Investigation of the Possible Correlation between Idiopathic Parkinson’s Disease and Diabetes Mellitus in Egyptian Patients: A Pilot Study

Objectives. To study the diabetes-Parkinson's disease (PD) linkage. Methods. The investigators recorded the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ) score for 60 diabetic patients: 30 patients were treated with metformin-inclusive sulfonylurea and 30 patients were treated with sulphonylurea(s) monotherapy and matched with 30 controls. We evaluated blood glucose kinetics during a 75 g oral glucose tolerance test for (22) nondiabetic parkinsonian patients and (10) controls. The motor complications scores were recorded for all parkinsonian patients using the relevant parts of the Unified Parkinson’s Disease Rating Scale (UPDRS) part IV. Results. Diabetics recorded higher scores of RBDSQ than controls ( p < 0.001 ), with no differences related to antidiabetic therapy. In nondiabetic PD patients, after oral glucose, blood glucose was significantly higher at T1 ( p < 0.001 ) than controls. Moreover, the total area under the time curve for blood glucose levels was significantly higher in PD compared to controls (281.22 ± 52.25 vs. 245.65 ± 48.63 mg.hr./dL; p = 0.013 ). Higher blood glucose levels were associated with motor abnormalities. Diabetic PD patients recorded higher scores of UPDRS ( p < 0.001 ). Conclusion. Diabetes mellitus and Parkinson’s disease are linked, which raises concerns about either of them, probably increasing the risk of the other. This trial is registered with NCT03685357.

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Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4

Infection and Immunity ◽

10.1128/iai.00277-17 ◽

2017 ◽

Vol 85 (9) ◽

Cited By ~ 9

Author(s):

Yuko Ohara-Nemoto ◽

Manami Nakasato ◽

Yu Shimoyama ◽

Tomomi T. Baba ◽

Takeshi Kobayakawa ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Dipeptidyl Peptidase ◽

Oral Glucose ◽

Content Type ◽

Dipeptidyl Peptidase 4 ◽

Glucose Levels ◽

Flight Mass Spectrometry ◽

Blood Glucose Levels ◽

Molecular Events

ABSTRACT Severe periodontitis is known to aggravate diabetes mellitus, though molecular events related to that link have not been fully elucidated. Porphyromonas gingivalis, a major pathogen of periodontitis, expresses dipeptidyl peptidase 4 (DPP4), which is involved in regulation of blood glucose levels by cleaving incretins in humans. We examined the enzymatic characteristics of DPP4 from P. gingivalis as well as two other periodontopathic bacteria, Tannerella forsythia and Prevotella intermedia, and determined whether it is capable of regulating blood glucose levels. Cell-associated DPP4 activity was found in those microorganisms, which was effectively suppressed by inhibitors of human DPP4, and molecules sized 73 kDa in P. gingivalis, and 71 kDa in T. forsythia and P. intermedia were immunologically detected. The k cat/Km values of recombinant DPP4s ranged from 721 ± 55 to 1,283 ± 23 μM−1s−1 toward Gly-Pro-4-methylcoumaryl-7-amide (MCA), while those were much lower for His-Ala-MCA. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) analysis showed His/Tyr-Ala dipeptide release from the N termini of incretins, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide, respectively, with the action of microbial DPP4. Moreover, intravenous injection of DPP4 into mice decreased plasma active GLP-1 and insulin levels, accompanied by a substantial elevation in blood glucose over the control after oral glucose administration. These results are the first to show that periodontopathic bacterial DPP4 is capable of modulating blood glucose levels the same as mammalian DPP4; thus, the incidence of periodontopathic bacteremia may exacerbate diabetes mellitus via molecular events of bacterial DPP4 activities.

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Influence of Nutrition Education with Calendar Method in Diabetic Patients' Blood Glucose

NurseLine Journal ◽

10.19184/nlj.v3i2.6627 ◽

2018 ◽

Vol 3 (2) ◽

pp. 72

Author(s):

Setyoadi Setyoadi ◽

Heri Kristianto ◽

Siti Nur Afifah

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Nutrition Education ◽

Community Health Center ◽

Control Group ◽

P Value ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Before And After

Diabetes mellitus is a disease that required good self-management. Noncompliance in diet and meal plans cause the instability of blood glucose levels. Nutrition education calendar method can improve knowledge and ability to consume food that matches the number, hours and types with dietary adjustments listed in the calendar diet. This study aimed to determine the effect of nutrition education calendar method on blood glucose levels of patients with type 2 diabetes mellitus in Community Health Center Pakis Malang. Pre-experimental design one group pretest-posttest with purposive sampling was conducted in this study and sample obtained as many as 21 people. Blood glucose levels were measured before and after the nutrition education calendar methods. Compliance in using calendar method with the observation sheet. Statistical analysis values obtained by Wilcoxon, the p-value of 0.007 (p <0.05). The results of the analysis, 16 respondents showed a decrease in blood glucose levels and 5 respondents experienced an increase in blood glucose levels after the given intervention. It can be concluded that there are differences between blood glucose levels before and after nutrition education calendar method. Differences in blood glucose levels can be influenced by controlling diet respondent in accordance with the calendar method in education, but also antidiabetic drugs, and sports. Should be added to the control group to determine objectively the effect of nutrition education on the calendar method.

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Study on the prevalence of dyslipidemia in type 2 diabetes mellitus

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20192239 ◽

2019 ◽

Vol 6 (3) ◽

pp. 786

Author(s):

Eda Dayakar ◽

C. Sathya Sree ◽

E. Sanjay

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Type 2 Diabetic

Background: Diabetes mellitus is a common health problem globally. Dyslipidaemia is a major risk factor to develop cardiovascular disease in diabetics. They present study was undertaken to find out the prevalence of dyslipidaemia in type 2 diabetic patients.Methods: The present study was a cross sectional study consisting of 46 (23 male and 23 female) known type 2 diabetes mellitus patients. Age, gender, duration of diabetes, body mass index (BMI) was recorder in all the diabetic patients. Fasting blood glucose levels, total cholesterol, triglycerides, HDL, LDL, VLDL levels were measured using standard methods and recorded.Results: The average total cholesterol, triglycerides, LDL, HDL and VLDL were 200±42mg/dl, 169.62±89.79mg/dl, 132.45±36.38mg/dl,39.1±16.6mg/dl and 35.85±17.09mg/dl respectively. The incidence of occurrence of hypercholesterolemia was 58.6% and hypertriglyceridemia 36.9%. Increased levels of LDL were observed in 30 (65.2%) patients and reduced HDL was observed in 43 (93.4%) patients. The incidence rate of dyslipidaemia was higher in female diabetic patients when compared to male diabetic patients.Conclusions: Awareness on the dyslipidaemia and its risk factors should be provided to the type 2 diabetic patients as they are more prone to get cardiovascular disease and lipid profile also should be monitored regularly along with blood glucose levels.

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Glucose levels during gestational diabetes pregnancy and the risk of developing postpartum diabetes or prediabetes

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-04352-w ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Chadakarn Phaloprakarn ◽

Siriwan Tangjitgamol

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Glycemic Control ◽

Gestational Diabetes ◽

Confidence Interval ◽

Control Group ◽

Oral Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

The Impact

Abstract Background Blood glucose levels during pregnancy may reflect the severity of insulin secretory defects and/or insulin resistance during gestational diabetes mellitus (GDM) pregnancy. We hypothesized that suboptimal glycemic control in women with GDM could increase the risk of postpartum type 2 diabetes mellitus (T2DM) or prediabetes. Our objective was to evaluate the impact of plasma glucose levels throughout GDM pregnancy on the risk of postpartum T2DM or prediabetes. Methods The medical records of 706 women with GDM who underwent a postpartum 75-g, 2-hour oral glucose tolerance test at our institution between January 2011 and December 2018 were reviewed. These women were classified into 2 groups according to glycemic control during pregnancy: ≤ 1 occasion of either fasting glucose ≥ 95 mg/dL or 2-hour postprandial glucose ≥ 120 mg/dL was defined as optimal glycemic control or else was classified as suboptimal glycemic control. Rates of postpartum T2DM and prediabetes were compared between women with optimal (n = 505) and suboptimal (n = 201) glycemic control. Results The rates of postpartum T2DM and prediabetes were significantly higher in the suboptimal glycemic control group than in the optimal glycemic control group: 22.4% vs. 3.0%, P < 0.001 for T2DM and 45.3% vs. 23.5%, P < 0.001 for prediabetes. In a multivariate analysis, suboptimal glucose control during pregnancy was an independent risk factor for developing either postpartum T2DM or prediabetes. The adjusted odds ratios were 8.4 (95% confidence interval, 3.5–20.3) for T2DM and 3.9 (95% confidence interval, 2.5–6.1) for prediabetes. Conclusion Our findings suggest that blood glucose levels during GDM pregnancy have an impact on the risk of postpartum T2DM and prediabetes.

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Impact of sleep duration during pregnancy on the risk of gestational diabetes in the Japan environmental and Children’s study (JECS)

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2632-9 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 3

Author(s):

Mai Myoga ◽

◽

Mayumi Tsuji ◽

Rie Tanaka ◽

Eiji Shibata ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factor ◽

Blood Glucose ◽

Gestational Diabetes ◽

Sleep Duration ◽

Reference Group ◽

Oral Glucose ◽

Random Blood Glucose ◽

Glucose Levels ◽

Blood Glucose Levels

Abstract Background Gestational diabetes mellitus (GDM) has serious effects on both mother and child. Like Type 2 Diabetes Mellitus, it is increasing in prevalence world-wide. In addition to obesity, sleep duration has been named an important risk factor. Using a large cohort study, including data from 48,787 participants of the Japan Environment and Children’s Study (JECS), we examined the association between sleep duration and both random blood glucose levels and GDM rates during pregnancy. Methods Random blood glucose levels were measured during pregnancy. GDM diagnosis was based on the results of 75 g oral glucose tolerance test. Additional anthropometric data was collected from questionnaires for statistical analysis. Results Compared to mothers averaging 7 to < 10 h sleep (reference group), women receiving < 5 h or ≥ 10 h sleep exhibited significantly elevated random blood glucose levels. This was associated with an elevated risk for positive GDM screening (< 5 h sleep: OR 1.17 (0.96–1.44) p = 0.126; ≥10 h sleep: OR 1.13 (1.03–1.25) p = 0.006). Calculating the risk for GDM, women sleeping < 5 h or ≥ 10 h exhibited elevated risks of 1.31-fold and 1.21 respectively. However, this trend was not found to be significant. Conclusions Sleep is a critical factor in glucose metabolism, with both abnormally long and short sleep duration increasing random blood glucose levels in pregnant women. Moreover, the risk for positive GDM screening increases significantly with elevated sleep, ≥10 h per night. These findings are promising because they support the idea that sleep duration is a modifiable risk factor, and can be focused upon to improve health and pregnancy outcome.

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The Potential of Noni (Moringa citrifolia) in Lowering Blood Glucose Levels in Diabetes Mellitus Patients

BIOEDUSCIENCE ◽

10.22236/j.bes/424919 ◽

2020 ◽

Vol 4 (2) ◽

pp. 120-123

Author(s):

Putri Dafriani ◽

Mutiara Karamika ◽

Siska Sakti Anggraini ◽

Roza Marlinda

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Intervention Group ◽

Control Group ◽

Diabetic Patients ◽

Test Results ◽

Glucose Levels ◽

Glucose Testing ◽

Blood Glucose Levels ◽

Reduce Blood Glucose

Background: Diabetes Mellitus is a chronic metabolic disorder caused by insulin resistance. Noni juice has the potential as herbal medicine which believed to reduce blood glucose levels. This study aims to determine the effect of noni juice on blood sugar levels on diabetic patients. Methods: This study used 16 respondents. They divided two groups, a control group and a treatment group. Each group consists of 8 respondents. The intervention group received 150 ml of noni juice which was given once a day for ten days. Glucose testing was carried out by the glucose-check method. The blood was taken from the respondent's fingertips capillary. The blood glucose levels between the control group and the intervention group were analyzed using independent t-test. Results: The average blood glucose level in the intervention group was 199.88 mg/dl, while the control group was 326.25 mg/dl. The test results of the mean blood glucose levels between the control group and the intervention group had a significant difference with a value of p = 0.003 (p ≤ 0.05). This indicates a significant effect between blood glucose levels in the control group and the intervention group. Conclusion: Noni can reduce blood glucose levels because it contains flavonoid. It has a hypoglycemic effect. Health workers can suggest consuming noni juice to decrease blood glucose in diabetic patients.

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Association Between Exercise and Blood Glucose Levels In Diabetic Patients

Jurnal Berkala Epidemiologi ◽

10.20473/jbe.v4i22016.188-199 ◽

2017 ◽

Vol 4 (2) ◽

pp. 188

Author(s):

Eryna Laili Putri

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Control Group ◽

Case Group ◽

Diabetic Patients ◽

Design Data ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Average Blood Glucose ◽

Intensity Of Exercise

Diabetes Mellitus (DM) is a chronic disease with high prevalence, associated with various debilitating complications and can decreases the quality of life in people with it. It is important for people with DM to doing exercise to control the stability of their blood glucose levels. The purpose of this study was to finding out the association between frequency, duration, and intensity of exercise with average blood glucose levels in people with DM. This was an observational study that used case control design. Data obtained from interview with 20 samples from case group and 20 samples from control group, that had been chosen with systematic random sampling technique. Dependent variable of this study was the average blood glucose levels and independents variables were frequency, duration, intensity, and the kind of exercise. This study used Chi Square test 3 × 2 contingency tables to finding out the association and risk of dependent variable with independent variables,. The results showed that exercise factors that associated to average blood glucose levels were duration of exercise (p = 0.022) and intensity of exercise (p = 0.021). The frequency of exercise does not associated to average blood glucose levels (p = 0.340). Diabetic patients who did not do any exercise have the risk of having uncontrolled blood glucose levels. The conclusion was duration and intensity of exercise related significantly to blood glucose levels. By doing exercise three times a week for 30 minutes or more can decreases the risk of uncontrolled blood glucose levels in people with DM.Keywords: Diabetes mellitus, exercise, average blood glucose levels

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Comparison of the Effects of Mitiglinide and Glibenclamide Administered in Combination with the Dipeptidyl Peptidase-IV Inhibitor Sitagliptin in Rats with Streptozotocin-Nicotinamide-Induced Type 2 Diabetes

Drug Research ◽

10.1055/s-0043-102951 ◽

2017 ◽

Vol 67 (07) ◽

pp. 396-403 ◽

Cited By ~ 1

Author(s):

Kenji Akahane ◽

Kazuma Ojima ◽

Ayaka Yokoyama ◽

Toshihiro Inoue ◽

Sumiyoshi Kiguchi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Blood Glucose ◽

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Oral Glucose ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Dpp Iv

Abstract We compared the individual effects of mitiglinide and glibenclamide administered in combination with the dipeptidyl peptidase-IV (DPP-IV) inhibitor sitagliptin on plasma DPP-IV activity and blood glucose levels in rats with streptozotocin-nicotinamide-induced type 2 diabetes (STZ-NA rats). We examined the inhibitory activity of mitiglinide and glibenclamide as well as their combination with sitagliptin on plasma DPP-IV activity in STZ-NA rats. The oral glucose tolerance test (OGTT) was used to compare effects of mitiglinide, glibenclamide, and their combination with sitagliptin on blood glucose levels in STZ-NA rats. Mitiglinide and glibenclamide did not inhibit rat DPP-IV and did not influence the inhibitory effect of sitagliptin on rat plasma DPP-IV activity. In STZ-NA rats, plasma glucose levels were stronger suppressed by a combination of mitiglinide and sitagliptin than by either drug used alone. However, no clear effect of the combination of glibenclamide and sitagliptin was observed. These results indicate that the combination of mitiglinide and sitagliptin has a lower risk of hypoglycemia in the rats with induced type 2 diabetes compared with the combination of glibenclamide and sitagliptin. The combination of mitiglinide and sitagliptin can be a promising combination for the treatment of diabetic patients.

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Controlled Type -II Diabetes Mellitus - No More Contra-Indication for Delayed Loading of Two Piece Dental Implants - A Case Report

Journal of Dentistry Oral Disorders and Therapy ◽

10.15226/jdodt.2019.001105 ◽

2019 ◽

Vol 7 (1) ◽

pp. 1-4

Author(s):

Alekhya Ayalapuram

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Type Ii Diabetes ◽

Survival Rates ◽

Type Ii Diabetes Mellitus ◽

Diabetic Patients ◽

Type Ii ◽

Obesity Prevalence ◽

Glucose Levels ◽

Blood Glucose Levels

With changing lifestyle and increasing obesity, prevalence of type -II Diabetes Mellitus is increasing in geriatric individuals, who are generally prone to tooth loss. As a result the demand for implants in these patients is also increasing and planning implants has been a challenge to present day dentists. Diabetes Mellitus causes impaired metabolism in general, especially bone metabolism resulting in impaired Osseointegration and poor wound healing. Growing demand of implants in Type II DM patients has initiated research towards implants survival rates. Extensive research till now states - poorly controlled diabetic patients have higher implant failure rates, where as Diabetic patients with controlled blood glucose levels respond to implants in similar way as healthy patients. The present article is one such trail to confirm that type II Diabetes Mellitus is no more contra-indication for Implants till Blood glucose levels are controlled to normal levels. Key words: Type-II Diabetes Mellitus; Two-piece implant; Delayed loading;

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Functional state of the hypothalamic-pituitary-gonadal axis in diabetes mellitus

Problems of Endocrinology ◽

10.14341/probl201056523-29 ◽

2010 ◽

Vol 56 (5) ◽

pp. 23-29 ◽

Cited By ~ 9

Author(s):

A O Shpakov

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Steroid Hormones ◽

Reproductive Function ◽

Diabetic Patients ◽

Reproductive Disorders ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Hormonal Action ◽

Gonadotropic Hormones

Diabetic patients present with a wide variety of reproductive disorders supposed to be underlain by changes in the functional activity of the hypothalamic-pituitary-gonadal axis (HPGA) and sensitivity of the reproductive system tissues to the regulatory hormonal action. The objective of the present review is to analyse the literature data and the results of original studies pertinent to the biosynthesis and secretion of hypothalamic LH releasing factor, pituitary gonadotropic hormones, steroid hormones, and susceptibility of their target tissues in patients with types 1 and 2 diabetes mellitus. It is concluded that the improvement of control over blood glucose levels constitutes a most efficacious approach to the correction and normalization of reproductive function in diabetic patients.

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