scholarly journals The Emerging Role of MicroRNAs in Breast Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Zhiguang Yang ◽  
Zhaoyu Liu
Keyword(s):  
Breast Cancer ◽  
Prognostic Markers ◽  
Recent Literature ◽  
New Drugs ◽  
Effective Management ◽  
Therapeutic Outcomes ◽  
Tumorigenesis And Progression ◽  
New Biomarkers ◽  
Common Malignancy

Breast cancer (BC) is the most common malignancy in women. Due to BC heterogeneity, complexity, and metastasis, many BC patients do not successfully respond to therapies. The effective management of BC depends on early diagnosis and monitoring of drug response. Therefore, identifying new biomarkers for the diagnosis, prognosis, and development of new drugs is urgently required. Dysregulation of microRNAs (miRNAs) participates in the tumorigenesis and progression of cancers, especially breast cancer (BC). Several studies demonstrated that miRNAs could perform their function as oncogenes or tumor suppressors. This review describes recent progress on the role of microRNAs in the diagnosis, prognosis, hallmark, and treatment of BC. According to a recent literature survey, miRNAs play a pivotal role in the regulation of hallmarks of cancer, such as proliferation, apoptosis, invasion, metastasis, and tumor stemness. Many miRNAs are potential biomarkers for BC for diagnosis, and some are indicators of prognosis. Moreover, circulating miRNA profiles, as minimally invasive, diagnostic, and prognostic markers, are broadly used in BC therapy, and some miRNAs are good predictors of therapeutic outcomes. Other miRNAs are involved in overcoming chemoresistance and in increasing BC drug sensitivity.

scholarly journals The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4576
Author(s):  
Hung-Yu Lin ◽  
Hui-Wen Ho ◽  
Yen-Hsiang Chang ◽  
Chun-Jui Wei ◽  
Pei-Yi Chu
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Drug Resistant ◽  
Therapeutic Targeting ◽  
The Past ◽  
Regulated Cell Death ◽  
Common Malignancy

Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.

Potential Role of Darvyadi Kwatha in the Management of Diabetes

The Healer ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 80-86
Author(s):  
Shankar Gautam ◽  
Abhishek Upadhyay ◽  
Rashmi Mutha ◽  
BINOD KUMAR SINGH ◽  
Ram Kishor Joshi
Keyword(s):  
Causes Of Death ◽  
Potential Role ◽  
Critical Role ◽  
Animal Experiments ◽  
Safety Evaluation ◽  
New Drugs ◽  
Effective Management ◽  
The Individual ◽  
Glucose 6 Phosphate Dehydrogenase

Diabetes is a clinical condition characterized by a spike in blood glucose in plasma. It is one of the 21st century's greatest public health crises and is among the top 10 causes of death worldwide. Although new drugs and therapeutics are emerging for its management but the prevalence is increasing at an alarming pace; thus, every system must contribute for effective management. An effort is made to review the efficacy and safety evaluation of the individual herbs of Darvyadi Kwatha (DK), an Ayurvedic formulation mentioned in Charaka Samhita. The constituents of the DK has some strong efficient antidiabetic/hypoglycaemic chemical principle having insulin-triggering and insulin-like behaviors which increases the activity of glucose-6-phosphate dehydrogenase (G6PD) and glucokinase and decreases glucose-6-phosphatase activity, reduce oxidative stress and prevention of glutathione reductase, superoxide dismutase, and catalase activity play a critical role in glucose homeostasis. DK also improve biochemical parameters such as SGPT, SGOT, cholesterol and triglycerides and is found to be safe in animal experiments. The various evidences clearly indicates that DK has definite hypoglycemic potential as well as anti-diabetic activity.

Prognostic Role of Estrogen Receptor Determination in Breast Cancer

1983 ◽  
Vol 69 (6) ◽  
pp. 527-530 ◽  
Author(s):  
Stefano Ciatto ◽  
Patrizia Bravetti ◽  
Gaetano Cardona ◽  
Luigi Cataliotti ◽  
Roberto Crescioli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Recent Literature ◽  
Disease Free Survival ◽  
Metastatic Breast ◽  
Prognostic Role ◽  
Free Survival ◽  
The Difference ◽  
Disease Free ◽  
Actuarial Method

The authors report on 283 primary, non-metastatic, breast cancer cases consecutively referred after surgery and followed-up from a minimum of 10 months to a maximum of 3.5 years. All cases were studied according to the presence of estrogen receptors (ER). ER presence was correlated with age and menstrual status, with ER+ cases more frequent in older patients. No correlation was found between ER and nodal status. Prognosis was evaluated in terms of disease-free survival at 2 years (actuarial method). No correlation between ER and survival was evident for N– cases, whereas a better prognosis was recorded for ER+N+ patients compared to ER-N+, although the difference was not statistically significant. The observed results are compared with recent literature data and agree with other recent reports, which did not confirm the previously undiscussed statement regarding the prognostic role of ER determination. According to these studies and to the present study, the prognostic role of ER determination seems at least questionable and particularly the postoperative adjuvant treatment of ER-N– cases should be reconsidered.

scholarly journals Utility of Different Immunohistochemical Stain for Diagnosis of Invasive Breast Cancer

2018 ◽  
Vol 5 (4) ◽  
pp. 3729-3733
Author(s):  
Dujuan Wang ◽  
Li Chen ◽  
Lihua Zeng ◽  
Shuzhen Han
Keyword(s):  
Breast Cancer ◽  
Prognostic Markers ◽  
Clinical Pathology ◽  
Cancer Death ◽  
Breast Cancers ◽  
Immunohistochemical Stain ◽  
Close Relationship ◽  
Positive Rate ◽  
Early Diagnostic

Breast cancer is a malignant tumor that seriously affects females’ physical health, which is the leading cause of cancer death among Chinese female. Estimating early diagnostic and  prognostic markers are helpful to conduct treatment for patients with breast cancer. Accumulating investigations focused on the role of Jab1 and S100A8 proteins in the development and metastasis. In our study, we performed the immunohistochemical stain for Jab1 and S100A8 in breast carcinoma and para-carcinoma samples. We have found that the positive rate of Jab1 and S100A8 in breast cancer was higher than that in para-carcinoma tissues. The expression level of Jab1 and S100A8 in breast cancer might have a close relationship with the histologic grade and lymphatic metastasis. The two proteins might be promising supplementary targets for the treatment and prognosis of breast cancers in clinical pathology.

Unveiling Role of MicroRNAs as Treatment Strategy and Prognostic Markers in Triple Negative Breast Cancer

2020 ◽  
Vol 21 (15) ◽  
pp. 1569-1575
Author(s):  
Acharya Balkrishna ◽  
Rashmi Mittal ◽  
Vedpriya Arya
Keyword(s):  
Breast Cancer ◽  
Effective Treatment ◽  
Triple Negative Breast Cancer ◽  
Treatment Strategy ◽  
Triple Negative ◽  
Prognostic Markers ◽  
Disease Free Survival ◽  
Free Survival ◽  
Global Regulators

Triple negative breast cancer is the highly aggressive form of breast cancer with high reoccurrence rate and is short of effective treatment strategy. The prognostic markers of it are also not well understood. miRNAs are the global regulators of various cancers on the virtue of its ability to post transcriptional regulation of genes involved in various pathways involved in complicating TNBC. In this review we studied the expression of miRNAs at different stages of TNBC and the role of miRNAs as a tumor suppressor to inhibit cell proliferation, angiogenesis, invasion and metastasis and to induce apoptosis and thereby proposing these miRNAs as an effective treatment strategy against TNBC. miRNA also acts as chemosenstizer in enhancing chemosensitivity of conventional drugs against resistant TNBC cells. The present review emphasizes the importance of miRNAs as prognostic markers to determine the overall survival, disease free survival and distant metastasis free survival rate in TNBC patients. We speculate that miRNA can present themselves as an effective treatment strategy and prognostic marker against TNBC.

scholarly journals The role of IL10, IL6 and TNFα as potential prognostic markers in breast cancer in Tunisia

2017 ◽  
Vol 28 ◽  
pp. xi13
Author(s):  
J.A. Braham ◽  
M. Balti ◽  
B.A. Mouna ◽  
A. Manel ◽  
A. Zribi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Markers

scholarly journals PROGNOSTIC BIOMARKERS IN TRIPLE NEGATIVE BREAST CANCER AS A POTENTIAL TARGET FOR FUTURE DRUG DISCOVERY

2017 ◽  
Vol 10 (6) ◽  
pp. 24
Author(s):  
Mekhla Gupta ◽  
Sanjeev Kumar Gupta ◽  
Rajesh Kumar Singh ◽  
Seema Khanna
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Poor Prognosis ◽  
Triple Negative ◽  
Treatment Options ◽  
New Drugs ◽  
Cancerous Cell ◽  
Cause Of Deaths ◽  
Future Drug ◽  
Common Malignancy

Breast cancer is the most common malignancy in women globally, in which triple-negative breast cancer (TNBC) is more aggressive with poor prognosis and very less response to targeted hormone based treatment. It is a major cause of deaths among the women with breast cancer because of very few treatment options. The biomarkers could be a product of cancerous cell or molecule generated in response to cancer. It is used to understand the mechanism, prognosis, diagnosis as well as target for design and discovery of new drugs. The purpose of the study is to give a brief review onmarkers of TNBC.

The role of ADAM17 in tumorigenesis and progression of breast cancer

Tumor Biology ◽  
2016 ◽  
Vol 37 (12) ◽  
pp. 15359-15370 ◽  
Author(s):  
Hongyu Shen ◽  
Liangpeng Li ◽  
Siying Zhou ◽  
Dandan Yu ◽  
Sujin Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumorigenesis And Progression

scholarly journals Regulation of Exosomes in the Pathogenesis of Breast Cancer

2021 ◽  
Author(s):  
Congjian Shi ◽  
Hongqin Yang ◽  
Zhengchao Wang ◽  
Zhenghong Zhang
Keyword(s):  
Breast Cancer ◽  
Lipid Bilayers ◽  
Cell Types ◽  
Cancer Diagnostics ◽  
Major Health Problem ◽  
Major Health ◽  
Diagnostic Strategies ◽  
Therapeutic Tools ◽  
Common Malignancy

Extracellular vesicles (EVs) are a heterogeneous group of endogenous nanoscale vesicles that are secreted by various cell types. Based on their biogenesis and size distribution, EVs can be broadly classified as exosomes and microvesicles. Exosomes are enveloped by lipid bilayers with a size of 30–150 nm in diameter, which contain diverse biomolecules, including lipids, proteins and nucleic acids. Exosomes transport their bioactive cargoes from original cells to recipient cells, thus play crucial roles in mediating intercellular communication. Breast cancer is the most common malignancy among women and remains a major health problem worldwide, diagnostic strategies and therapies aimed at breast cancer are still limited. Growing evidence shows that exosomes are involved in the pathogenesis of breast cancer, including tumorigenesis, invasion and metastasis. Here, we provide a straightforward overview of exosomes and highlight the role of exosomes in the pathogenesis of breast cancer, moreover, we discuss the potential application of exosomes as biomarkers and therapeutic tools in breast cancer diagnostics and therapeutics.

scholarly journals Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics

Cells ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 375 ◽  
Author(s):  
Natalia Riobo-Del Galdo ◽  
Ángela Lara Montero ◽  
Eva Wertheimer
Keyword(s):  
Breast Cancer ◽  
Hedgehog Signaling ◽  
Treatment Guidelines ◽  
Breast Development ◽  
Cell Renewal ◽  
Stem Cell Renewal ◽  
Cancer Pathogenesis ◽  
Tumorigenesis And Progression ◽  
Hh Signaling

Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine drug resistance and provide treatment guidelines that include personalized targeted therapies. The Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. Several lines of evidence endorse the important role of canonical and non-canonical Hh signaling in BC. In this comprehensive review we discuss the role of Hh signaling in breast development and homeostasis and its contribution to tumorigenesis and progression of different subtypes of BC. We also examine the efficacy of agents targeting different components of the Hh pathway both in preclinical models and in clinical trials. The contribution of the Hh pathway in BC tumorigenesis and progression, its prognostic role, and its value as a therapeutic target vary according to the molecular, clinical, and histopathological characteristics of the BC patients. The evidence presented here highlights the relevance of the Hh signaling in BC, and suggest that this pathway is key for BC progression and metastasis.

Sign in / Sign up

Export Citation Format

Share Document