Effect of Continuous Subcutaneous Injection of Insulin Analogues in Pregnant Women with Diabetes Mellitus Complicated with Ketoacidosis

Objective. To investigate the clinical effect of continuous subcutaneous injection of insulin analogues in pregnant women with diabetes mellitus complicated with ketoacidosis. Methods. A total of 92 pregnant patients with diabetes mellitus complicated with ketoacidosis from June 2014 to January 2021 were selected. All patients were randomly divided into an observation group and control group according to the method of random number. The control group received intravenous infusion of insulin, and the observation group received continuous subcutaneous infusion of quick-acting insulin analogues. The clinical effects of the two groups were observed. Results. The time needed to control blood glucose <13.8 mmol/L, the amount of insulin needed to control blood glucose <13.8 mmol/L, the time needed to correct DKA, and the amount of insulin needed to correct DKA in the observation group were significantly less than those in the control group ( P < 0.05 ). Compared with the control group, the average occurrence times of hypoglycemia, the length of stay, the total amount of insulin in hospital, and the total amount of insulin used during pregnancy in the observation group were significantly less than those in the control group ( P < 0.05 ). The values of SCr, CRP, BUN, arterial blood gas pH, and adiponectin in the two groups were significantly improved as compared with those before treatment, and the improvement in the observation group was significantly better than that in the control group ( P < 0.05 ). After treatment, the fasting blood glucose, 2-hour postprandial blood glucose, carbon dioxide binding capacity, and glycosylated hemoglobin in the experimental group were significantly better than those in the routine group, and the difference was statistically significant ( P < 0.05 ). Conclusion. Continuous subcutaneous injection of insulin analogues is effective in the treatment of diabetic patients with ketoacidosis, which can effectively improve blood glucose, carbon dioxide binding capacity, and glycosylated hemoglobin and accelerate the negative conversion of urinary ketone body. It is worth popularizing to reduce the occurrence of hypoglycemia and the dose of insulin and shorten the time of hospitalization.

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MENGENDALIKAN KADAR GLUKOSA DARAH PASIEN DIABETES MELITUS TIPE 2 DENGAN OLAH SEHAT LAFIDZI 21

Jurnal Riset Kesehatan Nasional ◽

10.37294/jrkn.v2i1.94 ◽

2018 ◽

Vol 2 (1) ◽

pp. 1

Author(s):

Sulastri S ◽

Tety Mulyati Arofi

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Blood Glucose ◽

Control Group ◽

Control Blood Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Quasi Experimental ◽

Diabetes Patients

Pendahuluan: Diabetes Mellitus merupakan suatu sindroma klinis kelainan metabolik yang ditandai oleh adanya hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Perawatan pasien Diabetes bertujuan mengendalikan kadar glukosa darah sehingga tidak menimbulkan komplikasi yang dapat mengganggu kehidupan normal pasien. Berbagai penatalaksanaan untuk mengendalikan kadar glukosa darah dapat dilakukan, di antaranya olah sehat Lafidzi 21. Penelitian ini bertujuan untuk mengetahui pengaruh Olah Sehat Lafidzi 21 terhadap kadar glukosa darah pasien Diabetes tipe 2 di Klub Diabetes Rumah Sakit Islam Jakarta Cempaka Putih. Metode: Penelitian ini merupakan penelitian kuantitatif dengan rancangan quasi-experimental dengan kelompok kontrol. Olah Sehat Lafidzi 21 dilakukan oleh penderita Diabetes setiap hari selama 14 hari. Hasil: penelitian menunjukkan penurunan kadar glukosa darah puasa yang signifikan pada kelompok intervensi setelah melakukan Olah Sehat Lafidzi 21 (p =0,00). Simpulan: Olah Sehat Lafidzi 21 mampu menurunkan kadar glukosa darah secara signifikan pada penderita diabetes tipe 2 di Diabetes Klub Jakarta Islamic Hospital Cempaka Putih. Kata kunci: Olah Sehat Lafidzi 21, kadar gula darah, diabetes mellitus tipe 2.AbstractIntroduction: Diabetes Mellitus is a clinical syndrome of metabolic abnormalities characterized by the presence of hyperglycemia that occurs due to insulin secretion abnormalities, insulin work or both. Treatment of Diabetes patients aims to control blood glucose levels so as not to cause complications that can interfere with the patient's normal life. Various management to control blood glucose levels can be done, including healthy Lafidzi 21. This study aims to determine the influence of Healthy Lafidzi 21 on blood glucose level of Type 2 Diabetes patients at Diabetes Club Jakarta Islamic Hospital Cempaka Putih. Methods: This was a quantitative study with a quasi-experimental design with a control group. Healthy Lafidzi 21 is done by diabetics every day for 14 days. Results: the study showed a significant decrease in fasting blood glucose levels in the intervention group after performing Healthy Lafidzi 21 (p = 0.00). Conclusion: Healthy Lafidzi 21 is able to lower blood glucose levels significantly in people with type 2 diabetes in Diabetes Club Jakarta Islamic Hospital Cempaka Putih. Keywords: Healthy Lafidzi 21, blood sugar level, diabetes mellitus type 2.

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Effect of the internet combined with exercise-based individualized nursing intervention in patients with gestational diabetes mellitus

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00738-0 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Yaer Chen ◽

Chunbo Qiu ◽

Jie Chen ◽

Lu Li ◽

Jichao Xu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnancy Outcomes ◽

Nursing Intervention ◽

Control Group ◽

Observation Group ◽

Nursing Satisfaction ◽

Adverse Pregnancy

Abstract Background Gestational diabetes mellitus (GDM) is the most frequent medical complication of pregnancy. This condition is manifested by glucose intolerance resulting in hyperglycemia of variable severity during pregnancy. One of the most important clinical tools for efficiently regulating maternal blood glucose is strictly monitoring blood glucose levels. However, due to a lack of appropriate intervention tools, managing the occurrence of GDM is still unfeasible. This study aimed to determine clinical efficacy of the internet combined with exercise-based individualized nursing intervention in patients with gestational diabetes mellitus (GDM). Methods In total, 139 patients with GDM were divided into two groups, with 79 patients in the observation group (internet combined with exercise-based individualized nursing intervention) and 60 patients in the control group (routine nursing intervention only). The two groups were given specified nursing intervention for 8 weeks and then compared for changes in their blood glucose, blood lipids, blood pressure, insulin resistance (IR), and rate of adverse pregnancy outcomes. Additionally, the psychological state was analyzed, and their nursing satisfaction with the care from nurses that they received was investigated before and after the nursing intervention. Results Compared with the control group, the following indices of the observation group were lowered: blood glucose-related indices (FBG and 2 h PG), blood lipids and blood pressure associated indices (TG, TC, and HbA1c, DBP, SBP, and MAP), and IR-related indices (FINS, 2 h INS, and HOMA -IR) (all P < 0.05). The observation group also showed a lower rate of adverse pregnancy outcomes than the control group (7.59% vs. 20.00%; P < 0.05). In addition, SAS and SDS scores of the observation group were both lower than the control group (P < 0.05). Accordingly, the nursing satisfaction score also displayed that the observation group (93.67%) had a higher satisfaction outcome than the control group (76.67%; P < 0.05). Conclusions Internet combined with exercise-based individualized nursing intervention in GDM patients can effectively improve their blood glucose, IR, and psychological status, thus significantly improving their pregnancy outcomes and mental condition.

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Oral hypoglycaemics for diabetes: when and which?

Drug and Therapeutics Bulletin ◽

10.1136/dtb.29.4.13 ◽

1991 ◽

Vol 29 (4) ◽

pp. 13-16

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Regular Exercise ◽

Control Blood Glucose ◽

District Policy ◽

Insulin Dependent ◽

Market Leader

People with non-insulin-dependent diabetes mellitus should modify their diet, avoid obesity and take regular exercise. An oral hypoglycaemic drug may be needed if these measures fail to control blood glucose, but it is now clear that they commonly cause hypoglycaemia. More than 3 million prescriptions were issued in 1988 for the sulphonylureas (eight currently available) and the biguanide, metformin. Glibenclamide is the market leader (1.4 million prescriptions in 1988), followed by metformin (950,000), chlorpropamide (280,000), tolbutamide (260,000) and gliclazide (200,000). Instituting a district policy to restrict the choice of sulphonylureas can improve care and save money.1 No new oral hypoglycaemics have been marketed since we last reviewed them2 but their place in overall management has been clarified.

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Influence of Nutrition Education with Calendar Method in Diabetic Patients' Blood Glucose

NurseLine Journal ◽

10.19184/nlj.v3i2.6627 ◽

2018 ◽

Vol 3 (2) ◽

pp. 72

Author(s):

Setyoadi Setyoadi ◽

Heri Kristianto ◽

Siti Nur Afifah

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Nutrition Education ◽

Community Health Center ◽

Control Group ◽

P Value ◽

Diabetic Patients ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Before And After

Diabetes mellitus is a disease that required good self-management. Noncompliance in diet and meal plans cause the instability of blood glucose levels. Nutrition education calendar method can improve knowledge and ability to consume food that matches the number, hours and types with dietary adjustments listed in the calendar diet. This study aimed to determine the effect of nutrition education calendar method on blood glucose levels of patients with type 2 diabetes mellitus in Community Health Center Pakis Malang. Pre-experimental design one group pretest-posttest with purposive sampling was conducted in this study and sample obtained as many as 21 people. Blood glucose levels were measured before and after the nutrition education calendar methods. Compliance in using calendar method with the observation sheet. Statistical analysis values obtained by Wilcoxon, the p-value of 0.007 (p <0.05). The results of the analysis, 16 respondents showed a decrease in blood glucose levels and 5 respondents experienced an increase in blood glucose levels after the given intervention. It can be concluded that there are differences between blood glucose levels before and after nutrition education calendar method. Differences in blood glucose levels can be influenced by controlling diet respondent in accordance with the calendar method in education, but also antidiabetic drugs, and sports. Should be added to the control group to determine objectively the effect of nutrition education on the calendar method.

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Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia

10.21203/rs.2.20116/v2 ◽

2020 ◽

Author(s):

Xiaomeng Sun ◽

Jia Liu ◽

Guang Wang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Treatment Group ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Control Group ◽

Diabetic Patients ◽

Fenofibrate Treatment

Abstract Background: This study was to research the efficacy of fenofibrate in the treatment of microalbuminuria in the patients with type 2 diabetes mellitus (T2DM) and hypertriglyceridemia. Methods: Type 2 diabetic patients (56) with microalbuminuria and hypertriglyceridemia aged 30 to 75 were randomly divided into the fenofibrate treatment group(n=28) and the control group (n=28) for 180 days. Urinary microalbumin /creatinine ratio (UACR) and other metabolic parameters were compared at baseline, during treatment and after treatment. Results: After 180 days, the reduction of levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in two groups were no differences. In treatment group, uric acid (UA) (296.42 ± 56.41 vs 372.46 ± 72.78), triglyceride (TG) [1.51(1.17, 2.06) vs 3.04(2.21, 3.29)], and UACR [36.45 (15.78,102.41) vs 129.00 (53.00, 226.25)] were significantly decreased compared with the baseline. The high-density lipoprotein cholesterol (HDL-C) levels were significantly increased (1.22 ± 0.26 vs 1.09 ± 0.24) compared with the baseline. The decrease in UACR [-44.05(-179.47, -12.16) vs -8.15(-59.69, 41.94)]in treatment group was significantly higher compared with the control group. The decrease in UACR was positively associated with the decreases in TG ( r = 0.447, P = 0.042) and UA ( r = 0.478, P = 0.024) after fenofibrate treatment. Conclusion: In the patients with hypertriglyceridemia and type 2 diabetes mellitus, fenofibrate can improve microalbuminuria and do not increase the deterioration of glomerular filtration rate

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Effectiveness of Motivational Interviewing on Self-Management of Type 2 Diabetes Mellitus Patients: A Systematic Review

Jurnal Kedokteran Brawijaya ◽

10.21776/ub.jkb.2021.031.04.11 ◽

2021 ◽

Vol 31 (4) ◽

pp. 11

Author(s):

Siska Puji Lestari ◽

Titin Andri Wihastuti ◽

Dina Dewi Sartika Lestari Ismail

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Blood Glucose ◽

Motivational Interviewing ◽

Self Management ◽

Dietary Compliance ◽

Control Blood Glucose ◽

Counseling Technique ◽

Dm Type 2

<p>Diabetes mellitus is a health problem that will affect the health status of patients. Motivational interviewing a counseling technique focusing on clients and it is designed for helping individuals explore and accomplish ambivalence in behavior. This systematic review aimed at describing effectiveness motivationaI interviewing on self-management of diabetes mellitus type 2 patients. There are 1359 articles of 526 ScienceDirect articles, 422 ProQuest, 290 PubMed, and 121 Ebsco articles. The systematic review method began by identifying 20 articles from four electronic databases for previous studies that were published during 2011-2021. The results of the systematic review obtained that motivational interviewing can provide improved self-management and control blood glucose DM type 2 patients. The conclusion motivational interviewing can affect the patient's self-management especially on blood glucose profile, dietary compliance, quality of life, self-efficacy, HbA1c levels of DM type 2 patients.</p>

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SUPERFICIAL CANDIDOSIS COURSE IN PATIENTS WITH CARBOHYDRATE METABOLISM DISORDER AND DIABETES MELLITUS

Wiadomości Lekarskie ◽

10.36740/wlek201901113 ◽

2019 ◽

Vol 72 (1) ◽

pp. 68-71

Author(s):

Оrysya О. Syzon ◽

Solomiya A. Turkevych ◽

Tetyana I. Rudnyk ◽

Svitlana V. Volbyn ◽

Marianna O. Dashko

Keyword(s):

Diabetes Mellitus ◽

Carbohydrate Metabolism ◽

Glucose Tolerance Test ◽

Glycosylated Hemoglobin ◽

Tolerance Test ◽

Control Group ◽

Clinical Tests ◽

Metabolism Disorder ◽

Mucous Membranes ◽

Reliable Detection

Introduction: One of the pressing issues of modern dermatology is the prevalence of diseases of skin and mucous membranes caused by yeast-like fungi. The aim: To study specific features of the course of skin and mucous membranes superficial candidosis against the background of initial carbohydrate metabolism disorders or diabetes mellitus. Materials and methods: We have examined 93 patients aged 18-75 suffering from superficial candidosis. Candidosis was diagnosed based on anamnesis data, results of clinical tests and laboratory studies. The study of carbohydrate metabolism included determining of the glucose level under fasting conditions to establish possible diabetes mellitus and glucose tolerance test (75 g glucose load), glycosylated hemoglobin (HbA1c) and fructosamine (FR). Results: In patients with mild and moderate candidosis we have detected an increased rates of НbA1с and fructosamine, as compared with the like indicators received in the control group, by 1.54 and 1.21 times respectively. In patients with severe candidosis and relapses the concentrations of НbA1с increased by 2.59 times, FR – by 2.26 times against the indicators received in the control group. Thus, increased levels of blood glycosylated protein indicate the pathogenetic importance of these processes in the development of candidosis. Conclusions: Consequently, increased levels of blood glycosylated protein indicates the pathogenetic importance of these processes in the development of candidal lesions. Tests for НbA1с and FR proved to be sensitive and allow reliable detection of individuals with diabetes mellitus and glucose intolerance among candidosis patients.

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Glucose levels during gestational diabetes pregnancy and the risk of developing postpartum diabetes or prediabetes

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-04352-w ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Chadakarn Phaloprakarn ◽

Siriwan Tangjitgamol

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Glycemic Control ◽

Gestational Diabetes ◽

Confidence Interval ◽

Control Group ◽

Oral Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

The Impact

Abstract Background Blood glucose levels during pregnancy may reflect the severity of insulin secretory defects and/or insulin resistance during gestational diabetes mellitus (GDM) pregnancy. We hypothesized that suboptimal glycemic control in women with GDM could increase the risk of postpartum type 2 diabetes mellitus (T2DM) or prediabetes. Our objective was to evaluate the impact of plasma glucose levels throughout GDM pregnancy on the risk of postpartum T2DM or prediabetes. Methods The medical records of 706 women with GDM who underwent a postpartum 75-g, 2-hour oral glucose tolerance test at our institution between January 2011 and December 2018 were reviewed. These women were classified into 2 groups according to glycemic control during pregnancy: ≤ 1 occasion of either fasting glucose ≥ 95 mg/dL or 2-hour postprandial glucose ≥ 120 mg/dL was defined as optimal glycemic control or else was classified as suboptimal glycemic control. Rates of postpartum T2DM and prediabetes were compared between women with optimal (n = 505) and suboptimal (n = 201) glycemic control. Results The rates of postpartum T2DM and prediabetes were significantly higher in the suboptimal glycemic control group than in the optimal glycemic control group: 22.4% vs. 3.0%, P < 0.001 for T2DM and 45.3% vs. 23.5%, P < 0.001 for prediabetes. In a multivariate analysis, suboptimal glucose control during pregnancy was an independent risk factor for developing either postpartum T2DM or prediabetes. The adjusted odds ratios were 8.4 (95% confidence interval, 3.5–20.3) for T2DM and 3.9 (95% confidence interval, 2.5–6.1) for prediabetes. Conclusion Our findings suggest that blood glucose levels during GDM pregnancy have an impact on the risk of postpartum T2DM and prediabetes.

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Effects of Marine Drug Propylene Glycol Alginate Sodium Sulfate on Glucose and Lipid Metabolism in Mice

Materiale Plastice ◽

10.37358/mp.21.2.5486 ◽

2021 ◽

Vol 58 (2) ◽

pp. 150-154

Author(s):

Haiyue Liang ◽

Qun Liu ◽

Yonghong Xiu

Keyword(s):

Lipid Metabolism ◽

Blood Glucose ◽

Sodium Sulfate ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Control Group ◽

Distilled Water ◽

Glucose And Lipid Metabolism ◽

Propylene Glycol Alginate

Previous studies have shown that marine drug propylene glycol alginate sodium sulfate (PSS) plays important roles in human diseases. This study mainly explored the effects of PSS on hyperglycemia and hyperlipidemia in diabetic db/db mouse models. The db/db mice were randomly divided into 5 groups (n=12), which were model control group (distilled water), positive control group (metformin), PSS low, medium, and high dose groups (PSS25, PSS50, PSS100) and normal control group (C57/BL, distilled water). The mice in each group had free diet and water for 90 days. During the experiment, food intake was recorded every day and body weight was recorded weekly. In addition, fasting blood glucose and glycosylated hemoglobin levels were measured regularly. Finally, the contents of triglyceride (TG), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c) and total cholesterol (TC) in the serum of mice were determined. PSS can significantly reduce fasting blood glucose and glycosylated hemoglobin levels in db/db mice, and improve insulin sensitivity. Moreover, PSS can reduce the fat accumulation of db/db mice and significantly improve the blood lipid level of db/db mice. PSS can significantly improve the symptoms of glucose and lipid metabolism disorders in db/db mice.

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Insulin Glargine and Acarbose in the treatment of elderly patients with diabetes

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.3.86 ◽

2019 ◽

Vol 35 (3) ◽

Author(s):

Jing Li ◽

Jinzhi Ji ◽

Fuyan Liu ◽

Lingling Wang

Keyword(s):

Quality Of Life ◽

Blood Glucose ◽

Elderly Patients ◽

Insulin Glargine ◽

Adverse Reactions ◽

Postprandial Blood Glucose ◽

Control Group ◽

Observation Group ◽

Patients With Diabetes

Objective: To investigate the clinical efficacy of insulin glargine combined with acarbose in the treatment of elderly patients with diabetes. Methods: One hundred and forty-four elderly patients with diabetes who received treatment between December 2016 and December 2017 in Binzhou People’s Hospital, China, were selected and divided into a control group and an observation group, 72 each, using random number table. The control group was treated with insulin glargine, while the observation group was treated with insulin glargine combined with acarbose. The therapeutic effect, improvement of quality of life and adverse reactions were compared between the two groups. Results: After treatment, fasting blood glucose (FBG), 2h postprandial blood glucose (PBG) and glycosylated hemoglobin (Hb Alc) of the two groups were lower than those before treatment, and the decrease degree of the observation group was significantly larger than that of the control group (P<0.05). The time needed for blood glucose reaching the standard level and daily insulin dosage of the observation group were significantly lower than that of the control group, and the differences were statistically significant (P<0.05). SF-36 scale score of the observation group was significantly better than the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of insulin Glargine and Acarbose can significantly control the blood glucose level of elderly patients with diabetes, improve the biochemical indicators, and enhance the quality of life. It is worth promotion in clinical practice. doi: https://doi.org/10.12669/pjms.35.3.86 How to cite this:Li J, Ji J, Liu F, Wang L. Insulin Glargine and Acarbose in the treatment of elderly patients with diabetes. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.86 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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