Lack of Association between rs4680 Polymorphism in Catechol-O-Methyltransferase Gene and Alcohol Use Disorder: A Meta-Analysis

Background. The underlying mechanisms of alcohol use disorder (AUD) are regarded to be strongly associated with genetic factors. Although great efforts have been made to identify the association of rs4680 polymorphism in the catechol-o-methyltransferase gene and risk to AUD, the outcomes were still inconsistent. This study is aimed at exploring the association of rs4680 polymorphism and AUD by using a meta-analysis approach. Methods. Literature searching was undertaken across PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. We set the search period before February 20, 2020. We used the Review Manager 5.3 (RevMan 5.3) software to estimate the effect sizes in five genetic models. Results. In total, eighteen case-control studies and two cohort studies were included in this study. The merged results of overall population indicated there was no significant association between rs4680 polymorphism and AUD: V vs. M, OR = 1.02 , 95% CI 0.93-1.12, P = 0.70 ; VV vs. MM, OR = 0.99 , 95% CI 0.79-1.23, P = 0.92 ; VM vs. MM, OR = 0.91 , 95% CI 0.81-1.03, P = 0.15 ; VV+VM vs. MM, OR = 0.95 , 95% CI 0.80-1.13, P = 0.65 ; VV vs. VM+MM, OR = 1.04 , 95% CI 0.91-1.18, P = 0.57 . Subgroup analysis by gender suggested rs4680 polymorphism was marginally associated with an elevated risk to AUD among males (VM vs. MM, OR = 0.81 , 95% CI 0.67-0.98, P = 0.03 ). However, subgroup analysis by race and diagnosis did not support any significant association. Conclusions. The present study suggests that rs4680 polymorphism has no association with AUD in the overall population, but it has a weak association with AUD in males. Carriers of VM genotype in males appear to have an increased risk to AUD.

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Meta-Analysis of the Association between Vitiligo and Human Leukocyte Antigen-A

BioMed Research International ◽

10.1155/2016/5412806 ◽

2016 ◽

Vol 2016 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Zhangjun Li ◽

Jianwen Ren ◽

Xinwu Niu ◽

Qingqiang Xu ◽

Xiaopeng Wang ◽

...

Keyword(s):

Human Leukocyte Antigen ◽

Subgroup Analysis ◽

Meta Analysis ◽

Human Leukocyte ◽

Case Control Studies ◽

Leukocyte Antigen ◽

Knowledge Infrastructure ◽

Increased Risk ◽

Typing Methods ◽

Chinese National Knowledge Infrastructure

Objective. The objective of this study was to systematically evaluate the association between vitiligo and human leukocyte antigen- (HLA-) A.Methods. PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, and reference lists were searched for relevant original articles.Results. Nineteen case-control studies comprising 3042 patients and 5614 controls were included, in which 33 HLA-A alleles were reported. Overall, three alleles (HLA-A⁎02,A⁎33, and Aw⁎31) were significantly associated with increased risk of vitiligo, two (HLA-A⁎09 and Aw⁎19) were associated with decreased risk, and the remaining 28 were unassociated. Twelve alleles, seven alleles, and 19 alleles were common to three ethnicities, both types of vitiligo, and both typing methods, respectively. In the subgroup analysis by ethnicity and typing methods, the association of six alleles and five alleles was inconsistent in three populations and both typing methods, respectively. In the subgroup analysis by clinical type, the association of all seven alleles was consistent in both types of vitiligo.Conclusion. The meta-analysis suggests that HLA-A⁎02,A⁎33, and Aw⁎31 are associated with increased risk of vitiligo, while HLA-A⁎09 and Aw⁎19 are associated with decreased risk of vitiligo. The association of some alleles varies in terms of ethnicity and typing methods.

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Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis

Frontiers in Immunology ◽

10.3389/fimmu.2021.592841 ◽

2021 ◽

Vol 12 ◽

Author(s):

Shuping Li ◽

Xiaohua Wang ◽

Yuming Zhao ◽

Juan Yang ◽

Tianjiao Cui ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Meta Analysis ◽

Tyrosine Phosphatase ◽

Mycobacterial Infection ◽

Case Control Studies ◽

Knowledge Infrastructure ◽

Increased Risk ◽

Autoimmune Conditions ◽

High Degree ◽

Chinese National Knowledge Infrastructure

It was previously published that single-nucleotide polymorphism rs2476601 (PTPN22 [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to Mycobacterium tuberculosis and M. leprae infection. However, the results were inconclusive despite a high degree of similarity between both parameters. Herein, we carried out this meta-analysis to systematically summarize and articulate the correlation between PTPN22-C1858T polymorphism and mycobacterial infection. The susceptibility of PTPN22-C1858T carriers with autoimmune conditions receiving immunosuppressive therapy to M. tuberculosis and M. leprae infection was determined. A systematic retrieval of studies on relevance of PTPN22-C1858T polymorphism to susceptibility of M. tuberculosis or M. leprae infection was performed in Chinese National Knowledge Infrastructure, PubMed and Embase databases. We regarded Odds ratios (ORs) and 95% confidence intervals (CIs) as the determined effect size. Finally, four and two case-control studies on tuberculosis and leprosy, respectively, were included. In all genetic models, without indicated association between PTPN22-C1858T polymorphism and tuberculosis’s susceptibility. [C versus T: OR = 0.22 (95% CI: 0.09–0.50, PH = 0.887); CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, PH = 0.889); TT+CT versus CC: OR = 0.21 (95% CI: 0.09–0.49, PH = 0.889)]. A significantly increased risk of leprosy was perceived in patients with the PTPN22-C1858T polymorphism [C versus T: OR = 2.82 (95% CI: 1.02–7.81, PH = 0.108)]. While the PTPN22-C1858T polymorphism is irrelevant to higher susceptibility to the infection of M. tuberculosis in Caucasians and Asians, it is relevant to increased susceptibility to the infection of M. leprae. However, the results of M. leprae are supposed to interpreted with prudence owing to the limited quantity of studies and heterogeneity. Further well-designed studies with sufficient populations are required to verify our conclusions.

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Risk factors associated with echinococcosis in Chinese general population: a meta-analysis and systematic review

10.21203/rs.3.rs-549342/v1 ◽

2021 ◽

Author(s):

tiantian zhang ◽

Bin Li ◽

Yuying Liu ◽

Shou Liu

Keyword(s):

Risk Factors ◽

Subgroup Analysis ◽

Human Life ◽

Meta Analysis ◽

Test Results ◽

Knowledge Infrastructure ◽

Pooled Prevalence ◽

Specific Subgroup ◽

And Control ◽

Chinese National Knowledge Infrastructure

Abstract Background Echinococcosis is a severe zoonotic disease that imposes a substantial burden on human life. Numerous studies on echinococcosis have involved a variety of risk factors, and it is difficult to evaluate the key risk factors. The objectives of this meta-analysis are to summarize available data on the prevalence of human echinococcosis and identify the key risk factors for echinococcosis. Methods Relevant studies were comprehensively searched in the PubMed, EMBASE, Web of Science, Cochrane, Chinese National Knowledge Infrastructure (CNKI), Chongqing VIP Information (VIP), Wanfang and SinoMed databases from database inception until August 22, 2020. A random-effects model was used to estimate the pooled odds ratio (OR) and 95% confidence interval (CI) by integrating the OR values of each risk factor. The I2 and Q statistics were calculated to evaluate the heterogeneity, and potential sources of heterogeneity were identified using sensitivity analysis and subgroup analysis. Publication bias was estimated by funnel plots and Egger’s test. Results A total of 1026 studies were identified through the database search, of which 26 were eligible for this meta-analysis. In total, 23 and 9 of the 26 studies were cystic echinococcosis (CE) and alveolar echinococcosis (AE) studies, respectively (6 papers included both AE and CE). The pooled prevalence of echinococcosis was 5.52% (95% CI: 5.47%-5.58%). Ethnicity (OR = 2.93, 95% CI: 1.81–4.75; I2 = 0), being a herder (OR = 2.66, 95%CI95% CI: 2.25–3.14; I2 = 8%), not washing hands before meals (OR = 2.40, 95% CI: 1.34–4.28; I2 = 82.8%) and being female (OR = 1.45, 95% CI: 1.26–1.66; I2 = 33.9%) were risk factors for AE. The top five risk factors for CE were ethnicity (OR = 3.18, 95% CI: 1.55–6.52; I2 = 79.2%), nomadism (OR = 2.71, 95% CI: 1.65–4.47; I2 = 55.8%), drinking nonboiled water (OR = 2.47, 95% CI: 1.36–4.47; I2 = 85.7), feeding viscera to dogs (OR = 2.35, 95% CI: 1.89–2.91; I2 = 21.5%), and being a herder (OR = 2.19, 95% CI: 1.67–2.86; I2 = 85.1%). The study design-specific subgroup analysis showed that the heterogeneity of CE risk factors decreased to varying degrees. Conclusions Specific characteristics (i.e., ethnicity and herder status) and behaviors (i.e., not washing hands before meals and feeding viscera to dogs ) are possible risk factors for echinococcosis. This study provided remarkable insight for future prevention and control of echinococcosis.

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TP53 codon 72 polymorphisms and breast carcinoma susceptibility: A meta-analysis

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e22171 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e22171-e22171

Author(s):

B. Zhu ◽

W. Zhuo ◽

Z. Chen

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Breast Carcinoma ◽

Meta Analysis ◽

Inclusion Criteria ◽

Codon 72 ◽

Knowledge Infrastructure ◽

Increased Risk ◽

Meta Analyses ◽

Chinese National Knowledge Infrastructure

e22171 Background: Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. Several studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to breast carcinoma and have yielded inconclusive results. The aim of the present study was to assess possible associations of breast cancer risk with TP53 codon 72 polymorphisms. Methods: We conducted a search in the Medline, EMBASE, OVID, Sciencedirect, and Chinese National Knowledge Infrastructure (CNKI) without a language limitation, covering all papers published up to Dec 2008. The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications. Results: Consequently, fifteen studies, including 3436 cases and 4394 controls, met the included criteria and thus were selected. Ultimately, the relevant data were extracted and further analyzed using systematic meta- analyses. The results showed that individuals carrying homozygote Arg/Arg genotype have a significant increased risk of breast cancer compared with those carrying Pro/Pro genotype (OR: 1.58, 95%CI:1.10–2.28). For Arg allele, no evidence indicated that individuals with Arg/Arg genotype have an increased risk of breast cancer compared with those with a combined Pro genotype (Arg/Pro+Pro/Pro) (OR: 1.68, 95%CI:1.24–2.29). For Pro allele, individuals with homozygote Pro/Pro genotype have a marked decreased susceptibility to breast cancer relative to those with a combined Arg genotype (Arg/Pro+Arg/Arg) (OR: 0.84, 95%CI:0.73–0.98). Conclusions: The results of the present study suggest that TP53 codon 72 polymorphisms might be a risk factor for breast cancer. Homozygote Arg allele genotype could significantly increase susceptibility to breast cancer, while Pro/Pro allele markedly decreases breast risk. No significant financial relationships to disclose.

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TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis

Epidemiology and Infection ◽

10.1017/s0950268820002666 ◽

2020 ◽

Vol 148 ◽

Author(s):

Haiyi Xue ◽

Huan Peng ◽

Jiaoming Li ◽

Mingming Li ◽

Song Lu

Keyword(s):

Bacterial Meningitis ◽

Genetic Model ◽

Meta Analysis ◽

Relevant Literature ◽

Cochrane Library ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Increased Risk ◽

The Cochrane Library

Abstract Some studies have suggested that the Toll-like receptor 9 polymorphism (TLR9 rs352140) is closely related to the risk of bacterial meningitis (BM), but this is subject to controversy. This study set out to estimate whether the TLR9 rs352140 polymorphism confers an increased risk of BM. Relevant literature databases were searched including PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure (CNKI) up to August 2020. Seven case-control studies from four publications were enrolled in the present meta-analysis. Odds ratios (OR) and confidence intervals (95% CI) were calculated to estimate associations between BM risk and the target polymorphism. Significant associations identified were allele contrast (A vs. G: OR 0.66, 95% CI 0.59–0.75, P = 0.000), homozygote comparison (AA vs. AG/GG: OR 0.62, 95% CI 0.49–0.78, P = 0.000), heterozygote comparison (A vs. G: OR 0.74, 95% CI 0.61–0.91, P = 0.005), recessive genetic model (AA vs. AG/GG: OR 0.78, 95% CI 0.65–0.93, P = 0.006) and dominant genetic model (AA vs. AG/GG: OR 0.70, 95% CI 0.57–0.85, P = 0.000). The findings indicate that, in contrast to some studies, the TLR9 rs352140 polymorphism is associated with a decreased risk for BM.

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Association Between Infections and Risk of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis

Frontiers in Immunology ◽

10.3389/fimmu.2021.768741 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xiao Zhang ◽

Zhe Sun ◽

Aihong Zhou ◽

Lei Tao ◽

Yingxin Chen ◽

...

Keyword(s):

Ankylosing Spondylitis ◽

Cohort Studies ◽

Subgroup Analysis ◽

Meta Analysis ◽

Random Effect ◽

Epidemiological Studies ◽

Case Control ◽

Total Risk ◽

Case Control Studies ◽

Increased Risk

BackgroundPrevious literature on the association between infections and the risk of developing ankylosing spondylitis (AS) presented controversial results. This meta-analysis aimed to quantitatively investigate the effect of infections on the risk of AS.MethodsWe searched the PubMed, Embase, and Web of Science databases until March 26, 2021 for analytical epidemiological studies on the association between infections and the risk of AS. Fixed or random effect models were used to calculate total risk estimates based on study heterogeneity. Subgroup analysis, and sensitivity analysis were also performed. Publication bias was estimated using funnel plots and Begg’s test.ResultsSix case-control articles (n=1,296,239) and seven cohort articles (n=7,618,524) were incorporated into our meta-analysis. The pooled odds ratio (OR) from these case-control studies showed that infections were associated with an increased risk of AS (OR=1.46, 95% confidence interval [CI], 1.23–1.73), and the pooled relative risk (RR) from the cohort studies showed the same findings (RR=1.35, 95% CI, 1.12–1.63). Subgroup analysis showed that infections in participants with unadjusted comorbidities (OR=1.66, 95% CI, 1.35–2.03), other types of infection (OR=1.40, 95% CI, 1.15–1.70), and infection of the immune system (OR=1.46, 95% CI, 1.42–1.49) were associated with the risk of AS in case-control studies. In cohort studies, infections with adjusted comorbidities (RR=1.39, 95% CI, 1.15–1.68), viral infection (RR=1.43, 95% CI, 1.22–1.66), other types of infection (RR=1.44, 95% CI, 1.12–1.86), and other sites of infection (RR=1.36, 95% CI, 1.11–1.67) were associated with an increased risk of AS.ConclusionsThe findings of this meta-analysis confirm that infections significantly increase the risks of AS. This is helpful in providing an essential basis for the prevention of AS via the avoidance of infections.

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ASSOCIATION OF TNF- α-308G>A POLYMORPHISM WITH SUSCEPTIBILITY TO CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201900000-20 ◽

2019 ◽

Vol 56 (1) ◽

pp. 88-94 ◽

Cited By ~ 11

Author(s):

Majid AFLATOONIAN ◽

Mansour MOGHIMI ◽

Mohammad Javad AKBARIAN-BAFGHI ◽

Majid MOROVATI-SHARIFABAD ◽

Mohammad Hossein JARAHZADEH ◽

...

Keyword(s):

Systematic Review ◽

Celiac Disease ◽

Disease Susceptibility ◽

Disease Risk ◽

Meta Analysis ◽

Knowledge Infrastructure ◽

Increased Risk ◽

Tnf Α ◽

Chinese National Knowledge Infrastructure ◽

Larger Sample

ABSTRACT BACKGROUND: There is increasing evidence to show that TNF-α -308G>A polymorphism may be a risk factor for celiac disease, but the results are inconsistent. OBJECTIVE: Thus, we aimed to perform a meta-analysis involving published studies up to January 2019 to elucidate the association. METHODS: To assess the effect of TNF-α -308G>A polymorphism on celiac disease susceptibility, we searched PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure (CNKI) databases to identify eligible studies, without restriction. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to celiac disease. RESULTS: A total of 11 studies with 1147 cases and 1774 controls were selected for this meta-analysis. The pooled results indicated that TNF-α -308G>A polymorphism was associated with increased risk of celiac disease (A vs G: OR=2.077, 95% CI=1.468-2.939, P=≤0.001; AA vs GG: OR=8.512, 95% CI=3.740-19.373, P=≤0.001; AA+AG vs GG: OR=1.869, 95% CI=1.161-3.008, P=0.010; and AA+AG vs GG: OR=4.773, 95% CI=3.181-7.162, P≤0.001). Subgroup analysis by ethnicity also revealed significant association in Caucasians. In addition, there was a significant association between TNF-α -308G>A polymorphism and celiac disease risk in Italy, Spain and PCR-FRLP group studies. CONCLUSION: Our meta-analysis suggests that the TNF-α -308G>A polymorphism plays an important role in celiac disease susceptibility. However, our results are still needed to strengthen by further studies in different ethnicities and larger sample sizes.

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Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies

Disease Markers ◽

10.1155/2018/2645963 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 3

Author(s):

Yao Li ◽

Ge Feng ◽

Yuejia Deng ◽

Jinglin Song

Keyword(s):

Subgroup Analysis ◽

Protective Factor ◽

Meta Analysis ◽

Aggressive Periodontitis ◽

Interleukin 10 ◽

Case Control Studies ◽

Increased Risk ◽

Significant Difference ◽

Ca Model ◽

Allele Model

Introduction. The association between interleukin-10- (IL-10-) 592 (-590, -597) C>A polymorphisms and susceptibility to chronic or aggressive periodontitis (CP or AgP) is conflicting. This meta-analysis is aimed at quantitatively estimating the association. Materials and Methods. PubMed, Embase, Web of Science, and WANFAN were searched for studies performed prior to January 31, 2018, to collect data for our research. Meta-analysis was performed using RevMan 5.3 or STATA 14.0. Results. In total, 18 studies that met our criteria were included. Overall or HWE subgroup analysis of individuals with this polymorphism revealed that in terms of CP susceptibility, there was a significant difference between case groups and control groups in the A allele versus C allele model (OR = 1.38, 95% CI = 1.17–1.64 or OR = 1.38, 95% CI = 1.12–1.70), in the AA versus CC+CA model (OR = 1.49, 95% CI =1.06–2.10 or OR = 1.42, 95% CI = 1.13–1.78), and in the CC versus CA+AA model (OR = 0.69, 95% CI = 0.51–0.92 or OR = 0.68, 95% CI = 0.49–0.93); subgroup analysis based on a nonsmoking population also displayed significance in the A allele versus C allele model (OR = 1.43, 95% CI = 1.15–1.79) and CC versus CA+AA model (OR = 0.62, 95% CI = 0.44–0.87). For this polymorphisms and AgP susceptibility, our analyses revealed a significant association in both the A allele versus C allele model (OR = 1.29, 95% CI = 1.01–1.63) and the AA versus CC+CA model (OR = 1.93, 95% CI = 1.30–2.89); subgroup analysis based on Caucasian or nonsmoking populations showed significant differences in the AA versus CC+CA model (OR = 6.29, 95% CI = 1.78–22.21 or OR = 3.24, 95% CI = 1.59–6.61). Conclusions. IL-10-592 (-590, -597) A allele and the associated AA genotype may be risk factors for the onset of CP or AgP—particularly for the AA genotype and the increased risk of AgP in Caucasian or nonsmoking populations. Conversely, the CC genotype may act as a protective factor against the onset of CP.

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Face masks to prevent transmission of COVID-19: a systematic review and meta-analysis

10.1101/2020.10.16.20214171 ◽

2020 ◽

Author(s):

Yanni Li ◽

Mingming Liang ◽

Liang Gao ◽

Mubashir Ayaz Ahmed ◽

John Patrick Uy ◽

...

Keyword(s):

Systematic Review ◽

Healthcare Workers ◽

Meta Analysis ◽

Current Status ◽

Cochrane Library ◽

Case Control Studies ◽

Knowledge Infrastructure ◽

Global Pandemic ◽

Reduce Risk ◽

Chinese National Knowledge Infrastructure

AbstractBackgroundBased on the current status of the COVID-19 global pandemic, there is an urgent need to systematically evaluate the effectiveness of wearing masks to protect public health from COVID-19 infection.MethodsWe conducted a systematic review and meta-analysis to evaluate the effectiveness of using face masks to prevent the spread of SARS-CoV-2. Relevant articles were retrieved from PubMed, Web of Science, ScienceDirect, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI), VIP (Chinese) database. There were no language restrictions. This study was registered with PROSPERO under the number CRD42020211862.ResultsA total of 6 case-control studies were included. In general, wearing a mask was associated with a significantly reduced risk of COVID-19 infection (OR = 0.38, 95% CI = 0.21-0.69, I2 = 54.1%). Heterogeneity modifiers were investigated by subgroup analysis. For healthcare workers group, masks were shown to have a reduce risk of infection by nearly 70%. Studies in China showed a higher protective effect than other countries. Adjusted estimates and subgroup analyses showed similar findings.ConclusionsThe results of this systematic review and meta-analysis support the conclusion that wearing a mask could reduce the risk of COVID-19 infection.

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Associations between Apolipoprotein E(APOE) polymorphisms and Cerebral Palsy: a meta-analysis

10.21203/rs.2.14542/v1 ◽

2019 ◽

Author(s):

Chen Hongyan ◽

Hua Yan ◽

Chao Chen ◽

Ying Cao ◽

Xinwen Zhang

Keyword(s):

Cerebral Palsy ◽

Apolipoprotein E ◽

Meta Analysis ◽

Experimental Studies ◽

Chinese Patients ◽

Neuronal System ◽

Knowledge Infrastructure ◽

Increased Risk ◽

The Relationship ◽

Chinese National Knowledge Infrastructure

Abstract Background Apolipoprotein E (APOE ) is one of the main apolipoproteins playing important roles in the central neuronal system. The relationship between polymorphisms and cerebral palsy (CP) is contradictory.Methods The overall experimental studies of APOE polymorphisms and CP risk were researched. We conducted eligible studies identified from Elsevier Science Direct, PubMed, Springer Link, WEB OF SCIENCE, Chinese National Knowledge Infrastructure and WanFang Data up to February 2019 to make a systematic review.Results Totally 10 eligible studies were used to meta-analysis (1570 CP cases and 1982 subjects). Significant associations with CP were observed for APOE polymorphisms in allele (ε4: P < 0.001, OR 2.05, 95% CI 1.40 to 2.99; ε2: P = 0.04, OR 1.41, 95% CI 1.01 to 1.96) and dominant (E4 carriers: P = 0.004, OR 1.90, 95% CI 1.23 to 2.92) models in overall analyses. Interestingly, subgroup analysis indicated a significant increased risk for CP in Chinese patients of CP with APOE ε4 (P<0.00001, OR 3.71, 95% CI 2.37 to 5.78) and E4 carriers(P<0.00001, OR 3.95, 95% CI 2.38 to 6.53), but not with APOE ε2 (P=0.69, OR 1.09, 95% CI 0.72 to 1.65).Conclusions Combined with the results of our analysis, we concluded that the risk of CP was significantly increased in ε4 individuals. But meta-analysis yielded an incongruent result for the APOE ε2 allele between in multi-ethnic samples and in Chinese subgroup. These conclusions should be confirmed through further studies.

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