scholarly journals A Case of Descending Necrotizing Mediastinitis in a Previously Healthy Child

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Toshihiko Okumura ◽  
Nobuyuki Tetsuka ◽  
Makoto Yamaguchi ◽  
Takako Suzuki ◽  
Yuka Torii ◽  
...  
Keyword(s):  
Antimicrobial Agent ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Rare Complication ◽  
Severe Disease ◽  
Multidisciplinary Treatment ◽  
Test Results ◽  
Descending Necrotizing Mediastinitis ◽  
Cervical Lymphadenitis ◽  
Appropriate Treatment ◽  
Team Medical Care

Descending necrotizing mediastinitis (DNM) is a rare complication of oropharyngeal and cervical infection, especially in children. We report a case of DNM secondary to a cervical abscess in a previously healthy 1-year-old boy. The patient presented with redness and swelling of the neck and fever. He was treated with an antimicrobial agent for the diagnosis of cervical lymphadenitis. On the sixth day, a huge mediastinal abscess was found, and he was admitted to the intensive care unit. He was successfully treated with surgical drainage and appropriate antimicrobial therapy. The pus culture isolated multiple bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Although we did not use an antimicrobial agent covering MRSA, the symptoms and test results improved. Washing with drainage was effective. The patient required multidisciplinary treatment, and we collaborated with specialists in other departments. DNM is a severe disease in which team medical care is needed to provide appropriate treatment.

scholarly journals Granulomatous Hepatitis Following Intra-Vesical Instillation of Bacillus Calmette–Guérin for Treatment of Bladder Cancer

2021 ◽  
Vol 13 (3) ◽  
pp. 611-618
Author(s):  
Elsa Alves Branco ◽  
Raquel Duro ◽  
Teresa Brito ◽  
António Sarmento
Keyword(s):  
Bladder Cancer ◽  
Hepatitis A ◽  
Adverse Reactions ◽  
Superficial Bladder Cancer ◽  
Rare Complication ◽  
Immunocompetent Patient ◽  
Clinical Suspicion ◽  
Bacillus Calmette Guerin ◽  
Granulomatous Hepatitis ◽  
Appropriate Treatment

Intra-vesical instillation of bacillus Calmette–Guérin (BCG) is an important treatment modality of superficial bladder cancer. It is usually well tolerated, although some adverse reactions can occur. One possible yet rare complication is granulomatous hepatitis, that is thought to be caused either by BCG infection or a hypersensitivity reaction to the bacillus. We present a case of a 79-year-old apparently immunocompetent patient who developed granulomatous hepatitis a few months after BCG administration for bladder cancer immunotherapy. It is important to notice that acid-fast smears and cultures are often negative, and these should not exclude diagnosis nor delay treatment. Our case highlights the importance of clinical suspicion and prompt initiation of appropriate treatment.

scholarly journals Profile of Patients with Mitral Stenosis in Dr. Soetomo General Hospital, Surabaya in January 2015 – December 2017

2021 ◽  
Vol 12 (1) ◽  
pp. 42
Author(s):  
Nadia Mulyanti Gunawan ◽  
Raden Mohammad Budiarto ◽  
Andriati Andriati
Keyword(s):  
High School ◽  
General Hospital ◽  
Disease Severity ◽  
Educational Level ◽  
Mitral Stenosis ◽  
Severe Disease ◽  
Educational Background ◽  
Vascular Medicine ◽  
Cross Sectional ◽  
Appropriate Treatment

Introduction: The most common valvular heart disease is mitral stenosis. Mitral stenosis is an abnormality of the heart valve which causes reduced blood flow from the left atria to the left ventricle due to narrowing of mitral valve orifice during its opening motion. If the condition continues, it will result in complications. The most common complications are pulmonary hypertension, atrial fibrillation, heart failure, and stroke. Appropriate treatment for mitral stenosis may produce more favorable prognosis in these patients. Therefore, the aim of this study was to describe the profile of patients with mitral stenosis in Department of Cardiology and Vascular Medicine, Dr. Soetomo General Hospital, Surabaya from January 2015 to December 2017. It is expected that mitral stenosis can be detected earlier, thus the appropriate treatment can be administered promptly and further complications can be prevented. Methods: This study was a descriptive retrospective study with cross-sectional approach and accidental sampling method obtained from the inpatients medical records of patients diagnosed with mitral stenosis from echocardiography in Department of Cardiology and Vascular Medicine Dr. Soetomo General Hospital, Surabaya from January 2015 to December 2017. The variables were age, gender, disease severity, and the patient’s educational background. The data was processed using Microsoft Excel and IBM SPSS version 20. Results:  This study obtained 41 patients who met the inclusion criteria, then the patients were categorized according to their age, gender, disease severity, and educational background. The results of the study showed that the subjects were dominated by those of productive age at 30-39 years old (39%), the most prevalent gender was female (85.4%), severe disease severity (85.4%), and educational level was from high school (85.4%). Conclusion: The majority of the patients with mitral stenosis were from productive age, female, with severe disease severity, and educational background from middle educational level (high school). 

scholarly journals Multidisciplinary treatment of deep neck infection associated with descending necrotizing mediastinitis: a single-centre experience

2019 ◽  
Vol 47 (12) ◽  
pp. 6027-6040 ◽  
Author(s):  
Chao Ma ◽  
Lian Zhou ◽  
Ji-Zhi Zhao ◽  
Run-Tai Lin ◽  
Tao Zhang ◽  
...  
Keyword(s):  
Thoracoscopic Surgery ◽  
Multidisciplinary Treatment ◽  
Multiple Organ ◽  
Deep Neck Infection ◽  
Descending Necrotizing Mediastinitis ◽  
College Hospital ◽  
Odontogenic Infections ◽  
Neck Infection ◽  
Medical College ◽  
Mediastinal Drainage

Objective Deep neck infection (DNI) associated with descending necrotizing mediastinitis (DNM) is a highly lethal condition. This retrospective review was performed to share our experience performing multidisciplinary management of DNI associated with DNM during a 7-year period. Methods We reviewed 16 patients who had been surgically treated for DNM at Peking Union Medical College Hospital from April 2010 to July 2017. The clinical outcomes were analysed to determine the most appropriate therapeutic strategy. Results Five women and 11 men were included in this study. Their mean age was 54.9 ± 14.3 years. DNM-associated infections most commonly occurred secondary to odontogenic infections (n = 10). Thirteen patients required tracheotomy because of tracheal compression. All patients underwent unilateral or bilateral cervicotomy. Six patients with DNM localized in the upper mediastinal space underwent transcervical mediastinal drainage, while 10 patients with DNM extending to the lower mediastinum were treated by cervicotomy and video-assisted thoracoscopic surgery. Three patients died of multiple organ failure. Conclusion Multidisciplinary treatment can achieve favourable outcomes in >80% of patients with DNM. Early diagnosis, proper airway management, and adequate surgical drainage are crucial for reducing mortality in patients with DNM, and minimally invasive procedures also play an important role.

Follow-up results in tuberculous cervical lymphadenitis

2005 ◽  
Vol 120 (2) ◽  
pp. 129-132 ◽  
Author(s):  
Mehmet F Oktay ◽  
Ismail Topcu ◽  
Abdurrahman Senyigit ◽  
Aslan Bilici ◽  
Adem Arslan ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Residual Disease ◽  
Surgical Excision ◽  
X Rays ◽  
Test Results ◽  
Cervical Lymphadenitis ◽  
Antituberculous Treatment ◽  
High Incidence ◽  
The Mean

Objective: To investigate the efficacy of medical antituberculous treatment in patients with tuberculous cervical lymphadenitis (TCL).Methods: In the period 1996–2002, 73 TCL patients were reviewed and the results of clinical and laboratory testing were documented. The efficacy of a four-drug chemotherapy regimen was investigated.Results: Purified protein derivatives (PPD) skin test results were positive in 58 (79 per cent) patients. Chest X-rays revealed changes consistent with tuberculosis in nine (12.3 per cent) patients. The mean duration of medical treatment was 10.04 months. In follow-up evaluation, 14 (20 per cent) patients were considered suspicious for resistant TCL and total excision of all nodes was performed. Histopathology confirmed TB in only 10 of these cases.Conclusion: The high incidence of residual disease in our study indicates that medical treatment (at least nine months of four combined antituberculous drugs) did not seem to be effective. If lymphadenopathy persists, total surgical excision of lymph nodes should be the treatment of choice.

Synthesis and structural studies of 1-phenyl-1,3-butanedione copper(II) complexes as an excellent antimicrobial agent against methicillin-resistant Staphylococcus aureus

2019 ◽  
Vol 484 ◽  
pp. 227-236 ◽  
Author(s):  
Hema M. Krishnegowda ◽  
Chimatahalli S. Karthik ◽  
Manukumar H. Marichannegowda ◽  
Karthik Kumara ◽  
Pampa J. Kudigana ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agent ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Structural Studies ◽  
Methicillin Resistant

scholarly journals Robotic prostatectomy leading to a delayed MRSA infected lymphocele: a case report and review of the literature

2017 ◽  
Vol 10 (1) ◽  
pp. 23-27
Author(s):  
Monica Kaminski ◽  
Rose Recco ◽  
Steven Siegel
Keyword(s):  
Case Report ◽  
Radical Prostatectomy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Rare Complication ◽  
Fluid Collection ◽  
Unknown Origin ◽  
Robotic Prostatectomy ◽  
Post Procedure ◽  
The Usa ◽  
Localized Disease

Prostate cancer is the second leading cancer-related cause of death in the USA with the majority presenting as localized disease. In the last decade minimally invasive, robotic-assisted laparascopic, radical prostatectomy has become the most favored treatment choice. A complication that has been observed in 27% of patients is the formation of an asymptomatic lymphocele. It is a very rare complication for these to become infected, and when they do 80% have occurred 2–12 months post-procedure. In this case report the patient presented with fever and leukocytosis of unknown origin and was found to have a methicillin-resistant Staphylococcus aureus (MRSA) infected lymphocele over 2 years after a radical prostatectomy. The infected fluid collection was drained percutaneously and the patient was treated with a 4-week course of intravenous ceftaroline with complete resolution of symptoms.

The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy

2016 ◽  
Vol 44 (3) ◽  
Author(s):  
Jane So ◽  
Elizabeth Young ◽  
Natalie Crnosija ◽  
Joseph Chappelle
Keyword(s):  
Severe Disease ◽  
Vital Signs ◽  
Retrospective Chart Review ◽  
Clinical Findings ◽  
Bivariate Analysis ◽  
Test Results ◽  
Quadrant Pain ◽  
Laboratory Findings ◽  
Abnormal Laboratory ◽  
Laboratory Test Results

AbstractPreeclampsia is the 2A retrospective chart review of women who presented for evaluation of hypertension in pregnancy during 2010. Demographic information, medical history, symptoms, vital signs, and laboratory results were collected. Bivariate analysis was used to investigate associations between predictors and the outcome.Of the 481 women in the sample, 22 were identified as having abnormal laboratory test results (4.6%). Women who reported right upper quadrant pain or tenderness had significantly increased likelihood of having laboratory abnormalities compared to those without the complaint.Only a small percentage of women evaluated were determined to have abnormal laboratory findings, predominantly among women with severe preeclampsia. Right upper quadrant pain or tenderness was positively correlated with laboratory abnormalities. The restriction of laboratory analysis in women with clinical evidence of severe disease may be warranted – a broader study should, however, first be used to confirm our findings.

Inflammation of periapical tissues of the teeth, complicated by a fistula of the cheek skin

2018 ◽  
Vol 7 (4) ◽  
pp. 1-5
Author(s):  
Przemysław Krawczyk ◽  
Daniel Majszyk ◽  
Antoni Bruzgielewicz ◽  
Kazimierz Niemczyk
Keyword(s):  
Rare Complication ◽  
Correct Diagnosis ◽  
Primary Site ◽  
Cutaneous Fistula ◽  
Therapeutic Challenge ◽  
Medical Specialists ◽  
Diagnostic Protocol ◽  
Appropriate Treatment

Inflammation of the periapical tissue may lead to the development of complications involving cooperation between many medical specialists. The cutaneous fistula is a rare complication of chronic alveolus inflammation being diagnostic and therapeutic challenge due to unspecific symptoms. The correct diagnostic protocol may influence correct diagnosis, localization of the primary site of inflammation and the appropriate treatment.

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