scholarly journals Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Ebrahim M. Yimer ◽  
Kald Beshir Tuem ◽  
Aman Karim ◽  
Najeeb Ur-Rehman ◽  
Farooq Anwar
Keyword(s):  
Potential Role ◽  
Viral Infections ◽  
Nigella Sativa ◽  
Antioxidant Property ◽  
Biological Properties ◽  
Chemotherapeutic Agents ◽  
Active Constituent ◽  
Black Cumin ◽  
Inflammatory Conditions ◽  
Wide Range

The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.

scholarly journals An Overview on Composition and Therapeutic Potentials of the Black Seed (Nigella sativa)

2021 ◽  
Vol 9 (12) ◽  
pp. 1966-1975
Author(s):  
Yusra Tafheem S
Keyword(s):  
Nigella Sativa ◽  
Herbal Medicines ◽  
Extended Period ◽  
Herbaceous Plant ◽  
Medical Systems ◽  
Active Constituent ◽  
Black Cumin ◽  
Toxicological Effects ◽  
Black Seed ◽  
Wide Range

Abstract: Nigella sativa is an annual herbaceous plant that belongs to the Ranunculaceae family and produces seeds known as black seed or black cumin. Black seed has been used in various civilization around the world for centuries to treat various ailments. It is widely used in a variety of traditional medical systems, including Unani, Ayurveda, and Siddha. Black seed is considered to be nutritionally dense, with high levels of fat, protein, dietary fibre, calcium, and iron. The seed is known to have a wide range of pharmacological properties which are supported by numerous studies. Extensive research has been carried out over decades to confirm the seed’s anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, antilipidemic, anti-cancer, gastroprotective, hepatoprotective, neuroprotective properties etc. Black seed has earned a position among the top ranked evidence-based herbal medicines due to its marvellous healing properties. Studies have revealed that the presence of thymoquinone, a major bioactive component of the seed essential oil, is responsible for the majority of its therapeutic properties. Consumption of the seeds for an extended period of time has been shown to have significant effects on lowering blood glucose levels, improving lipid profiles, and other biochemical parameters. The minor or negligible toxicological effects of black seed and its active constituent, thymoquinone, support its long-term use in traditional food and medicine. Because of their low toxicity, black seed is frequently used in food as a flavouring agent, additive in breads, and pickles. The current review summarises the composition, important pharmacological studies, dosage and toxicity of the Blackseed and its application in food industry.

Reverse Screening Bioinformatics Approach to Identify Potential Anti Breast Cancer Targets Using Thymoquinone from Neutraceuticals Black Cumin Oil

2019 ◽  
Vol 19 (5) ◽  
pp. 599-609 ◽  
Author(s):  
Sumathi Sundaravadivelu ◽  
Sonia K. Raj ◽  
Banupriya S. Kumar ◽  
Poornima Arumugamand ◽  
Padma P. Ragunathan
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cell Cycle ◽  
Cell Death ◽  
In Silico ◽  
Chemotherapeutic Agents ◽  
Normal Cells ◽  
Black Cumin ◽  
In Silico Docking ◽  
Wide Range

Background: Functional foods, neutraceuticals and natural antioxidants have established their potential roles in the protection of human health and diseases. Thymoquinone (TQ), the main bioactive component of Nigella sativa seeds (black cumin seeds), a plant derived neutraceutical was used by ancient Egyptians because of their ability to cure a variety of health conditions and used as a dietary food supplement. Owing to its multi targeting nature, TQ interferes with a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Additionally, TQ can specifically sensitize tumor cells towards conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells besides being cost effective and safe. TQ was found to play a protective role when given along with chemotherapeutic agents to normal cells. Methods: In the present study, reverse in silico docking approach was used to search for potential molecular targets for cancer therapy. Various metastatic and apoptotic targets were docked with the target ligand. TQ was also tested for its anticancer activities for its ability to cause cell death, arrest cell cycle and ability to inhibit PARP gene expression. Results: In silico docking studies showed that TQ effectively docked metastatic targets MMPs and other apoptotic and cell proliferation targets EGFR. They were able to bring about cell death mediated by apoptosis, cell cycle arrest in the late apoptotic stage and induce DNA damage too. TQ effectively down regulated PARP gene expression which can lead to enhanced cancer cell death. Conclusion: Thymoquinone a neutraceutical can be employed as a new therapeutic agent to target triple negative breast cancer which is otherwise difficult to treat as there are no receptors on them. Can be employed along with standard chemotherapeutic drugs to treat breast cancer as a combinatorial therapy.

scholarly journals Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights

2021 ◽  
Vol 22 (16) ◽  
pp. 9078
Author(s):  
Md. Abdul Hannan ◽  
Md. Sarwar Zahan ◽  
Partha Protim Sarker ◽  
Akhi Moni ◽  
Hunjoo Ha ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Kidney Diseases ◽  
Nigella Sativa ◽  
Close Association ◽  
Kidney Injury ◽  
Antioxidant Defense System ◽  
Chemotherapeutic Agents ◽  
Environmental Chemicals ◽  
Protective Effects ◽  
Black Cumin

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and a close association between acute kidney injury (AKI) and CKD has recently been identified. Black cumin (Nigella sativa) has been shown to be effective in treating various kidney diseases. Accumulating evidence shows that black cumin and its vital compound, thymoquinone (TQ), can protect against kidney injury caused by various xenobiotics, namely chemotherapeutic agents, heavy metals, pesticides, and other environmental chemicals. Black cumin can also protect the kidneys from ischemic shock. The mechanisms underlying the kidney protective potential of black cumin and TQ include antioxidation, anti-inflammation, anti-apoptosis, and antifibrosis which are manifested in their regulatory role in the antioxidant defense system, NF-κB signaling, caspase pathways, and TGF-β signaling. In clinical trials, black seed oil was shown to normalize blood and urine parameters and improve disease outcomes in advanced CKD patients. While black cumin and its products have shown promising kidney protective effects, information on nanoparticle-guided targeted delivery into kidney is still lacking. Moreover, the clinical evidence on this natural product is not sufficient to recommend it to CKD patients. This review provides insightful information on the pharmacological benefits of black cumin and TQ against kidney damage.

scholarly journals Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Lilla Paragh ◽  
Daniel Törőcsik
Keyword(s):  
Factor Xiii ◽  
Potential Role ◽  
Cell Types ◽  
Subunit A ◽  
Therapeutic Implications ◽  
Inflammatory Conditions ◽  
Dermal Cell ◽  
Wide Range

The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed.

scholarly journals Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 226
Author(s):  
Juveriya Farooq ◽  
Rokeya Sultana ◽  
Tahreen Taj ◽  
Syed Mohammed Basheeruddin Asdaq ◽  
Abdulkhaliq J. Alsalman ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Low Cost ◽  
Middle Eastern ◽  
Antioxidant Properties ◽  
Volatile Oil ◽  
Chemotherapeutic Agents ◽  
Herbal Remedies ◽  
Protective Effects ◽  
Drug Induced ◽  
Black Cumin

The drugs used to treat cancer not only kill fast-growing cancer cells, but also kill or slow the growth of healthy cells, causing systemic toxicities that lead to altered functioning of normal cells. Most chemotherapeutic agents have serious toxicities associated with their use, necessitating extreme caution and attention. There is a growing interest in herbal remedies because of their pharmacological activities, minimal side effects, and low cost. Thymoquinone, a major component of the volatile oil of Nigella sativa Linn, also known as black cumin or black seeds, is commonly used in Middle Eastern countries as a condiment. It is also utilized for medicinal purposes and possesses antidiabetic, anti-cancer, anti-inflammatory, hepatoprotective, anti-microbial, immunomodulatory, and antioxidant properties. This review attempts to compile the published literature demonstrating thymoquinone’s protective effect against chemotherapeutic drug-induced toxicities.

Inhibitory effect of black cumin (Nigella sativa) seed essential oil on Fusobacterium nucleatum L-methionine-γ-lyase (L-methioninase) activity

2021 ◽  
Author(s):  
Masao Ishikawa ◽  
Takatoshi Murata ◽  
Masaaki Okamoto ◽  
Mayu Miyanohara ◽  
Mamiko Yamashita ◽  
...  
Keyword(s):  
Essential Oil ◽  
Nigella Sativa ◽  
Fusobacterium Nucleatum ◽  
Inhibitory Effect ◽  
Methyl Mercaptan ◽  
Kinetic Assay ◽  
Black Cumin ◽  
Wide Range ◽  
Lyase Activity ◽  
Deodorizing Activity

Abstract The enzyme L-methionine-γ-lyase is commonly found in a wide range of bacteria and catalyzes the α-elimination and γ-elimination of L-methionine to produce methyl mercaptan, α-ketobutyrate, and ammonia. Black cumin seed essential oil (BC oil) reportedly exhibits deodorizing activity against methyl mercaptan. Therefore, we hypothesized that BC oil may also suppress methyl mercaptan production. In this study, we aimed to evaluate the inhibitory effect of BC oil on L-methionine-γ-lyase activity in Fusobacterium nucleatum. Recombinant L-methionine-γ-lyase was incubated under appropriate conditions with BC oil and its constituent thymoquinone. To analyze L-methionine-γ-lyase activity, α-ketobutyric acid and ammonia concentrations were determined. The concentrations of α-ketobutyric acid and ammonia were significantly decreased by 10 µg mL−1 of BC oil (P < 0.01) and 16.4 µg mL−1 of thymoquinone (P < 0.05). An enzyme kinetic assay showed a mixed inhibition pattern between L-methionine-γ-lyase and thymoquinone. In conclusion, BC oil not only had a deodorizing effect against methyl mercaptan but also an inhibitory effect on methyl mercaptan production through the suppression of L-methionine-γ-lyase activity. Thymoquinone may be mainly responsible for these effects of BC oil. Thus, application of natural BC oil may be adapted not only for medical use but also in other areas of life.

Parameter estimation of the stochastic model for oral cancer in response to thymoquinone (TQ) as anticancer therapeutics

2021 ◽  
Vol 2 (1) ◽  
pp. 52-56
Author(s):  
Shabana Tabassum ◽  
Norhayati Rosli ◽  
Solachuddin Jauhari Arief Ichwan
Keyword(s):  
Oral Cancer ◽  
Nigella Sativa ◽  
Model Parameters ◽  
Global Public Health ◽  
Black Cumin ◽  
Linear Stochastic Differential Equation ◽  
Sample Paths ◽  
Wide Range ◽  
Oral Cancer Cells ◽  
Black Seeds

Oral Cancer is considered as one of the common problems of global public health and despite the progress in advanced research, the mortality rate has not been improved significantly in the last few decades. A natural product such as Thymoquinone, black seeds (TQ), is an active component of Nigella sativa or black cumin elicits cytotoxic effects on various oral cancer cell lines. A wide range of studies have been concluded that the TQ has two different anti-neoplastic actions that might trigger apoptosis, have the capacity to induce cell death in oral cancer cells. In the presence of TQ, oral cancer has been proved experimentally shows the decelerating trend of the growth. This article models the decelerating of the oral cancer growth by using a linear stochastic differential equation (SDEs). The Markov Chain Monte Carlo (MCMC) method used to estimate model parameters for 100, 500,1000 and 2000 simulations. The best set of kinetic parameters are identified. It can be seen that for 1000 simulations of the sample paths, the model fitted well the data, hence indicating a good fit. However, if the number of simulation is incerasing up to 2000, the parameter obtained shows instablity of the solution. This is due to the high numbers of noise generated, may influenced the stability of the solution.

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