c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas

2016 ◽  
Vol 61 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Archana George Vallonthaiel ◽  
Deepali Jain ◽  
Varsha Singh ◽  
Kavneet Kaur ◽  
Karan Madan ◽  
...  
Keyword(s):  
Lower Respiratory Tract ◽  
Fusion Transcript ◽  
Clinicopathological Parameters ◽  
The Novel ◽  
Diagnostic Biomarker ◽  
Male Predominance ◽  
Adenoid Cystic ◽  
Three Samples ◽  
The Mean ◽  
Myb Protein

Aims: Adenoid cystic carcinoma (AdCC) is a malignant epithelial neoplasm that occurs rarely in the lower respiratory tract (LRT). AdCC at various sites is associated with the novel fusion transcript MYB-NFIB, along with the overexpression of the Myb protein. The expression of the Myb protein in AdCC of the LRT has not been evaluated much. Study Design: Cases of AdCC of the LRT diagnosed on cytology or histology were retrieved from our institutional archives. c-Myb expression was analyzed on immunocytochemistry/immunohistochemistry (ICC/IHC) and was correlated with clinicopathological parameters. Results: Twenty-three samples of AdCC originating from the LRT were included in the study. Four cases were diagnosed on cytology, 3 of which had corresponding histology specimens. The remaining 19 cases had either biopsy or resection. Most of the patients presented with endobronchial mass. The mean age was 49.4 years and a male predominance was seen. ICC and IHC for c-Myb showed positivity in 75 and 59% of the cases, respectively. Western blot was used to validate IHC results. Conclusion: AdCC of the LRT is rare and hence poses diagnostic difficulty. Cytology smears can be utilized for c-Myb ICC. The presence of c-Myb immunopositivity in most cases may possibly make Myb a diagnostic biomarker and a therapeutic target for personalized treatment.

Application of Novel Low Current OBIRCH Amplifier and Nanoprobing to Identify Subtle Leakages in Advanced Node Technologies

2018 ◽  
Author(s):  
Satish Kodali ◽  
Liangshan Chen ◽  
Yuting Wei ◽  
Tanya Schaeffer ◽  
Chong Khiam Oh
Keyword(s):  
Signal To Noise Ratio ◽  
Semiconductor Industry ◽  
Fault Isolation ◽  
Ring Oscillator ◽  
High Signal ◽  
The Novel ◽  
Resistance Change ◽  
Three Samples ◽  
Relative Threshold ◽  
First Time

Abstract Optical beam induced resistance change (OBIRCH) is a very well-adapted technique for static fault isolation in the semiconductor industry. Novel low current OBIRCH amplifier is used to facilitate safe test condition requirements for advanced nodes. This paper shows the differences between the earlier and novel generation OBIRCH amplifiers. Ring oscillator high standby leakage samples are analyzed using the novel generation amplifier. High signal to noise ratio at applied low bias and current levels on device under test are shown on various samples. Further, a metric to demonstrate the SNR to device performance is also discussed. OBIRCH analysis is performed on all the three samples for nanoprobing of, and physical characterization on, the leakage. The resulting spots were calibrated and classified. It is noted that the calibration metric can be successfully used for the first time to estimate the relative threshold voltage of individual transistors in advanced process nodes.

STRUKTUR NARASI NOVEL CA BAU KAN, KARYA REMY SYLADO ANALISIS SEMIOTIK

2017 ◽  
Vol 4 (1) ◽  
pp. 70
Author(s):  
Sri Sabakti
Keyword(s):  
Narrative Structure ◽  
Literary Analysis ◽  
The Novel ◽  
Basic Scheme ◽  
Library Research ◽  
The Mean

This research is aimed to expose the narrative structure of the novel Ca Bau Kan by using semiotical theory. The source of the data is the novel Ca Bau kan written by Remy Silado and published by KPG, eight edition, 2004. The data is collected by doing the library research. The teory applied in this research is the emiotical theory, especially the literary analysis of Subur Laksono Wardoyo that the analysis of the text of prose can be applied by using three fases; the analysis of the basic scheme narrative, the analysis of mean signifier, and the analysis of syntagmatics and pragmatics. The result of this research showed that the narrative structure in the novel CBK that (1) the life of Tinung before being a ca bau kan, (2) the life of Tinung as a ca bau kan, and (3) the life of Tinung after not being a ca bau kan anymore. Based on the narrative structure, it was found that “ Love is only one. No measurement is needed” is the mean signifier and able to be clarified by the analysis of syntagmatics-paradigmatics based on the biner oposition of weak x strong.AbstrakPenelitian ini bertujuan mengungkapkan stuktur narasi dalam novel Ca Bau Kan (CBK) dengan menggunakan teori semiotika. Penelitian ini menggunakan sumber data novel CBK karya Remy Silado yang diterbitkan oleh KPG, cetakan kedelapan tahun 2004. Pengumpulan data dilaksanakan dengan teknik kepustakaan. Teori yang digunakan dalam penelitian ini adalah teori semiotika, khususnya analisis sastra menurut Subur Laksono Wardoyo bahwa analisis teks prosa dapat dilakukan melalui tiga tahap, yaitu: analisis skema naratif dasar, analisis signifier utama, dan analisis sintagmatik-paradigmatik. Hasil penelitian menggambarkan bahwa struktur narasi pada novel CBK adalah sebagai berikut: 1) kehidupan Tinung sebelum menjadi ca bau kan, 2) kehidupan Tinung sebagai ca bau kan, dan 3) kehidupan Tinung setelah tidak menjadi ca bau kan. Berdasarkan struktur narasi, maka didapatkan bahwa “Cinta cuma satu, kagak perlu takaran” merupakan penanda utama dan dapat diperjelas melalui analisis sintagmatik-paradigmatik yang didasarkan atas sebuah oposisi biner lemah x kuat.

scholarly journals Novel Radiographic Indexes for Elbow Stability Assessment: Part B—Preliminary Clinical Study

2021 ◽  
Author(s):  
Francesco Luceri ◽  
Davide Cucchi ◽  
Enrico Rosagrata ◽  
Carlo Eugenio Zaolino ◽  
Alessandra Menon ◽  
...  
Keyword(s):  
Case Series ◽  
Radiographic Evaluation ◽  
Healthy Population ◽  
X Rays ◽  
The Novel ◽  
Level Of Evidence ◽  
Orthopaedic Surgeons ◽  
Joint Congruency ◽  
Radiological Parameters ◽  
The Mean

Abstract Introduction The coronoid process plays a key-role in preserving elbow stability. Currently, there are no radiographic indexes conceived to assess the intrinsic elbow stability and the joint congruency. The aim of this study is to present new radiological parameters, which will help assess the intrinsic stability of the ulnohumeral joint and to define normal values of these indexes in a normal, healthy population. Methods Four independent observers (two orthopaedic surgeons and two radiologists) selected lateral view X-rays of subjects with no history of upper limb disease or surgery. The following radiographic indexes were defined: trochlear depth index (TDI); anterior coverage index (ACI); posterior coverage index (PCI); olecranon–coronoid angle (OCA); radiographic coverage angle (RCA). Inter-observer and intra-observer reproducibility were assessed for each index. Results 126 subjects were included. Standardized lateral elbow radiographs (62 left and 64 right elbows) were obtained and analysed. The mean TDI was 0.46 ± 0.06 (0.3–1.6), the mean ACI was 2.0 ± 0.2 (1.6–3.1) and the mean PCI was 1.3 ± 0.1 (1.0–1.9). The mean RCA was 179.6 ± 8.3° (normalized RCA: 49.9 ± 2.3%) and the mean OCA was 24.6 ± 3.7°. The indexes had a high-grade of inter-observer and intra-observer reliability for each of the four observers. Significantly higher values were found for males for TDI, ACI, PCI and RCA. Conclusion The novel radiological parameters described are simple, reliable and easily reproducible. These features make them a promising tool for radiographic evaluation both for orthopaedic surgeons and for radiologists in the emergency department setting or during outpatient services. Level of evidence Basic Science Study (Case Series). Clinical relevance The novel radiological parameters described are reliable, easily reproducible and become handy for orthopaedic surgeons as well as radiologists in daily clinical practice.

scholarly journals POS1018 IMPORTANCE OF LATERAL SPINE VIEW IN DXA BONE DENSITOMETRY IN PATIENTS WITH SPONDYLOARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 776.3-777
Author(s):  
S. Miri ◽  
H. Ferjani ◽  
K. Maatallah ◽  
A. Kasraoui ◽  
D. Kaffel ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Structural Changes ◽  
Age Of Onset ◽  
Posterior Part ◽  
Lateral View ◽  
Mineral Density ◽  
Lateral Spine ◽  
Male Predominance ◽  
T Score ◽  
The Mean

Background:Osteoporosis is an increasingly important health problem among patients with spondyloarthritis (SPA). The Measure of Bone Mineral Density BMD is routinely carried out in an anteroposterior (AP) view of the spine. However, the syndesmophytes, ligaments calcifications, and the posterior part of vertebrae affect AP scanning. A lateral spine view is a more sensitive tool in assessing bone loss in trabecular bone.Objectives:We aimed to evaluate the association between lateral lumbar DXA and syndesmophyte grading in patients with SPA.Methods:We conducted a retrospective study including 75 patients with SPA. Bone density of the hip and lumbar spine was measured with a GE Lunar Prodigy Advance Bone Densitometer equipment. All patients had lumbar lateral, AP, and proximal femur DXA scans. The T-score, which measures the difference between a patient’s BMD and young-normal subjects, was computed and age-matched.Results:The mean age of the patients was 36±11 years. Male predominance was noted with a sex ratio of 4.76. The mean BMI was 25±5 kg/m2. Eight percent were obese. Fifty-two percent had Vitamin D deficiency.Forty-eight percent of the patients had axial SPA, while 52% had axial and peripheral symptoms.The mean age of onset was 27±7 years. Fifty-two percent of the patients had high inflammatory biomarkers. The BASDAI, ASDAS-VS, and ASDAS-CRP mean levels were respectively: 3.5±2.4, 3.1±0.9, and 3±0.8. The mean BASRI and mass were respectively 8 + 4.8 and 16.4 + 19.4. Analyses of T-score values obtained over the femoral neck revealed osteoporosis in 18.7% of the cases and osteopenia in 32% of the cases. On the other hand, analyses of AP, spine views revealed osteoporosis in 25.3% and osteopenia in 45.3% of patients (p=0.028, r=0.254). We detected the highest percentage of osteoporosis in lateral lumbar view and T-scores matched more closely with femoral neck values; osteoporosis in 29.3%, and osteopenia in 22.7% of the patients (p<10-3, r=0.562). BMD measured in AP, and lateral views were in good agreement (p<10-3, p=0.592). Age was inversely but not significantly associated with BMD in lateral (p=0.442, r=-0.09), AP (p=0.319, r=-0.117) and femoral neck projections (p=0.179, r=-0.157). Femoral neck BMD was associated with the activity of SPA (ASDAS vs (p=0.027, r= -0.295), and the mobility limitation BASMI (p=0.032, r= -0.247). Coxitis, BASRI, or mSASS were independent of BMD.Conclusion:We conclude that spine lateral view in DXA accurately measures BMD exceeding the AP spine views and femoral neck values. Therefore, structural changes do not affect this measurementDisclosure of Interests:None declared.

An Examination of Language Samples Obtained under Three Experimental Conditions

1982 ◽  
Vol 13 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Louise D. Stalnaker ◽  
Nancy A. Creaghead
Keyword(s):  
Preschool Children ◽  
Head Start ◽  
Experimental Conditions ◽  
Semantic Relationships ◽  
Three Samples ◽  
The Mean ◽  
Mean Length Of Utterance ◽  
Language Sample

Language samples were obtained from 12 Head Start preschool children under the following three experimental conditions: Condition I, Retelling a Story with Toys; Condition II, Playing with Toys; Condition III, Toys with Questions. The quantity and quality of the three samples gathered from each child were compared by analyzing the total number of utterances, the proportion of the total utterances which were sentence fragments, the number of transformations and adverbial expansions, the number of different semantic relationships, and the mean length of utterance (MLU). Results indicated that retelling a story produced the largest MLU, but toys and questions produced more utterances. These findings indicated that questioning children does not inhibit their language and asking them to retell a story may be a fruitful approach to use when gathering a language sample.

Neutrophil gelatinase associated lipocalin, an early biomarker for diagnosis of acute kidney injury after percutaneous coronary intervention

2017 ◽  
Vol 43 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Nakhshab Choudhry ◽  
Amna Ihsan ◽  
Sadia Mahmood ◽  
Fahim Ul Haq ◽  
Aamir Jamal Gondal
Keyword(s):  
Acute Kidney Injury ◽  
Percutaneous Coronary Intervention ◽  
Serum Creatinine ◽  
Kidney Injury ◽  
Coronary Intervention ◽  
Diagnostic Biomarker ◽  
Elective Percutaneous Coronary Intervention ◽  
Percutaneous Coronary ◽  
Significant Difference ◽  
The Mean

AbstractObjectives:This study was designed to find the reliability of serum NGAL as an early and better diagnostic biomarker than that of serum creatinine for acute kidney injury after percutaneous coronary intervention in Pakistani population.Materials and methods:One hundred and fifty-one patients undergoing elective percutaneous coronary intervention were included and demographic data were recorded. Blood was drawn by venipuncture in clot activator vacutainers and serum was separated and stored at 4°C. Sample was drawn before the percutaneous procedure and subsequently sampling was done serially for 5 days.Results:The mean±SD serum NGAL pre-PCI (39.92± 10.35 μg/L) and 4 h post-PCI (100.42±26.07 μg/L) showed highly significant difference (p<0.001). The mean±SD serum creatinine pre-PCI (70.1±11.8 μmol/L) and post-PCI (71.2±11.6 μmol/L) showed significant difference (p=0.005) on day 2 onwards but mean microalbumin showed insignificant results (p=0.533). The serum NGAL predicted CI-AKI with sensitivity of 95.8% and specificity of 97.6% for a cut off value of 118 μg/L.Conclusion:Our results suggest that NGAL is an excellent early diagnostic biomarker for acute kidney injury in patients undergoing elective percutaneous coronary intervention.

scholarly journals Zooplankton community dynamics and environmental factors in Lake Ozeros (Greece)

2013 ◽  
Vol 14 (3) ◽  
pp. 32 ◽  
Author(s):  
E. CHALKIA ◽  
G. KEHAYIAS
Keyword(s):  
Community Dynamics ◽  
Zooplankton Community ◽  
Trophic State Index ◽  
Zooplankton Abundance ◽  
The Novel ◽  
Effective Management ◽  
Eutrophic Lakes ◽  
State Index ◽  
The Mean ◽  
One Year

A one year investigation of the zooplankton community composition and dynamics in Lake Οzeros (western Greece) revealed 25 invertebrate species (16 rotifers, three copepods, five cladocerans and one mollusc larva). The mean zooplankton abundance fluctuated between 59.4 to 818 ind l-1, having maximum values in spring. The species composition and seasonal variation do not differentiate Lake Ozeros from the nearby lakes. The presence of the dominant calanoid copepod Eudiaptomus drieschi and some of the rotifer species recorded are characteristics of either oligo- or eutrophic lakes. According to the trophic state index (TSI) Lake Ozeros is a meso-eutrophic ecosystem, in which the eutrophic character was possibly the result of the high charge with phosphorus (being raised by 28.9 % in comparison to previous decades), which came into the lake via the surrounding agricultural cultivations and mainly the pig-raising activities. In contrast, the concentrations of ΝΟ3, ΝΟ2 and NH4 have considerably decreased possibly due to the termination of the tobacco cultivations around the lake during the last years. The novel information on the abiotic and especially the biotic elements of Lake Ozeros provided by the present study can contribute to the effective management of this aquatic ecosystem in the future.

scholarly journals EFFECTIVENESS OF ANTAGONISTIC FUNGI Gliocladium sp. AND Trichoderma harzianum TO CONTROL Colletotrichum spp. on chili (Capsicum annuum L.)

Agrivet ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 17
Author(s):  
Siti Dailah ◽  
Mofit Eko Poerwanto ◽  
Supono Budi Sutoto
Keyword(s):  
Direct Method ◽  
Block Design ◽  
Fresh Weight ◽  
Antagonistic Fungi ◽  
Anthracnose Disease ◽  
Randomized Block Design ◽  
Three Samples ◽  
Colletotrichum Spp ◽  
The Mean

The productivity of chili in terms of both quality and quantity is suppressed by the attacks of anthracnose disease caused by Colletotrichum spp. Pesticides is commonly used to control the disease. Researched was conducted to determine the antagonistic fungi and the effective dose in inhibiting the growth of the Colletotrichum spp. Antagonistic tests were performed in vivo using the direct method with three replicates. Inhibition test was arranged in a Complete Randomized Block Design (RCBD) with 7 treatments: Control, Gliocladium sp (150, 250, and 350 mL/plant) and T. harzianum (150, 250, and 350 mL/plant) with four replicates and three samples out of 20 plants per treatment. The results showed that the percentage of inhibition of T. harzianum against Colletotrichum sp. is 55% while Gliocladium sp. is 70.33% in antagonistic test. The mean of disease intensity at 11 up to 32 DAI on control is 5.61 ± 0.71% up to 20.30 ± 1.35 % respectively. It is significantly higher than Gliocladium sp. 350 mL/Plant (1.94 ± 0.45 % up to 11.15 ± 0.87 %), T. harzianum 350 mL/Plant (1.10 ± 0.58 % up to 8.68 ± 0.91 %), and T. harzianum 250 mL/Plant (2.28 ± 0.43 % up to 8.75 ± 0.79 %). No significant different is observed on mean of fresh weight of red chili fruit yield per plant. T. harzianum and Gliocladium sp. fungi are effective in controlling the attack of anthracnose disease in chili. The most efficient dose to control anthracnose disease is the application of T. Harzianum or Gliocladium sp at the dose of 250 mL/plant.Key Words: Chilli, Anthracnose, Gliocladium, Trichoderma, Colletotrichum.

scholarly journals Oestrogen levels in serum and urine of premenopausal women eating low and high amounts of meat

2013 ◽  
Vol 17 (9) ◽  
pp. 2087-2093 ◽  
Author(s):  
Brook E Harmon ◽  
Yukiko Morimoto ◽  
Fanchon Beckford ◽  
Adrian A Franke ◽  
Frank Z Stanczyk ◽  
...  
Keyword(s):  
Mixed Models ◽  
Repeated Measures ◽  
Premenopausal Women ◽  
Least Square ◽  
Serum Samples ◽  
Meat Eating ◽  
Three Samples ◽  
Blood And Urine Samples ◽  
The Mean ◽  
Serum And Urine

AbstractObjectiveBased on the hypothesis that high-meat diets may increase breast cancer risk through hormonal pathways, the present analysis compared oestrogens in serum and urine by meat-eating status.DesignIntervention with repeated measures.SettingTwo randomized soya trials (BEAN1 and BEAN2) among premenopausal healthy women.SubjectsBEAN1 participants completed seven unannounced 24 h dietary recalls and donated five blood and urine samples over 2 years. BEAN2 women provided seven recalls and three samples over 13 months. Serum samples were analysed for oestrone (E1) and oestradiol (E2) using RIA. Nine oestrogen metabolites were measured in urine by LC–MS. Semi-vegetarians included women who reported consuming <30 g of red meat, poultry and fish daily, and pescatarians those who reported consuming <20 g of meat/poultry but >10 g of fish daily. All other women were classified as non-vegetarians. We applied mixed models to compute least-square means by vegetarian status adjusted for potential confounders.ResultsThe mean age of the 272 participants was 41·9 (sd 4·5) years. Serum E1 (85 v. 100 pg/ml, P = 0·04) and E2 (140 v. 154 pg/ml, P = 0·04) levels were lower in the thirty-seven semi-vegetarians than in the 235 non-vegetarians. The sum of the nine urinary oestrogen metabolites (183 v. 200 pmol/mg creatinine, P = 0·27) and the proportions of individual oestrogens and pathways did not differ by meat-eating status. Restricting the models to the samples collected during the luteal phase strengthened the associations.ConclusionsGiven the limitations of the study, the lower levels of serum oestrogens in semi-vegetarians than non-vegetarians need confirmation in larger populations.

P037 Does perinatal history and delivery enhance the risk of hip involvement in Juvenile Idiopathic Arthritis patients? A case-control study

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_5) ◽  
Author(s):  
Makhlouf Yasmine ◽  
Hanene Ferjani ◽  
Affes Hassen ◽  
Kaouther Maatallah ◽  
Dorra Ben Nessib ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Birth Weight ◽  
Mode Of Delivery ◽  
Hip Dislocation ◽  
Normal Growth ◽  
Psychomotor Development ◽  
Delivery Mode ◽  
Cross Sectional ◽  
Male Predominance ◽  
The Mean

Abstract Background Children are vulnerable to congenital and developmental hip disorders. One of the causes of coxitis among children is juvenile idiopathic arthritis (JIA). Existing data on associations between maternal and early childhood exposures highlighted the potential role of prematurity in JIA [1]. The aim of this study was to compare perinatal history in JIA children with coxitis compared with patients with other causes of hip involvement. Methods We conducted a cross-sectional study including children with JIA complicated with coxitis and patients with other causes of hip involvement. We recorded sociodemographic data and the hip disorder. The mode of delivery, the values of the neonatal birth weight as well as the delivery method (vaginal, cesarean (C) section) were retrieved from medical records. We divided the patients into two groups: G1: JIA patients with coxitis and G2: patients with other causes of hip involvement. We compared delivery mode, as well as perinatal outcomes between the two groups. Results The study included 81 patients. There was a male predominance (59.3% males vs 40.7% females) with a sex-ratio of 1.45. The mean age of diagnosis was 9.9 years [1–16]. The mean disease duration was 9 months [0.1–156]. Hip disorders were distributed as follows: Legg-Calvé-Perthes disease (n = 3), epiphysiolysis of the femur head (n = 30), transient synovitis of the hip n = 7, septic hip (n = 10), tumor (n = 4), hip dislocation (n = 8), hip dysplasia (n = 4), juvenile idiopathic arthritis with coxitis (n = 15). The mean birth weight of the children was 3.4 kg [1.3–9]. About half of the patients had a natural delivery (55.6%) and most of them a face presentation (71.6%). A twin pregnancy was reported only in 2.5% of cases. Childbirth complications were reported in 7.4% of cases: umbilical cord prolapse (n = 1), Meconium aspiration syndrome (n = 1), failure to descend (n = 1), acute fetal distress (n = 3). Most of them had a normal growth and psychomotor development (96% and 97% respectively). There was no statistical difference between the two groups regarding delivery mode and fetal presentation before birth (P = 0.07, P = 0.48 respectively). Similarly, weight at birth was similar between JIA children and patients with other hip involvement (P = 0.52). Conclusion Our study showed that maternal and perinatal history did not differ between JIA patients with coxitis and patients with other causes of hip involvement.

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