scholarly journals Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects

Planta Medica ◽  
2015 ◽  
Vol 82 (01/02) ◽  
pp. 8-16 ◽  
Author(s):  
Bahareh Amin ◽  
Hossein Hosseinzadeh
Keyword(s):  
Nigella Sativa ◽  
Active Constituent ◽  
Black Cumin ◽  
Anti Inflammatory

scholarly journals Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes

Antioxidants ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 51 ◽  
Author(s):  
Laura Bordoni ◽  
Donatella Fedeli ◽  
Cinzia Nasuti ◽  
Filippo Maggi ◽  
Fabrizio Papa ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Nigella Sativa ◽  
Antioxidant Properties ◽  
Mediterranean Area ◽  
Low Grade ◽  
Mean Values ◽  
Black Cumin ◽  
Marche Region ◽  
Anti Inflammatory

The oil obtained from the seeds of Nigella sativa L. (N. sativa), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. The aim of the present study was to evaluate the antioxidant and anti-inflammatory properties of the oil extracted from seeds of a N. sativa cultivar produced in the Marche region of Italy, and to determine if the thymoquinone content, antioxidant properties, and biological activity would decay during storage. Cytotoxicity and anti-inflammatory properties of N. sativa oil were tested in an in vitro model of low-grade inflammation in Simpson–Golabi–Behmel syndrome human pre-adipocytes. The fresh extracted oil (FEO) contained 33% more thymoquinone than stored extracted oil (SEO), demonstrating that storage affects its overall quality. In addition, the thymoquinone content in the N. sativa oil from the Marche region cultivar was higher compared with other N. sativa oils produced in the Middle East and in other Mediterranean regions. Pro-inflammatory cytokines (e.g., Interleukin (IL)-1alpha, IL-1beta, IL-6) were differently modulated by fresh and stored extracts from N. sativa oils: FEO, containing more thymoquinone reduced IL-6 levels significantly, while SEO inhibited IL-1beta and had a higher antioxidant activity. Total antioxidant activity, reported as µM of Trolox, was 11.273 ± 0.935 and 6.103 ± 0.446 for SEO and FEO (p = 1.255 × 10−7), respectively, while mean values of 9.895 ± 0.817 (SEO) and 4.727 ± 0.324 (FEO) were obtained with the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay (p = 2.891 × 10−14). In conclusion, the oil capacity to counteract proinflammatory cytokine production does not strictly depend on the thymoquinone content, but also on other antioxidant components of the oil.

scholarly journals STUDY OF ENHANCED ANTI-INFLAMMATORY POTENTIAL OF NIGELLA SATIVA IN TOPICAL NANOFORMULATION

2018 ◽  
Vol 10 (7) ◽  
pp. 41 ◽  
Author(s):  
Faisal Obaid Alotaibi ◽  
Gulam Mustafa ◽  
Alka Ahuja
Keyword(s):  
Zeta Potential ◽  
Size Distribution ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Nigella Sativa ◽  
In Vitro Release ◽  
Spherical Shape ◽  
Active Constituent ◽  
Anti Inflammatory

Objective: Formulate a nanocarrier for enhancing the anti-inflammatory activity of thymoquinone (Tq), a major active constituent of Nigella sativa.Methods: Nanoformulation of Tq was developed by low energy emulsification techniques. NanoTqs were pre-screened by different thermodynamic stability tests, followed by in vitro release, zeta potential, viscosity, the transmittance (%), globule size distribution and ex vivo studies. The morphology of the optimized NanoTq was determined by transmission electron microscopy (TEM) which revealed fairly spherical shape and good correlation with particle size distribution study. The formulation used for assessment of the anti-inflammatory potential and permeability enhancement contained mixture of essential oil of Nigella sativa: Capryol 90 (3:7, 10%, v/v), Tween 80 (21.75%, v/v), PEG 400 (7.25%, v/v) and double distilled water (61%, v/v).Results: The in vitro permeation of Tq from optimized formulations was found extremely significant (p<0.001) in comparison to apiTq. The steady state flux (Jss), the permeability coefficient (Kp) and enhancement ratio (Er) of NanoTq gel was determined and compared with apiTq. The comparative anti-inflammatory effects of the optimized formulations NanoTq, apiTq and DicloGel was assessed on the edema in the carrageenan-induced paw model in Wistar rats. Therapeutic potential of NanoTq was found statistically extremely significant (P<0.0001) compared to apiTq and insignificant comparable with standard DicloGel. Storage stability of NanoTq showed insignificant changes in the zeta potential, droplet size and was free from any physical instability.Conclusion: The optimized nano formulation with a lower dose of Tq showed better anti-inflammatory effects, indicating greater absorption capability through the stratum corneum.

scholarly journals An Overview on Composition and Therapeutic Potentials of the Black Seed (Nigella sativa)

2021 ◽  
Vol 9 (12) ◽  
pp. 1966-1975
Author(s):  
Yusra Tafheem S
Keyword(s):  
Nigella Sativa ◽  
Herbal Medicines ◽  
Extended Period ◽  
Herbaceous Plant ◽  
Medical Systems ◽  
Active Constituent ◽  
Black Cumin ◽  
Toxicological Effects ◽  
Black Seed ◽  
Wide Range

Abstract: Nigella sativa is an annual herbaceous plant that belongs to the Ranunculaceae family and produces seeds known as black seed or black cumin. Black seed has been used in various civilization around the world for centuries to treat various ailments. It is widely used in a variety of traditional medical systems, including Unani, Ayurveda, and Siddha. Black seed is considered to be nutritionally dense, with high levels of fat, protein, dietary fibre, calcium, and iron. The seed is known to have a wide range of pharmacological properties which are supported by numerous studies. Extensive research has been carried out over decades to confirm the seed’s anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, antilipidemic, anti-cancer, gastroprotective, hepatoprotective, neuroprotective properties etc. Black seed has earned a position among the top ranked evidence-based herbal medicines due to its marvellous healing properties. Studies have revealed that the presence of thymoquinone, a major bioactive component of the seed essential oil, is responsible for the majority of its therapeutic properties. Consumption of the seeds for an extended period of time has been shown to have significant effects on lowering blood glucose levels, improving lipid profiles, and other biochemical parameters. The minor or negligible toxicological effects of black seed and its active constituent, thymoquinone, support its long-term use in traditional food and medicine. Because of their low toxicity, black seed is frequently used in food as a flavouring agent, additive in breads, and pickles. The current review summarises the composition, important pharmacological studies, dosage and toxicity of the Blackseed and its application in food industry.

scholarly journals Antioxidant, Anti-inflammatory, and Anti-arthritic Effect of Thymoquinone-rich Black Cumin (Nigella sativa) oil (BlaQmax®) on Adjuvant-induced Arthritis

2021 ◽  
Vol 10 (1) ◽  
pp. 52
Author(s):  
M. Ratheesh ◽  
Jose P. Svenia ◽  
Saji Sangeeth ◽  
S. Sheethal ◽  
Rajan Sony ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Inflammatory Cytokines ◽  
Nigella Sativa ◽  
Autoimmune Disorder ◽  
Gene Expressions ◽  
Black Cumin ◽  
Nigella Sativa Oil ◽  
Adjuvant Induced Arthritis ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

Rheumatoid Arthritis (RA) is a complex autoimmune disorder involving chronic and persistent inflammation, principally influencing the synovial joints which further prompting the obliteration of articular cartilage. Although black cumin (Nigella sativa) oil has already studied for its anti-arthritic properties, the current study was focused on the comparative evaluation of the antioxidant and anti-inflammatory properties of a thymoquinone (TQ)-rich (5% w/v) black cumin oil (BQ) with the commonly available standard black cumin oil (BM) containing 0.4% (w/v) TQ, and subsequent investigation on the potential application of BQ in the management of RA. Adjuvant-induced arthritis (AA) was instigated by a single intradermal infusion of 0.1 mL of Complete Freund&#39;s adjuvant (CFA) on the paw of adult Wistar rats. Based on the primary dose-response study using the carrageenan-induced paw edema model, 50 mg/kg b.wt. of BQ was employed for the treatment. The endogenous antioxidants (SOD, Catalase, GPx, and GSH), pro-inflammatory cytokines (COX-2, Nitrate, iNOS, TNF-&alpha;, IL-6), lipid peroxidation, and histopathology were evaluated to monitor the influence of BQ in AA rats. Adjuvant-induced animals showed a critical downregulation in antioxidant status with elevated levels of pro-inflammatory cytokines and lipid peroxidation. But, the treatment with BQ significantly reversed the antioxidant and inflammatory markers with downregulation of the pro-inflammatory gene expressions. Histopathology showed a significant reduction in the massive cell infiltration and epidermal edema of the paw tissue in AA rats when administered with BQ and indicated its potential effect to alleviate RA conditions in experimental rats.

Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling

2018 ◽  
Vol 37 (10) ◽  
pp. 1092-1104 ◽  
Author(s):  
YS Abulfadl ◽  
NN El-Maraghy ◽  
AA Eissa Ahmed ◽  
S Nofal ◽  
Y Abdel-Mottaleb ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inflammatory Responses ◽  
Nigella Sativa ◽  
Interleukin 1 ◽  
Amyloid Β ◽  
Active Constituent ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Anti Inflammatory

Alzheimer’s disease (AD) is characterized by a robust inflammatory response elicited by the accumulation and deposition of amyloid-β (Aβ) within the brain. Aβ induces detrimental inflammatory responses through toll-like receptors (TLRs) signaling pathway. Thymoquinone (TQ), the main active constituent of Nigella sativa oil, has been reported by several previous studies for its potent anti-inflammatory effect. The aim of this study is to elucidate the effect of TQ in improving learning and memory, using a rat model of AD induced by a combination of aluminum chloride (AlCl3) and d-galactose (d-Gal). TQ was administered orally at doses of 10, 20, and 40 mg/kg/day for 14 days after AD induction. Memory functions were assessed using the step through passive avoidance test. Amyloid plaques were shown to be present using hematoxylin and eosin staining. Tumor necrosis factor-alpha (TNF-α) and Interleukin-1beta (IL-1β) levels in brain were assessed via ELISA and profiling TLR-2, TLR-4, myeloid differential factor 88, toll–interleukin-1 receptor domain-containing adapter-inducing interferon-β, interferon regulatory factor 3 (IRF-3), and nuclear factor-κB (NF-κB) expressions via real-time polymerase chain reaction. TQ improved AD rat cognitive decline, decreased Aβ formation and accumulation, significantly decreased TNF-α and IL-1β at all levels of doses and significantly downregulated the expression of TLRs pathway components as well as their downstream effectors NF-κB and IRF-3 mRNAs at all levels of doses ( p < 0.05). We concluded that TQ reduced the inflammation induced by d-Gal/AlCl3 combination. It is therefore reasonable to assign the anti-inflammatory responses to the modulation of TLRs pathway.

scholarly journals Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Ebrahim M. Yimer ◽  
Kald Beshir Tuem ◽  
Aman Karim ◽  
Najeeb Ur-Rehman ◽  
Farooq Anwar
Keyword(s):  
Potential Role ◽  
Viral Infections ◽  
Nigella Sativa ◽  
Antioxidant Property ◽  
Biological Properties ◽  
Chemotherapeutic Agents ◽  
Active Constituent ◽  
Black Cumin ◽  
Inflammatory Conditions ◽  
Wide Range

The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.

scholarly journals Jintan Hitam sebagai Imunomodulator dan Anti Inflamasi pada Pasien Asma

2019 ◽  
Vol 1 (1) ◽  
pp. 115-120
Author(s):  
Maharani Amanulloh ◽  
Ester Krisdayanti
Keyword(s):  
Literature Review ◽  
Nigella Sativa ◽  
Review Literature ◽  
Pharmacological Effects ◽  
Inflammatory Reactions ◽  
Black Cumin ◽  
Asthma Patients ◽  
Antibody Titers ◽  
Herbal Plants ◽  
Anti Inflammatory

Jintan hitam merupakan salah satu tanaman herbal yang memiliki berbagai efek farmakologis diantaranya yaitu sebagai antioksidan, antidiabetes, antialergi, antiinflamasi, dan sebagai imunomodulator, sehingga jintan hitam (Nigella sativa) seringkali digunakan sebagai obat herbal. Tujuan literature review ini yaitu untuk mengetahui efek jintan hitam sebagai imunomodulator dan anti inflamasi pada pasien asma. Metode yang digunakan adalah metode literature review dari 47 artikel PubMed NCBI, Google Schoolar, dan Elsevier yang diperoleh hanya 23 artikel yang digunakan dari tahun 2009 hingga tahun 2019. Dari beberapa penelitian yang dilakukan didapatkan hasil bahwa jintan hitam bermanfaat sebagai immunomodulator dengan meningkatkan titer antibodi dan peningkatan limfosit dan monosit serta menurunkan kadar neutrofil. Senyawa aktif yang terdapat di dalam jintan hitam (Nigella sativa) salah satunya yaitu thymoquinone dan thymohidroquinone yang mana senyawa tersebut diketahui dapat mengurangi pemasukan ion kalsium sehingga dapat mengurangi degranulasi sel mast dan sebagai imunomodulator yang dapat menekan reaksi inflamasi.   Kata kunci: jintan hitam, immunomodulator, anti inflamasi, asma   BLACK JINTAN AS AN IMMUNOMODULATOR AND ANTI INFLAMATION IN ASMA PATIENTS   ABSTRACT Black cumin (nigella sativa) is one of the herbal plants that has various pharmacological effects including antioxidant, antidiabetic, hypo-allergenic, anti-inflammatory, and as an immunomodulator, so black cumin (nigella sativa) is often used as an herbal medicine. the purpose of this review literature is to determine the effect of black cumin as an immunomodulator and anti-inflammatory in asthma patients. the method used is the literature review method of 47 articles pubmed ncbi, google schoolar, and elsevier obtained only 23 articles used from 2009 to 2019. from several studies conducted it was found that black cumin is useful as an immunomodulator by increasing antibody titers and increased lymphocytes and monocytes and decreased neutrophil levels. active compounds contained in black cumin (nigella sativa), one of which is thymoquinone and thymohidroquinone which compounds are known to reduce the intake of calcium ions so that it can reduce mast cell degranulation and as an immunomodulator that can suppress inflammatory reactions.  Keywords: black cumin, immunomodulator, anti-inflammatory, asthma

Optimisation of the Oil Extraction from Nigella sativa Seeds Using Response Surface Methodology

2017 ◽  
Vol 68 (2) ◽  
pp. 331-336
Author(s):  
Gabriela Isopencu ◽  
Mirela Marfa ◽  
Iuliana Jipa ◽  
Marta Stroescu ◽  
Anicuta Stoica Guzun ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Nigella Sativa ◽  
Polynomial Equation ◽  
Herbaceous Plant ◽  
Box Behnken Design ◽  
Pareto Analysis ◽  
Black Cumin ◽  
Mediterranean Countries ◽  
Experimental Values

Nigella sativa, also known as black cumin, an annual herbaceous plant growing especially in Mediterranean countries, has recently gained considerable interest not only for its use as spice and condiment but also for its healthy properties of the fixed and essential oil and its potential as a biofuel. Nigella sativa seeds fixed oil, due to its high content in linoleic acid followed by oleic and palmitic acid, could be beneficial to human health. The objective of this study is to determine the optimum conditions for the solvent extraction of Nigella sativa seeds fixed oil using a three-level, three-factor Box-Behnken design (BBD) under response surface methodology (RSM). The obtained experimental data, fitted by a second-order polynomial equation were analysed by Pareto analysis of variance (ANOVA). From a total of 10 coefficients of the statistical model only 5 are important. The obtained experimental values agreed with the predicted ones.

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

2017 ◽  
Vol 6 (9) ◽  
pp. 5474 ◽  
Author(s):  
Basant Mahmoud Morsy ◽  
Ghada Mohamed Safwat ◽  
Doaa Ahmed Hussein ◽  
Reem Mohamed Samy
Keyword(s):  
Valproic Acid ◽  
Nigella Sativa ◽  
Liver Lipid ◽  
Black Cumin ◽  
Enzymatic Antioxidant ◽  
Nigella Sativa Oil ◽  
Active Chemical ◽  
Oil Extract ◽  
Liver Lipid Peroxidation

Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa Oil (NSO) extract on the neurotoxic and hepatotoxic potentials from Valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study’s case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the non-enzymatic antioxidant, brain and liver lipid peroxidation (LPO) and glutathione (GSH) concentration and the enzymatic antioxidant, brain and liver catalase(CAT) activity.

Sign in / Sign up

Export Citation Format

Share Document