinical symptoms. Results: Of all the 198 TB cases, 18 were identified as DIH. Prevalence of DIH was 9.1%. Hepatitis after FLD was independently associated with age>60 years (adjusted OR [aOR] 28.49, 95% CI 2.68 to 302.95, p=0.005) and serum albumin <3.5 g/dL (aOR 20.97, 95% CI 2.11 to 208.51, p=0.009). Conclusion: Age of more than 60 years and low serum albumin of less than 3.5 g/dL were significant risk factors associated with first-line anti-TB drugs induced hepatoxicity. Keywords: Hepatoxicity, Anti-tuberculosis drug, Risk factor, Thailand

scholarly journals GAMBARAN NILAI HEMATOKRIT DAN LAJU ENDAP DARAH PADA ANAK DENGAN INFEKSI VIRUS DENGUE DI MANADO

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Sitti S. P. Kamuh ◽  
Arthur E. Mongan ◽  
Maya F. Memah
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Dengue Virus Infection ◽  
Erythrocyte Sedimentation

Abstract: Dengue is a major public health problem that can be found throughout the tropical and subtropical countries around the world. Spectrum of clinical manifestations of dengue virus infection varies greatly. In addition to clinical symptoms, the diagnosis of dengue virus infection need to be supported by blood tests such as hematocrit and erythrocyte sedimentation rate. This study aimed to determine the hematocrit value and erythrocyte sedimentation rate (ESR) in children with dengue virus infection in Manado. This study used a cross-sectional design and was conducted from Desember 2014 to January 2015 at GMIM Pancaran Kasih, Advent, and Robert Wolter Mongisidi hospitals in Manado. There were 37 patients that fulfilled the inclusion criteria, consisted of 17 males and 20 females. The results showed that of 37 patients, there were 36 with hematocrit within normal limits. Moreover, of 37 patients only 6 patients performed the ESR examination; only 1 child had a rapid ESR result (> 15mm/h). Conclusion: In this study, most of the pediatric patients with dengue virus infection in Manado had normal hematocrit. Of 6 patients who had performed ESR test, only 1 had rapid ESR.Keywords: dengue, hematocrit, erythrocyte sedimentation rateAbstrak: Dengue merupakan masalah kesehatan masyarakat yang utama dan dapat ditemui diseluruh daerah tropis dan subtropis di seluruh dunia. Spektrum manifestasi klinis infeksi virus dengue sangat bervariasi. Selain gejala klinis, diagnosis infeksi virus dengue perlu ditunjang hasil uji darah di laboratorium antara lain hematokrit dan laju endap darah (LED). Penelitian ini bertujuan untuk mengetahui nilai hematokrit dan LED pada anak dengan infeksi virus dengue di Manado. Penelitian ini menggunakan desain potong lintang, dilakukan pada bulan Desember 2014 sampai Januari 2015 di RSU GMIM Pancaran Kasih Manado, RS Advent Manado, dan RSAD Robert Wolter Mongisidi Teling17 anak laki-laki dan 20 anak perempuan. Hasil penelitian memperlihatkan 36 dari 37 pasien mempunyai hematokrit normal. Dasri 37 pasien, hanya 6 anak yang menjalani pemeriksaan LED; hanya 1 anak dengan LED cepat (> 15mm/jam). Simpulan: Pada studi ini, sebagian besar pasien anak dengan infeksi virus dengue di Manado mempunyai nilai hematokrit normal. Dari 6 pasien yang dilakukan pemeriksaan LED, 1 anak mempunyai hasil LED cepat.Kata kunci: dengue, hematrokrit, laju endap darah.

scholarly journals Prevalence and clinical profile of celiac disease among malnourished children in South Rajasthan, India

2018 ◽  
Vol 5 (3) ◽  
pp. 997 ◽  
Author(s):  
Mukesh Sharma ◽  
Sanjay Mandot
Keyword(s):  
Celiac Disease ◽  
Abdominal Distension ◽  
Clinical Profile ◽  
Chi Square ◽  
Medical College ◽  
Presenting Symptoms ◽  
Malnourished Children ◽  
High Prevalence ◽  
Upper Gi Endoscopy ◽  
Work Up

Background: Celiac disease (CD) is the most common genetically related food intolerance, worldwide. The objective of this study was to study the prevalence and clinical profile of malnourished children.Methods: It was a prospective and observational study. The present study was conducted in the Department of Paediatrics, Geetanjali Medical College and Hospital, Udaipur, Rajasthan. Two hundred and one children were studied. All malnourished children were initially selected and those fulfilling inclusion criteria were included in the study. A detailed interview of all the children/parents was conducted regarding symptoms commonly associated with celiac disease. All cases found positive for t-TGA (>10au/ml) were subjected to upper GI Endoscopy.  Subjects were labelled as celiac disease if tissue trans-glutaminase IgA antibodies were >10 au/ml and histopathology was suggestive. Statistical analysis was done by one way ANOVA test and Chi-square as per requirements also Fisher exact and Man Whitney were applied.Results: Celiac disease was present in 23.9% of malnourished patients. Most common presenting symptoms were diarrhoea (40.2%), abdominal distension (39.9%) and abdominal pain (36.8%) and most common clinical sign was pallor, which was present in more than three-fourth of the patients (85.9%) followed by multivitamin deficiency (25.4%).Conclusions: There is a high prevalence of Celiac disease in malnourished children. Screening for Celiac disease (especially in presence of diarrhoea and abdominal distension, pain abdomen) should be an essential part of work-up in all malnourished children.

scholarly journals Study of association and prognostic correlation of cardiac troponin I estimation in acute decompensated heart failure patients

2020 ◽  
Vol 8 (1) ◽  
pp. 26
Author(s):  
Sunil Kumar Tripathi ◽  
Vikas A. Mishra ◽  
Amit B. Kinare ◽  
Vishwa Deepak Tripathi ◽  
Ravi Shankar Sharma
Keyword(s):  
Heart Failure ◽  
Troponin I ◽  
Acute Decompensated Heart Failure ◽  
Public Health Problem ◽  
Decompensated Heart Failure ◽  
Major Public Health Problem ◽  
Positive Group ◽  
Medical College ◽  
Follow Up Study

Background: Heart failure is a major public health problem since last few decades affecting significant number of people worldwide. Acute decompensated heart failure is a major cause of hospitalization in elderly people with a high mortality rate. Heterogeneity and non-specificity of symptoms makes diagnosis of heart failure by clinical presentation alone more challenging. Aim of current study was to investigate troponin biomarkers in diagnosis, prognosis and management of acute decompensated heart failure.  Methods: Present study was a prospective observational study conducted on 100 patients at Department of Cardiology, Superspeciality hospital, NSCB medical college Jabalpur and Department of cardiology Superspeciality hospital, SS medical college Rewa from October 2019 to August 2020. Patients were investigated for clinical, echocardiographic parameters and NYHA classification. Cardiac functions were analyzed by color doppler echocardiography. Results: According to study findings, 65.2% of TnI positive patients were males whereas 34.8% were females. Mean age of TnI positive group was observed to be higher. Majority of troponin positive patients were in NYHA class IV. Recurrent hospitalization was observed more in TnI positive group. Logistic regression analysis depicted systolic blood pressure reduced significantly (p<0.001) on follow up study in TnI positive patients, FBS was significantly more in TnI positive patients (131.4+42.9 mg/dl) (p=0.049). LVID was significantly more in TnI positive patients (p=0.022). Reduction in EF was statistically significant (p=0.03) at the three months follow up study.  Conclusions: A positive prognostic correlation was established between ADHF and troponin positivity, large prospective randomized trials are necessary to recommend quantitative troponin I determination in all patients of acute decompensated heart failure for prognosis and guiding therapy.

scholarly journals Clinical profile and deformities in leprosy patients: a record based study

2020 ◽  
Vol 6 (2) ◽  
pp. 156
Author(s):  
Anita Sanker ◽  
Sandhya George ◽  
Sindhu Chunangat Bhaskaramenon
Keyword(s):  
Public Health Problem ◽  
Mycobacterium Leprae ◽  
Clinical Profile ◽  
Current Status ◽  
Age Group ◽  
Medical College ◽  
Tribal Area ◽  
Leprosy Patients ◽  
Multibacillary Leprosy

<p class="abstract"><strong>Background:</strong> Leprosy is a chronic disease caused by <em>Mycobacterium leprae</em>, infectious in some cases, and affecting the peripheral nervous system, skin and certain other tissues. Even though leprosy was declared eliminated as a public health problem in India on December 2005, new cases of leprosy continue to appear. Hence a study on clinical profile and deformities in all leprosy cases registered in the last 5 years was done to know the current status of leprosy in this area.</p><p class="abstract"><strong>Methods: </strong>This was a retrospective record-based study of leprosy cases done at Government Medical College, Manjeri, for a period of 5 years from October 2014 to September 2019.<strong></strong></p><p class="abstract"><strong>Results:</strong> 42 cases from the record were included in the study. Maximum cases belonged to the age group of 31 to 40 and males were more than females. 81% of the patients were multibacillary leprosy (MB) and 8 cases belonged to paucibacillary (PB) leprosy. Four child cases were registered as PB cases. Mostly encountered clinical diagnosis was borderline tuberculoid leprosy (23 out of 42) and two had type 1 reaction. Seven patients had deformity of which two had grade 2 deformity and rest had grade 1 deformity.</p><p><strong>Conclusions:</strong> One patient who presented with grade 2 deformity and type 1 reaction was from tribal area indicating low awareness about leprosy among them. More number of cases in the multibacillary group and presence of child cases and deformities reinforces the need for strict surveillance to eradicate leprosy. </p>

scholarly journals Osteoporosis awareness among Indian women

2017 ◽  
Vol 6 (7) ◽  
pp. 2822 ◽  
Author(s):  
. Ayesha ◽  
Rina Sharma ◽  
Yasir Ali Khan
Keyword(s):  
Rural Women ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Chi Square ◽  
Level Of Education ◽  
Primary Schooling ◽  
Female Patients ◽  
Rural Background ◽  
Awareness Campaigns ◽  
Level Of Significance

Background: Osteoporosis is a major public health problem globally. Despite being a common problem, majority of the women are unaware of it. Awareness varies widely according to the level of education. In present study we have tried to assess the awareness of female patients attending the hospital.Methods: 100 female patients attending gynae OPD were asked to fill a simple questionnaire after taking informed consent. Age, parity, address, and level of education were noted. Data was analysed statistically by SPSS and level of significance was calculated by Chi square test.Results: Majority of these women belonged to rural background (85%) and around 64% of the women were educated (primary schooling and beyond). About 46% of the women had some awareness regarding osteoporosis and its prevention. Majority (54%) were unaware. Level of awareness varied significantly with level of education (p=0.006). Urban dwellers were more aware about osteoporosis when compared to rural women (p=0.004).Conclusions: Overall awareness about osteoporosis is low and here is a need to have community based awareness campaigns regarding osteoporosis. Educational programmes need to target on women coming from rural background and those with low education.

scholarly journals Renal Function Evaluation of Hypertensive Patients by Renogram in a Teaching Hospital

2016 ◽  
Vol 11 (1) ◽  
pp. 11-14
Author(s):  
Jayanta Kumar Saha ◽  
ARM Saifuddin Ekram ◽  
Mohammed Shahadat Hossain ◽  
ATM Ataur Rahman ◽  
Prodip Kumar Biswas ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Involvement ◽  
Public Health Problem ◽  
Function Evaluation ◽  
Major Public Health Problem ◽  
College Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Hypertensive Patients ◽  
Medical College

Arterial Hypertension is the most common cardiovascular disease and is a major public health problem in both developed and developing countries. The aim of the study was to assess renal involvement in hypertensive patient by renogram, which is not detected by conventional biochemical test. This was a cross sectional observational study. Consecutive 30 hypertensive patients admitted in the medicine wards from March, 2006 to April, 2007 in Rajshahi Medical College Hospital, Bangladesh were taken as case. Informed consent was taken from all the study patients or from their attendants. Detail history was taken from each patient or from their attendants' then clinical examination and relevant investigations were done. Emphasis was laid to find out renal involvement in long standing hypertensive patients by renogram. After initial selection; laboratory investigations like Urine for R/M/E, Blood Sugar 2ABF, S. Creatinine, USG of KUB, ECG and Hb% were done for every patients. All patients included in this study renogram were done. Majority of the patient (40%) were between the age of 41-50 years and Male: Female ratio was 3:2. Most of the patient lead a moderately active life (66.67%). Serum Creatinine was raised in 23.33% patient whereas renal parenchymal insufficiency evidenced by renogram was found in 50% case. In this study, we found that a significant number of cases (26.67%) having renal parenchymal insufficiency were not detected by S. Creatinine level, but detected by renogram. Renogram is superior to conventional biochemical renal function test for early detection of hypertensive nephropathy.Faridpur Med. Coll. J. Jan 2016;11(1): 11-14

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