scholarly journals Body Height of Children with Bronchial Asthma of Various Severities

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Tatiana I. Eliseeva ◽  
Natalia A. Geppe ◽  
Elena V. Tush ◽  
Olga V. Khaletskaya ◽  
Ivan I. Balabolkin ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Bronchial Asthma ◽  
Clinical Setting ◽  
Body Height ◽  
Physical Development ◽  
Control Group ◽  
Healthy Population ◽  
Healthy Children ◽  
Healthy Group ◽  
Reduced Height

Influence of bronchial asthma (BA) severity on physical development in children patients was evaluated in comparison with healthy population. Materials and Methods. 1042 children and adolescents (768 boys) with atopic BA were evaluated. All children underwent standard examination in a clinical setting, including anthropometry. The control group included 875 healthy children of a comparable age (423 boys). Results. The fraction of patients with the normal, lower, and increased height among the whole group of patients with BA is close to the corresponding values in the healthy population (χ2=3.32, p=0.65). The fraction of BA patients with the reduced physical development is increased monotonically and significantly when the BA severity increases: healthy group, 8.2% (72/875), BA intermittent, 4.2% (6/144), BA mild persistent 9% (47/520), BA moderate persistent, 11.7% (36/308), and BA severe persistent, 24.3% (17/70) (χ2=45.6, p=0,0009). Conclusion. The fraction of the children with the reduced height is increased monotonically and significantly in the groups of increasing BA severities. At the same time, the fraction of such children in groups of intermittent and mild persistent BA practically does not differ from the conditionally healthy peers.

ОЦЕНКА ЦИТОКИНОВОГО ПРОФИЛЯ СЫВОРОТКИ КРОВИ И СУБПОПУЛЯЦИЙ Т-ЛИМФОЦИТОВ У ДЕТЕЙ С АЛЛЕРГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ ОРГАНОВ ДЫХАНИЯ

2019 ◽  
pp. 52-60
Author(s):  
E.V. Prosekova ◽  
A.I. Turyanskaya ◽  
N.G. Plekhova ◽  
M.S. Dolgopolov ◽  
V.A. Sabynych
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cytokine ◽  
Immunological Parameters ◽  
Low Level ◽  
Level Of Significance

Расширение спектра изучаемых клонов Тхелперов определило более сложные иммунные механизмы реализации аллергического воспаления. Цель. Характеристика показателей и взаимосвязей цитокинового профиля сыворотки и субпопуляционного состава Тлимфоцитов периферической крови у детей с бронхиальной астмой и аллергическим ринитом. Материалы и методы. Проведено комплексное обследование 150 детей в возрасте 311 лет с верифицированным диагнозом бронхиальной астмы, аллергического ринита и 30 здоровых сверстников. Иммунологические параметры крови оценивали методом проточной цитометрии, концентрации интерлейкинов и IgE в сыворотке крови определяли методом твердофазного иммуноферментного анализа. При статистической обработке использовали программы Statistica 10 с критическим уровнем значимости р0,05. Результаты. У детей с аллергическими заболеваниями в сыворотке крови определены высокие уровни содержания интерлейкинов4, 8, 13, 17А, сопоставимый с показателями группы контроля уровень IL17F и низкое содержание IFNy. При бронхиальной астме и аллергическом рините у детей выявлено увеличение количества CD3CD8CD45RO, CD3CD8CD45RACD45RO Тлимфоцитов и CD3CD4 Тхелперов и повышение количество Th17 при снижении CD3CD4CD45RO клеток памяти. В группе здоровых детей популяция Th17 составляла 9,491,6, у детей с аллергическими заболеваниями количество данных клеток было значимо выше 14,50,77 (р0,001). Анализ сывороточного содержания цитокинов у детей с изолированным течением БА и в сочетании с аллергическим ринитом выявил разнонаправленные корреляции, отличающиеся по силе и направленности от таковых в группе здоровых детей. Заключение. У детей при изолированном течении бронхиальной астмы и в сочетании с аллергическим ринитом выявлены: сопоставимое с показателями здоровых детей количество CD3CD4 Тклеток, дисбаланс в субпопуляционном составе Тхелперов за счет преобладания Th2 и Th17, активация синтеза IL17A, IL4, IL8, IL13, низкий уровень сывороточного IFNy, изменения силы и направленности взаимосвязей цитокинового профиля и спектра субпопуляций Тлимфоцитов.Expansion of the range of examined Thelper clones has determined more complex immune mechanisms for the implementation of allergic inflammation. Objective. To characterize the parameters and relationships between the serum cytokine profile and Tlymphocyte subpopulation in peripheral blood of children with bronchial asthma and allergic rhinitis. Materials and methods. 150 children aged between 311 years old with bronchial asthma, and allergic rhinitis and 30 healthy volunteers were examined. Immunological parameters were assessed by flow cytometry, the concentration of serum interleukins and IgE were determined by means of enzymelinked immunosorbent assay. Statistical analysis was performed with Statistica 10 program with a critical level of significance p0.05. Results. High levels of interleukins 4, 8, 13, 17A were determined, IL7F level was not significantly different from that in control group and low level of IFNy was found in the serum of children with allergic diseases. The number of CD3CD8CD45RO, CD3CD8CD45RACD45RO Tlymphocytes, CD3CD4 Thelper cells and Th17 were increased and at the same time CD3CD4CD45RO memory cells were decreased In bronchial asthma and allergic rhinitis children. Number of Th17 cells in healthy children was 9.491.6, in allergic children it was significantly higher 14.50.77 (p0.001). Analyses of serum cytokine count in children with isolated BA and in association with allergic rhinitis revealed multidirectional correlations differing in strength and direction from those in the group of healthy children. Conclusion. In children with isolated bronchial asthma and associated with allergic rhinitis the following parameters were found: CD3CD4 Tcells count was comparable to that in healthy children, the imbalance of Thelper subpopulation: prevalence of Th2 and Th17, activation of IL17A, IL4, IL8, IL13 synthesis and low level of serum IFNy.

Physical development in children and adolescents with bronchial asthma

2013 ◽  
Vol 187 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Wioleta Umławska ◽  
Grzegorz Gąszczyk ◽  
Dorota Sands
Keyword(s):  
Children And Adolescents ◽  
Bronchial Asthma ◽  
Physical Development

scholarly journals Evaluation of depression and self-esteem in children with monosymptomatic nocturnal enuresis: A controlled trial

2014 ◽  
Vol 86 (3) ◽  
pp. 212 ◽  
Author(s):  
Orhan Koca ◽  
Mehmet Akyüz ◽  
Bilal Karaman ◽  
Zeynep Yesim Özcan ◽  
Metin Öztürk ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Nocturnal Enuresis ◽  
Depression Scale ◽  
Self Esteem ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Significant Difference ◽  
Monosymptomatic Nocturnal Enuresis ◽  
Age Range

Objectives: Nocturnal enuresis (NE) is very common and is one of the most common causes for patients to be admitted to urology, pediatrics, child psychiatry and child surgery departments. We aimed to investigate the effect on depression and self-esteem of this disorder that can cause problems on person's social development and human relations. Material and methods: 90 patients who were admitted to our clinic with complaints of nocturnal enuresis were enrolled. Investigations to rule out organic causes were performed in this group of patients. Out of them 38 children and adolescents (age range 8-18 years) with primary monosymptomatic nocturnal enuresis (PMNE) agreed to participate in the study In the same period 46 healthy children and adolescents with a similar age range without bed wetting complaint were included in the study as a control group. The age of the family, educational and socioeconomic level were questioned and Piers-Harris Children's Self-Concept Scale (PHCSCS) and Children's Depression Inventory (CDI) forms were filled out. Results: Mean age of the cases (18 females or 47.4% and 20 males or 52.6%) was 10.76 ± 3.82 years whereas mean age of controls (26 females or 56.5% and 20 males or 43.5%) was 10.89 ± 3.11 years. Depression scale was significantly higher (p = 0.001) in the case group than in the control group (10.42 ± 4.31 vs 7.09 ± 4.35). In both groups there was no statistically significant difference by age and sex in terms of depression scale (p > 0.05). Conclusion: NE is widely seen as in the community and is a source of stresses either for children and for their families. When patients were admitted to physicians for treatment, a multidisciplinary approach should be offered and the necessary psychological support should be provided jointly by child psychiatrists and psychologists.

Pulmonary elasticity in children and adolescents

1976 ◽  
Vol 40 (6) ◽  
pp. 953-961 ◽  
Author(s):  
A. Zapletal ◽  
T. Paul ◽  
M. Samanek
Keyword(s):  
Children And Adolescents ◽  
Body Surface ◽  
Body Height ◽  
Somatic Growth ◽  
Esophageal Pressure ◽  
Lung Compliance ◽  
Healthy Children ◽  
Elastic Recoil ◽  
Valid Index ◽  
Age Range

Static (Cst(L)), dynamic (Cdyn(L)), and “specific lung compliance (CL/TLC, CL/FRC) and the elastic recoil pressure of the lungs (Pst/(L)) were measured in 131 healthy children and the adolescents (age 6 to 17 years) from simultaneous recordings of esophageal pressure and lung volume. Esophageal elastance and vertical esophageal pressure gradients were also studied. Pst(L), measured at different lung volumes (fractional) from the expiratory quasi-static pressure-volume (PV) curves of the lungs, increased significantly with increasing body height, age, and body surface. Cst(L), determined from the midportion of PV curves, and Cdyn(L) measured during normal breathing at frequencies around 20/min also increased significantly with somatic growth. “Specific” Cst(L) decreased with increasing body height, age, and body surface. “Specific” Cdyn(L), esophageal elastance, and the vertical esophageal pressure gradient were independent of body height, age, and body surface, Cdyn(L) was less than Cst(L) mainly in smaller and younger children, and was not considered a valid index of pulmonary elasticity. Values of Pst(L), “specific” Cst(L), and the change of slope of the midportion of PV curves in children and adolescents suggested developmental changes of pulmonary elasticity in man over the age range studied.

scholarly journals Reference Intervals of Central Aortic Blood Pressure and Augmentation Index Assessed with an Oscillometric Device in Healthy Children, Adolescents, and Young Adults from Argentina

2018 ◽  
Vol 2018 ◽  
pp. 1-19
Author(s):  
Alejandro Diaz ◽  
Yanina Zócalo ◽  
Daniel Bia ◽  
Edmundo Cabrera Fischer
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Augmentation Index ◽  
Body Height ◽  
Reference Intervals ◽  
Adolescents And Young Adults ◽  
Healthy Population ◽  
Healthy Children ◽  
Age Related ◽  
Percentile Curves

Age-related reference intervals (RIs) of central (aortic) systolic blood pressure (cSBP) and augmentation index (cAIx) obtained from large healthy population are lacking in Argentina (South America). Aims. To analyze the existence of associations among cSBP and cAIx with demographic, anthropometric, and hemodynamic parameters and to generate percentile curves and RIs adjusted to each level of age and gender and/or body height. cSBP and cAIx were measured in 1038 healthy children, adolescents, and young adults. First, we evaluated if RIs for males and females were necessary using correlation and covariate analysis. Second, mean (M) and standard deviation (SD) age-related equations were obtained for cSBP and cAIx, using parametric regression methods based on fractional polynomials. Third, age specific percentiles curves were generated. Fourth, body height specific percentiles curves were generated using a similar procedure. The obtained equations (considering age as independent variable) for all subjects (cSBP0.26 and (cAIx + 12.001)0.5) were as follows: cSBP Mean = 3.0581 + 0.2189 log(Age) − 0.001044Age; cSBP SD = −0.03919 + 0.1535 log(Age) − 0.004564Age; cAIx mean = 9.5226 − 6.1599 log(Age) + 0.1450Age; cAIx SD = 1.3880 − 0.8468 log(Age) + 0.03212Age. This study, performed in Argentinean healthy children, adolescents, and young adults with ages of 5 to 22 years, provides the first RIs and percentile curves of cSBP and cAIx. Additionally, specific body height-related cAIx percentiles are reported for the analyzed population. The RIs and percentiles contribute to the knowledge of arterial dynamic evolution along the normal aging process and the interpretation of data obtained in clinical research and daily clinical practice.

scholarly journals Neuropsychiatric features of children with systemic somatovegetative disorders (by the example of atopic dermatitis, bronchial asthma and gastroesophageal reflux disease)

2019 ◽  
Vol 10 (3) ◽  
pp. 40-48
Author(s):  
T. S. Petrenko ◽  
K. Yu. Retyunskiy ◽  
M. D. Borovskikh ◽  
D. R. Devyatkina ◽  
A. V. Pereshitova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Bronchial Asthma ◽  
Reflux Disease ◽  
Energy Functional ◽  
Control Group ◽  
Healthy Children ◽  
Central Nervous System Damage ◽  
Neuropsychological Disorders

Objective: to study the clinical neuropsychiatric and neuropsychological features of children suffering from systemic somatovegetative disorders.Materials and methods: the study involved children from 5 to 12 years old with an established diagnosis of bronchial asthma — 108 children; atopic dermatitis — 105 children; gastroesophageal reflux disease — 112 children; the control group consisted of 60 same age healthy children. All children underwent clinical-anamnestic, neurological, psychopathological and neuropsychological research.Results: the children with systemic somatovegetative disorders have a significantly high incidence of pathogenic factors of central nervous system damage in early stages of ontogenesis (pathology of pregnancy and childbirth). Early sensory and motor deprivation due to somatic suffering aggravates neuropsychiatric deficiency. Neuropsychological disorders were predominantly represented by a violation of the perception of their body, lack of kinesthetic and motor functions, spatial and quasi-spatial representations.Conclusion: the clinical dynamics of neuropsychiatric disorders in children with systemic somatovegetative disorders corresponds to the dynamics of residual cerebral organic impairment with a stage-age changes of syndromes. The revealed neuropsychological disorders correspond to preferential damage to the first (energy) functional block of the brain.

scholarly journals The effects of interventions implemented during a rehabilitation camp on changes in motor skills parameters and body mass in patients with simple obesity

2017 ◽  
Vol 31 (3) ◽  
pp. 5-15
Author(s):  
Agata Świst ◽  
Krzysztof Graff ◽  
Dorota Chałubińska ◽  
Aleksandra Zielińska ◽  
Anna Łukaszewska
Keyword(s):  
Physical Activity ◽  
Body Mass ◽  
Motor Skills ◽  
Body Height ◽  
Exercise Programme ◽  
Clinical Psychologist ◽  
Control Group ◽  
Healthy Children ◽  
Simple Obesity ◽  
Jump Velocity

Abstract Introduction:According to the latest UNICEF report, Polish children put on weight at the highest pacein Europe. The number of overweight children has doubled in the last decade. The aim of the work was to assess the effects of kinesiotherapy implemented during a 3-week rehabilitationcamp on changes in motor skills parameters measured on the Leonardo dynamometric platform (Novotec Medical) and on body mass in patients with simple obesity. Materialand methods:The study group included 32 children and youth aged 7-16 with simple obesity who underwent an exercise programme during a 3-week rehabilitation camp. The subjects were examined twice, i.e. at the beginning and at the end of the camp. The control group consisted of 70 healthy children within the same age range who were examined once. Body mass and body height were measured and the BMI was calculated (taking into account centile charts) for all the study participants. Motor skills were assessed on the basis of avertical jump performed on the Leonardo GRFP (GroundReaction Force Platform). The following data were registered: jump velocity, maximum jump height, strength, power, power with reference to body mass and the Esslinger Fitness Index (EFI). Daily kinesiotherapy included exercises in the form of circuit training and water exercises. All the patients participated in meetings with a dietician and a clinical psychologist. Results:Statistically significant reduction in body mass after a 3-week rehabilitation camp was noted in 27 patients with simple obesity (84.1%) (p<0.05). Motor parameters did not improve significantly. Conclusions:Regular physical activity resulted in weight loss only. However, physical activity did not bring about positive changes in motor parameters.

scholarly journals Vitamin D levels in children and adolescents with autism

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093463
Author(s):  
Esma Şengenç ◽  
Ertuğrul Kıykım ◽  
Sema Saltik
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Children And Adolescents ◽  
Autism Spectrum ◽  
Control Group ◽  
Healthy Children ◽  
Birth Season ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Calcium Phosphorus

Objective This study aimed to investigate the relationship between autism spectrum disorder (ASD) and vitamin D levels in children and adolescents. Methods We measured serum 25-hydroxyvitamin D (25-OHD) levels in 1529 patients with ASD aged 3 to 18 years, without any additional chronic diseases. Levels of 25-OHD were compared according to sex, age (<11 or ≥11 years), and birth season. Additionally, laboratory parameters (calcium, phosphorus, alkaline phosphatase, and 25-OHD) of 100 selected patients with ASD were compared with those of the healthy control group. Results Vitamin D deficiency or insufficiency was found in approximately 95% of all patients. Levels of 25-OHD in adolescent patients with ASD aged 11 to 18 years were significantly lower than those in patients aged younger than 11 years. In the 100 selected patients with ASD, mean serum 25-OHD levels were significantly lower and alkaline phosphatase levels were higher compared with those in healthy children. Conclusion Our study suggests a relationship between vitamin D and ASD in children. Monitoring vitamin D levels is crucial in autistic children, especially adolescents, to take protective measures and treat this condition early.

scholarly journals PHENOTYPES OF EOSINOPHILS IN THE DIAGNOSIS OF ATOPIC BRONCHIAL ASTHMA IN CHILDREN

2019 ◽  
Vol 29 (3) ◽  
pp. 79-83
Author(s):  
Elena Asiryn ◽  
Pavel Novikov ◽  
Volha Matsiushchanka ◽  
Laimutė Vaidelienė ◽  
Goda Misevičiūtė ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Control Group ◽  
Healthy Children ◽  
Absolute Level ◽  
Relative Level ◽  
Relative Index ◽  
Asthmatic Children ◽  
Atopic Bronchial Asthma ◽  
The Absolute

The aim of the research was to study the phenotype of eosinophils in children with atopic bronchial asthma and their role as diagnostic criteria of the disease. Materials and methods. We have examined 130 children aged from 6 to 18 years old with atopic bronchial asthma. The control group consisted of 40 healthy children from 6 to 18 years old, who didn’t have allergic diseases. During the research the relative and absolute levels of eosinophils, the level of eosinophils carrying FcεRI and FcεRII (CD23) – receptors were established. Results. The relative level of eosinophils in asthmatic children was 6.00% [3.00; 8.00], the absolute level – 417.00 cells/μL [232.00; 636,00], which is significantly higher compared to control group, where the relative level was 2.50% [1.00; 3.00%] and the absolute level was 166.50 cells/μl [86.00; 213.00] (p&lt;0.001). The level of eosinophils carrying the FcεRI receptor was 420,00 cells/μl [250,00; 660,00], which is significantly higher than in the control group – 200,00 cells/μl [140,00; 240.00] (p&lt;0.001). The relative level of eosinophils carrying CD23 receptor on their surface was 62.20% [35.40; 76.60] and the absolute level –223.37 cells/μl [105.30; 375.24]. The results are significantly higher than those of the control group: 25.45% [14.30; 30,60] (p&lt;0,001), and 30,88 cells/μl [25,63; 42.84] (p &lt;0.0001) respectively. It was found in the ROC-analysis that there is high evidence of presence of atopic bronchial asthma if absolute levels of eosinophils carrying CD23 receptor was 73.008 cells/μl or more or the relative index – 35.10% and more. Conclusions. The relative and absolute levels of eosinophils, as well as eosinophils carrying FcεRI and CD23 receptors are statistically significantly higher in atopic bronchial asthma than in control group patients. Increased number or relative index (73.008 cells/μl or ≥ 35.10% respectively) of eosinophils carrying CD 23 receptors can be considered as a diagnostic criterion of atopic bronchial asthma.

scholarly journals Diagnostic Value of Diurnal Variability of Orthostatic Heart Rate Increment in Children and Adolescents With POTS

2021 ◽  
Vol 9 ◽  
Author(s):  
Hong Cai ◽  
Shuo Wang ◽  
Runmei Zou ◽  
Fang Li ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Heart Rate ◽  
Children And Adolescents ◽  
External Validation ◽  
Time Of Day ◽  
Control Group ◽  
Postural Tachycardia Syndrome ◽  
Healthy Children ◽  
Diurnal Variability ◽  
Predictive Values ◽  
Sensitivity Specificity

Objectives: This study aims to investigate the diurnal variability of heart rate (HR) increment after standing (ΔHR) in pediatric postural tachycardia syndrome (POTS) and explore appropriate cutoff values of ΔHR at different times for the POTS diagnosis.Materials and Methods: Seventy-eight patients (9–14 years) who presented with orthostatic intolerance symptoms were enrolled. Forty-three patients were diagnosed as POTS (ΔHR ≥40 bpm), and 35 patients were assigned to the non-POTS group (ΔHR &lt;40 bpm). Twenty-six healthy children served as the control group. All subjects completed three standing tests in the morning, afternoon, and evening. Orthostatic HR parameters were analyzed to predict the diagnosis of POTS. Additionally, 41 patients were recruited as an external validation group.Results: Orthostatic HR increments in both the POTS and non-POTS groups exhibited diurnal variability, which was markedly larger in the morning (P &lt; 0.05), whereas it did not differ with the time of day in the control group. Among the POTS patients, 100% met the diagnostic criteria for POTS in the morning, 44.2% in the afternoon, and 27.9% in the evening. Almost half of the POTS patients (51.2%) displayed a positive result only in the morning standing test. However, in the three standing tests at different times, ΔHR from 1 to 10 min after standing and ΔHRmax were the highest in the POTS group compared with in the non-POTS and control groups (P &lt; 0.05). Furthermore, the maximum ΔHR (ΔHRmax) and ΔHR at 5 and 10 min in the afternoon and evening standing tests yielded moderate predictive values for the POTS diagnosis. The external validation test showed that the afternoon ΔHRmax ≥30 bpm to diagnose POTS yielded sensitivity, specificity, and accuracy of 85, 71.4, and 78%, respectively, and the evening ΔHRmax ≥25 bpm yielded sensitivity, specificity, and accuracy of 85, 76.2, and 80.5%, respectively.Conclusions: The orthostatic HR increment exhibits diurnal variability in children and adolescents with POTS that may affect the diagnosis of POTS. Supplementary criteria are proposed for the POTS diagnosis based on diurnal variability.

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