scholarly journals Cognitive Function Declines Significantly during Haemodialysis in a Majority of Patients: A Call for Further Research

2018 ◽  
Vol 45 (4) ◽  
pp. 347-355 ◽  
Author(s):  
Indranil Dasgupta ◽  
Mitesh Patel ◽  
Nuredin Mohammed ◽  
Jyoti Baharani ◽  
Thejasvi Subramanian ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Assessment ◽  
Self Management ◽  
Common Condition ◽  
Delayed Recall ◽  
Haemodialysis Session ◽  
Dialysis Vintage ◽  
Before And After ◽  
Language Abstraction ◽  
Associated Risk Factors

Introduction: Cognitive impairment (CI) is very common condition that occurs in haemodialysis patients and it is associated with reduced functional capacity and mortality. We assessed the change in cognitive function during haemodialysis and associated risk factors. Methods: All patients ≥50 years, on haemodialysis for ≥3 months, no dementia from 2 dialysis centres were selected. Cognition was assessed before and after a haemodialysis session using parallel versions of the Montreal Cognitive Assessment (MOCA) tool. Multiple regression was used to examine potential confounders. Results: Eight-two patients completed both tests – median age 73 (52–91) years, 59% male, dialysis vintage 41 (3–88) months. Sixty-two (76%) had CI at baseline. Cognition declined over dialysis (MOCA 21 ± 4.8 to 19.1 ± 4.1, p < 0.001) and domains affected were attention, language, abstraction and delayed recall. Age and dialysis vintage were independently associated with decline. Conclusion: Cognitive function declines over a haemodialysis session and this has significant clinical implications over health literacy, self-management and tasks like driving. More research is needed to find the cause for this decline in cognition.

scholarly journals The effect of vitamin D on cognitive functions in young female patients: a prospective controlled study using the Montreal Cognitive Assessment

2019 ◽  
Vol 77 (1) ◽  
pp. 19-24
Author(s):  
Ozlem Balbaloglu ◽  
Nermin Tanık
Keyword(s):  
Vitamin D ◽  
Cognitive Functioning ◽  
Cognitive Assessment ◽  
Young Female ◽  
Montreal Cognitive Assessment ◽  
Controlled Study ◽  
Delayed Recall ◽  
Female Patients ◽  
Vitamin D Levels ◽  
Before And After

ABSTRACT Aim: Our aim was to determine whether there is a relationship between vitamin D [25(OH)D] and cognitive functioning in women with low 25(OH)D levels. Methods: Ninety female patients, 25-45 years of age, who attended our outpatient clinic and had 25(OH)D levels < 30 ng/mL, were included. The Montreal Cognitive Assessment (MoCA) scale was used to determine cognitive functioning; the scale is divided into seven subgroups. Patients were divided into three subgroups according to their 25(OH)D levels. After a three-month period of 25(OH) D replacement, the patients underwent a re-evaluation using the MoCA scale. Results: The total MoCA score before treatment was significantly different from the score after treatment (p < 0.05). Language and delayed recall functions were significantly different before and after treatment (p < 0.05). Conclusion: Vitamin D levels were related to cognitive functioning in our study group.

scholarly journals EFEKTIVITAS DONEPEZIL TERHADAP FUNGSI KOGNITIF PASIEN TUMOR INTRAKRANIAL PASCAOPERASI

2020 ◽  
Vol 37 (2) ◽  
Author(s):  
Yusril Harun ◽  
Yunni Diansari ◽  
Selly Marisdina ◽  
Yuli Felistia
Keyword(s):  
Cognitive Function ◽  
Mental State ◽  
Cognitive Assessment ◽  
Mini Mental State Examination ◽  
Montreal Cognitive Assessment ◽  
Double Blind Study ◽  
Intracranial Tumour ◽  
Delayed Recall ◽  
The Third ◽  
State Examination

EFFECTIVITY OF DONEPEZIL IN COGNITIVE FUNCTION OFPOSTOPERATIVE INTRACRANIAL TUMOUR PATIENTSABSTRACTIntroduction: There is still a lack of effective therapy in improving cognitive dysfunction in intracranial tumour patients after surgery. Donepezil is an acetylcholinesterase inhibitor that has been a therapy of Alzheimer's disease and has a significant effect on improving cognitive function.Aim: To determine the effectiveness of donepezil on cognitive function in patients with postoperative intracranial tumours.Methods: A clinical, randomized, double-blind study was conducted on postoperative intracranial tumour patients categorized into two groups (donepezil and placebo). The intervention was donepezil 5mg once a day for three months. For assessment of cognitive function, Mini-Mental State Examination (MMSE) and Indonesian Version of Montreal Cognitive Assessment (MoCA-Ina) was checked at weeks 0 (baseline), 4 (end of the first month), 8 (end of the second month), and 12 (end of the third month). Data were analyzed using SPSS 22.Results: Twenty patients, equally distributed in two groups, were included in the study. Compared to baseline, MMSE and MoCA-Ina scores in the donepezil group increased significantly on the second and third month (p<0.001). There was a remarkable difference in cognitive function between two groups on the third month based on MMSE and MoCA-Ina scores (p=0.027 and 0.024, respectively). At post-intervention, orientation and recalldomain in MMSE showed marked improvement, while visuospatial and delayed recall domain experienced as well in MoCA-Ina. There were no significant side effects of donepezil.Discussion: This results can be considered for administration of donepezil in patients with intracranial tumours after surgery with impaired cognitive function.Keywords: Cognitive function, donepezil, intracranial tumour, MMSE, MoCA-Ina, surgeryABSTRAKPendahuluan: Saat ini belum ada terapi yang efektif dalam memperbaiki gangguan fungsi kognitif pada pasien tumor intrakranial pascaoperasi. Donepezil merupakan inhibitor asetilkolinesterase yang telah menjadi terapi dari penyakit Alzheimer dan memiliki efek yang bermakna dalam memperbaiki fungsi kognitif.Tujuan: Mengetahui efektivitas donepezil terhadap fungsi kognitif pasien tumor intrakranial pascaoperasi.Metode: Studi uji klinis, acak, tersamar ganda dilakukan pada pasien tumor intrakranial pascaoperasi dengan gangguan kognitif yang terbagi dalam dua kelompok (donepezil dan plasebo). Intervensi yang dilakukan berupa pemberian donepezil 5mg satu kali sehari selama 3 bulan. Evaluasi fungsi kognitif menggunakan Mini Mental State Examination (MMSE) dan Montreal Cognitive Assessment Versi Indonesia (MoCA-Ina) pada minggu 0 (awal), 4 (akhir bulan ke-1), 8 (akhir bulan ke-2), dan 12 (akhir bulan ke-2). Data dianalisis menggunakan perangkat SPSS 22.Hasil: Sebanyak 20 subjek yang terbagi sama pada dua kelompok diikutsertakan pada penelitian ini. Dibandingkan dengan kondisi awal, nilai MMSE dan MoCA-Ina pada kelompok donepezil meningkat secara signifikan pada bulan ke-2 dan ke-3 (p<0,001). Terdapat perbedaan bermakna fungsi kognitif antara kelompok terapi dengan placebo pada bulan ke-3 berdasarkan nilai MMSE (p=0,027) dan MoCA-Ina (p=0,024). Domain pada MMSE yang mengalami perbaikan bermakna setelah terapi donepezil adalah orientasi dan recall, sedangkan pada MoCA-Ina adalah domain visuospasial dan delayed recall. Tidak didapatkan efek samping donepezil yang bermakna.Diskusi: Hasil penelitian ini dapat menjadi pertimbangan dalam pemberian donepezil pada pasien dengan tumor intrakranial pascaoperasi yang memiliki gangguan fungsi kognitif.Kata kunci: Donepezil, fungsi kognitif, MMSE, MoCA-Ina, operasi, tumor intrakranial

scholarly journals ASSESSMENT OF COGNITIVE FUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 11 ◽  
Author(s):  
Maheshwari P
Keyword(s):  
Chronic Kidney Disease ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Kidney Disease ◽  
Cognitive Assessment ◽  
Ckd Stage ◽  
Significant Difference ◽  
Initiation Of Dialysis ◽  
Before And After ◽  
One Way Anova

Objectives: The objectives of this study were to evaluate cognitive profile in patients with chronic kidney disease (CKD) pre-dialysis and post-dialysis, to assess the severity of cognitive impairment in patients with kidney disease before and after dialysis, and to determine the association of cognitive impairment in relation to dialysis.Methods: A total of 59 patients were recruited with CKD Stage V on dialysis for >6 months. Cognitive function of the patient was assessed by Montreal Cognitive Assessment test scale method for three intervals (before dialysis and two intervals post-dialysis), and the incidence of impairment was analyzed using one-way ANOVA variance test.Results: Among the 59 patients, there were 13 patients with the age of 18–33 years (22.033%), 11 patients with from age 34 to 49 years (18.64%), 21 patients at the age of 50–65 years (35.59%), and 15 patients around 66–80 years (25.42%). From the above categories, population with the age of 50–65 years is at maximum affected by CKD. Among the 59 patients, 24 patients (40.677%) are male and 35 patients (59.33%) are female. There was a mild significant difference seen in cognitive functioning between pre-dialysis and post-dialysis (p≤0.02).Conclusion: It was found that patients with CKD had mild-to-moderate cognitive dysfunction due to morbidities associated with CKD. Inthis study, significant differences of cognitive function result in CKD patients and the severity of cognitive impairment was associatedwith the severity of the kidney disease, which improved with dialysis. Finally, our study suggests that cognitive performance wasimproved after initiation of dialysis and that further management through medications could provide a better outcome in cognitiveperformance.

Assessment of Cognitive Function Before and After Surgery for Posterior Cranial Fossa Lesions

Skull Base ◽  
2009 ◽  
Vol 19 (03) ◽  
Author(s):  
Shinya Ishimura ◽  
Takayuki Ohira ◽  
Masahito Kobayashi ◽  
Tadashige Kano ◽  
Maaya Orii ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Posterior Cranial Fossa ◽  
Before And After ◽  
Cranial Fossa

Effects of use of an eHealth platform e-Vita for COPD patients on disease specific quality of life domains

2020 ◽  
Keyword(s):  
Quality Of Life ◽  
Functional State ◽  
Mental State ◽  
Self Management ◽  
Copd Patients ◽  
Before And After ◽  
Ehealth Intervention ◽  
The Impact ◽  
Disease Specific

Background: Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and maintain a healthier lifestyle. Eventhough there is mixed evidence of the impact of eHealth on quality of life (QoL) in different settings. Aim: The primary aim of the e-Vita-COPD-study was to investigate the effect of use of eHealth patient platforms on disease specific QoL of COPD patients. Methods: We evaluated the impact of an eHealth platform on disease specific QoL measured with the clinical COPD questionnaire (CCQ), including subscales of symptoms, functional state and mental state. Interrupted time series (ITS) design was used to collect CCQ data at multiple time points. Multilevel linear regression modelling was used to compare trends in CCQ before and after the eHealth intervention. Results: Of 742 invited COPD patients, 244 signed informed consent. For the analyses, we only included patients who actually used the eHealth platform (n = 123). The decrease of CCQ-symptoms was 0,20% before the intervention and 0,27% after the intervention; this difference was statistically significant (P=0.027). The decrease of CCQ-mental was 0,97% before the intervention and after the intervention there was an increase of 0,017%; this difference was statistically significant (P=0,01). No significant difference was found in the slopes of CCQ (P=0,12) and CCQ-function (P=0,11) before and after the intervention. Conclusion: The e-Vita eHealth platform had a potential beneficial impact on the CCQ-symptoms of COPD patients, but not on functional state. The CCQ-mental state remained stable after the intervention, but this was a deterioration compared to the improving situation before the start of the eHealth platform. In conclusion, this study shows that after the introduction of the COPD platform, patients experienced fewer symptoms, but their mental state deteriorated slightly at the same time. Therefore, health care providers should be aware that, although symptoms improve, there might be a slight increase in anxiety and depression after introducing an eHealth intervention to support self-management.

scholarly journals A preliminary study on diabetes self-management education and glycemic control among patients with diabetes mellitus

2019 ◽  
Vol 9 (9) ◽  
pp. 98 ◽  
Author(s):  
Kisokanth G. ◽  
Indrakumar J. ◽  
Prathapan S. ◽  
Joseph J. ◽  
Ilankoon I.M.P.S.
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Management Education ◽  
Self Management ◽  
Rank Test ◽  
Diabetic Patients ◽  
Effective Measure ◽  
Before And After ◽  
Patients With Diabetes ◽  
Preliminary Study

This study was aimed to assess the effectiveness of diabetes self-management education (DSME) in the improvement of glycemic control among patients with type 2 Diabetes Mellitus (T2DM) in Batticaloa District, Sri Lanka. The study was a prospective interventional study and conducted as a preliminary study at medical clinic, Base hospital, Kaluwanchikudy, Batticaloa. Thirty patients with T2DM were included based on inclusion and exclusion criteria. A structured individual diabetes self-management education for 10 hours (one hour per week) was delivered to diabetic patients by the trained Nurse Health Educator. Glycosylate hemoglobin (HbA1c) was assessed as a main outcome measure and Fasting Blood Sugar (FBS), Body Mass Index (BMI) of each patient were also measured and recorded before and after the intervention. The respondent rate was 96.7% (n = 29). Majority of them were females (n = 25, 86.2%). A Wilcoxon signed rank test showed that DSME had a statistically significant reduction in HbA1c [8.60 (IQR 2.60) vs. 7.40 (IQR 2.10), p = .000] and FBS level [159.00 (IQR 77.50) vs. 134.00 (IQR 40.50), p = .002] at 3 months of intervention. The mean BMI at baseline was higher compared to 3 months of intervention [24.88 (SD ± 3.06) vs. 24.19 (SD ± 2.79)] which was statistically significant (p = .000). Majority of participants (n = 22, 75.9%) had improved their HbA1c level by ≥ 0.5% in 3 months. The diabetes self-management education is an effective measure in improving glycemic control and other clinical parameters among patients with T2DM. Thus, DSME needs to be implemented among clinic patients with T2DM for the better outcome and the preventions of complications.

scholarly journals Regular Taekwondo Training Affects Mood State and Sociality but Not Cognitive Function among International Students in South Korea

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 820
Author(s):  
Ju-Yong Bae ◽  
Hee-Tae Roh
Keyword(s):  
International Students ◽  
Cognitive Function ◽  
South Korea ◽  
Physical Fitness ◽  
Mood State ◽  
Control Group ◽  
Peer Relationship ◽  
Physical Fitness Test ◽  
Before And After ◽  
Experimental Group

We aimed to investigate the effect of Taekwondo training on physical fitness, mood, sociality, and cognitive function among international students in South Korea. We randomly assigned 24 international students to a control group (CG, n = 12) and experimental group (EG, n = 12). The EG performed Taekwondo training for 16 weeks, while the CG did not train. Each participant underwent a physical fitness test and sociability questionnaire before and after the intervention. We also examined changes in mood state and cognitive function, using the Korean version of the Profile of Mood State-Brief (K-POMS-B), and the Stroop Color and Word test, respectively. Regarding the physical fitness variables, sit-and-reach records in the EG significantly increased after intervention (p < 0.05). In the sub-variable of K-POMS-B, Vigor-Activity scores significantly increased (p < 0.05) after intervention, while the Fatigue-Inertia scores significantly decreased in the EG (p < 0.05). Furthermore, in the EG, peer relationship scores, a sub-variable of sociability, significantly decreased after intervention (p < 0.05). These findings suggest that Taekwondo training can not only improve flexibility among physical fitness factors, but can also be effective in improving the mood state and sociality of international students.

scholarly journals The Association between the Montreal Cognitive Assessment and Functional Activity Questionnaire in the Systolic Blood Pressure Intervention Trial (SPRINT)

2018 ◽  
Vol 34 (6) ◽  
pp. 814-824
Author(s):  
Carolyn H Still ◽  
Nicholas M Pajewski ◽  
Gordon J Chelune ◽  
Stephen R Rapp ◽  
Kaycee M Sink ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Function ◽  
Systolic Blood Pressure ◽  
Functional Activity ◽  
Cognitive Assessment ◽  
Intervention Trial ◽  
Functional Difficulties ◽  
Global Cognitive Function ◽  
Functional Activity Questionnaire ◽  
Activity Questionnaire

Abstract Objective To examine the association of global cognitive function assessed via the Montreal Cognitive Assessment (MoCA) and deficiencies in instrumental activities of daily living (IADL) on the Functional Activity Questionnaire (FAQ) in hypertensive older adults in the Systolic Blood Pressure Intervention Trial (SPRINT). Methods In cross-sectional analysis, 9,296 SPRINT participants completed the MoCA at baseline. The FAQ was obtained from 2,705 informants for SPRINT participants scoring <21 or <22 on the MoCA, depending on education. FAQ severity ranged from no dysfunction (Score = 0) to moderate/severe dysfunction (Score = 5+). Results Participants who triggered FAQ administration were older, less educated, and more likely to be Black or Hispanic (p < 0.001). Sixty-one percent (n = 1,661) of participants’ informants reported no functional difficulties in IADLs. An informant report, however, of any difficulty on the FAQ was associated with lower MoCA scores after controlling for age, sex, race/ethnicity, and education (p < 0.05). Partial proportional odds regression indicates that participants scoring lower on the MoCA (in the 10th to <25th, fifth to <10th, and <fifth percentiles) had higher adjusted odds of their informant indicating dysfunction on the FAQ, relative to participants scoring at or above the 25th percentile on the MoCA (p < 0.001). Conclusions While lower global cognitive function was strongly associated with IADL deficits on FAQ, informants indicated no functional difficulties for the majority of SPRINT participants, despite low MoCA scores. These findings can help with designing future studies which aim to detect mild cognitive impairment and/or dementia in large, community-dwelling populations.

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