Efficacy of Nimodipine Plus Yufeng Ningxin Tablets for Patients with Frequent Migraine

Pharmacology ◽  
2018 ◽  
Vol 102 (1-2) ◽  
pp. 53-57
Author(s):  
Hongmei Mu ◽  
Liyong Wang
Keyword(s):  
Treatment Group ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Response Rate ◽  
Control Group ◽  
Migraine Treatment ◽  
Cure Rate ◽  
High Cure Rate ◽  
Vas Score ◽  
Significant Difference

Background/Aims: To test the effects of Nimodipine plus Yufeng Ningxin tablets on frequent migraine. Methods: Two hundred forty-two patients with frequent migraine were divided into the control group with those consuming Flunarizine (120 cases) and the treatment group with those consuming Nimodipine plus Yufeng Ningxin tablets (122 cases). The course of frequent migraine treatment lasted 7 weeks. The number of migraine days, visual analogue scale (VAS) score, and response rate were measured. Results: There was significant difference in the cure rate as the Nimodipine plus Yufeng Ningxin tablets group compared with the Flunarizine group (78.7 vs. 21.7%; p < 0.001). Fewer migraine days and VAS score were observed in the treatment group when compared with the control group (p < 0.05). Nimodipine plus Yufeng Ningxin tablets were superior to Flunarizine in terms of the response rate at week 7 (p < 0.05). Conclusion: Due to its high cure rate, treatment with Nimodipine plus Yufeng Ningxin tablets is recommended to control frequent migraine, and this hypothesis needs to be confirmed through further studies conducted on a more extensive population.

scholarly journals Tablet Hisap Dan Relaksasi Nafas Dalam Untuk Mengurangi Nyeri Tenggorok Pada Pasien Post Operasi Dengan General Anesthesia (GA)

2020 ◽  
Vol 7 (2) ◽  
pp. 409-414
Author(s):  
Arip Susianto ◽  
Hikmi Muharromah Pratiwi ◽  
Evi Komala Simamora
Keyword(s):  
Visual Analogue Scale ◽  
General Anesthesia ◽  
Endotracheal Tube ◽  
Sore Throat ◽  
Analogue Scale ◽  
Intervention Group ◽  
Control Group ◽  
Deep Breath ◽  
Vas Score ◽  
Quasi Experimental

Latar belakang: Standar prosedur penanganan pada pasien paska bedah di RSUP Dr Kariadi belum cukup efektif untuk mengurangi nyeri tenggorok paska operasi dengan pamasangan endotrakeal tube pada General Anesthesia (GA). Penggunaan tablet hisap terbukti mampu menurunkan nyeri tenggorok, akan tetapi bukti penelitian masih terbatas. Penelitian ini untuk menguji keefektivitasan pemberian tablet hisap dan relaksasi napas dalam untuk mengurangi derajat nyeri tenggorok paska operasi. Metode: Penelitian dilakukan dengan desain quasi experimental pre-posttest pada 11 Juli – 30 Oktober 2019. Subyek penelitian berjumlah 60 pasien paska operasi dengan general anesthesia yang dikelompokan menjadi 30 kelompok intervensi dan 30 kelompok kontrol. Nyeri tenggorok paska operasi diukur dengan menggunakan Visual Analogue Scale (VAS) pada 6 jam paska operasi dan dievaluasi tiap 12 jam selama 48 jam. Hasil: Perbedaan rerata skor VAS antara kelompok kontrol dan kelompok intervensi secara signifikan terjadi pada penilaian nyeri 36 jam paska operasi (t = -3,70, p = 0,002) dan 48 jam paska operasi ( t = -4,28, p = 0,000). Skor VAS pada kelompok intervensi lebih rendah secara signifikan dibandingan dengan skor VAS pada kelompok kontrol. Simpulan: Pemberian tablet hisap dan relaksasi napas dalam secara signifikan menurunkan tingkat nyeri tenggorak paska operasi. Pemberian tablet hisap dapat dijadikan sebagai intervensi alternatif untuk penangangan pasien dengan komplikasi nyeri tenggorok paska operasi. Key words: Nyeri tenggorok, Endotracheal Tube, Tablet hisap, Relaksasi napas dalam, Visual Analogue Scale (VAS)   Background: The standard procedures of post operative patients at RSUP Dr Kariadi Semarang was ineffective to reduce post operative sore throat with Endotracheal Tube insertion in General Anesthesia. Lozenges was proven may reduce sore throat while the evidences were still limited. Methods: The research design was quasi experimental pre-post test on 11 july - 30 october 2019. The study subjects were 60 post operative patients with General Anesthesia grouped into 30 intervention grups and 30 control groups. Post operative sore throat was measured using Visual Analogue Scale (VAS) at 6 hours after surgery then evaluated every 12 hours for 48 hours. Results: Mean difference VAS score between intervention group and control group significantly in the assessment of pain 36 hours (t = -3,70, p = 0,002) and 48 hours ( t = -4,28, p = 0,000) post operatively. VAS score in intervention group was significantly lower than VAS score in control group. Conclusion: Lozenges and deep breath relaxation reduce significantly post operative sore throat. Lozenges could be used as an alternative intervention to treat patients with post operative sore throat. Keywords: Sore Throat, Endotracheal Tube, Lozenges, Deep Breath Relaxation, Visual Analogue Scale.

scholarly journals Impact of Pilates on the Intensity of Pain in the Spine of Women of the First Mature age

2020 ◽  
Vol 20 (1) ◽  
pp. 12-17
Author(s):  
Vitalii Kashuba ◽  
Yuliia Tomilina ◽  
Nataliia Byshevets ◽  
Inna Khrypko ◽  
Olha Stepanenko ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Cervical Region ◽  
Control Group ◽  
Sports Club ◽  
Significant Difference ◽  
Thoracic And Lumbar Spine ◽  
Experimental Group ◽  
Different Parts

The purpose of the study is to determine the dynamics of pain intensity in different parts of the spine in women of the first mature age under the influence of pilates. Materials and methods. 64 women took part in research. The women were divided into two groups, each of which included 32 people. The study was carried out at the Sokol sports club and the Olimp fitness club in Kiev. We used the questionnaire “Visual analogue scale of pain”.  Results. We measured the level of pain in the cervical, thoracic and lumbar spine of women of the first mature age. It was found that only 4.69 % of women do not have pain. It was found that women of the first mature age the most often feel painin the cervical region. The women of the control group were engaged in a typical Pilates program. The women of the experimental group were engaged in the author’s program, a feature of which was the use of large equipment during classes. In addition, women who could not attend classes were offered the Pilates computer program. For the experiment, no statistically significant difference between the level of pain in different parts of the spine of women was established. After the experiment, a statistically significant decrease in the level of pain in the lumbar section of women in the experimental group was recorded compared with women in the control group.  Conclusions. The results indicate the effectiveness of large equipment to reduce the level of pain in the back of a woman.

scholarly journals The efficacy of a topical application comprising Calendula officinalis Ø and Olea europaea in the management of seborrheic dermatitis of the scalp (dandruff)

2017 ◽  
Author(s):  
◽  
Silindelo Minenhle Zondi
Keyword(s):  
Treatment Group ◽  
Visual Analogue Scale ◽  
Olive Oil ◽  
Topical Application ◽  
Olea Europaea ◽  
Analogue Scale ◽  
Seborrheic Dermatitis ◽  
Control Group ◽  
Calendula Officinalis ◽  
Olea Europaéa

Background Seborrheic dermatitis (SD) also known as pityriasis capitis is a common skin condition that affects mainly the scalp, causing scaly patches, red skin and stubborn dandruff (Preedy 2012). It has been reported that dandruff occurs in at least 50% of the world’s adult population and approximately 15% to 20% of the world’s total population (Mia 2016). Recent studies suggest that a scalp specific yeast called Malasseiza globosa appears to be responsible for SD (Zhang, Ran, Xie and Zhang 2013). Seborrheic dermatitis does not affect overall health but it can be uncomfortable and may cause embarrassment and low self-esteem (Del Rosso 2011; Preedy 2012). Anecdotal evidence at Ukuba Nesibindi Homoeopathic Community Clinic (UNHCC) indicated that patients with SD responded positively to Calendula officinalis Ø in combination with Olea europaea (olive oil). Notwithstanding this, there is a dearth of clinical data available to validate the aforesaid patient’s positive response. Hence this study aims to provide clinical evidence to prove or disprove patient’s response to Calendula officinalis Ø in combination with Olea europaea (olive oil). Objective The aim of this double blind randomized controlled study was to determine the efficacy of a topical application comprising Calendula officinalis Ø with Olea europaea in the management of SD of the scalp (dandruff). Material and methods The sample was selected by means of non-probability convenience sampling and consisted of 64 consenting participants between the ages of 18 to 50 years who had read the information letter and met the inclusion criteria. Participants were evenly distributed between the treatment and control groups according to the randomization list (32 participants in each group). The treatment group received Calendula officinalis Ø with Olea europaea and the control group received Olea europaea only. Three participants withdrew from the study resulting in only 61 completing the study, 30 from the control group and 31 from the treatment group. The study was conducted at the Durban University of Technology Homoeopathic Day Clinic (DUTHDC) under the supervision of a qualified and registered homoeopathic clinician. The duration of the study was six weeks with three consultations in total. Consultations took place on day 1, day 22 and day 43. At each consultation the participants were assessed by three individuals – the participant themselves, the researcher, and an independent party (the homoeopathic clinician on duty that day). The assessment tools included the Visual Analogue Scale (VAS) for the researcher and clinician consisting of the following categories: irritation, flaking, greasiness, percentage of the scalp involved and overall impression; and the Patient Perception Questionnaire (PPQ) for the patient consisting of the following categories: irritation, flaking, greasiness, itching and overall impression. This was accompanied by a detailed case history and physical examination performed by the researcher. Results Both the control and treatment groups displayed overall improvement in terms of Patient Perception Questionnaire and Visual Analogue Scale which means that a combination of Olea europeae with Calendula officinalis Ø (treatment group) and Olea europeae only (control group) were effective in the management of SD. There was no statistically significant difference between the effect of a combination of Olea europaea with Calendula officinalis Ø and Olea europaea only. In terms of the VAS and PPQ categories, there was a statistical significance between the groups, with the exception of irritation. Significant differences found were as follows: Flaking (clinician and patient rated p = 0.019) on visit 3 for the control group. Greasiness (clinician and patient rated p = 0.027) on visit 3 for the control group. Greasiness (researcher and patient rated p = 0.012) on visit 2 for the treatment group. Percentage of the scalp involved (researcher and clinician rated p = 0.013) on visit 2 for the treatment group. Overall impression (researcher and patient rated p = 0.026) on visit 2 for the control group. Overall impression (researcher and clinician rated p = 0.026) on visit 3 for the treatment group. Conclusion Both the combination of Olea europaea with Calendula officinalis Ø and Olea europaea only improve SD. Therefore, a topical application comprising Calendula officinalis Ø and Olea europaea is effective in the management of SD of the scalp (dandruff) and therefore permits further investigation.

Cefazolin plus Ceftazidime versus Imipenem / Cilastatin Monotherapy for Treatment of Capd Peritonitis — a Randomized Controlled Trial

2004 ◽  
Vol 24 (5) ◽  
pp. 440-446 ◽  
Author(s):  
Chi-Bon Leung ◽  
Cheuk-Chun Szeto ◽  
Kai-Ming Chow ◽  
Bonnie Ching-Ha Kwan ◽  
Angela Yee-Moon Wang ◽  
...  
Keyword(s):  
Treatment Group ◽  
Response Rate ◽  
Controlled Trial ◽  
Group Versus ◽  
Similar Efficacy ◽  
Primary Response ◽  
Control Group ◽  
Cure Rate ◽  
Open Label ◽  
Complete Cure

Background Peritonitis is a serious complication of peritoneal dialysis (PD). We studied the efficacy of imipenem / cilastatin monotherapy in the treatment of PD-related peritonitis. Methods We performed an open-label, randomized control study comparing imipenem / cilastatin monotherapy (treatment group) versus cefazolin plus ceftazidime (control group) in the treatment of PD peritonitis. The result was further compared to a historic group treated with cefazolin plus netilmycin. Outcome measures were primary response rate at day 10 and complete cure rate. Results We enrolled 51 patients in the treatment group, 51 in the control group, and identified 96 in the historic group. The primary response rate to the assigned antibiotics was 49.0%, 51.0%, and 49.0% for the treatment, control, and historic groups, respectively ( p = 0.97). The primary response rate allowing for change in antibiotic was 82.4%, 90.2%, and 82.3%, respectively, for the three groups ( p = 0.41). The complete cure rate was 72.5%, 80.4%, and 82.3%, respectively ( p = 0.60). Tenckhoff catheter removal was needed in 6 cases in the treatment group, 6 cases in the control group, and 13 cases in the historic group ( p = 0.90). Conclusions We concluded that monotherapy of imipenem / cilastatin has similar efficacy compared to the two standard regimens of cefazolin plus ceftazidime or netilmycin in the treatment of PD peritonitis.

scholarly journals Preoperative Oral Pregabalin Reduces Acute Pain after Thoracotomy

2018 ◽  
Vol 6 (9) ◽  
pp. 1606-1610 ◽  
Author(s):  
Hossein Sattari ◽  
Morteza Hashemian ◽  
Mohammad Reza Lashkarizadeh ◽  
Hamid Jalalifard
Keyword(s):  
Postoperative Pain ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Intervention Group ◽  
Nausea And Vomiting ◽  
New Drugs ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Significant Difference

BACKGROUND: Nowadays pain control is one of the most important challenges for physicians, surgeons and anesthesiologists. New drugs and procedures to control pain have always been a major topic for researches. AIM: In this study, we evaluated the effects of preoperative pregabalin administration on relieving postoperative pain after thoracotomy surgery. MATERIALS AND METHODS: This study is a randomised, double-blind clinical trial, performed on 60 patients who underwent thoracotomy at Afzalipour hospital in Kerman, Iran. They were divided into case and control groups. Two hours before surgery an oral capsule of 300 mg pregabalin or placebo was given to patients. All patients similarly underwent general anaesthesia. Pain, nausea and vomiting were evaluated based on the visual analogue scale (VAS) and frequency. This study was verified and obtained the ethics committee code of K/92/489 from Kerman University of Medical Sciences. RESULTS: The average age of the pregabalin group was 39.7 ± 5.8 years and the control group 41.3 ± 6.1 years. The average pain score after regaining consciousness was 6.1 ± 0.2 in the case group and 7.9 ± 0.1 in the control group, and there was a significant difference between the 2 groups (p-value = 0.002). In the control group, 2 patients and the intervention group 3 patients, experienced nausea and vomiting. There was a significant difference between the overall average pethidine consumption and the average visual analogue scale in both groups. CONCLUSION: Pregabalin administration before thoracotomy is effective to reduce postoperative pain in patients. More research is needed to determine the optimal dose of pregabalin for preoperative administration.

scholarly journals The Effect of Helicobacter Pylori Eradication on Migraine: A Randomized, Double Blind, Controlled Trial

2012 ◽  
Vol 6;15 (6;12) ◽  
pp. 495-498 ◽  
Author(s):  
Nader Zarinfar
Keyword(s):  
Helicobacter Pylori ◽  
Treatment Group ◽  
Migraine Headache ◽  
Treatment Result ◽  
Control Group ◽  
Migraine Treatment ◽  
Double Blind ◽  
Significant Difference ◽  
H Pylori ◽  
And Control

Background: Recent studies have shown a positive correlation between Helicobacter pylori (H. pylori)infection and migraine headache. Objective: To study the impact of H. pylori eradication on migraine headache. Study Design: Double blind, randomized, controlled clinical trial. Setting: Sixty-four patients diagnosed with migraine-type headache were included in the study. The patients were randomly allocated into 2 groups: a treatment group that received migraine treatment and H.pylori eradication treatment, and a control group that received migraine treatment and a placebo in place of H. pylori eradication treatment. Methods: There were 25 women and 7 men in the treatment group and 22 women and 10 men in the control group. The MIDAS (Migraine Disability Assessment) questionnaire was used to assess the severity of symptoms, before and after treatment. Result: There was no significant difference between treatment group patients and control group patients with respect to age (44.6 ± 8.8 vs. 43.8 ± 13.8), clinical symptoms and signs. In the beginning of the study, patients in the treatment group had a higher MIDAS compared to patients in the control group (28.87 ± 6.18 vs. 25.43 ± 7.13, P < 0.05). There was no significant difference between the treatment and control groups, with respect to the MIDAS, after treatment (20.09 ± 1.14 vs. 20.00 ± 1.150, P = 0.5). General linear model, repeated measures demonstrated that the reduction in the MIDAS score was more prominent in the treatment group (Mean Square 164.25, F: 2.02, P = 0.05). Limitations: Short-term follow up. Conclusion: H. pylori eradication may have a beneficial role on migraine headache. This shows the significance of H. pylori treatment in the management of migraine headache among Iranian patients. Key words: Helicobacter pylori, migraine headache

Effects of Audience Response Systems on Student Achievement and Long-Term Retention

2011 ◽  
Vol 39 (10) ◽  
pp. 1431-1439 ◽  
Author(s):  
Selcuk Karaman
Keyword(s):  
Academic Success ◽  
Treatment Group ◽  
Undergraduate Students ◽  
Course Design ◽  
Control Group ◽  
Audience Response ◽  
Multiple Choice Questions ◽  
Audience Response Systems ◽  
Significant Difference ◽  
Response Systems

The effects of audience response systems (ARS) on students' academic success and their perceptions of ARS were examined in this study. Participants, comprising 44 undergraduate students, were randomly assigned to a control or treatment group. The course design was the same for both groups and the instructor prepared the multiple-choice questions in advance; students in the control group responded to these questions verbally whereas the treatment group used ARS. Two paper-based examinations were used to measure the learning of concepts and skills that were taught. Students' perceptions of ARS were collected via a questionnaire. Results showed that ARS usage has a significant learning achievement effect in the first 4 weeks but not at the end of the second 4 weeks. There was no significant difference in retention between either group. Students perceived the ARS tool positively, finding it very enjoyable and useful.

scholarly journals Donepezil for mild cognitive impairment in Parkinson’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyoungwon Baik ◽  
Seon Myeong Kim ◽  
Jin Ho Jung ◽  
Yang Hyun Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Treatment Group ◽  
Outcome Measures ◽  
Rating Scale ◽  
Secondary Outcome ◽  
Control Group ◽  
Significant Difference

AbstractWe investigated the efficacy of donepezil for mild cognitive impairment in Parkinson’s disease (PD-MCI). This was a prospective, non-randomized, open-label, two-arm study. Eighty PD-MCI patients were assigned to either a treatment or control group. The treatment group received donepezil for 48 weeks. The primary outcome measures were the Korean version of Mini-Mental State Exam and Montreal Cognitive Assessment scores. Secondary outcome measures were the Clinical Dementia Rating, Unified Parkinson’s Disease Rating Scale part III, Clinical Global Impression scores. Progression of dementia was assessed at 48-week. Comprehensive neuropsychological tests and electroencephalography (EEG) were performed at baseline and after 48 weeks. The spectral power ratio of the theta to beta2 band (TB2R) in the electroencephalogram was analyzed. There was no significant difference in the primary and secondary outcome measures between the two groups. However, the treatment group showed a significant decrease in TB2R at bilateral frontotemporoparietal channels compared to the control group. Although we could not demonstrate improvements in the cognitive functions, donepezil treatment had a modulatory effect on the EEG in PD-MCI patients. EEG might be a sensitive biomarker for detecting changes in PD-MCI after donepezil treatment.

scholarly journals The Minimum Clinically Significant Difference in Visual Analogue Scale Pain Score in a Local Emergency Setting

2009 ◽  
Vol 16 (4) ◽  
pp. 233-236 ◽  
Author(s):  
MSM Mark ◽  
TTS Au ◽  
YF Choi ◽  
TW Wong
Keyword(s):  
Visual Analogue Scale ◽  
Pain Score ◽  
Analogue Scale ◽  
Education Level ◽  
Chinese Patients ◽  
Visual Analogue Scale Pain ◽  
Emergency Setting ◽  
Significant Difference ◽  
Analogue Scale Pain ◽  
Clinically Significant

Objectives To determine whether the minimum clinically significant difference (MCSD) in visual analogue scale (VAS) pain score varies with age, gender, education level and cause of pain (trauma versus non-trauma) in Chinese patients. Methods This was a prospective descriptive study of local Chinese patients 15 years of age or older who presented with pain to the accident & emergency department. On presentation, patients were asked to indicate their current pain severity with a single mark through a standard 100–mm visual analogue scale. Then they would be offered an analgesic for pain-relief. After 30–45 minutes, the patients were asked to give a verbal categorical rating of their pain as ‘a lot better’, ‘a little better’, ‘much the same’, ‘a little worse’, or ‘much worse’ and to mark the level of pain on a VAS of the same type as used previously. The MCSD in VAS pain score was defined as the mean difference between the current and preceding scores when the subject reported ‘a little worse’ or ‘a little better’ in pain. Data were compared based on gender, age, education level, and traumatic versus non-traumatic causes of pain. Results 186 patients were enrolled in the study, yielding 77 evaluable comparisons where pain was rated as ‘a little better’ or ‘a little worse’. Overall, the MCSD in VAS pain score in the group was 17 mm (95%CI 13.6 mm to 20.6 mm). There were statistically significant differences between the MCSD in VAS pain score between genders and causes of pain (trauma versus non-trauma). Conclusions The MCSD in VAS pain scores was found to be 17 mm. There was significant differences in MCSD in VAS pain score in different genders and between trauma and non-trauma cases.

Effectiveness of sustained natural apophyseal glides in females with cervicogenic headache: A randomized controlled trial

2021 ◽  
pp. 1-7
Author(s):  
Muhammad Kashif ◽  
Nosheen Manzoor ◽  
Rimsha Safdar ◽  
Hafsa Khan ◽  
Maryam Farooq ◽  
...  
Keyword(s):  
Treatment Group ◽  
Controlled Trial ◽  
Neck Disability Index ◽  
Placebo Treatment ◽  
Cervicogenic Headache ◽  
Control Group ◽  
P Value ◽  
Head Positioning ◽  
Significant Difference ◽  
Neck Disability

BACKGROUND: Cervicogenic headache (CGH) is a common condition that results in significant disability. To treat this dysfunction, Mulligan described sustained natural apophyseal gliders (SNAGs) as a manual therapy approach. However, only inconclusive short-term evidence exists for treating CGH with SNAGs. OBJECTIVE: The present study aims to investigate the effect of SNAGs in the treatment of CGH. METHODS: Fourty female patients ranging from 20 to 40 years with CGH were randomly assigned to two groups: 20 in a treatment group and 20 in a control group. SNAGs were applied to the treatment group while the control group received placebo treatment. Both groups received their respective treatment for 20 minutes, alternately three times per week, for a total of 12 times in four weeks. The outcome measures were the Neck Disability Index (NDI) and the Visual Analogue Scale (VAS). Participants were assessed at baseline and at the end of each week. The data was analyzed using SPSS version 20. Independent t-testing was used to reveal changes between groups. One-way ANOVA was used to determine changes within groups. The level of significance was P< 0.05. RESULTS: Twenty participants (100%) in the treatment group and 17 (85%) in the control group had a history of headache aggravation with active movements or passive head positioning. There was no significant difference at baseline (p> 0.05), indicating that both groups were homogeneous at the time of recruitment. The p value (p< 0.05) showed a significant difference in pain and level of disability at three and four weeks (p< 0.05) in patients treated with SNAGs. However, the cervical range of motion (ROM) showed a statistically significant improvement in flexion and extension in the treatment group (p< 0.05) while there was no significant improvement in side flexion and rotation ROM in both groups (p> 0.05). CONCLUSION: This study found that SNAGs were effective in reducing pain and neck disability and improved ROM in females with CGH.

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