Serum Level Changes of Neurotrophin-3 after Performing Diabetic Foot Exercise in Diabetic Neuropathy
The research aimed to determine the pattern of changes in serum levels of NT-3 in the improvement of diabetic neuropathy, after doing diabetic foot exercise. A true experimental study with randomaized pre – post test control trial. A total of 36 subjects meeting the inclusion and exclusion criteria were included in the exercise group or the control one with age matched systematic random sampling method. Exercise group had a significant improvement on the score of ABI (<em>p</em>.0.002), systolic blood pressure (<em>p</em>.0.014), diastolic blood pressure (<em>p</em>.0.055), DNS (<em>p</em>.0.01), DNE (<em>p</em>.0.001) and increased of serum level of NT-3 (<em>p</em>.0.049). Control group had result respectively on ABI (<em>p</em>.0.131), systolic blood pressure (<em>p</em>.0.668), diastolic blood pressure (<em>p</em>.0.216), DNS (<em>p</em>.1.00), DNE (<em>p</em>.0.543), and increase of NT-3 (<em>p</em>.0.264). The comparation results of the two groups had a significant different on the score of ABI (<em>p</em>.0.01), systolic blood pressure (<em>p</em>.0.01), diastolic blood pressure (<em>p</em>.0.01), DNS (<em>p</em>.0.01), DNE (<em>p</em>.0.01), and increased of NT-3 (<em>p</em>.0.01). Diabetic foot exercise had a peripheral affect on a clinically significant improvement based on ABI scores, systolic and diastolic blood pressure, DNS and DNE, and increase of serum level of NT-3.