scholarly journals Whitening Efficacy of Tranexamic Acid Cataplasm on Melasma in Chinese Women

2017 ◽  
Vol 4 (3-4) ◽  
pp. 154-160 ◽  
Author(s):  
Jun Lu ◽  
Lili Yang ◽  
Ping Xu ◽  
Fenghua Bian ◽  
Huimin Zhang
Keyword(s):  
Tranexamic Acid ◽  
Skin Color ◽  
Chinese Women ◽  
Severity Index ◽  
Therapeutic Modality ◽  
Control Group ◽  
Color Tone ◽  
Separate Control ◽  
The Face ◽  
Area Score

Background/Aims: Oral tranexamic acid (TXA) has been reported to be effective for treating melasma. However, the effect of topical TXA on melasma remains controversial. The aim of this study was to assess the effects of topical TXA cataplasm on melasma. Methods: Eighty-four patients with melasma were randomly assigned to a treatment group or a separate control group. They were instructed to apply 2 pieces of cataplasm with or without TXA. The melasma area severity index (MASI), skin color tone scale (SCTS), and area score were evaluated by dermatologists blinded to the treatment. Results: A significant decrease in the MASI and SCTS was observed on either or both sides of the face by the end of 8 weeks compared to the control group (p < 0.05). The area score was also significantly reduced on both tested sides compared to the control group (p < 0.05). Conclusion: Based on these results, we believe that localized cataplasm of TXA may be used as a potentially new, effective, and safe therapeutic modality for treating melasma.

scholarly journals Comparative Study of Arjun Twak Lepa and Arjun Twak Kukkutand Pottali in Management of Vyanga with Special Reference to Melasma

2021 ◽  
pp. 209-217
Author(s):  
Priyanka Shelotkar ◽  
Shweta Parwe ◽  
Swapnil Borage
Keyword(s):  
Comparative Study ◽  
Special Reference ◽  
Clinical Features ◽  
Egg Yolk ◽  
Severity Index ◽  
Control Group ◽  
Self Confidence ◽  
The Face ◽  
Local Use ◽  
Experimental Group

Background: A person's beauty and self-confidence are both enhanced by healthy and glowing facial skin.A darkening of the skin caused by an excess of the pigment melanin in the skin is known as hyperpigmentation.Vyanga is a Kshrudraroga with appearance of Niruja (painless) and Shavavarna Mandalas (bluish-brownish) on the face. Melasma, one of the hyper pigmented disorders, can be compared to it.based on clinical features. Whole raw egg/egg yolk alone/with herbs have shown very good results in tightening of skin, complexion and healing in skin disorders, when it is locally applied. So, in present study egg is used with Arjun Twak Churna in the form of Pottali in experimental group for better result in management of Vyanga. Aim and Objectives: To study the effect of Arjun Twak Kukkutand Pottali on MSI (Melasma Severity Index) and to compare the effect of ArjunTwak Kukkutand Pottali and Arjun Twak Lepa on MSI. Methodology: Total no. of 44 patients will be enrolled (22 in each group). In control group for a period of 21 days, Arjun Twak Lepa will be available for local use. While in experimental group, ArjunTwak Kukkutand Pottali will be given for local application for 21 days. The assessment will be done on 0 & 21st day. Results: Changes will be observed as per subjective & objective parameters. Conclusion: ArjunTwak Kukkutand Pottali will be more effective on MSI (Melasma Severity Index).

scholarly journals Comparative study of localised intradermal microinjection of tranexamic acid and oral tranexamic acid for the treatment of melasma

2018 ◽  
Vol 4 (3) ◽  
pp. 363 ◽  
Author(s):  
Vinma H. Shetty ◽  
Monisha Shetty
Keyword(s):  
Tranexamic Acid ◽  
Comparative Study ◽  
Subjective Assessment ◽  
Therapeutic Modality ◽  
Treatment Modalities ◽  
Before And After ◽  
The Face ◽  
Group A ◽  
Good Improvement ◽  
Group B

<p class="abstract"><strong>Background:</strong> Melasma is an acquired hypermelanosis affecting the sun- exposed areas of the skin, most commonly the face and neck. Different treatment modalities have been utilized in different studies with varying, not so satisfactory outcomes. The aim of the study was to compare the efficacy of localized intradermal microinjection of tranexamic acid with oral tranexamic acid in melasma patients.</p><p class="abstract"><strong>Methods:</strong> It is a prospective comparative study. All patients enrolled in the study were divided into 2 groups - twenty in each treatment group. In group A, patients were given intradermal injections of tranexamic acid (4 mg/ml) once at three week intervals (0, 3, 6, 9, 12 weeks) for 12 weeks. Group B patients were given oral tranexamic acid 250 mg twice a day for 12 weeks. Following parameters were evaluated before and after 12 weeks of treatment: a) digital photographs b) MASI score c) patient subjective assessment d) dermoscopic photographs. Software (SPSS, version 16.0 statistical packages) was used.<strong></strong></p><p class="abstract"><strong>Results:</strong> Clinical efficacy of the treatment in 2 different groups showed higher efficacy with intradermal microinjection (35.6%) compare to oral tranexamic acid (21.7%). Patient's subjective assessment showed good improvement in 63.15% of cases in group A, whereas in group B 27.8% of cases showed good improvement.</p><p class="abstract"><strong>Conclusions:</strong> Intralesional localized microinjection of tranexamic acid is a promising new therapeutic modality for the treatment of resistant melasma.</p>

scholarly journals Impulsive Facial-Threat Perceptions After Exposure to Stereotypic Crime News

2015 ◽  
Vol 44 (6) ◽  
pp. 793-816 ◽  
Author(s):  
Florian Arendt
Keyword(s):  
Treatment Group ◽  
Face Processing ◽  
Skin Color ◽  
Control Group ◽  
Media Priming ◽  
Threat Perceptions ◽  
Facial Displays ◽  
The Face ◽  
Crime News ◽  
Facial Threat

Tests were performed to learn whether exposure to news about crimes committed by dark-skinned criminals increases impulsive facial-threat perceptions of meeting dark-skinned strangers in a subsequent situation (media-priming hypothesis), but only when the facial displays are ambiguous (ambiguity hypothesis). The assumption is that news stereotypes prime the “dark-skinned criminal” stereotype, which, in turn, influences subsequent face processing. An experiment with two groups was used to test this prediction. Participants allocated to the treatment group ( n = 53) read about crimes committed by dark-skinned criminals. In contrast, for the control group ( n = 52), cues indicating skin color were not mentioned at all. As predicted, the treatment increased the perceived facial threat of dark-skinned strangers, but only when the facial displays were ambiguous. Given the importance of the face in social interaction, I discuss important, real-world implications for recipients as well as for journalists and media organizations.

When Death Is Compelling

2015 ◽  
Vol 46 (6) ◽  
pp. 352-360 ◽  
Author(s):  
Simon Schindler ◽  
Marc-André Reinhard
Keyword(s):  
Terror Management Theory ◽  
Mortality Salience ◽  
Terror Management ◽  
Management Theory ◽  
Control Group ◽  
Norms And Values ◽  
Hypothetical Scenario ◽  
The Face ◽  
Scenario Study ◽  
Norm Of Reciprocity

Abstract. Research on terror management theory has found evidence that people under mortality salience strive to live up to activated social norms and values. Recently, research has shown that mortality salience also increases adherence to the norm of reciprocity. Based on this, in the current paper we investigated the idea that mortality salience influences persuasion strategies that are based on the norm of reciprocity. We therefore assume that mortality salience should enhance compliance for a request when using the door-in-the-face technique – a persuasion strategy grounded in the norm of reciprocity. In a hypothetical scenario (Study 1), and in a field experiment (Study 2), applying the door-in-the-face technique enhanced compliance in the mortality salience condition compared to a control group.

Evaluation of anti-psoriatic activity of selected phytochemicals on UV-induced psoriasis in mouse tail model

2020 ◽  
Vol 64 ◽  
pp. 123-128
Author(s):  
Jada Naga Lakshmi ◽  
A. Narendra Babu ◽  
Rama Rao Nadendla
Keyword(s):  
Disease Control ◽  
Ellagic Acid ◽  
Uv Light ◽  
Severity Index ◽  
Treated Group ◽  
Control Group ◽  
Standard Group ◽  
Significant Activity ◽  
Epidermal Thickness ◽  
Psoriasis Severity

Objectives: To evaluate anti-psoriatic activity of Phytochemicals on UV-Induced psoriasis in mouse tail model. Materials and Methods: Anti-psoriatic activity of selected phytochemicals on UV-Induced psoriasis in mouse tail model. The animals were dividing into 05 groups and each group contain 5 animals. Disease control group did not receive any treatment only exposure to UV-light, vehicle control treated with simple ointment, standard group treated with salicylic acid (1%w/w) ointment, remaining group are treated 1% and 2% selective phytochemical at two concentrations of ointment to topically on the tail skin. And the data were analysed using one way ANOVA followed by two-way ANOVA (Dunnett’s multiple comparisons test). Results: There was significant decrease in epidermal thickness (P < 0.05) as compared with control group. In 2% phytoconstituents has shown a significant reduction in the total epidermal thickness 8.4****±0.748, 7.6**±0.6781 and 8*±0.8366 in geraniol, glycyrrhizic acid and ellagic acid treated group, when compare to the disease induced animal, there was no lesion of Munro’s microabscess, capillary loop dilation along with elongation of rete ridges in the section of skin of rats. Psoriasis Severity Index was reduced in test treated groups as compared with that of disease control group. It was slowly reduced to 2nd week, totally (55-70%) reduction in PSI is observed at the time of third week of treatment period. Conclusion: The result of the study showed that the 2% of geraniol, ellagic acid, glycyrrhizicacid and hesperidin, exhibited significant activity on UV-induced psoriasis in rodents. The study implies that selected phytoconstituents are a promising research for further investigations to prove its anti-psoriatic activity.

Face detection in single and multiple images using different skin color models

2020 ◽  
Vol 13 ◽  
Author(s):  
Manpreet Kaur ◽  
Jasdev Bhatti ◽  
Mohit Kumar Kakkar ◽  
Arun Upmanyu
Keyword(s):  
Face Detection ◽  
Skin Color ◽  
Input Image ◽  
Morphological Operations ◽  
Reliability Model ◽  
Multiple Images ◽  
Face Region ◽  
Bounding Box ◽  
The Face ◽  
Precision And Accuracy

Introduction: Face Detection is used in many different steams like video conferencing, human-computer interface, in face detection, and in the database management of image. Therefore, the aim of our paper is to apply Red Green Blue ( Methods: The morphological operations are performed in the face region to a number of pixels as the proposed parameter to check either an input image contains face region or not. Canny edge detection is also used to show the boundaries of a candidate face region, in the end, the face can be shown detected by using bounding box around the face. Results: The reliability model has also been proposed for detecting the faces in single and multiple images. The results of the experiments reflect that the algorithm been proposed performs very well in each model for detecting the faces in single and multiple images and the reliability model provides the best fit by analyzing the precision and accuracy. Moreover Discussion: The calculated results show that HSV model works best for single faced images whereas YCbCr and TSL models work best for multiple faced images. Also, the evaluated results by this paper provides the better testing strategies that helps to develop new techniques which leads to an increase in research effectiveness. Conclusion: The calculated value of all parameters is helpful for proving that the proposed algorithm has been performed very well in each model for detecting the face by using a bounding box around the face in single as well as multiple images. The precision and accuracy of all three models are analyzed through the reliability model. The comparison calculated in this paper reflects that HSV model works best for single faced images whereas YCbCr and TSL models work best for multiple faced images.

scholarly journals Oral Tranexamic Acid for the Treatment of Melasma

2014 ◽  
Vol 10 (4) ◽  
pp. 40-43 ◽  
Author(s):  
D Karn ◽  
S KC ◽  
A Amatya ◽  
EA Razouria ◽  
M Timalsina
Keyword(s):  
Tranexamic Acid ◽  
Controlled Trial ◽  
Severity Index ◽  
Sustained Improvement ◽  
Treatment Measures ◽  
Group A ◽  
Group B ◽  
Novel Concept ◽  
High Treatment

Background Melasma poses a great challenge as its treatment is unsatisfactory and recurrence is high. Treatment of melasma using tranexamic acid (oral, topical or intralesional) is a novel concept. Objective To compare the efficacy of oral tranexamic acid with routine topical therapies for the treatment of melasma. Methods It is a prospective, interventional, randomized controlled trial conducted among 260 melasma patients. Patients were divided into two groups consisting of 130 patients each. First group (Group A) was given routine treatment measures and oral Tranexamic Acid while second group (Group B) was treated only with routine topical measures. Capsule Tranexamic Acid was prescribed at a dose of 250 mg twice a day for three months and cases were followed for three months. Response was evaluated on the basis of Melasma Assessment Severity Index (MASI). Mean scores between the two groups were then compared. Results Statistically significant decrease in the mean Melasma Assessment Severity Index from baseline to 8 and 12 weeks was observed among group A patients (11.08±2.91 vs 8.95±2.08 at week 8 and vs. 7.84±2.44 at week 12; p<0.05 for both). While among group B patients the decrease in mean score was significant at 8 weeks and insignificant at 12 weeks follow up (11.60±3.40 vs 9.9±2.61 at 8 weeks and vs. 9.26±3 at 12 weeks; p<0.05 for former but p>0.05 for later). Conclusion Addition of oral tranexamic acid provides rapid and sustained improvement in the treatment of melasma. DOI: http://dx.doi.org/10.3126/kumj.v10i4.10993 Kathmandu Univ Med J 2012;10(4):40-43

scholarly journals Assessment the role of tranexamic acid in prevention of postpartum hemorrhage

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Nevein Gerges Fahmy ◽  
Fahmy Saad Latif Eskandar ◽  
Walid Albasuony Mohammed Ahmed Khalil ◽  
Mohammed Ibrahim Ibrahim Sobhy ◽  
Amin Mohammed Al Ansary Amin
Keyword(s):  
Blood Loss ◽  
Cesarean Section ◽  
Tranexamic Acid ◽  
Postpartum Hemorrhage ◽  
Postoperative Bleeding ◽  
Control Group ◽  
Study Group ◽  
Mortality And Morbidity ◽  
Lower Segment Cesarean Section ◽  
Prophylactic Use

Abstract Background Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. It is believed that hemostatic imbalance secondary to release of tissue plasminogen activator (tPA) and subsequent hyperfibrinolysis plays a major role in PPH pathogenesis. Antifibrinolytic drugs such as tranexamic acid (TXA) are widely used in hemorrhagic conditions associated with hyperfibrinolysis. TXA reduced maternal death due to PPH and its use as a part of PPH treatment is recommended, and in recent years, a number of trials have investigated the efficacy of prophylactic use of TXA in reducing the incidence and the severity of PPH. The study is aiming to assess the efficacy of tranexamic acid in reducing blood loss throughout and after the lower segment cesarean section and reducing the risk of postpartum hemorrhage. Results The amount of blood loss was significantly lower in the study group than the control group (416.12±89.95 and 688.68±134.77 respectively). Also the 24-h postoperative hemoglobin was significantly higher in the study group (11.66±0.79 mg/dl) compared to the control group (10.53±1.07mg/dl), and the 24-h postoperative hematocrit value was significantly higher in the study group (34.99±2.40) compared to control (31.62±3.22). Conclusion Prophylactic administration of tranexamic acid reduces intraoperative and postoperative bleeding in cesarean section and the incidence of postpartum hemorrhage.

Evaluating the alliance in videolink teletherapy

1997 ◽  
Vol 3 (1_suppl) ◽  
pp. 33-35 ◽  
Author(s):  
G J Ghosh ◽  
P M Mclaren ◽  
J P Watson
Keyword(s):  
Working Alliance ◽  
Psychological Treatment ◽  
Single Case ◽  
Personality Factors ◽  
Control Group ◽  
Face To Face ◽  
Working Alliance Inventory ◽  
The Face

The use of videoconferencing in psychotherapy remains largely unexplored. Videoconferencing compromises the range and quality of interactional information and thus might be expected to affect the working alliance (WA) between client and therapist, and consequently the process and outcome of therapy. A single case study exploring the effect of videoconferencing on the development of the WA in the psychological treatment of a female–male transsexual is described. The self-rated Working Alliance Inventory (WAI) was used to measure client and therapist perceptions of the WA after each session over 10 sessions of eclectic therapy conducted over a videolink. The serial WAI measurements charting the development of the WA in 4 cases of 10-session, face-to-face therapy by Horvath and Marx1 were used as a quasi-control. Therapist and client impressions of teletherapy are described. WAI scores were essentially similar to the face-to-face control group except for lower client-rated bond subscale scores. It is suggested that client personality factors accounted for this difference and that videoconferencing did not impair the development of an adequate working alliance or successful therapeutic outcome.

scholarly journals Association between serum visfatin levels and psoriasis and their correlation with disease severity: a meta-analysis

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052110023
Author(s):  
Qian Zou ◽  
Jiawei Si ◽  
Yatao Guo ◽  
Jiayu Yu ◽  
Huijuan Shi
Keyword(s):  
Body Mass Index ◽  
Meta Analysis ◽  
Severity Index ◽  
Cochrane Library ◽  
Control Group ◽  
Inclusion Criteria ◽  
Subgroup Analyses ◽  
Mean Differences ◽  
The Cochrane Library ◽  
Psoriasis Severity

Objective To determine the association between serum visfatin levels and psoriasis and to evaluate the correlation between serum visfatin levels and the severity of psoriasis. Methods The electronic databases PubMed®, Embase® and the Cochrane Library were searched for articles published from inception to 1 May 2020. Data were extracted and then standard mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for pooled estimates. Results A total of 11 studies met the inclusion criteria and were included (448 patients diagnosed with psoriasis and 377 controls). This meta-analysis demonstrated that patients with psoriasis had significantly higher levels of visfatin than the controls (SMD = 0.90, 95% CI 0.52, 1.28). Subgroup analyses showed that differences in serum visfatin levels between the patient group and the control group were associated with ethnicity, Psoriasis Area and Severity Index (PASI) and body mass index. Additionally, a meta-analysis of correlations showed that visfatin levels in patients with psoriasis were positively correlated with PASI ( r = 0.51, 95% CI 0.14, 0.75). Conclusions This meta-analysis showed that serum visfatin levels in patients with psoriasis were significantly higher than those in the controls and a positive correlation between serum visfatin levels and psoriasis severity was observed.

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