Factors That Determine the Likelihood of Giving Birth to the First Child within 10 Months after Marriage

Background. One of the major aims of marriage is to procreate or give birth to a child. Childbirth is so crucial in marriage that it often determines the happiness of the couple. Too much delay in childbirth after marriage or the likelihood that one cannot give birth after marriage can lead to divorce. However, causes of delay in childbirth are often difficult to detect by both the Gynaecologist and the couple involved. This makes proposing solutions to issues related to childbirth usually unsuccessful. Methods. It is against this background that we conducted this study to identify factors that determine childbirth within 10 months or after 10 months of marriage (birth length) among women in Ghana. This was achieved by using a logistic regression model for the dichotomous birth length variable, adjusting for risk factors/predictors of birth length. The data used for the study were obtained from the 2014 Ghana Demographic and Health Survey, consisting 6,525 complete cases with 18 predictor variables. Statistical analyses were carried out using STATA version 14.1. Results. The results show that respondents who have ever terminated pregnancy are more likely (OR=0.178, 95%CI=0.044, 0.312) to deliver after 10 months, wives whose husbands have higher education are less likely (OR=‐0.162, 95%CI=‐0.236, ‐0.088) to give birth after 10 months of marriage, wives who reported that beating is justified if she goes out without her husband’s notice are more likely (OR=0.466, 95%CI=0.305, 0.628) to give birth after 10 months, wives who reported that beating is justified if she neglects the child are more likely (OR=‐0.305, 95%CI=‐0.461, ‐0.149) to give birth within 10 months, and wives who reported that beating is justified when she argues with her husband are less likely (OR=‐0.301, 95%CI=‐0.451, ‐0.152) to give birth after 10 months of marriage. Every unit increase in the age of the respondent at marriage increases the likelihood of giving birth after 10 months of marriage, and a unit increase in the age of the respondent at first sex decreases the likelihood of giving birth after 10 months in marriage. Conclusions. For conception within 1 month of marriage, wives and husbands should/are encouraged to have frequent sex, any negative social behaviour or policies must be discouraged, experts’ advice on contraceptive use must be sought, and women are encouraged to desist from termination of pregnancy at any time of their life. Husbands should openly express their desire and love for their children since this increases the likelihood of wives’ desire to give birth. This leads to frequent sex, which then reduces conception time, and hence childbirth within the shortest possible time.

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Regional comparative analysis of factors that may delay child-birth for at least 10 months among women in Ghana after marriage

10.21203/rs.3.rs-389294/v1 ◽

2021 ◽

Author(s):

Abdul-Karim Iddrisu ◽

Mustapha Adams ◽

Akuye-Shika Odametey ◽

Nana Kofi Mensah ◽

Paul A. Kwotua

Keyword(s):

Risk Factors ◽

Characteristic Curve ◽

Information Criterion ◽

Birth Length ◽

Health Concern ◽

Child Birth ◽

Factors Associated ◽

First Child ◽

Unit Increase ◽

Best Fitting

Abstract Introduction: Infertility or difficulty related to conception and childbirth is still a global health concern including Ghana. Infertility or child-birth associated difficulties after marriage can lead to divorce. However, risk factors associated with child-birth difficulties are often difficult to detect by both the Gynaecologist and the couple involved. This makes proposing solutions to issues related to child-birth usually unsuccessful.Methods: This study seeks to identify risk factors associated with child-birth among married women in Ghana. This was achieved by using a logistic regression model for the dichotomous birth length (birth within 10 months or after 10 months in marriage) variable, adjusting for risk factors of birth length. The data used for the study were obtained from the 2014 Ghana Demographic and Health Survey, consisting of 5,004 complete cases. Statistical analyses were carried out using STATA version 14.1, best-fitting model selected from candidate models using their respective Akaike Information Criterion or Bayesian Information Criterion and the predictive power of such model determined using the Receiver Operating Characteristic curve.Results: Respondents with Akan ethnic background are less likely to deliver their first child after 10 months of marriage, wives who reported that beating is justified if she goes out without her husband's notice are more likely to give birth to their first child after 10 months of marriage, wives who reported that beating is justified when she burns food are less likely to give birth to their first child after 10 months of marriage. A unit increase in the age of respondent at first sex at first cohabitation decreases the likelihood of giving birth to the first child after 10 months in marriage. Rich and middle-class wives are more likely to give birth after 10 months in marriage.Discussion and Conclusions: For wives to conceive within 10 months of marriage, wives and husbands should or are encouraged to have frequent sex, any negative social behavior or policies must be discouraged. Husbands should openly express their desire and love for their children since this increases the likelihood of wives desire to give birth. This leads to frequent sex, which then reduces conception time, and hence, child-birth within the shortest possible time.

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Regional comparative analysis of factors that affect child-birth among women in Ghana after marriage.

10.21203/rs.3.rs-389294/v2 ◽

2021 ◽

Author(s):

Abdul-Karim Iddrisu ◽

Mustapha Adams ◽

Akuye-Shika Odametey ◽

Nana Kofi Mensah ◽

Paul A. Kwotua

Keyword(s):

Risk Factors ◽

Characteristic Curve ◽

Information Criterion ◽

Birth Length ◽

Health Concern ◽

Child Birth ◽

Factors Associated ◽

First Child ◽

Unit Increase ◽

Best Fitting

Abstract Introduction: Infertility or difficulty related to conception and childbirth is still a global health concern including Ghana. Infertility or child-birth associated difficulties after marriage can lead to divorce. However, risk factors associated with child-birth difficulties are often difficult to detect by both the Gynaecologist and the couple involved. This makes proposing solutions to issues related to child-birth usually unsuccessful. Methods: This study seeks to identify risk factors associated with child-birth among married women in Ghana. This was achieved by using a logistic regression model for the dichotomous birth length (birth within 10 months or after 10 months in marriage) variable, adjusting for risk factors of birth length. The data used for the study were obtained from the 2014 Ghana Demographic and Health Survey, consisting of 5,004 complete cases. Statistical analyses were carried out using STATA version 14.1, best-fitting model selected from candidate models using their respective Akaike Information Criterion or Bayesian Information Criterion and the predictive power of such model determined using the Receiver Operating Characteristic curve. Results: Respondents with Akan ethnic background are less likely to deliver their first child after 10 months of marriage, wives who reported that beating is justified if she goes out without her husband's notice are more likely to give birth to their first child after 10 months of marriage, wives who reported that beating is justified when she burns food are less likely to give birth to their first child after 10 months of marriage. A unit increase in the age of respondent at first sex at first cohabitation decreases the likelihood of giving birth to the first child after 10 months in marriage. Rich and middle-class wives are more likely to give birth after 10 months in marriage. Discussion and Conclusions: For wives to conceive within 10 months of marriage, wives and husbands should or are encouraged to have frequent sex, any negative social behaviour or policies must be discouraged. Husbands should openly express their desire and love for their children since this increases the likelihood of wife’s desire to give birth. This leads to frequent sex, which then reduces conception time, and hence, child-birth within the shortest possible time.

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A comprehensive, contemporary assessment of the association between hepatosteatosis and coronary artery calcium scoring

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeaa356.234 ◽

2021 ◽

Vol 22 (Supplement_1) ◽

Author(s):

T Heseltine ◽

SW Murray ◽

RL Jones ◽

M Fisher ◽

B Ruzsics

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Coronary Artery ◽

Regression Model ◽

Coronary Artery Calcium ◽

Logistic Regression Model ◽

Prediction Models ◽

Multinomial Logistic Regression ◽

Cvd Risk ◽

Male Sex

Abstract Funding Acknowledgements Type of funding sources: None. onbehalf Liverpool Multiparametric Imaging Collaboration Background Coronary artery calcium (CAC) score is a well-established technique for stratifying an individual’s cardiovascular disease (CVD) risk. Several well-established registries have incorporated CAC scoring into CVD risk prediction models to enhance accuracy. Hepatosteatosis (HS) has been shown to be an independent predictor of CVD events and can be measured on non-contrast computed tomography (CT). We sought to undertake a contemporary, comprehensive assessment of the influence of HS on CAC score alongside traditional CVD risk factors. In patients with HS it may be beneficial to offer routine CAC screening to evaluate CVD risk to enhance opportunities for earlier primary prevention strategies. Methods We performed a retrospective, observational analysis at a high-volume cardiac CT centre analysing consecutive CT coronary angiography (CTCA) studies. All patients referred for investigation of chest pain over a 28-month period (June 2014 to November 2016) were included. Patients with established CVD were excluded. The cardiac findings were reported by a cardiologist and retrospectively analysed by two independent radiologists for the presence of HS. Those with CAC of zero and those with CAC greater than zero were compared for demographic and cardiac risks. A multivariate analysis comparing the risk factors was performed to adjust for the presence of established risk factors. A binomial logistic regression model was developed to assess the association between the presence of HS and increasing strata of CAC. Results In total there were 1499 patients referred for CTCA without prior evidence of CVD. The assessment of HS was completed in 1195 (79.7%) and CAC score was performed in 1103 (92.3%). There were 466 with CVD and 637 without CVD. The prevalence of HS was significantly higher in those with CVD versus those without CVD on CTCA (51.3% versus 39.9%, p = 0.007). Male sex (50.7% versus 36.1% p= <0.001), age (59.4 ± 13.7 versus 48.1 ± 13.6, p= <0.001) and diabetes (12.4% versus 6.9%, p = 0.04) were also significantly higher in the CAC group compared to the CAC score of zero. HS was associated with increasing strata of CAC score compared with CAC of zero (CAC score 1-100 OR1.47, p = 0.01, CAC score 101-400 OR:1.68, p = 0.02, CAC score >400 OR 1.42, p = 0.14). This association became non-significant in the highest strata of CAC score. Conclusion We found a significant association between the increasing age, male sex, diabetes and HS with the presence of CAC. HS was also associated with a more severe phenotype of CVD based on the multinomial logistic regression model. Although the association reduced for the highest strata of CAC (CAC score >400) this likely reflects the overall low numbers of patients within this group and is likely a type II error. Based on these findings it may be appropriate to offer routine CVD risk stratification techniques in all those diagnosed with HS.

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Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study

Scientific Reports ◽

10.1038/s41598-021-86853-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Anping Guo ◽

Jin Lu ◽

Haizhu Tan ◽

Zejian Kuang ◽

Ying Luo ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Liver Disease ◽

Length Of Stay ◽

Regression Model ◽

Logistic Regression Model ◽

Hospital Length ◽

Clinical Treatment ◽

Hospital Length Of Stay ◽

Female Sex

AbstractTreating patients with COVID-19 is expensive, thus it is essential to identify factors on admission associated with hospital length of stay (LOS) and provide a risk assessment for clinical treatment. To address this, we conduct a retrospective study, which involved patients with laboratory-confirmed COVID-19 infection in Hefei, China and being discharged between January 20 2020 and March 16 2020. Demographic information, clinical treatment, and laboratory data for the participants were extracted from medical records. A prolonged LOS was defined as equal to or greater than the median length of hospitable stay. The median LOS for the 75 patients was 17 days (IQR 13–22). We used univariable and multivariable logistic regressions to explore the risk factors associated with a prolonged hospital LOS. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated. The median age of the 75 patients was 47 years. Approximately 75% of the patients had mild or general disease. The univariate logistic regression model showed that female sex and having a fever on admission were significantly associated with longer duration of hospitalization. The multivariate logistic regression model enhances these associations. Odds of a prolonged LOS were associated with male sex (aOR 0.19, 95% CI 0.05–0.63, p = 0.01), having fever on admission (aOR 8.27, 95% CI 1.47–72.16, p = 0.028) and pre-existing chronic kidney or liver disease (aOR 13.73 95% CI 1.95–145.4, p = 0.015) as well as each 1-unit increase in creatinine level (aOR 0.94, 95% CI 0.9–0.98, p = 0.007). We also found that a prolonged LOS was associated with increased creatinine levels in patients with chronic kidney or liver disease (p < 0.001). In conclusion, female sex, fever, chronic kidney or liver disease before admission and increasing creatinine levels were associated with prolonged LOS in patients with COVID-19.

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Characteristics of Adenocarcinoma of the Gallbladder Following Cholecystectomies in the Hispanic Population

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz113.067 ◽

2019 ◽

Vol 152 (Supplement_1) ◽

pp. S64-S65

Author(s):

David Gustafson ◽

Osvaldo Padilla

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Logistic Regression Analysis ◽

Incidental Finding ◽

Conditional Logistic Regression ◽

Gallbladder Disease ◽

Predictor Variables ◽

Wall Thickening ◽

Conditional Logistic Regression Analysis

Abstract Introduction Gallbladder adenocarcinoma (GBC) is a rare malignancy. Frequency of incidental adenocarcinoma of the gallbladder in the literature is approximately 0.2% to 3%. Typically, GBC is the most common type and is discovered late, not until significant symptoms develop. Common symptoms include right upper quadrant pain, nausea, anorexia, and jaundice. A number of risk factors in the literature are noted for GBC. These risk factors are also more prevalent in Hispanic populations. This study sought to compare patients with incidental gallbladder adenocarcinomas (IGBC) to those with high preoperative suspicion for GBC. Predictor variables included age, sex, ethnicity, radiologic wall thickening, gross pathology characteristics (wall thickness, stone size, stone number, and tumor size), histologic grade, and staging. Methods Cases of GBC were retrospectively analyzed from 2009 through 2017, yielding 21 cases. Data were collected via Cerner EMR of predictor variables noted above. Statistical analysis utilized conditional logistic regression analysis. Results The majority of patients were female (n = 20) and Hispanic (n = 19). There were 14 IGBCs and 7 nonincidental GBCs. In contrast with previous research, exact conditional logistic regression analysis revealed no statistically significant findings. For every one-unit increase in AJCC TNM staging, there was a nonsignificant 73% reduction in odds (OR = 0.27) of an incidental finding of gallbladder carcinoma. Conclusion This study is important in that it attempts to expand existing literature regarding a rare type of cancer in a unique population, one particularly affected by gallbladder disease. Further studies are needed to increase predictive knowledge of this cancer. Longer studies are needed to examine how predictive power affects patient outcomes. This study reinforces the need for routine pathologic examination of cholecystectomy specimens for cholelithiasis.

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Pre-Existing Lymphopenia Increases the Risk of Hospitalization and Death after SARS-CoV-2 Infection

Infectious Disease Reports ◽

10.3390/idr14010003 ◽

2022 ◽

Vol 14 (1) ◽

pp. 20-25

Author(s):

Riccardo Garbo ◽

Francesca Valent ◽

Gian Luigi Gigli ◽

Mariarosaria Valente

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Cohort Study ◽

General Population ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Logistic Regression Model ◽

Protective Factor ◽

Absolute Lymphocyte Count ◽

Limited Information

There is limited information regarding the severity of COVID-19 in immunocompromized patients. We conducted a retrospective cohort study considering the period from 1 March 2020 to 31 December 2020 to determine whether previously existing lymphopenia increases the risk of hospitalization and death after SARS-CoV-2 infection in the general population. The laboratory and hospital discharge databases of the Azienda Sanitaria Universitaria Friuli Centrale were used, and 5415 subjects infected with SARS-CoV-2 and with at least one recent absolute lymphocyte count determination before SARS-CoV-2 positivity were included. In total, 817 (15.1%) patients had severe COVID-19. Patients developing severe COVID-19 were more frequently males (44.9% of the severe COVID-19 group vs. 41.5% in the non-severe COVID-19 group; p < 0.0001) and were older (73.2 ± 13.8 vs. 58.4 ± 20.3 years; p < 0.0001). Furthermore, 29.9% of the lymphopenic patients developed severe COVID-19 vs. 14.5% of the non-lymphopenic patients (p < 0.0001). In a logistic regression model, female sex remained a protective factor (OR = 0.514, 95%CI 0.438–0.602, p < 0.0001), while age and lymphopenia remained risk factors for severe COVID-19 (OR = 1.047, 95%CI 1.042–1.053, p < 0.0001 for each additional year of age; OR = 1.715, 95%CI 1.239–2.347, p = 0.0011 for lymphopenia). This provides further information to stratify the risk of COVID-19 severity, which may be an important element in the management of immunosuppressive therapies.

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Screening Risk Factors and Interaction Analysis of Hypertension in Overweight and Obesity Population based on Three Statistical Models

10.21203/rs.3.rs-390569/v1 ◽

2021 ◽

Author(s):

Li Lu Wei ◽

Yu jian

Keyword(s):

Neural Network ◽

Risk Factors ◽

Logistic Regression ◽

Regression Model ◽

Bp Neural Network ◽

Logistic Regression Model ◽

Classification Tree ◽

Overweight And Obesity ◽

Tree Model ◽

Classification Tree Model

Abstract Background Hypertension is a common chronic disease in the world, and it is also a common basic disease of cardiovascular and brain complications. Overweight and obesity are the high risk factors of hypertension. In this study, three statistical methods, classification tree model, logistic regression model and BP neural network, were used to screen the risk factors of hypertension in overweight and obese population, and the interaction of risk factors was conducted Analysis, for the early detection of hypertension, early diagnosis and treatment, reduce the risk of hypertension complications, have a certain clinical significance.Methods The classification tree model, logistic regression model and BP neural network model were used to screen the risk factors of hypertension in overweight and obese people.The specificity, sensitivity and accuracy of the three models were evaluated by receiver operating characteristic curve (ROC). Finally, the classification tree CRT model was used to screen the related risk factors of overweight and obesity hypertension, and the non conditional logistic regression multiplication model was used to quantitatively analyze the interaction.Results The Youden index of ROC curve of classification tree model, logistic regression model and BP neural network model were 39.20%,37.02% ,34.85%, the sensitivity was 61.63%, 76.59%, 82.85%, the specificity was 77.58%, 60.44%, 52.00%, and the area under curve (AUC) was 0.721, 0.734,0.733, respectively. There was no significant difference in AUC between the three models (P>0.05). Classification tree CRT model and logistic regression multiplication model suggested that the interaction between NAFLD and FPG was closely related to the prevalence of overweight and obese hypertension.Conclusion NAFLD,FPG,age,TG,UA, LDL-C were the risk factors of hypertension in overweight and obese people. The interaction between NAFLD and FPG increased the risk of hypertension.

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The effect of women’s bargaining power within couples on contraceptive use in Cameroon

Gates Open Research ◽

10.12688/gatesopenres.13100.2 ◽

2021 ◽

Vol 4 ◽

pp. 20

Author(s):

Dimitri Tchakounté Tchuimi ◽

Benjamin Fomba Kamga

Keyword(s):

Logistic Regression ◽

Maternal Death ◽

Contraceptive Method ◽

Bargaining Power ◽

Logistic Regression Model ◽

Contraceptive Use ◽

Modern Contraceptive ◽

Death Rates ◽

Modern Contraceptive Method ◽

Modern Contraceptive Use

Background: The prevalence of contraception among married women, evaluated at 23%, is low in Cameroon. Maternal death rates, estimated at 782 deaths per 100,000 live births, are very worrying. The National Strategic Plan for Reproductive, Maternal, Newborn and Child Health (2015-2020) and the Health Sector Strategy (2016-2027) focuses on increasing modern contraceptive prevalence as a means to reduce maternal death. This paper identifies women’s bargaining power as a factor that may stimulate contraceptive use. The objective of this study is to analyze the association between women's bargaining power within couples and modern contraceptive use. Methods: The data used come from the fifth Demographic and Health Survey (DHS) conducted in 2018. Women’s bargaining power within couple is measured by a Woman Bargaining Power Composite Index (WBPCI) built through a multiple correspondence analysis. The logistic regression model was used to analyze the relationship between WBPCI and modern contraceptive use. Results: The results of the descriptive statistics show that women's bargaining power is higher among women who use contraception than for those who do not. The results of the logistic regression model show that an increase of WBPCI was significantly associated with higher chances of using a modern contraceptive method (OR = 1.352; 95% CI: 1.257, 1.454; p <0.01). The education of women is also a key determinant since educated women were at least two times more likely to use a modern contraceptive method than uneducated women. Conclusions: To reduce high maternal death rates in Cameroon, public health policies should not only focus on the health system itself, but should also focus on social policies to empower women in the household.

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Independent Predictors of In-Hospital Mortality in Elderly and Non-elderly Adult Patients Undergoing Emergency Admission for Hemorrhoids

The American Surgeon ◽

10.1177/00031348211060420 ◽

2022 ◽

pp. 000313482110604

Author(s):

Lior Levy ◽

Abbas Smiley ◽

Rifat Latifi

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Elderly Patients ◽

Diagnostic Procedure ◽

Logistic Regression Model ◽

Emergency Admission ◽

Adult Patients ◽

Elderly Adult ◽

Multivariable Logistic Regression Model ◽

Invasive Diagnostic Procedure

Background The study explored determinants of mortality of admitted emergently patients with the primary diagnosis of hemorrhoids, during the years 2005-2014. Methods Demographics, clinical data, and outcomes were obtained from the National Inpatient Sample, 2005-2014, in elderly (65+ years) and non-elderly adult patients (18-64 years) with hemorrhoids who underwent emergency admission. Multivariable logistic regression model with backward elimination was used to identify predictors of mortality. Results 25 808 adult and 26 978 elderly patients were included. Female patients consisted of 42.5% and 59.3% in adult and elderly, respectively. 42 (.2%) adults died, of which 50% were female and 125 (.5%) elderly patients died, of which 60% were female. Mean (SD) age of the adult patients was 47.8 (11) years and in elderly patients was 78.7 (8) years. 82.2% and 85.7% had internal hemorrhoids in adult and elderly patients, respectively. 9326 (36.1%) adult and 7282 (27%) elderly patients underwent an operation. In the final multivariable logistic regression model for adult patients with operation, delayed operation and invasive diagnostic procedures increased the odds of mortality, whereas in elderly patients, delayed operation and frailty index were the risk factors of mortality. In both adults and elderly with no operation, increased hospital length of stay (HLOS) significantly increased the odds of mortality, and undergoing an invasive diagnostic procedure significantly decreased the odds of mortality. Conclusion In all operated patients, increased time to operation and undergoing an invasive diagnostic procedure were the risk factors for mortality. On the other hand, in non-operated emergency hemorrhoids patients, increased age and increased HLOS were the risk factors for mortality while undergoing an invasive diagnostic procedure decreased the odds of mortality.

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Abstract P014: Cardiovascular Risk Factors Associated with Low Dehydroepiandrosterone Sulfate

Circulation ◽

10.1161/circ.125.suppl_10.ap014 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Monik C Jimenez ◽

JoAnn E Manson ◽

Kathryn M Rexrode

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Heart Disease ◽

Dehydroepiandrosterone Sulfate ◽

Stepwise Logistic Regression ◽

Postmenopausal Hormone ◽

Reactive Protein ◽

Unit Increase ◽

History Of ◽

Hormone Use

Introduction: Low dehydroepiandrosterone sulfate (DHEAS) levels recently have been related to elevated risk of ischemic stroke. However, the association between DHEAS and traditional cardiovascular risk factors remains unclear. Methods: Blood samples were collected in 1989-1990 among 32,826 participants of the Nurses’ Health Study. Samples were assayed for DHEAS, lipids, and other biomarkers as part of a nested case control study evaluating risk of ischemic stroke and 340 stroke-free controls with complete data were available. Lifestyle covariates were ascertained in 1988. Stepwise logistic regression models were used to evaluate the association of between CVD risk factors and low DHEAS (<42 μ g/dL), while stepwise linear regression was used to evaluate the association with continuous DHEAS. Stepwise models utilized an entry threshold of α=0.20 and exit criterion of α=0.10. Results: The mean level of DHEAS was 78.38 μ g/dL (s.d. 50.02; median=67.03) in this population of women aged 43-69 years (median=62). Age was strongly associated with lower DHEAS. Women with history of heart disease and higher total/HDL cholesterol were more likely to have low DHEAS. In stepwise logistic regression analyses, age (OR=2.94; 95%CI: 1.73-5.00 for 10 yrs) and history of heart disease (OR=1.84; 95% CI: 0.91-3.70) were identified as risk factors for low DHEAS. In stepwise linear regression modeling, age, postmenopausal hormone use, history of heart disease and C-reactive protein (CRP) were associated with lower DHEAS levels while alcohol use was associated with higher DHEAS levels (Table 1). Body mass index, smoking, diabetes, glycosylated hemoglobin and lipids were not associated with low DHEAS. Conclusions: In this population of healthy women, lower levels of DHEAS were associated with older age, history of heart disease, postmenopausal hormone use, higher CRP and lower levels of alcohol consumption. Further research is needed to explore these associations. Table 1 Multivariable * adjusted estimates for DHEAS by cardiovascular disease risk factors DHEAS (continuous μ g/dL) β † 95%CI Age ‡ −28.40 −36.75, -20.05 History of Heart disease −18.76 −39.23, 1.71 Postmenopausal Hormone Therapy Use & −12.01 −21.99, -2.04 CRP £ (mg/L) −0.66 −1.37, 0.04 Alcohol # (g/day) 2.95 0.46, 5.45 * All variables mutually adjusted for one another † Estimated from stepwise logistic regression model ‡ per 10 year increase in age & Ref = No use of postmenopausal hormone therapy £ per 1 unit increase in C-reactive protein (CRP- mg/L) # per 5 unit increase in alcohol consumption (g/day)

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