scholarly journals Intervention Effect of Probiotics in Gastric Cancer Patients with Complications of Coronary Heart Disease and Heart Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hui Yu ◽  
Anqin Dong ◽  
Luosha Zhao ◽  
Ping Li ◽  
Qiujun Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gastric Cancer ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Observation Group ◽  
Group A ◽  
Group 2 ◽  
Gastric Cancer Patients ◽  
Group 1

Objective. To investigate the characteristics of intestinal flora in patients with gastric cancer complicated by coronary heart disease and heart failure and the guiding value of probiotics intervention for clinical treatment. Methods. (1) One hundred and sixty-eight gastric cancer patients with complications of coronary heart disease and heart failure from August 2017 to December 2020 were selected as the observation group. A total of 125 patients with coronary heart disease treated at the same time were selected as control group 1, and 89 healthy subjects were selected as control group 2. Fecal samples were retained to extract the total RNA, and high-throughput sequencing was applied to complete the analysis of microbial diversity and structure differences, so as to obtain the biological species information of the specimens. (2) Patients in the observation group were randomly divided into two equal groups of 84 patients, namely, group A and group B. Group A was treated with conventional methods, and group B was combined with probiotics intervention on the basis of group A; then, the differences in the intestinal mucosal barrier between the two groups were compared. Results. The Chao, ACE, and Simpson index in the observation group were lower than those in control group 1 ( P < 0.05 ), and the Shannon index was higher than that in control group 1 ( P < 0.05 ). The Chao, ACE, and Shannon index in control group 1 were lower than those in control group 2 ( P < 0.05 ), whereas the Simpson index was higher than in control group 2 ( P < 0.05 ). The abundance of Bacteroidetes in the observation group was lower than that in control group 1 and control group 2 ( P < 0.05 ). The abundance of Firmicutes was higher than that of control group 1 and control group 2 ( P < 0.05 ). Four weeks after treatment, the levels of ET, D-lactic acid, and PCT in the group B were (0.10 ± 0.01), (3.99 ± 0.32), and (0.41 ± 0.10), respectively, which were lower than those in group A (0.19 ± 0.03), (4.51 ± 0.46), and (0.81 0.13). Conclusion. Gastric cancer patients with complications of coronary heart disease and heart failure are associated with intestinal flora disorder, which may be involved in the occurrence and development of the disease. Probiotics intervention is helpful to repair the intestinal mucosal barrier in patients, which is worthy of popularization and application.

scholarly journals Otsenka vliyaniya priverzhennosti rekomendatsiyampo profilaktike osteoporoza na mineral'nuyuplotnost' kostey predplech'ya i chastotu komorbidnoypatologii v lechenii osteoporoza

2008 ◽  
Vol 12 (1) ◽  
pp. 23-26
Author(s):  
A. A. Popov ◽  
N. V. Izmozherova ◽  
M. I. Fominykh
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Glucose Metabolism Disorders ◽  
X Ray ◽  
Comorbid Diseases ◽  
Group 2 ◽  
Mineral Bone Density ◽  
Group 1

Aim: to assess compliance to osteoporosis (OP) prophylaxis recommendations and its influence on mineral bone density (BMD) and development of comorbid diseases in postmenopause. Methods: prospective cohort study included 404 postmenopausal women aged from 47 to 59 with OP risk factors. BMD was assessed by distant forearm X-ray absorptiometry. Comorbid diseases were registered. Compliance to recommendations was assessed by questionnaire.. Results. Group 1 consisted of 276 non-compliant women. Group 2 (128 persons) changed their lifestyle and consumed recommended amount of daily calcium and vitamin D. Group 1 demonstrated significant increase of coronary heart disease, chronic heart failure and a fraction of persons in whom BMD decreased during 2 years of survey(x2 = 6.986; P = 0.017).. Relative risk of arterial hypertension, coronary heart disease, chronic heart failure and glucose metabolism disorders significantly decreased in group 2. Comclusion: constant co-operation between doctors and patients is necessary to keep the patient compliant and to obtain clinically relevant results in OP prophylaxis.

The clinical course of atrial fibrillation in patients with coronary heart disease

2016 ◽  
Vol 94 (8) ◽  
pp. 591-595 ◽  
Author(s):  
V. I. Podzolkov ◽  
Aida I. Tarzimanova ◽  
R. G. Gataulin
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Clinical Course ◽  
History Of ◽  
Group 2 ◽  
Group 1

The modern medical literature practically does not contain clinical publications reporting studies of factors responsible for progression of atrial fibrillation (AF) in patients with coronary heart disease (CHD). It accounts for the importance of investigations into evolution of the clinical course of AF in such patients.Aim. To elucidate evolution of the clinical course of AF in patients with CHD in a long-term prospective study.Materials and methods. The study included. 112 patient aged 57-74 (mean 67.44±3.3) years with CHD and paroxysmal form of AF carried outfrom 2011 to 2015. Evolution of the clinical course of AF was evaluated based on the number of arrhythmic attacks during the last 3 months. The appearance ofprolonged persistent AF episodes or permanent AF was regarded as progression of arrhythmia.Results. During the 4 year study, 64 (57,2%) patients (group 1) did not experiencea rise in the frequency and duration of AF attacks. Progression of arrhythmia was documented in 48 (42,8%) of the 112 (100%) patients (group 2). These patients more frequently had the history of myocardial infarction and chronic heart failure than patients of group 1. The latter had the mean values of left ventricular (LV) ejection fraction 61,23±6,24%, i.e. significantly higher than 48,47±8,4% in group 2.47 and 28 % of the patients in group 2and 1 respectively suffered mitral regurgitation (p<0,05). Patients of group 2 had significantly more akineticzones. Intake of nitroglycerin in group 1 resulted in positive dynamics of local LV contractility that did not change in patients of group 2. Conclusion. 42,8% of the patients with CHD and paroxysmal form of AF experienced progression of arrhythmia into a persistent or permanent form. Predictors of AF progression in patients with CHD are the history of myocardial infarction, chronic heart failure, mitral regurgitation, and irreversible changes in local myocardial LV contraction.

scholarly journals How is juvenile rheumatic heart disease different: baseline results from a prospective north Indian registry

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Mahajan ◽  
D.R Prakash Chand Negi
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Funding Source ◽  
Thromboembolic Events ◽  
Group 3 ◽  
Group 2 ◽  
Rheumatic Heart ◽  
Group 1

Abstract Introduction Juvenile rheumatic heart disease (RHD) refers to RHD in patients &lt;20 years of age. There are no contemporary data highlighting the differences between juvenile and older RHD patients. Purpose We aim to report the age related differences in the pattern, and consequencies of valvular dysfunction in patients of RHD. Methods The 2475 consecutive patients of RHD diagnosed using clinical and echocardiographic criteria were registered prospectively from 2011 till December 2019. Patients were divided into 3 groups according to their age: Group 1 (Juvenile RHD), Group 2 (21–50 years), and Group 2 (&gt;51 years).The data concerning the socio-demographic and clinical profile were recorded systematically, and the nature and severity of valvular dysfunction was assessed by echocardiography. The data were analyzed using the Epi-InfoTM Software. Results Out of 2475 RHD patients, Juvenile RHD comprised of 211 (8.5%) patients. Group 2 and 3 comprised of 1691 (68.3%) and 573 (23.2%) patients respectively. Overall, 1767 (71.4%) patients were females, however this female predilection was less pronounced in juvenile RHD (55.5% females vs 44.5% males) as compared to older groups. Past history of acute rheumatic fever was more commonly recorded in Juvenile RHD group (37.9% vs 18.8% in group 2 and 10% in group 3, p=0.0001). At the time of registration, the presence of advanced heart failure symptoms (dyspnea class III and IV) (11.4% group 1 vs 13.9% group 2 vs 20.6% group 3, p&lt;0.0001), right heart failure symptoms (0.9% group 1 vs 2.5% group 2 vs 7.3% group 3, p&lt;0.01), thromboembolic events (0% group 1 vs 4.1% group 2 vs 3.3% group 3, p&lt;0.01), atrial fibrillation (2.8% group 1 vs 24.5% group 2 vs 45.9% group 3, p&lt;0.0001), and pulmonary hypertension (27.1% group 1 vs 40.3% group 2 vs 51.9% group 3, p&lt;0.01), were all more commonly recorded in non-juvenile older RHD groups. Multivalvular involvement was also less common in juvenile RHD (34.6% vs 42.4% and 44.5%, p=0.04). Mitral regurgitation was the most common lesion in Juvenile RHD followed by aortic regurgitation (68.7% and 40.2% respectively). Stenotic lesions (both mitral and aortic) were present more commonly in older age groups. Conclusion RHD is predominantly a disease of females, however the predilection is less common in juvenile patients. Juvenile RHD predominantly affects the mitral valve and mainly leads to regurgitant lesions. As the age advances, the complications of RHD, mainly heart failure symptoms, thromboembolic events, pulmonary hypertension, and atrial fibrillation, become more common. Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): Self sponsored registry

scholarly journals Prevalence of Metabolic Syndrome and of Cardiovascular Risk Factors

2018 ◽  
Vol 15 (5) ◽  
pp. 35-42
Author(s):  
Manta Andrei ◽  
Maștaleru Alexandra ◽  
Oancea Andra ◽  
Anghel Razvan Constantin ◽  
Roca Mihai ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Public Health Problem ◽  
Left Ventricular ◽  
Lifestyle Changes ◽  
Therapeutic Success ◽  
The Metabolic Syndrome ◽  
Group 2 ◽  
Group 1

AbstractObesity, a component of the metabolic syndrome, is a rising public health problem, continuously increasing in the European countries. The therapeutic success of the patient with metabolic syndrome requires a multidisciplinary approach to lifestyle changes, weight loss, continuous and dynamic dietary improvement, sedentary reduction, normalization of blood pressure, glycemia and lipid parameters. We performed a retrospective study that was conducted in the Clinical Rehabilitation Hospital in Iasi, with 4627 patients that were admitted in the Cardiovascular Rehabilitation Clinic from January 2011 to December 2015 with the diagnosis of metabolic syndrome according to WHO definition (Group 1) or with other comorbidities (Group 2). In the first group were included 1064 patients diagnosed with metabolic syndrome. This group has predominantly smoking female patients. Also, in group 1 were diagnosed more patients with left ventricular hypertrophy and coronary heart disease compared to group 2. Most of the patients with inflammatory syndrome were included in the group without metabolic syndrome (group 2). The results of our study confirm that metabolic syndrome is a cluster of abnormalities whose evolution determines the development of coronary heart disease. All this would advocate for treating metabolic syndrome as the primary method of preventing cardiovascular disease.

scholarly journals Study of Scraping with Copper Stone Based on Theory of Midnight-Noon Ebb-Flow in Angina Pectoris with Coronary Heart Disease of Qi Stagnation and Blood Stasis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xianwen Tang ◽  
Jinguo Yang ◽  
Zhong Feng ◽  
Jingyu Piao ◽  
Quanhao Yan ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chinese Medicine ◽  
Angina Pectoris ◽  
Clinical Efficacy ◽  
Blood Stasis ◽  
Control Group ◽  
Inflammatory Factor ◽  
Observation Group ◽  
Qi Stagnation

Angina pectoris (AP) with coronary heart disease (CHD) is one of the common cardiovascular diseases in clinical practice, which can be classified as “chest paralysis” in Chinese medicine according to its symptoms, and it is described in many ancient documents. Ancient Chinese medicine believes that the main pathogenesis of the disease is poor blood flow leading to paralysis of the heart and veins, so it is often treated by activating blood and removing blood stasis. In this study, 120 patients with AP of CHD of Qi stagnation and blood stasis type were randomly divided into the observation (n = 60) and the control group (n = 60). In the control group, basic care, conventional treatment, and unselected copper acupuncture scraping were used, while in the observation group, copper acupuncture scraping was performed at the right time of the heart meridian (11 : 00–13 : 00) on the basis of the control group, and all patients received the treatment for a total duration of 4 weeks. We collected data on the traditional Chinese medical (TCM) syndrome score, frequency and duration of angina attacks, nitroglycerin dosage, inflammatory factor levels, and hematological indices pretreatment and posttreatment in both groups. Patients’ adverse effects during treatment were recorded, and the clinical efficacy and ECG efficacy in both groups were evaluated after 4 weeks. We used SPSS.20 statistical software to statistically analyze the above data, and the results showed that the clinical efficacy and ECG efficacy of the observation group were significantly higher than the control group posttreatment. After treatment, the TCM symptom score, angina attack frequency, attack duration and nitroglycerin dosage, serum interleukin-8 (IL-8), hypersensitive C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) levels, whole blood viscosity (WBV), plasma viscosity (PV), fibrinogen (FIB), and hematocrit (Hct) were significantly lower in both groups compared with those posttreatment. And the observation group showed a greater decrease when compared with the control group. The results also showed that the overall incidence of adverse reactions was lower in both groups during the treatment period. The above results indicate that while ensuring high safety, the copper stone based on theory of midnight-noon ebb-flow can more effectively improve the symptoms and inflammatory response of the body and reduce the viscosity of the blood in AP with CHD of Qi stagnation and blood stasis, and it has better therapeutic effects.

scholarly journals The efficacy of secondary prevention programs with remote support in coronary heart disease patients with abdominal obesity

Kardiologiia ◽  
2019 ◽  
Vol 59 (11) ◽  
pp. 21-30 ◽  
Author(s):  
N. V. Pogosova ◽  
A. O. Salbieva ◽  
O. Y. Sokolova ◽  
A. K. Ausheva ◽  
A. V. Karpova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Secondary Prevention ◽  
Dietary Patterns ◽  
Prevention Programs ◽  
P Values ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background Long-term secondary preventive programs in coronary heart disease (CHD) are of highest efficacy but numerous logistical problems often compromise their implementation. Contemporary remote technologies have a potential to overcome these barriers. Aim: To assess  the impact of 2 preventive counselling programs with subsequent remote support in CHD patients with concomitant obesity. Methods: A prospective randomized parallel-group study in 120 stable CHD patients hospitalized for elective coronary revascularization who were from 40 to 65 years old and had concomitant obesity. Patients were randomized (1:1:1) into 3 groups (n=40 each). Before discharge, Groups 1 and 2 received a single-session comprehensive counselling with focus on diet followed by remote counselling by phone (Group 1) or via text messages (Group 2). Remote counselling was delivered weekly (Months 1-3) and then monthly (Months 4-6). Group 3 received only standard advice from their attending physicians. The patients were followed for 12 months with assessment of adiposity measures, self-reported dietary patterns, physical activity (IPAQ questionnaire), smoking status, blood pressure (BP), fasting blood glucose, lipids and C-reactive protein (CRP) levels, as well as of clinical events. Results: At 1 year of follow-up, the patients from both intervention groups showed a marked improvement of several risk factors including obesity: the body mass index was reduced by 1.48±0.13 kg/m² in Group 1 and by 1.53±0.18 kg/m² in Group 2; the waist circumference went down by 7.62±0.49 and by 7.41±0.74 cm, respectively; the height-normalized fat mass decreased by 4.66±0.40 kg and 5.98±0.63 kg, respectively (all P values are <0.01 vs corresponding changes in the control group). These changes were coupled with more healthy dietary patterns and less sedentary lifestyles in both intervention groups: the proportion of patients with low activity level fell from 87.5% to 2.5% in Group 1 and from 80% to 10% in Group 2 (both p values <0.01 vs control). In Group 1, BP decreased by 18.08±2.20 mmHg (systolic) and 8.56±1.61 mmHg (diastolic); both р values <0.01 vs Group 3. In Group 2 systolic BP dropped by only 11.95±2.50 mmHg (non-significant) and diastolic BP by 6.33±1.52 mmHg (р<0.05 vs control). The proportion of smokers went down from 30% to 5% in Group 1 and from 22.5% to 0% in Group 2 (both p values <0.01 vs control). The fasting glucose levels decreased by 0.21±0.20 mmol/L in Group 1 and by 0.48±0.25 mmol/L in Group 2 (<0.01 vs control, both), but there were no meaningful improvements in blood lipids or CRP. Conclusion: Long-term (6 months) secondary prevention programs incorporating remote support technologies result into sustained improvement of key secondary prevention indicators in obese CHD patients, irrespective of the support modality (by phone or via electronic messaging).

scholarly journals Gastric cancer patients treated by a general or gastric cancer surgical team: a comparative study

2008 ◽  
Vol 45 (1) ◽  
pp. 28-33
Author(s):  
Fernando O. Souza ◽  
Dalnei V. Pereira ◽  
Luís H. Santos ◽  
Luis Antunes ◽  
Juarez Chiesa
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Survival Rates ◽  
University Hospital ◽  
Surgical Team ◽  
Pathologic Features ◽  
Number Of Patients ◽  
Group 2 ◽  
Gastric Cancer Patients ◽  
Group 1

BACKGROUND: Although gastric cancer has been decreasing in incidence in many countries, it is still the second most common cause of cancer deaths worldwide. Its prognosis is poor and depends, among other factors, on early diagnosis as well as on surgeon expertise. AIM: To compare the outcomes of gastric cancer patients treated at a university hospital by a general surgical team and later on by a gastric cancer surgical team. METHODS: Gastric cancer patients were separated into two groups according to whether they were treated by a general surgical team (group 1, n = 136; 1984 to 1993) or by gastric cancer team (group 2, n = 149; 1994 to 2003). Clinical and pathologic features and survival rates were assessed. RESULTS: During a 20-year period, a decreased number of patients underwent surgical resection in the second period (94% vs 86%), a greater number of upper gastrointestinal endoscopies were performed resulting in an increased number of tumors diagnosed as stage I (5% vs 22%). Also, D2 gastrectomies were more frequently performed instead of D0 gastrectomies and negative surgical margins were adequate. Mortality decreased from 9% to 6% in group 1 and 2, respectively and adjuvant therapy has been considered. CONCLUSION: Surgical specialized units for gastric cancer are necessary if better results are to be expected since this approach definitely provides better patient care.

scholarly journals Functional properties of hemostasis in piglets after short-term overheating against the background of corrective action

2020 ◽  
Vol 17 ◽  
pp. 00169
Author(s):  
Vladimir V. Zaitsev ◽  
Marina V. Mekhanikova ◽  
Svetlana V. Shestakova ◽  
Tatyana P. Ryzhakina
Keyword(s):  
Platelet Aggregation ◽  
Control Group ◽  
Platelet Activity ◽  
Large White ◽  
White Breed ◽  
Negative Effect ◽  
Group A ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1

Catosal is considered to be a highly effective bio-stimulator. It showed his properties in animals, realizing the stimulation of their tissues and organs. The purpose of this research is to determine the effect of Catosal on hemostatic parameters in piglets that experienced overheating. 58 piglets at the age of 2.5 months, which belonged to a large white breed, were taken into work. All animals as a result of an accidental emergency shutdown of the air conditioning system in the pigsty suffered overheating for 3 hours. These animals were randomly divided into two comparable groups. One was named experimental; the other was called control 1. Pigs of the experimental group (21 heads) received intramuscular injections of 2.5 ml of Catosal daily for 5 consecutive days, from the next day after an overheating episode. The control group 1 consisted of piglets with a total number of 21. After an overheating episode, they were under the usual conditions of a pigsty and did not receive any effects. In experimental piglets and piglets of the control group 1, all indicators were recorded in the outcome and after 30 days. Control group 2 consisted of 32 completely healthy piglets that were kept under standard conditions of a pigsty for their entire lives. They were examined once. Catosal injections in the observed piglets after overheating led to a decrease in spontaneous and stimulated platelet aggregation to normal levels. Against the background of the use of Catosal in the piglets that made up the experimental group, a weakening of hemocoagulation was found, which improved blood circulation in their tissues. Piglets of control group 1 showed an increase in platelet aggregation and blood coagulation. This had a very negative effect on hemorheology in them and weakened their metabolism. We can assume that in piglets after overheating, in the absence of optimizing effects, hemostasis is activated. This adversely affects the course of microcirculation and inhibits growth. Injections in piglets after overheating of the Catosal lead to a weakening of hemocoagulation and platelet activity to optimum values. This normalizes the course of microcirculation in the internal organs of animals.

scholarly journals Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension

2013 ◽  
Vol 70 (8) ◽  
pp. 728-734
Author(s):  
Janko Pejovic ◽  
Svetlana Ignjatovic ◽  
Marijana Dajak ◽  
Nada Majkic-Singh ◽  
Zarko Vucinic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systolic Function ◽  
Nyha Class ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Ventricular Systolic Function ◽  
Function Group ◽  
Group 2 ◽  
Group 1

Background/Aim. Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. The aim of this study was to evaluate NT-proBNP in patients with longstanding hypertension and in patients with signs of hypertensive cardiomyopathy. Methods. The study involved 3 groups, with 50 subjects each: ?healthy? persons (control group), patients with hypertension and normal left ventricular systolic function (group 1) and patients with longstanding hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (group 2). We measured levels of NT-proBNP, Creactive protein and creatinine according to the manufacturer?s instructions. All the patients were clinically examined including physical examination of the heart with blood pressure, pulse rate, electrocardiogram (ECG) and echocardiogram. Results. Our results showed that the determined parameters generally differed significantly (Student?s t-test) among the groups. The mean (? SD) values of NT-proBNP in the control group, group 1 and group 2 were: 2.794 (? 1.515) pmol/L, 9.575 (? 5.449) pmol/L and 204.60 (84,93) pmol/L, respectively. NTproBNP correlated significantly with the determined parameters both in the group 1 and the group 2. In the group 1, the highest correlation was obtained with Creactive protein (r = 0.8424). In the group 2, the highest correlation was obtained with ejection fraction (r = - 0.9111). NT-proBNP showed progressive increase in proportion to the New York Heart Association (NYHA) classification. The patients in thegroup 2 who belonged to the II and III NYHA class had significantly higher levels of NTproBNP than those in the NYHA class I (ANOVA test, p = 0.001). Conclusion. The obtained results suggest that NTproBNP is a useful biomarker in the treatment of patients with longstanding hypertension who are at risk for heart failure.

scholarly journals The Difference of ACE and ACE2 Gene Expression in Patients With Acute Aortic Dissection and Coronary Heart Disease

2021 ◽  
Author(s):  
Yang Li ◽  
Long Mao ◽  
Zongwei Xiao ◽  
Sandeep Bhushan
Keyword(s):  
Gene Expression ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Arterial Wall ◽  
Acute Aortic Dissection ◽  
Venous Blood ◽  
Control Group ◽  
The Difference ◽  
Group 2 ◽  
Ace2 Gene

Abstract BackgroundTo explore whether there is a difference in the expression of ACE and ACE2 genes in patients with acute AD and CHD. MethodsBlood samples from 68 patients, including 34 cases of acute AD (including Stanford type A and B), 21 cases of CHD, and 13 cases of control group. 2 ml of venous blood is submitted for plasma ACE concentration. The arterial wall tissue was taken during the operation for mRNA detection. ResultsThe ACE concentration in the AD group was (17.9 ± 7. 9) U / L, in the CHD group was (33.5 ± 8.1) U / L, and the ACE concentration in the control group was (38.4) ±4.8) U/L, statistically significant (P<0.05). The expression of ACE gene in the AD group was (0.2265 ± 0.3783); the expression in the CHD group was (7.085 7 ± 7.692 9), with significant (P < 0. 05). The expression of ACE2 gene in the AD group was (0.766 2 ± 0.858 6); in the CHD group was (9.612 7 ± 11.542 6), and the difference was significant (P < 0. 05). The expression of the ratio of ACE / ACE2 in the AD group was (0.413 8 ± 0.448); the expression in the CHD group was (0.811 1 ± 0.256 3), the difference was statistically significant (P <0. 001). ConclusionPlasma ACE concentration, ACE and ACE2 gene expression are significantly reduced in acute AD. The imbalance of ACE and ACE2 expression may be involved in the pathogenesis of AD.

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