scholarly journals Isotretinoin in Acne Vulgaris Complicated by Underlying Major Depression: A Case Report and Review of Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Matthew DeLuca ◽  
Maxsaya Baez Nuñez ◽  
Ezequiel Rodriguez ◽  
Krishan Chirimunj

We relay the case of a teenage female with severe facial acne vulgaris and a past psychiatric history of major depressive disorder who presented to the emergency department with a primary complaint of ongoing suicidal ideation. Defining features of this case stem from the patient endorsing that her suicidal ideation was a result of her severe acne and the coinciding social perturbation it caused. Additionally, the patient reported that just four months prior to the current presentation, her dermatologist started her on isotretinoin therapy for the management of acne vulgaris. To the best of the authors’ knowledge, there have been no reported cases which describe a teenage female presenting with active suicidal ideation secondary to severe acne vulgaris while concurrently undergoing treatment with isotretinoin. Given the controversial but reported association between isotretinoin and increased suicidality, we considered the appropriateness of continuing this medication for our patient. We then conducted a literature search evaluating the evidence concerning this association. In what follows, we present a unique case report and provide a thorough review of the evidence—or lack thereof—surrounding the relationship between isotretinoin and suicidality. Additionally, the authors aim to provide recommendations for the management of future patients who may present under similar circumstances.

CNS Spectrums ◽  
2007 ◽  
Vol 12 (7) ◽  
pp. 553-556 ◽  
Author(s):  
Alzbeta Juven Wetzler ◽  
Rachela Elias ◽  
Leah Fostick ◽  
Joseph Zohar

ABSTRACTThis case report illustrates the relationship between stress and obsessive-compulsive disorder (OCD) by describing an unusual case of OCD sequelae following a suicide attempt. The patient is a 29-year-old married woman who suffered a major depressive episode without OCD and tried to commit suicide by drinking household cleaner. Following the attempt, violent obsessive thoughts of harming herself and others emerged along with avoidance behavior. After exposure therapy, there was a decrease in her obsessive thoughts, less anxiety, and no avoidance behavior. This report highlights not only the existence of “posttraumatic obsession” but also the importance of accurate interpretation of suicidal preoccupation, leading to the diagnosis of OCD rather then suicidal ideation secondary to depression.


2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Godwin Tong ◽  
Kieran Groom ◽  
Louisa Ward ◽  
Muhammad Naeem

Dissociation is a disconnection between a person’s thoughts, memories, feelings, actions, or sense of who he or she is. Dissociative disorders can be described and understood using the combination of five core symptoms: amnesia, depersonalisation, derealisation, identity confusion, or identity alteration. They are frequently associated with previous experience of trauma. The challenge in diagnosis and the lifetime prevalence of approximately 10% in the general population and clinical psychiatric setting ensures the relevance of this case. We write about a 21-year-old gentleman with history of autism and obsessive compulsive disorder, but no significant medical history was presented to the emergency department with increased anxiety, subsequently progressing to agitation, pacing, and becoming nonverbal. No significant findings were uncovered on laboratory blood testing (other than prolactin 737 mu/L and phosphate 0.35 mmol/L), lumbar puncture, or brain imaging. Consequently, he was admitted to a psychiatric unit for assessment. The patient continued to present with severe disorientation, limited speech, and altered state of consciousness with occasional spastic-like movements. Antipsychotic and benzodiazepine medication was initiated, with no significant change in presentation. The patient continued to be witnessed wandering and having incoherent speech. First signs of improvement came 21 days postadmission with brief conversation and lucidity. This continued to improve over the next 7 days where he was reported to be at his baseline mental state. Environmental stressors including university examinations, the COVID-19 pandemic, and recent contact with his estranged father were possible precipitants to the episode. The patient reported almost complete unawareness of the psychiatric admission. A diagnosis of dissociative disorder, unspecified, was given. This case shows the management and diagnostic challenges of patients presenting with the aforementioned symptoms. There are no formal guidelines for the management of treating dissociative episodes, and this case report suggests the possible benefits of a drug-free period of watchful waiting upon admission.


e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Fifin R. T. Sole ◽  
Pieter L. Suling ◽  
Tara S. Kairupan

Abstract: Acne vulgaris is a chronic skin condition involving inflammation of the pilosebaceous follicle. The highest prevalence of acne vulgaris is at the age of 16-17 years. Pathogenic factors contributing to the development of acne vulgaris include increased sebum production, pilosebaceous follicular blockage, and increased colonization of Propionibacterium acnes. Personal hygiene is suggested as an important factor that needs to be maintained in acne prevention. Males tend to lack of awareness to seek information and health services in dealing with acne problems. This study was aimed to evaluate the relationship between facial washing and the incidence of acne vulgaris in adolescent males in Manado. This was an analytical and observational study using a cross-sectional design. Subjects were male students of 3rd grade at SMA Negeri 9 Manado, aged 16-19 years old, and met the inclusion and exclusion criteria, with a total number of 95 students. Subjects who washed their faces 2-3 times a day were 38 students (40%) while those who washed their faces less than twice or more than thrice a day were 57 students (60%). Subjects with no or mild acne vulgaris were 39 students (41.1%), while those with moderate to severe acne vulgaris were 56 students (58.9%). The chi-square showed a p-value of 0.004 for the relationship between the frequency of facial washing and the incidence of acne vulgaris. In conclusion, there was a significant relationship between facial washing and the incidence of acne vulgaris in adolescent males in Manado.Keywords: facial washing, acne vulgaris Abstrak: Akne vulgaris merupakan peradangan kronis folikel pilosebasea dengan prevalensi tertinggi pada usia 16-17 tahun. Faktor yang memengaruhi terjadinya akne vulgaris antara lain peningkatan produksi sebum, penyumbatan folikel pilosebasea, dan peningkatan kolonisasi bakteri Propionibacterium acnes. Kebersihan diri merupakan faktor penting yang perlu dijaga sebagai salah satu usaha untuk mencegah timbulnya akne. Laki-laki cenderung kurang memiliki kesadaran untuk mencari informasi dan pelayanan kesehatan dalam menangani masalah akne. Penelitian ini bertujuan untuk menilai hubungan antara mencuci wajah dengan kejadian akne vulgaris pada remaja laki-laki di Manado. Jenis penelitian ialah observasional analitik dengan desain potong lintang. Subjek penelitian ialah siswa laki-laki kelas 3 di SMA Negeri 9 Manado, usia 16-19 tahun, dan memenuhi kriteria inklusi dan eksklusi, dengan jumlah total 95 siswa. Subjek yang mencuci wajah 2-3 kali sehari sebanyak 38 siswa (40%) sedangkan yang mencuci wajah kurang dari 2 kali atau lebih dari 3 kali sehari sebanyak 57 siswa (60%). Subjek tanpa akne vulgaris atau akne derajat ringan sebanyak 39 siswa (41,1%) sedangkan yang dengan akne vulgaris derajat sedang sampai berat sebanyak 56 siswa (58,9%). Uji chi-square memperlihatkan nilai p=0.004 terhadap hubungan antara frekuensi mencuci wajah dengan kejadian akne vulgaris. Simpulan penelitian ini ialah terdapat hubungan bermakna antara mencuci wajah dengan kejadian akne vulgaris pada remaja laki-laki di Manado.Kata kunci: mencuci wajah, akne vulgaris


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Juan Chen ◽  
Na Meng ◽  
Bingrong Cao ◽  
Yinghua Ye ◽  
Ying Ou ◽  
...  

Abstract Background Restless arms syndrome (RAS) is characterized by uncomfortable aching or burning sensations in the arms. RAS is regarded as an upper limb variant of restless legs syndrome (RLS). The lack of specific diagnostic criteria makes it difficult to recognize the RAS. Therefore, RAS is usually neglected in clinical practice. Moreover, when a patient was diagnosed with RAS, the adjustment of medications was the first choice for doctors, which may make the patient’s condition unstable. Case presentation A 33-year-old woman was diagnosed with schizophrenia and major depressive disorder. Starting with 0.6 g/d amisulpride, 0.1 g/d quetiapine, 75 mg/d venlafaxine sustained-release tablets, the patient reported symptoms of RAS (itching arms) on the fourth day since the latest hospitalization. After ruling out other factors, her RAS was suspected to be induced by antidepressants or antipsychotics. Without medication adjustment, RAS spontaneously remitted. Conclusions This case suggests that psychiatrists should pay attention to RAS when using antipsychotics and/or antidepressants. Moreover, RAS may be transitory. When a patient manifests RAS, observation may be one choice instead of an immediate medication adjustment.


Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Jinhui Joo ◽  
Seungyoung Hwang ◽  
Joseph J. Gallo

Abstract. Background: Suicide is strongly associated with depression, but many without depression have thoughts of death. Aims: To characterize persons who did not meet criteria for depressive illness but endorsed death ideation or suicidal ideation over the course of a 10-year follow-up. Method: Subjects included 753 participants of the Baltimore sample of the Epidemiologic Catchment Area Program, a population-based 10-year follow-up survey, who neither met criteria for major depressive disorder nor reported death or suicidal ideation in 1994. Results: Persons with death ideation or suicidal ideation in 2004 were generally distressed as measured by the General Health Questionnaire. At baseline, both groups endorsed difficulty with concentration, feeling unhappy, and taking things hard. Functional problems such as social withdrawal were endorsed by both groups. Those with suicidal ideation had a longer lifetime history of social phobia. Persons with death ideation did not use more health services but sought help from persons in their social network. Conclusion: Thoughts of death are associated with distress even in persons who do not have depressive illness. This group of persons may have subclinical depressive symptoms that will not be detected by depression screening. Detection of these persons will require broadening our concept of persons at risk.


Author(s):  
Rajesh Hadia ◽  
Idrisi Mohammed Tousif ◽  
Avani Kapadia ◽  
Suchitra Pillai ◽  
Hemraj Singh Rajput ◽  
...  

Background: Acne vulgaris remains one of the commonest diseases to afflict humanity, with over 90% of males and 80% of females affected by the age of 21 years. Objectives: The aim of this study was to assessing the specific risk factors, determine the epidemiology and etiology of Acne Vulgaris. Methodology: It is a cross-sectional observational study conducted for a period of six month in the department of dermatology, Dhiraj General Hospital, Vadodara. Patients who were diagnosed with acne vulgaris and fulfilled the inclusion criteria were enrolled in the study. Data was collected by filling the patient medical record sheet. Result: Total 300 patients were included in the study. Out of which 38.67% males and 61.33% females were found affected by Acne Vulgaris. The mean age group affected were found to be 21.77±4.06 years. When compared their social habits, patients consumed more caffeine (49.67%) than alcohol (24.67%), smoking (15.33%) and tobacco (5.67%). 32.33% patients also had history of seborrheic dermatitis. Using GAGS scale, we found 94% patients suffered from moderate Acne condition while 6% suffered from severe Acne condition. Conclusion: Acne Vulgaris was predominantly found in females in adolescence and in males in adulthood. The severity was found more in males than females. The common site for Acne Vulgaris was found to be face while comedones and papules were the common types of lesions. Stress was found to be one of the major aggravating factors for severity of Acne Vulgaris.


2022 ◽  
Vol 4 ◽  
pp. 133-141
Author(s):  
Bipin Sohanraj Jain ◽  
Akshata Damodar Nayak

Chronic relapsing pancreatitis in the paediatric age group is a challenging case, especially when presenting in its acute exacerbation. This case report highlights the management of chronic relapsing pancreatitis in a 9-year-old female patient with homoeopathic treatment. The patient reported a year-long history of recurrent fever, abdominal pain, and raising titres of lipase and amylase; she had been admitted to a higher centre twice. The totality was constructed on day 1 and a homoeopathic remedy was prescribed. Detailed case taking, done after a week, confirmed the same remedy. Later, when the patient had an acute exacerbation, the same remedy-frequently repeated, helped settle the acute episode in a couple of days. The patient has been following up regularly for 3 years; the frequency and intensity of relapses reduced considerably over time and there have been no episodes for more than a year.


Author(s):  
Bose Surajit ◽  
Bhakta Ipsita ◽  
Karar Chandan Kumar ◽  
Singh Dharvind Kumar ◽  
Banerjee Abhishek

The separation of the follicle from around the crown of an unerupted tooth causes formation of dentigerous cyst. It may undergo metaplasia in several cases. In this case a 30 year old female patient reported with a history of dentigerous cyst with respect to impacted 48. The swelling started growing gradually causing facial asymmetry. On intraoral examination the swelling seem to extend from 48 to 46 region and cortical plates were expanded. The histopathological examination revealed the sample to be cystic ameloblastoma (mural variety). This paper sends a message that the potential of a cyst should never be understated, instead it must be kept in an observation or understanding the biological behavior over a course of time.


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