scholarly journals Serum Level Changes of Neurotrophin-3 after Performing Diabetic Foot Exercise in Diabetic Neuropathy

2015 ◽  
Vol 4 (4) ◽  
pp. 304
Author(s):  
Tri Wahyuliati ◽  
Agung Pranoto ◽  
Samekto Wibowo

The research aimed to determine the pattern of changes in serum levels of NT-3 in the improvement of diabetic neuropathy, after doing diabetic foot exercise. A true experimental study with randomaized pre – post test control trial. A total of 36 subjects meeting the inclusion and exclusion criteria were included in the exercise group or the control one with age matched systematic random sampling method. Exercise group had a significant improvement on the score of ABI (<em>p</em>.0.002), systolic blood pressure (<em>p</em>.0.014), diastolic blood pressure (<em>p</em>.0.055), DNS (<em>p</em>.0.01), DNE (<em>p</em>.0.001) and increased of serum level of NT-3 (<em>p</em>.0.049). Control group had result respectively on ABI (<em>p</em>.0.131), systolic blood pressure (<em>p</em>.0.668), diastolic blood pressure (<em>p</em>.0.216), DNS (<em>p</em>.1.00), DNE (<em>p</em>.0.543), and increase of NT-3 (<em>p</em>.0.264). The comparation results of the two groups had a significant different on the score of ABI (<em>p</em>.0.01), systolic blood pressure (<em>p</em>.0.01), diastolic blood pressure (<em>p</em>.0.01), DNS (<em>p</em>.0.01), DNE (<em>p</em>.0.01), and increased of NT-3 (<em>p</em>.0.01). Diabetic foot exercise had a peripheral affect on a clinically significant improvement based on ABI scores, systolic and diastolic blood pressure, DNS and DNE, and increase of serum level of NT-3.

2015 ◽  
Vol 4 (4) ◽  
pp. 304
Author(s):  
Tri Wahyuliati ◽  
Agung Pranoto ◽  
Samekto Wibowo

The research aimed to determine the pattern of changes in serum levels of NT-3 in the improvement of diabetic neuropathy, after doing diabetic foot exercise. A true experimental study with randomaized pre – post test control trial. A total of 36 subjects meeting the inclusion and exclusion criteria were included in the exercise group or the control one with age matched systematic random sampling method. Exercise group had a significant improvement on the score of ABI (<em>p</em>.0.002), systolic blood pressure (<em>p</em>.0.014), diastolic blood pressure (<em>p</em>.0.055), DNS (<em>p</em>.0.01), DNE (<em>p</em>.0.001) and increased of serum level of NT-3 (<em>p</em>.0.049). Control group had result respectively on ABI (<em>p</em>.0.131), systolic blood pressure (<em>p</em>.0.668), diastolic blood pressure (<em>p</em>.0.216), DNS (<em>p</em>.1.00), DNE (<em>p</em>.0.543), and increase of NT-3 (<em>p</em>.0.264). The comparation results of the two groups had a significant different on the score of ABI (<em>p</em>.0.01), systolic blood pressure (<em>p</em>.0.01), diastolic blood pressure (<em>p</em>.0.01), DNS (<em>p</em>.0.01), DNE (<em>p</em>.0.01), and increased of NT-3 (<em>p</em>.0.01). Diabetic foot exercise had a peripheral affect on a clinically significant improvement based on ABI scores, systolic and diastolic blood pressure, DNS and DNE, and increase of serum level of NT-3.


2019 ◽  
Vol 1 (2) ◽  
pp. 80-87
Author(s):  
Zul Fikar Ahmad ◽  
Siti Surya Indah Nurdin

Hypertension is one of the public health problems that cause mortality and inability to reach life expectancy. The aim of the research is to assess the effect of juice cucumber (Cucumis sativus Linn) on blood pressure of hypertension patients. The research used a quasi experiment design with Non-Randomized Control Group Pre-test Post-test Design. The populations include pre-hypertension and hypertension grade I patients of women childbearing age in the working area of Telaga Biru Health Centre of Gorontalo Regency. The samples were 42 pre-hypertension and hypertension grade I patients. They were divided into two groups, a group given cucumber juice without seeds and another group given cucumber juice with seeds. The data were analyzed using Paired-samples t Test and Independent-samples t Test. The result of the study indicate that giving cucumber juice without seeds decrease of systolic blood pressure by 18,524 mmHg (p = 0,000) and decrease diastolic blood pressure by 8,905 mmHg (p = 0,000). Giving cucumber juice with seeds could decrease systolic blood pressure by 15,952 mmHg (p = 0,000) and diastolic blood pressure by 7,571 mmHg (p = 0,000). There was no difference between giving cucumber juice without seeds and giving cucumber juice with seeds in the decrease of systolic blood pressure (p = 0,257) and the decrease of diastolic blood pressure (p = 0,414). This shows that giving cucumber juice can decrease blood pressure.


2021 ◽  
Vol 10 (2) ◽  
pp. 469
Author(s):  
Dwi Yunita Rahmadhani

Non-Communicable Diseases (PTM) is one of the world's health problems that is still a concern in the world of health because it is one of the causes of death. Hypertension is a condition where systolic blood pressure is 140 mmHg or higher and diastolic blood pressure is 90 mmHg or higher. The cause of hypertension is due to abnormal water and salt retention, sensitivity to angiostensin, obesity, hypercholesteroemia, disturbed emotions / stress and smoking. One of the non-pharmacological therapies that can be used for the management of hypertension is to use wet cupping therapy. The purpose of this study was to analyze the effect of wet cupping on the blood pressure of hypertensive patients.Blood pressure as the dependent variable and wet cupping as an independent variable. This study uses a Pre Experimental Design study with "Two Group Pre Test and Post Test Design". The sample consisted of 20 people with hypertension with 10 respondents in the intervention group and 10 respondents in the control group in the Al-Thaf Nursing home in Jambi City on March to July 2021 with the Purposive Sampling technique. He statistical test carried out is to use paired t-test. From the results obtained p value systolic blood pressure = 0,000 and p value diastolic blood pressure = 0,000.The conclusion of this study is that there is an effect of wet cupping therapy on blood pressure stabilization in hypertensive patients in the city of Jambi


2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.


2021 ◽  
Vol 49 (1) ◽  
pp. 60-66
Author(s):  
Onur Güralp ◽  
Nevin Tüten ◽  
Koray Gök ◽  
Kübra Hamzaoglu ◽  
Huri Bulut ◽  
...  

AbstractObjectivesTo evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE).MethodsThe clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus.ResultsMean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.ConclusionsSerum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.


2021 ◽  
Vol 10 (7) ◽  
pp. 1426
Author(s):  
Bok-Nam Seo ◽  
Ojin Kwon ◽  
Siwoo Lee ◽  
Ho-Seok Kim ◽  
Kyung-Won Kang ◽  
...  

Postmenopausal women have a higher prevalence of hypertension compared to premenopausal women. Hypertension is a risk factor for cardiovascular diseases, the prevalence of which is ever increasing. This study investigated the effects of long-term acupuncture on lowering the blood pressure of postmenopausal women with prehypertension and stage 1 hypertension. Participants were 122 postmenopausal women aged less than 65 years, diagnosed with prehypertension or stage 1 hypertension (systolic blood pressure 120–159 mmHg or diastolic blood pressure 80–99 mmHg). We used a propensity score-matched design. The experimental group (n = 61) received acupuncture for four weeks every six months over a period of two years. The control group (n = 61) received no intervention. An Analysis of covariance (ANCOVA) was performed for the primary efficacy analysis. Relative risk ratios were used to compare group differences in treatment effects. Acupuncture significantly reduced the participants’ diastolic blood pressure (−9.92 mmHg; p < 0.001) and systolic blood pressure (−10.34 mmHg; p < 0.001) from baseline to follow-up. The results indicate that acupuncture alleviates hypertension in postmenopausal women, reducing their risk of developing cardiovascular diseases and improving their health and quality of life.


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Peng Li ◽  
Li He

With the accelerating pace of life, increasing stress and unhealthy diet make cardiovascular disease one of the important diseases that endanger human health, among which the incidence of acute angina is gradually increasing. At present, there are many clinical treatment studies on acute angina pectoris, but the relevant imaging analysis is very lacking. In order to study the clinical treatment of patients with acute angina pectoris and analyze the relevant medical images, to arrive at a more effective treatment method, this article launched an in-depth study. First, we selected 88 patients with acute angina in a hospital as the research object and randomly divided them into a control group (n = 44) and an experimental group (n = 44) Yan et al. (2020). The control group was treated with conventional acute angina pectoris drugs, while the experimental group was treated with clopidogrel on this basis. The two groups were treated at the same time, and the treatment time lasted for 3 months. Then, the risk factors of the two groups of patients were analyzed, and the differences were statistically significant ( P < 0.05 ). Then, the medical images of the two groups of patients were analyzed, and the diastolic blood pressure, systolic blood pressure, and coronary artery stenosis were compared before and after treatment. After treatment, the diastolic blood pressure and systolic blood pressure of the experimental group were 88.31 ± 3.15 mmHg and 125.63 ± 4.16 mmHg, respectively. The proportion of patients with zero-vessel disease and single-vessel disease in the experimental group increased to 15.91% and 56.82%. The treatment plan received by the experimental group patients had a better improvement effect. Finally, the clinical efficacy was compared. The total effective rates of the control and experimental groups were 72.7% and 88.6%, respectively. This shows that the treatment method adopted by the experimental group of patients has a better curative effect and is worthy of clinical promotion.


2019 ◽  
Vol 4 (1) ◽  
pp. 31
Author(s):  
Mutammi Desira ◽  
Niketut Sulendri ◽  
Fifi Luthfiyah ◽  
Suhaema Suhaema

Background: hypertension or high blood pressure is an increase in one's blood pressure, wherein systolic blood pressure ≥ 140 mmHg and or diastolic blood pressure ≥ 90 mmHg on repeated examinations.  Hypertension often occurs in the elderly caused by changes occurring during the aging process that cause the walls of blood vessels to undergo thickening and hardening so that it becomes stiff, the diameter of the cavity of the blood vessels shrink or Narrows. One form of non-pharmacological treatment in overcoming hypertension is by herbal medicine, namely by utilizing the content of potassium in fruits and vegetables, such as bananas and tomatoes containing high potassium that can decrease blood pressure, especially in elderly groups. Research Methods: Type of Quasy-experimental research with Pretest- Posttest with Control Group Draft. The samples in this study were elderly hypertension as many as 18 people with random techniques divided into 2 groups. Group intervention with the giving of tomato banana pudding ambon as much as 175 gram/day for 6 days, while the control group is not given treatment. Research Result: There is a decrease in systolic blood pressure as much as17.8 mmHg (P = 0,002) and diastolic blood pressure as much as 8.9 mmHg(P = 0,347) in the intervention group. Conclusio: There is an influence on the systolic blood pressure but there is no  influence  on  diastolic  blood  pressure  before  and  after  given  banana tomato pudding Ambon.


2021 ◽  
Vol 4 (1) ◽  
pp. 77-81
Author(s):  
Abdi Lestari Sitepu ◽  
Pratiwi Christa Simarmata ◽  
Sari Desi Esta Ulina Sitepu ◽  
Amelia Sarma ◽  
Elfrida Simanjuntak

Hypertension is one of the deadliest diseases in the world, hypertension is an increase in systolic blood pressure above the normal limit of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg, factors that cause increased blood pressure are physical activity, emotion, age, gender , nutritional status, drinking alcohol, smoking, stress. Data from the Grandmed Lubuk Pakam Hospital in 2018 the number of hypertension patients there were 178 cases of hypertension, the number of men was 82 people and women 96 people. One of the non-pharmacological therapies offered to reduce hypertension is massage therapy. The massage technique can remove blockages in the blood vessels so that blood and energy flow in the body returns smoothly. This research was conducted using a quasi-experimental design with the type of design to be used, namely the static group comparison method, the sampling technique used was non-probability sampling with purposive sampling technique, where the sample of this study was 20 people. The results showed that the pre-test sample in the treatment group was known to have the highest value of 160/100 mmHg and the lowest value of 130/90 and post-test mmHg with an average pre-test blood pressure value of 142.00 on systolic and 93.00 on diastolic, and 110.00 post-test. in systole and 79.00 in diastole. Based on the results above, it can be concluded that there is a relationship between  reflexology neck massage with a decrease in blood pressure in patients with hypertension where the Wilcoxon Test results obtained p = 0.004 (systolic blood pressure) and p = 0.005 (diastolic blood pressure).


2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Liota Marsha Renardiyarto ◽  
Dwi Ari Murti Widigdo ◽  
Tulus Puji Hastuti

Hypertension is a high blood pressure disorder which disrupts blood flow resulting in blocking of oxygen and nutrition carried by the blood to body tissue. Based on Dinas Kesehatan Jawa Tengah's data, hypertension became one of the health issues with a percentage of 37%. One of non-pharmacological therapy is foot-reflexology therapy. This method gives a relaxation effect that could make blood circulating better, decay the blocking in blood vessel, nourish muscles and nerves, and strenghten heart activity. Objective: To determine the effect of foot reflection therapy toward systolic blood pressure in primary hypertension patient at Ngadirojo, Secang, Magelang Method: This study used the pre-experiment method with one group pre-test post-test design without a control group. Simple random sampling technic was used to get 46 subjects. Result: Wilcoxon Test result showed different significant in this study between pre-post test foot reflection therapy by p=0.000 (p<0.05). It meant there was an effect of foot-reflection therapy on systolic blood pressure in primary hypertension. The average of blood pressure decrease was 3,7 mmHg. Although, the results of this study showed that there was a significantly different decrease in this decrease was not clinically significant. The recommendation is made to conduct a study in a combination of pharmacology and non-pharmacology intervention to lower blood pressure.


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