A Comparison between Intermittent Peritoneal Dialysis and Automatic Peritoneal Dialysis on Urgent Peritoneal Dialysis

2017 ◽  
Vol 45 (6) ◽  
pp. 540-548 ◽  
Author(s):  
Chang Wang ◽  
Xiao Fu ◽  
Yuan Yang ◽  
Jun Deng ◽  
Hong-qing Zhang ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
First Year ◽  
Mechanical Complication ◽  
Chi Square ◽  
Technique Survival ◽  
Mechanical Complications ◽  
Increased Risk ◽  
Significant Difference ◽  
Chi Square Test ◽  
Feasible Alternative

Background: Urgent-start dialysis is a major problem for incident dialysis population. Urgent start on hemodialysis is associated with an increased risk of infectious or mechanical complications, and its mortality is equal to or higher than that of urgent start on peritoneal dialysis (PD). However, compared to patients starting PD in a planned setting, those on urgent-started PD have an increased risk of mechanical complications and lower technique survival. Methods: In this study, 101 adult incident dialysis patients (≥18 years old) who underwent Tenckhoff catheter implantation were enrolled. All of the patients were grouped according to the urgent PD mode: the intermittent PD (IPD) or automatic PD (APD) group, and patients were followed for 1 year. The paired or independent t test was used to analyze the change of laboratory variables. Pearson chi-square test was applied to compare the short outcome between the 2 groups. Results: When PD was treated for 7 days and 1 month, the APD group has the lower serum potassium and phosphorus levels than the IPD group. The incidence of catheter dysfunction was significantly lower in the APD group. The morbidity of infection associated with PD in the first year was lower in the APD group despite no significant difference existing. The technique survival and patient survival rate have no evident difference between the 2 groups. Conclusion: Compared to IPD, urgent start on APD could reduce the risk of mechanical complication, which could be considered a gentle, safe, and feasible alternative to urgent start on IPD.

scholarly journals A double-blind randomized placebo-controlled study of low dose mirtazapine once daily in patients of major depressive disorders on escitalopram

2019 ◽  
Vol 8 (5) ◽  
pp. 1067
Author(s):  
Mallikarjuna Rao I. ◽  
Usha Kiran Prayaga ◽  
Dharma Rao Uppada ◽  
Ramachandra Rao E. ◽  
B. L. Kudagi
Keyword(s):  
Depressive Disorders ◽  
Low Dose ◽  
Rating Scale ◽  
Controlled Study ◽  
P Value ◽  
Chi Square ◽  
Double Blind ◽  
Increased Risk ◽  
Significant Difference ◽  
Chi Square Test

Background: The SSRIs being used as 1st line therapy in treatment of depression have delayed therapeutic effect which makes the patient vulnerable to an increased risk of suicide and decreased adherence to the treatment and will prematurely discontinue the therapy. The present study was conducted to evaluate if low dose mirtazapine-escitalopram combination therapy has any add on benefit over monotherapy with escitalopram.Methods: In a single-centered, comparative study involving patients with depression attending the out-patient after screening and exclusion, 60 eligible patients were randomly assigned to receive tablet mirtazapine 7.5 mg plus tablet escitalopram 10 mg intervention or tablet escitalopram 10 mg plus placebo intervention in a double-blind 6-week treatment phase. The primary outcome measure was the change in the 17-item Hamilton Depression Rating Scale (HDRS) and Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline. Participants were evaluated at baseline, 1st, 2nd,4th and 6th week. Results were analyzed using Chi-Square test for adverse effects and independent t-test analysis for efficacy parameter.Results: In the analysis of results at 6th week the numbers of patients achieved remission in mirtazapine group are more with a p-value of 0.018 which is significant and the numbers of responders in mirtazapine group are also more which is statistically significant on chi-square test. There is no significant difference was observed between the two groups with reference to occurrence of adverse effect.Conclusions: Adding low dose mirtazapine has an added benefit in terms of efficacy and getting remission early with more number of responders in the treatment of major depression.

scholarly journals Evaluation of the Restoration Success of Endodontic Therapy of the Primary Molars

2011 ◽  
Vol 05 (04) ◽  
pp. 415-422 ◽  
Author(s):  
Zuhal Kirzioglu ◽  
Ozge Erken Gungor ◽  
Z Zahit Ciftci
Keyword(s):  
United States Public Health ◽  
Primary Molars ◽  
First Year ◽  
Success Rates ◽  
Chi Square ◽  
Primary Molar ◽  
Significant Difference ◽  
Chi Square Test ◽  
Usphs Criteria ◽  
Second Year

ABSTRACTObjectives: The aim of this study was to evaluate the clinical and radiographic success rates of pulpotomized primary molar teeth restored with a compomer material with using United States Public Health Service (USPHS) criteria. Methods: In 173 primary molars of 156 child patients, aged within 4-9 years (mean age: 6.1±1.4 years), conventional pulpotomy treatment were performed. The teeth treated using calcium hydroxide, formocresol or ferric sulphate. After pulpotomy procedure, teeth were restored with compomer material. The teeth were evaluated as clinically and radiographically during a period of 12-24 months. Both of success of pulpotomy treatment and also restorative material (compomer material) were evaluated during follow-up period. The data were assessed with chi-square test. Results: At the end of the first year, 45% of initial treated teeth were checked, but only 18% were checked at the end of the second year. The first year success rates in the groups treated with CH, FC, and FS were 87.5%, 95%, and 79%, respectively, and, as the number of controllable patients was lower, the success rates on available teeth were determined to be 88.3% and 80%, respectively, according to the materials at the end of the second year. Restorations having been made, they were analyzed in accordance with USPHS criteria. Conclusions: At the end of the first year, 67.5% of compomer restorations were detected to be original and healthy and at the end of the second year, 57% were deemed healthy. No statistically significant relationships were found between marginal adaptation, secondary caries and pulpotomy success (chi-square test, P>.05). Among the three groups, there is no significant difference in terms of success. The least successful age group was defined as 4-6 years. (Eur J Dent 2011;5:415-422)

scholarly journals Impact of Break-In Period on the Short-Term Outcomes of Patients Started on Peritoneal Dialysis

2014 ◽  
Vol 34 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Yaorong Liu ◽  
Lin Zhang ◽  
Aiwu Lin ◽  
Zhaohui Ni ◽  
Jiaqi Qian ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Surgical Intervention ◽  
Major Effect ◽  
Short Term ◽  
Technique Survival ◽  
Mechanical Complications ◽  
Catheter Dysfunction ◽  
Increased Risk ◽  
Stage Renal Disease ◽  
Technique Failure

ObjectivesPeritoneal dialysis (PD) is one of the first-line modalities of renal replacement therapy in patients with end-stage renal disease. Guidelines recommended a break-in period of at least 2 weeks before full PD start. However, the optimal duration of the break-in period is still unclear. In the present study, we investigated the effect of various break-in periods on short-term outcomes in patients on PD.MethodsAll patients who underwent Tenckhoff catheter implantation and initiated PD in Renji Hospital, Shanghai Jiao Tong University School of Medicine, between 1 January 2001 and 31 December 2010 were included. Patients were grouped according to the duration of their break-in period: 7 days or less (BI≤7), 8 - 14 days (BI814), and more than 14 days (BI>14). Kaplan-Meier curves and log-rank tests were used to compare short-term outcomes in the various groups.ResultsOur study enrolled 657 patients (44.5% men), of whom 344, 137, and 176 patients were in the respective break-in groups. Compared with BI>14patients, BI≤7patients had a lower estimated glomerular filtration rate (5.34 ± 1.86 mL/min/1.73 m2vs 6.55 ± 1.71 mL/min/1.73 m2, p < 0.001) and lower serum albumin (33.29 ± 5.36 g/L vs 36.64 ± 5.40 g/L, p < 0.001). The incidence of mechanical complications during the first 6 months was significantly higher in BI≤7patients than in BI>14patients (8.4% vs 1.7%, p = 0.004). However, we observed no significant differences between the three groups with respect to the prevalence of catheter dysfunction requiring surgical intervention ( p > 0.05). Logistic regression analysis showed that BI≤7[relative risk: 4.322; 95% confidence interval (CI): 1.278 to 14.608; p = 0.019] was an independent predictor of catheter dysfunction, but not of catheter dysfunction requiring surgical intervention ( p > 0.05). Catheter dysfunction [hazard ratio (HR): 20.087; 95% CI: 7.326 to 55.074; p < 0.001] and peritonitis (HR: 4.533; 95% CI: 1.748 to 11.751; p = 0.002) were risk factors for technique failure during the first 6 months, but BI≤7was not correlated with technique failure.ConclusionsPatients starting PD with a break-in period of less than 1 week might experience a minor increased risk of mechanical complications, but no major effect on technique survival.

scholarly journals Frequency of Anemia and Iron Deficiency among Children Starting First Year of School Life and Their Association with Weight and Height

Anemia ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Mirza Sultan Ahmad ◽  
Hadia Farooq ◽  
Sumaira Noor Maham ◽  
Zonaira Qayyum ◽  
Abdul Waheed ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Regression Models ◽  
First Year ◽  
School Life ◽  
Chi Square ◽  
Independent Variables ◽  
Significant Difference ◽  
Weight One ◽  
Chi Square Test ◽  
Spearman Test

The objectives of the study were to ascertain frequency of anemia and iron deficiency among children starting first year of school life and test association with height and weight. One in four children starting first year of school life in five schools of Rabwah, Pakistan, was included. Full blood counts and ferritin levels of the children included in the study were checked. Status of their height and weight was determined according to Z-score charts. Chi-square test was used to test association. Two hundred and ninety-five children with median age of 67 months were included in the study. Out of 295, 240 (81.4%) had normal Hb and 55 (18.6%) had anemia. Ferritin levels were found to be below normal level in 242 (82%) children. There was no significant difference between hemoglobin and ferritin levels of children belonging to different categories of height and weight. Spearman test showed that there was very weak correlation between ferritin and hemoglobin levels (rs=.163). Our conclusions were that iron deficiency without anemia is very frequent among children starting first year of school. Regression models show that ferritin levels cannot be predicted by independent variables like status of height and weight on Z-score charts, age, gender, and anemia.

scholarly journals Association of MTR A2756G Gene Polymorphism with Risk of Head and Neck Cancer

2020 ◽  
Vol 1 (3) ◽  
pp. 6
Author(s):  
Muhammad Tahir ◽  
Aamer Ali Khattak ◽  
Erum Monis ◽  
Sana Gul
Keyword(s):  
Head And Neck ◽  
Age Groups ◽  
P Value ◽  
Chi Square ◽  
Normal Individuals ◽  
Increased Risk ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Chi Square Test ◽  
History Of

Objective: To perform genotyping for MTR A2756G polymorphism and identification of risk factors associated with head and neck squamous cell carcinoma (HNSCC). Study Design: Cross section, comparative study. Place and Duration of Study: The study was carried out at the Department of Biochemistry of Quaid-i- Azam University, Islamabad from October 2014 to August 2015. Materials and Methods: In this study, 292 diagnosed patients HNSCC and 324 normal individuals without any history of cancer were enrolled. Blood samples of patients and controls were collected in ethylenediamine tetra acetic acid (EDTA) and DNA was extracted using conventional method. All samples were genotyped for the MTR A2756G polymorphism using PCR-RFLP. Frequency of polymorphism was compared between HNSCC patients andcontrols. MultipleLogisticRegression(MLR)andchi-squaretestwasperformedtoexaminetheassociation of MTR A2756G polymorphism with risk factor. Results: Chi-square test of independence showed statistically significant difference among the variables of age, smoking and MTR A2756G genotype (p-value<0.05). Multivariate analysis showed that smoking (adjusted OR, 3.7; 95% CI, 2.3 – 6.0), age groups 41 – 50 years (adjusted OR, 3.6; 95% CI, .9 – 6.7) and > 60 years (adjusted OR, 3.5; 95% CI, 1.7 – 7.3), MTR 2756 AG genotype (adjusted OR, 2.1; 95% CI, 1.3 – 3.5) is associated with increased risk of HNSCC. Conclusion: The results suggest that the genetic polymorphism MTR A2756G is associated with the occurrence of HNSCC in the Pakistani population while the individuals between 40 to 50 years of age and those who are smokers are at a greater risk of developing HNSCC.

scholarly journals Impact of Exclusive English Language Use in Physiology Lecture on Student’s Physiology Learning in Bangladesh

2017 ◽  
Vol 12 (1) ◽  
pp. 28-32
Author(s):  
Mohammad Uzire Azam Khan ◽  
Mohammad Mohaimenul Abedin
Keyword(s):  
English Language ◽  
Language Use ◽  
Individual Component ◽  
Pass Rate ◽  
First Year ◽  
Chi Square ◽  
Medical College ◽  
Significant Difference ◽  
Chi Square Test ◽  
The Impact

Background: Medical students of Bangladesh have to encounter English as learning media. But teachers often do not use English exclusively in their lectures thinking that students may not understand English clearly.Objective: To assess the impact of exclusive use of English language in physiology lectures on student’s learning.Method: This comparative study was conducted in the Department of Physiology, Abdul Malek Ukil Medical College, Noakhali, Bangladesh during January – November, 2013. One hundred and sixteen first year MBBS students of two sessions of a government medical college were enrolled for the study by purposive sampling. Exclusive English was used in physiology lectures of 1st term course for the students of 2012-2013 session (group EE) and mixed Bengali and English was used to teach the students of 2011-2012 session (group BE). First term examination results were compared by Student’s ‘t’ test and Chi-square test as applicable.Result: The students of EE obtained significantly higher mean marks both in written (p<0.001) and oral (p<0.001) examinations than those of group BE. However there was no significant difference between groups in pass rate (p>0.05)).Conclusion: The students who attended the lectures with exclusive English obtained better marks in individual component of assessment than the students who attended the lectures with mixed Bengali and English. However, English language use in teaching showed no effect on the pass rate.Bangladesh Soc Physiol. 2017, June; 12(1): 28-32

scholarly journals Ruxolitinib-treated polycythemia vera patients and their risk of secondary malignancies

2021 ◽  
Author(s):  
Rohit Sekhri ◽  
Parvis Sadjadian ◽  
Tatjana Becker ◽  
Vera Kolatzki ◽  
Karlo Huenerbein ◽  
...  
Keyword(s):  
Polycythemia Vera ◽  
Rank Test ◽  
Secondary Malignancies ◽  
Chi Square ◽  
Increased Risk ◽  
Single Center Study ◽  
Significant Difference ◽  
Chi Squared ◽  
Chi Square Test

AbstractRecently, there has been increased concern about a risk of secondary malignancies (SM) occurring in myelofibrosis (MF) patients receiving ruxolitinib (RUX). In polycythemia vera (PV), on the other hand, only limited data on the risk of SM under RUX treatment are available. To investigate the association between RUX therapy in PV and SM, we conducted a retrospective, single-center study that included 289 PV patients. RUX was administered to 32.9% (95/289) of patients for a median treatment duration of 48.0 months (range 1.0–101.6). Within a median follow-up of 97 months (1.0–395.0) after PV diagnosis, 24 SM occurred. Comparing the number of PV patients with RUX-associated SM (n = 10, 41.7%) with the 14 (58.3%) patients who developed SM without RUX, no significant difference (p = 0.34, chi square test) was found. No increased incidences of melanoma, lymphoma, or solid “non-skin” malignancies were observed with RUX (p = 0.31, p = 0.60, and p = 0.63, respectively, chi square test). However, significantly more NMSC occurred in association with RUX treatment (p = 0.03, chi-squared test). The “SM-free survival” was not significantly different by log rank test for all 289 patients (p = 0.65), for the patients (n = 208; 72%) receiving cytoreductive therapy (p = 0.48) or for different therapy sequences (p = 0.074). In multivariate analysis, advanced age at PV diagnosis (HR 1.062 [95% CI 1.028, 1.098]) but not administration of RUX (HR 1.068 [95% CI 0.468, 2.463]) was associated with an increased risk for SM (p = 0.005). According to this retrospective analysis, no increased risk of SM due to RUX treatment could be substantiated for PV.

The Influence of Age and Gender on Mandibular Indices among the Libyan Population

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Negative Correlation ◽  
Bone Mineralization ◽  
Age Groups ◽  
T Test ◽  
Chi Square ◽  
Age And Gender ◽  
Significant Difference ◽  
Chi Square Test ◽  
And Gender ◽  
Libyan Population

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization. Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population. Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender

scholarly journals Prognostic significance of peritoneal cytology in low-risk endometrial cancer: comparison of laparoscopic surgery and laparotomy

2021 ◽  
Author(s):  
Satoe Fujiwara ◽  
Ruri Nishie ◽  
Shoko Ueda ◽  
Syunsuke Miyamoto ◽  
Shinichi Terada ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Laparoscopic Surgery ◽  
Retrospective Study ◽  
Prognostic Significance ◽  
Low Risk ◽  
Peritoneal Cytology ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
Positive Peritoneal Cytology

Abstract Background There is uncertainty surrounding the prognostic value of peritoneal cytology in low-risk endometrial cancer, especially in laparoscopic surgery. The objective of this retrospective study is to determine the prognostic significance of positive peritoneal cytology among patients with low-risk endometrial cancer and to compare it between laparoscopic surgery and conventional laparotomy. Methods From August 2008 to December 2019, all cases of pathologically confirmed stage IA grade 1 or 2 endometrial cancer were reviewed at Osaka Medical College. Statistical analyses used the Chi-square test and the Kaplan–Meier log rank. Results A total of 478 patients were identified: 438 with negative peritoneal cytology (232 who underwent laparotomy and 206 who undertook laparoscopic surgery) and 40 with positive peritoneal cytology (20 who underwent laparotomy and 20 who received laparoscopic surgery). Survival was significantly worse among patients with positive peritoneal cytology compared to patients with negative peritoneal cytology. However, there was no significant difference among patients with negative or positive peritoneal cytology between laparoscopic surgery and laparotomy. Conclusion This retrospective study suggests that, while peritoneal cytology is an independent risk factor in patients with low-risk endometrial cancer, laparoscopic surgery does not influence the survival outcome when compared to laparotomy.

scholarly journals Effect of corneal refractive surgery on accommodative and binocular dysfunctions among civilian pilots in Southwest China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ye Wu ◽  
Zhen Zhang ◽  
Meng Liao ◽  
Qi Li ◽  
Xue Lin Tang ◽  
...  
Keyword(s):  
Binocular Vision ◽  
Refractive Surgery ◽  
Visual Symptom ◽  
Chi Square ◽  
Visual Symptoms ◽  
Significant Difference ◽  
Symptom Scores ◽  
Chi Square Test ◽  
Corneal Refractive Surgery ◽  
Normal Binocular Vision

Abstract Background To analyze whether corneal refractive surgery (CRS) is associated with the distribution of different accommodative dysfunctions (ADs) and binocular dysfunctions (BDs) in civilian pilots. A further aim was to analyze the percentages and visual symptoms associated with ADs and/or BDs in this population. Methods One hundred and eight civilian pilots who underwent CRS from January 2001 to July 2012 (age: 30.33 ± 4.60 years) were enrolled, the mean preoperative SE was − 1.51 ± 1.15 D (range: − 1.00- − 5.00 D). Ninety-nine emmetropic civilian pilots (age: 29.64 ± 3.77 years) who were age- and sex-matched to the CRS group were also enrolled. Refractive status, accommodative and binocular tests of each subject were performed. Visually related symptoms were quantified using the 19-item College of Optometrists in Vision Development Quality of Life (COVD-QOL) questionnaire. The 19 items were summed to obtain visual symptom scores that might indicate visual dysfunctions. The chi-square test was used to analyze differences in percentages of ADs and/or BDs between the CRS and emmetropic groups. The Mann-Whitney U test was used to compare visual symptom scores between pilots with ADs and/or BDs and pilots with normal binocular vision. Results No significant difference was observed between the CRS and emmetropic groups in the overall prevalence of ADs and BDs (15.7% and 15.2% in the CRS and emmetropic groups, respectively; P = 0.185). ADs were present in 4.63% and 3.03% of the CRS and emmetropic group, respectively. BDs were observed in 11.1% and 12.1% of the CRS and emmetropic group, respectively, yielding no significant differences between the groups in the prevalence of ADs or BDs (AD: P = 0.094; BD: P = 0.105). Pilots with ADs and/or BDs had significantly more visual symptoms than pilots with normal binocular vision (p < 0.001). Conclusions CRS for civilian pilots with low-moderate myopia might not impact binocular functions. ADs and/or BDs commonly occur in both emmetropia pilots and pilots who undergo CRS, and pilots with ADs and/or BDs are associated with increased symptoms. This study confirms the importance of a full assessment of binocular visual functions in detecting and remedying these dysfunctions in this specific population.

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