Profile of Patients with Mitral Stenosis in Dr. Soetomo General Hospital, Surabaya in January 2015 – December 2017

Introduction: The most common valvular heart disease is mitral stenosis. Mitral stenosis is an abnormality of the heart valve which causes reduced blood flow from the left atria to the left ventricle due to narrowing of mitral valve orifice during its opening motion. If the condition continues, it will result in complications. The most common complications are pulmonary hypertension, atrial fibrillation, heart failure, and stroke. Appropriate treatment for mitral stenosis may produce more favorable prognosis in these patients. Therefore, the aim of this study was to describe the profile of patients with mitral stenosis in Department of Cardiology and Vascular Medicine, Dr. Soetomo General Hospital, Surabaya from January 2015 to December 2017. It is expected that mitral stenosis can be detected earlier, thus the appropriate treatment can be administered promptly and further complications can be prevented. Methods: This study was a descriptive retrospective study with cross-sectional approach and accidental sampling method obtained from the inpatients medical records of patients diagnosed with mitral stenosis from echocardiography in Department of Cardiology and Vascular Medicine Dr. Soetomo General Hospital, Surabaya from January 2015 to December 2017. The variables were age, gender, disease severity, and the patient’s educational background. The data was processed using Microsoft Excel and IBM SPSS version 20. Results: This study obtained 41 patients who met the inclusion criteria, then the patients were categorized according to their age, gender, disease severity, and educational background. The results of the study showed that the subjects were dominated by those of productive age at 30-39 years old (39%), the most prevalent gender was female (85.4%), severe disease severity (85.4%), and educational level was from high school (85.4%). Conclusion: The majority of the patients with mitral stenosis were from productive age, female, with severe disease severity, and educational background from middle educational level (high school).

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Poor Physical Capacity in Bronchiectasis Patients Is Correlated with Poor Quality of Life

10.21203/rs.3.rs-148679/v1 ◽

2021 ◽

Author(s):

Jarkko Mäntylä ◽

Tanja Törölä ◽

Witold Mazur ◽

Paula Bergman ◽

Paula Kauppi

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Disease Severity ◽

Bacterial Colonization ◽

Severe Disease ◽

Poor Quality ◽

Physical Capacity ◽

Bacterial Colonisation ◽

Cross Sectional

Abstract BackgroundTo study the risk factors associated with quality of life (QoL) in a cohort of Finnish non-cystic fibrosis bronchiectasis (BE) patients. We aimed to evaluate which of the clinical characteristics were risk factors for poor quality of life, how patients with frequent exacerbations differed from those with only few exacerbations and if QoL symptom domains were correlated with dyspnoea or severity of BE.MethodsA cross-sectional study and part of the EMBARC study including questionnaire data and medical record data. Study participants were recruited between August 2016 and March 2018 from three different pulmonary clinics in Helsinki University Central Hospital (HUH) catchment area, Finland. The study included 95 adult patients with (mean age was 69 (SD± 13) years).A Finnish translation of the disease-specific quality of life-bronchiectasis (QoL-B) questionnaire was applied, and scores in the lowest quarter (25%) of the scale were considered to indicate poor QoL. The bronchiectasis severity index (BSI) and FACED (including FEV1, age, pulmonary bacterial colonization, affected lobes and dyspnoea) score were used. The severity of dyspnoea was examined using the modified Medical Research Council (mMRC) dyspnoea scale.ResultsAlmost all (82%) presented with chronic sputum production and exacerbations, with a median rate of 1.7 (SD ±1.6). Exacerbations (OR 1.7, p < 0.01), frequent exacerbations (OR 4.9, p < 0.01), high BSI score (OR 1.3, p < 0.01) and extensive disease (OR 3.7, p = 0.05) were predictive of poor QoL. Frequent exacerbations were associated with bronchial bacterial colonisation, low forced expiratory volume in one second (FEV1) and radiological disease severity. Based on the BSI, 34.1% of our cohort had severe disease, whereas 11.6% were classified as severe according to the FACED score. The mMRC dyspnoea score (r = -0.57) and BSI (r = -0.60) were negatively correlated with physical domain in QoL-B questionnaire. ConclusionFrequent exacerbations, radiological disease severity and high BSI score were predictive of poor QoL. Reduced physical capacity was correlated with dyspnoea and severity of disease. Interventions to reduce bacterial colonisation and to maintain physical functioning should be used to minimize exacerbations and to improve quality of life in BE patients.Study registrationUniversity of Helsinki, faculty of medicine; 148/16.08.2017

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Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia

Interdisciplinary Perspectives on Infectious Diseases ◽

10.1155/2017/8965729 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Muluken Birhanu ◽

Yaregal Asres ◽

Wondimagegn Adissu ◽

Tilahun Yemane ◽

Endalew Zemene ◽

...

Keyword(s):

General Hospital ◽

Severe Malaria ◽

Disease Severity ◽

Hematological Parameters ◽

Study Participant ◽

Cross Sectional Study ◽

Hematological Parameter ◽

Sectional Study ◽

Cross Sectional ◽

Study Participants

Hematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional study was conducted at Pawe General Hospital from July 31 to December 30, 2014. Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigations. Data were analyzed using SPSS version 20. The overall prevalence of anemia was 40.3%, most of which were mildly anemic. Leukocytosis was found in 15.4% of study participants. More than a fourth (27%) of the children had severe malaria. Hemozoin-containing monocytes and neutrophils were found in 80.1% and 58.9% of the study participants, respectively. Under-five years of age (AOR = 3.01, 95% CI: 1.83–7.39,P<0.001), leukocytosis (AOR = 3.20, 95% CI: 1.65–6.24,P=0.001), mean hemozoin-containing monocytes >5% (AOR = 6.26, 95% CI: 2.14–14.29,P<0.001), mean hemozoin-containing neutrophils >5% (AOR = 7.93, 95% CI: 3.09–16.86,P<0.001), and high density parasitemia (AOR = 1.90, 95% CI: 1.13–3.18,P=0.015) were associated with severe malaria. Hemozoin-containing leukocytes, leukocytosis, and other identified associated factors should be considered for proper management of children with severe malaria.

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Poststroke Erectile Dysfunction in Cameroon: Prevalence, Associated Factors, and Quality of Life

Stroke Research and Treatment ◽

10.1155/2021/9988841 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Daniel Gams Massi ◽

Gervais Ngoupayou Mountap ◽

Hervé Edouard Moby ◽

Frantz Guy Epoupa Ngalle ◽

Sidick Mouliom ◽

...

Keyword(s):

Quality Of Life ◽

Erectile Dysfunction ◽

General Hospital ◽

Predictive Factors ◽

Erectile Function ◽

Associated Factors ◽

Severe Disease ◽

Stroke Patients ◽

Cross Sectional

Background. Stroke is a severe disease due to its morbidity-mortality. It is the first cause of acquired disability including erectile dysfunction (ED). The purpose of this study was to determine the prevalence of ED in stroke patients at the Douala General Hospital, to identify associated factors and to evaluate their quality of life. Materials and Methods. A cross-sectional study was conducted over a period of seven months from November 2016 to May 2017 on two groups of patients in neurology, cardiology, and endocrinology units of the Douala General Hospital (Cameroon): stroke patients (stroke+) and nonstroke patients (stroke-). We collected sociodemographic and clinical data using a preestablished questionnaire. Erectile function was assessed using International Index of Erectile Function (IIEF-5). Associated and predictive factors were determined using univariate and multivariate analyses. Results were significant for a p value < 0.05. Results. A total of 269 patients were included, among them 87 stroke+ (32.34%) and 182 stroke- (67.66%) (controlled group). The mean age was 56.37 ± 12.89 years and 57.18 ± 10.24 years of stroke+ and stroke-, respectively ( p = 0.608 ). Prevalence of poststroke ED was 64.4% ( OR = 3.41 , 95% CI: 1.99-5.82, p < 0.001 ). The average time of occurrence of the poststroke ED was 5 ± 5.85 months. Diabetes and dyslipidemia were the predictive factors of occurrence of poststroke ED. Depression was found both in stroke+ with ED and stroke+ without ED with no difference ( p = 0.131 ). Conclusion. About two-thirds of stroke patients developed ED. Diabetes and dyslipidemia were predictive factors of ED in stroke patients.

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Poor Physical Capacity in Bronchiectasis Patients Is Correlated with Poor Quality of Life

10.21203/rs.3.rs-32115/v1 ◽

2020 ◽

Author(s):

Jarkko Mäntylä ◽

Witold Mazur ◽

Tanja Törölä ◽

Paula Bergman ◽

Paula Kauppi

Keyword(s):

Quality Of Life ◽

Disease Severity ◽

Clinical Care ◽

Severe Disease ◽

Healthcare Utilisation ◽

Forced Expiratory Volume ◽

Physical Capacity ◽

Bacterial Colonisation ◽

Cross Sectional

Abstract Background: Bronchiectasis (BE) is an increasing burden on healthcare systems, and there is an urgent need for improved treatments, better clinical care and for clinical and translational research on this condition. Reducing the number of exacerbations is one of the key goals in BE management. Patients who suffer from frequent exacerbations are likely to experience more exacerbations, which have negative effects on quality of life (QoL), healthcare utilisation and mortality. Thus, we aimed to investigate the risk factors associated with quality of life (QoL) in a cohort of Finnish non-cystic fibrosis BE patients.Methods: A cross-sectional study is part of the EMBARC. Recruitment occurred between August 2016 and March 2018 from three clinics in Helsinki University Central Hospital, Finland. The study included 95 adult patients (mean age was 69 (SD± 13) years). Seventy nine percent were women. A disease-specific quality of life-bronchiectasis (QoL-B) questionnaire was applied, and scores in the lowest quarter (24%) indicate poor QoL. The bronchiectasis severity index (BSI) and FACED score were used. The severity of dyspnoea was examined using the modified Medical Research Council (mMRC) dyspnoea scale. Results: Almost all (82%) presented with chronic sputum production and exacerbation, with a median rate of 1.7 (SD ±1.6). Exacerbations (OR 1.7), frequent exacerbations (OR 4.9, p < 0.01), high BSI score (OR 1.3, p < 0.01) and extensive disease (OR 3.7, p = 0.05) were predictive of poor QoL. Frequent exacerbations were associated with bronchial bacterial colonisation, low forced expiratory volume in one second (FEV1) and radiological disease severity. Based on the BSI, 34.1% of our cohort had severe disease, whereas 11.6% were classified as severe according to the FACED score. The mMRC dyspnoea score (r = -0.57) and BSI (r = -0.60) were negatively correlated with physical domain in QoL-B questionnaire. Conclusion: Frequent exacerbations, radiological disease severity and high BSI score were predictive of poor QoL. Reduced physical capacity was correlated with dyspnoea and severity of disease. Interventions to reduce bacterial colonisation and to maintain physical functioning should be used to minimize exacerbations and to improve QoL.Study registration: University of Helsinki, faculty of medicine; 148/16.08.2017; Registered 16 August 2017; https://researchportal.helsinki.fi/

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Knowledge and societal perceptions regarding autopsy amongst different educational backgrounds in Karachi, Pakistan

Journal of the Pakistan Medical Association ◽

10.47391/jpma.02-283 ◽

2021 ◽

pp. 1-12

Author(s):

Marvi Masood Farooqui ◽

Muhammad Ikram Ali ◽

Qudsia Hassan ◽

Rabbia Mahrukh ◽

Nasibullah Ahmed

Keyword(s):

Educational Level ◽

General Public ◽

Educational Background ◽

High Educational Level ◽

Sample Population ◽

Cross Sectional ◽

Educational Backgrounds ◽

Organ Removal ◽

N 93 ◽

Age Range

Abstract Objective: The purpose of this study is to find out awareness levels about legislation/authorization and objectives of autopsy amongst the general public, in addition to their opinions about the topic based on the different levels of education. Methods: A cross-sectional questionnaire-based study design was implemented to collect data on their knowledge, perceptions and concerns regarding autopsy from a sample population of 260 citizens aged 18 and above from all educational backgrounds of District South Karachi, Pakistan. Results: Out of total respondents 47.1% (n=122) fell within the age range of 18-25. Males were 41.7% (n=106) and females were 56.3% (n=143) in the study. Out of the 82% (n=208) who marked “Yes” to knowing the meaning of autopsy, 55.3% (n=115) of the respondents belonged to high educational level, 44.7% (n=93) belonged to low educational level. Only 44.7% (n=93) participants correctly knew the purpose for conducting an autopsy. For concerns regarding autopsy a vast majority of respondents marked “Organ removal” (21.7%, n=135) and “Disfigurement of body” (18.3%, n=114) as the top two concerns across regardless of educational level. Conclusion: Although most people held positive perception of autopsy, in depth questioning revealed a clear lack of correct information amongst the general public regarding autopsies. This has led to many falsely held beliefs including fear of body disfigurement and organ removal and less faith in the medicolegal system, irrespective of educational background. Continuous....

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New insights into the burden and costs of multiple sclerosis in Europe

Multiple Sclerosis Journal ◽

10.1177/1352458517694432 ◽

2017 ◽

Vol 23 (8) ◽

pp. 1123-1136 ◽

Cited By ~ 186

Author(s):

Gisela Kobelt ◽

Alan Thompson ◽

Jenny Berg ◽

Mia Gannedahl ◽

Jennifer Eriksson ◽

...

Keyword(s):

Multiple Sclerosis ◽

Disease Severity ◽

Purchasing Power Parity ◽

Burden Of Illness ◽

Normal Population ◽

Severe Disease ◽

Resource Consumption ◽

Independent Effect ◽

Power Parity ◽

Cross Sectional

Background: The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. Objectives: This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society. Methods: A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity). Results: The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing–remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility. Conclusion: Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.

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Disease Severity, Clinical Characteristics and Outcome of Patients Hospitalized with Novel Coronavirus Disease at a Tertiary Care Hospital, Rawalpindi

Life and Science ◽

10.37185/lns.1.1.180 ◽

2021 ◽

Vol 2 (4) ◽

pp. 6

Author(s):

Muhammad Mahtab Shabir ◽

Shazia Nisar ◽

Zobia Urooj ◽

Uzma Qayyum ◽

Fozia Fatima ◽

...

Keyword(s):

Kidney Disease ◽

Pulmonary Disease ◽

Disease Severity ◽

Clinical Characteristics ◽

Severe Disease ◽

Tertiary Care ◽

Care Hospital ◽

Cross Sectional ◽

Number Of Patients ◽

Novel Coronavirus

Objective: To describe the clinical characteristics, signs & symptoms, disease severity, and outcome of patientsadmitted with novel coronavirus infection.Study Design: Comparative cross-sectional study.Place and Duration of Study: The study was conducted in the Department of Medicine of Pak-Emirates Militaryst th Hospital, (PEMH), Rawalpindi from May 1 , 2020 to June 30 , 2020.Materials and Methods: Patients hospitalized with novel corona virus infection during the study period wereprospectively enrolled in this study. Patients at least 15 years and above, either gender, hospitalized withconfirmed diagnosis of covid-19 (SARS-CoV-2) were eligible to be enrolled. The study outcomes includeddisease presentation, severity at time of reporting, admission to critical care or intensive care unit andmortality. Patients were identified as mild, moderate, severe and critical in accordance with World HealthOrganization guidelines, based on symptom severity, laboratory and imaging findings.Results: There were 400 hospitalized patients with confirmed SARS-CoV-2, out of which 51 (12.8%) werefemales, while 349 (87.3%) were males with overall mean age of 48.45±16.2 years. There were 300 (75.0%)patients with mild disease severity, while 65 (16.3%), 20 (5.0%) and 15 (3.8%) with moderate, severe and criticaldisease condition, respectively. The number of patients died were 22, with fatality rate of 5.5%. Age andpresence of comorbidities (cardiac disease, diabetes, hypertension, pulmonary disease, kidney disease) weresignificantly associated with disease severity and death due to novel coronavirus infection.Conclusion: Patients with older age, diabetes, hypertension, pulmonary disease, kidney disease were at higherrisk of developing severe disease condition and death due to novel coronavirus infection.

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Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting

BMC Pediatrics ◽

10.1186/s12887-021-03015-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Osita Ezenwosu ◽

Barth Chukwu ◽

Ifeyinwa Ezenwosu ◽

Ndubuisi Uwaezuoke ◽

Christopher Eke ◽

...

Keyword(s):

Children And Adolescents ◽

Disease Severity ◽

Sickle Cell ◽

Educational Level ◽

Sickle Cell Anaemia ◽

Sampling Technique ◽

Resource Limited Setting ◽

Cross Sectional ◽

Resource Limited ◽

Limited Setting

Abstract Background Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting. Methods Systematic random sampling technique was used in this cross-sectional study to select children and adolescents aged 7–17 years at the weekly sickle cell clinic of the University of Nigeria Teaching hospital (UNTH) Enugu, Nigeria. Pretested, structured questionnaire was used to collect sociodemographic and disease severity data while depression was assessed using the Children’s Depression Inventory. Results Age and educational level had significant positive linear relationships with depression (r = 0.253, p = 0.02; r = 0.225, p = 0.04 respectively) while gender (χ2 = 0.531, p = 0.466), socioeconomic status (χ2 = 0.451, p = 0.798) and disease severity (χ2 = 0.422, p = 0.810) had no relationship with depression in children and adolescents with SCA. Conclusion Depression in children and adolescents with SCA increased with increasing age and educational level. Psychological evaluation should be integrated into routine assessment of children with SCA during their follow up visits as they get older and progress in class.

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Clinical features and disease severity in an Iranian population of COVID-19 patients

10.21203/rs.3.rs-51568/v1 ◽

2020 ◽

Author(s):

Shima Nabavi ◽

Zahra Javidarabshahi ◽

Abolghasem Allahyari ◽

Mohammad Ramezani ◽

Mohsen Seddigh-Shamsi ◽

...

Keyword(s):

Disease Severity ◽

Clinical Features ◽

Clinical Laboratory ◽

Severe Disease ◽

Cross Sectional Study ◽

Cross Sectional ◽

Reactive Protein ◽

Radiologic Findings ◽

Severity Of The Disease ◽

Lung Ct

Abstract Objectives: Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 patients with different severities.Methods: This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February-April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P<0.05 was considered statistically significant.Results: Overall, 200 patients with mean age of 69.75±6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P<0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities. O2 saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR=0.342, 45.93, and 25.48, respectively; P<0.05).Conclusions: Our results indicate O2 saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors as possible predictors of severe disease in COVID-19 patients.

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Prevalence of Peripheral Arterial Disease among Adult Patients Attending Outpatient Clinic at a General Hospital in South Angola

Scientifica ◽

10.1155/2016/2520973 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6

Author(s):

Feliciano Chanana Paquissi ◽

Arminda Bimbi Paquissi Cuvinje ◽

Almeida Bailundo Cuvinje

Keyword(s):

Peripheral Arterial Disease ◽

General Hospital ◽

Outpatient Clinic ◽

Statistical Significance ◽

Severe Disease ◽

Ankle Brachial Index ◽

Outpatient Service ◽

Arterial Disease ◽

Cross Sectional ◽

Peripheral Arterial

Background. Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis, whose prevalence is increasing worldwide, and is associated with all-cause mortality. However, no study has assessed this disease in Huambo. The aim of this study was to evaluate the prevalence of PAD in patients attending an outpatient clinic at a general hospital in Huambo, South Angola.Methods. A cross-sectional study, including 115 patients aged 40 years and older attending an outpatient service. The evaluation included a basic questionnaire for lifestyle and medical history and ankle-brachial index (ABI) measurement using hand-held Doppler. PAD was defined as an ABI ≤0.9 in either lower limb.Results. Of 115 patients, 62.60% were women with a median age of 52.5 (range of 40 to 91) years. The prevalence of PAD was 42.6% (95% confidence intervals [CI]: 95%: 33.91–52.17%). Among patients with PAD, 95.92% had mild disease and 4.08% moderate to severe disease. The main risk factor for PAD was age (≥60 years) (χ2=3.917,P≤0.05). The prevalence was slightly higher in men and hypertensive subjects, but without statistical significance with ORs of 1.5 (95% CI: 0.69–3.21) and 1.42 (95% CI: 0.64–3.17), respectively. Hypertension was also high in the group (66.95%).Conclusion. The prevalence of PAD was 42.6%, higher in those aged 60 years and older. More studies, with representative samples, are necessary to clarify PAD prevalence and associated risk factors.

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