scholarly journals NEW TENDENCIES IN DIAGNOSTICS AND TREATMENT OF DISEASES OF THE CERVIX (LITERATURE REVIEW)

2018 ◽  
pp. 114-117
Author(s):  
A. V. Boychuk ◽  
V. S. Shadrina ◽  
O. I. Chlibovska ◽  
B. O. Onyskiv ◽  
O. O. Fedchenko
Keyword(s):  
Diagnostic Method ◽  
Modern Method ◽  
Cellular Protein ◽  
Vaginal Flora ◽  
Diagnosis And Treatment ◽  
Adequate Treatment ◽  
Cervical Epithelium ◽  
Apoptosis Index ◽  
Definition Of ◽  
Degree Of Severity

In the problem of resolving the pathology of the cervix in recent years, a lot of information about etiology, causes of origin, diagnosis and treatment has been accumulated. The article summarizes the new possibilities of diagnosis and treatment of the pathology of the cervix, which contributes to a significant improvement in the resolution of the problem of the pathology of the cervix. There are 4 main groups of etiologic factors that lead to morphofunctional changes in the cervical epithelium. In the course of a violation of the transformation of the epithelialization of the cylindrical epithelium, the violation of local and humoral immunity is important. The definition of apoptosis index is a new modern method for predicting the development of precancerous and cervical cancer. Routine but informative methods for diagnosing cervical pathologies such as cytological and colposcopic, in recent years, have been replenished with an important immunohistochemical diagnostic method for detecting p161NK4a cellular protein, as well as by fluorescence spectrometry. The presented complex of diagnostic researches allows us to choose the method of adequate treatment of pathological processes taking into account the age of the patient, the nature and degree of severity of epithelial changes, the type of cervical and vaginal flora, as well as the hormonal status of the patient and concomitant pathology.

Consensus on the change of criteria for cure of acromegaly during the last decade

2011 ◽  
Vol 152 (18) ◽  
pp. 703-708 ◽  
Author(s):  
Gábor László Kovács ◽  
Judit Dénes ◽  
Erika Hubina ◽  
László Kovács ◽  
Sándor Czirják ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Disease Control ◽  
Short Communication ◽  
Consensus Statement ◽  
Diagnosis And Treatment ◽  
Clinical Aspects ◽  
Insulin Like Growth Factor ◽  
Criteria For Diagnosis ◽  
Definition Of

The Acromegaly Consensus Group redefined the consensus criteria for cure of acromegaly. 74 neurosurgeons and experienced endocrinologists summarized the latest results on diagnosis and treatment of acromegaly. In this consensus statement the reliable growth hormone and insulin-like growth factor-1 assays were established. Definition of disease control was discussed based on the available publications and evidence. This short communication summarizes the clinical aspects of consensus criteria for diagnosis and cure of acromegaly based on the original article. Orv. Hetil., 2011, 152, 703–708.

scholarly journals Diagnostic and treatment barriers to persistent somatic symptoms in primary care – representative survey with physicians

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Marco Lehmann ◽  
Nadine Janis Pohontsch ◽  
Thomas Zimmermann ◽  
Martin Scherer ◽  
Bernd Löwe
Keyword(s):  
Primary Care ◽  
Primary Care Physicians ◽  
Rating Scales ◽  
Treatment Guidelines ◽  
Somatic Symptoms ◽  
Diagnosis And Treatment ◽  
Treatment Barriers ◽  
Adequate Treatment ◽  
Physical Disease ◽  
Federal States

Abstract Background Many patients consult their primary care physician with persistent somatic symptoms such as pain or sickness. Quite often these consultations and further diagnostic measures yield no medical explanation for the symptoms – patients and physicians are left in uncertainty. In fact, diagnostic and treatment barriers in primary care hinder timely health-care provision for patients suffering from persistent somatic symptoms (PSS). The significance of individual barriers is still unknown. We compare and quantify these barriers from the perspective of primary care physicians and identify subpopulations of primary care physicians who experience particular barriers as most severe. Methods We mailed a questionnaire to primary care physicians (PCP) in Germany and asked them which barriers they consider most important. We invited a random sample of 12,004 primary care physicians in eight federal states in Germany. Physicians provided anonymous mailed or online responses. We also mailed a postcard to announce the survey and a mail reminder. Main measures were Likert rating scales of items relating to barriers in the diagnosis and treatment of PSS in primary care. Information on demography and medical practice were also collected. Results We analyzed 1719 data sets from 1829 respondents. PCPs showed strongest agreement with statements regarding (1.) their lack of knowledge about treatment guidelines, (2.) their perceptions that patients with PSS would expect symptom relief, (3.) their concern to overlook physical disease in these patients, and (4.) their usage of psychotropic drugs with these patients. More experienced PCPs were better able to cope with the possibility of overlooking physical disease than those less experienced. Conclusions The PCPs in our survey answered that the obligation to rule out severe physical disease and the demand to relieve patients from symptoms belong to the most severe barriers for adequate treatment and diagnosis. Moreover, many physicians admitted to not knowing the appropriate treatment guidelines for these patients. Based on our results, raising awareness of guidelines and improving knowledge about the management of persistent somatic symptoms appear to be promising approaches for overcoming the barriers to diagnosis and treatment of persistent somatic symptoms in primary care. Trial registration German Clinical Trials Register (Deutschen Register Klinischer Studien, DRKS) https://www.drks.de/drks_web/setLocale_EN.do The date the study was registered: October 2nd 2017 The date the first participant was enrolled: February 9th 2018 DRKS-ID: DRKS00012942

What Is Anaphylaxis? Pediatric Residents’ Perception and Treatment of Anaphylactic Reactions

2020 ◽  
Vol 60 (1) ◽  
pp. 25-31
Author(s):  
Ronald M. Ferdman
Keyword(s):  
Allergic Reaction ◽  
Clinical Outcomes ◽  
Diagnosis And Treatment ◽  
Organ Involvement ◽  
Allergy Clinic ◽  
Pediatric Residents ◽  
Criteria For Diagnosis ◽  
Definition Of ◽  
Single Organ

To assess knowledge regarding symptoms and treatment of anaphylaxis, a vignette of a child having an allergic reaction to a peanut was presented to residents in an allergy clinic. Twelve sets of clinical outcomes ranging from severe multi-organ to mild single organ involvement were described, and residents were asked if each symptom set met criteria for diagnosis of anaphylaxis, whether epinephrine should be administered acutely and prescribed at follow-up, and whether peanuts should be avoided in the future. Of cases that met the definition of anaphylaxis 28.8% were incorrectly diagnosed, in 13.6% of cases they would allow peanuts to be eaten again, and in 23.9% of cases they would not prescribe epinephrine at follow-up. In 26.1% of cases meeting criteria for acute anaphylaxis residents would not administer epinephrine. Deficits regarding the diagnosis and treatment of anaphylaxis by residents were identified, and increased educational efforts are needed.

scholarly journals The role of membrane-destabilizing processes in the pathogenesis and clinical manifestations of perinatal encephalopathy in children

2001 ◽  
Vol 82 (2) ◽  
pp. 137-138
Author(s):  
E. V. Levitina ◽  
G. A. Ivanichev ◽  
M. M. Minnibaev
Keyword(s):  
Nervous System ◽  
Early Diagnosis ◽  
Clinical Manifestations ◽  
Perinatal Period ◽  
Diagnosis And Treatment ◽  
Definition Of ◽  
Methods Of Treatment ◽  
All Diseases ◽  
Made In

2/3 of all diseases of the nervous system in children begin to develop in the perinatal period. In recent decades, great strides have been made in perinatal neurology in the development of criteria for early diagnosis and treatment of diseases. Further study of the biochemical foundations of perinatal lesions of the nervous system with the definition of objective markers of the severity of the lesion will reveal new links in its pathogenesis and develop more effective methods of treatment.

scholarly journals Diagnostics of Cognitive Function in Women of Menopausal Period at Level of Primary Health Care

2014 ◽  
Vol 3 ◽  
Author(s):  
N. Zhilgeldina ◽  
T. Ulykbassova
Keyword(s):  
Cognitive Function ◽  
Cognitive Deficits ◽  
Transition Period ◽  
Hormone Replacement ◽  
Standard Of Care ◽  
Medical Community ◽  
Adequate Treatment ◽  
Care Services ◽  
Menopausal Women ◽  
Definition Of

Introduction. In the medical community, there is no consensus on whether or not climacteric changes are pathologic and require treatment. One of the main problems related to menopause is misperception of menopause; consequently, there is no consensus on treatments for psychological dysfunction and cognitive deficits in menopausal women. Timely diagnosis and adequate treatment of psychological disorders and cognitive dysfunction are imperative and complicated. The purpose of this study was to evaluate physician perceptions of cognitive and psychological deficits in menopausal women in outpatient settings.Methods. 215 obstetricians-gynecologists working in out-patient services were surveyed using a multiple choice questionnaire assessing perceptions and knowledge of menopausal transition.Results. Of total respondents, 42.0% ± 2.5 of physicians found it hard to define menopausal period, and 67.5% ± 3.2 could not give a clear definition of hormone replacement therapy. On the question “cognitive function includes…,” 62.5% ± 2.1 of physicians selected “memory,” 32.3% ± 1.8 selected attention, 77.5% ± 3.2 selected mood and/or imagination, 37.4% selected intellect, 36.3% ± 3.1 of respondents selected character traits, and 6.2% ± 1.7 selected speech. Regarding the question “how do you study memory status function?” it was estimated that 71.2% ± 2.5 of study participants have studied the memory only on the basis of subjective complaints, and none of the respondents (100%) have ever used neuropsychological tests.Conclusion. The survey allows us to ascertain that primary medical care services lack the ability to appropriately recognize and diagnose cognitive deficits in women of menopausal age. Based on these data, we can assume that proper mental care is not provided. Thus, the study indicates a need to create training programs for general practitioners and other specialists (cardiologists, neurologists, and endocrinologists) to fulfill this need. Implementation of a standard of care, testing, and treatment of cognitive and psychological function, such as the use of neuropsychological tests and questionnaires, in an out-patient setting for menopausal women would improve the quality of life during a woman’s transition period.

Primary Headache Associated with Sexual Activity in Adolescents: Illustrative Cases

2021 ◽  
Author(s):  
Jinal Patel ◽  
David A. Rothner
Keyword(s):  
Sexual Activity ◽  
Primary Headache ◽  
Diagnosis And Treatment ◽  
Psychosexual Development ◽  
Adequate Treatment

AbstractPrimary headache associated with sexual activity (PHASA) is well described in adults, but reports in adolescents are lacking. PHASA is likely underreported in adolescents. A delay in or an absence of timely and adequate treatment has the potential to negatively impact normal adolescent psychosexual development. Physicians should consider this disorder in adolescents presenting with headaches, and understand the characteristics, diagnosis, and treatment. We report two cases of PHASA in adolescents and review the epidemiology, presentation, and management.

Infections in Patients With Hematologic Malignancies

2012 ◽  
pp. 428-442
Author(s):  
John W Wilson ◽  
Michelle A Elliott
Keyword(s):  
Infectious Diseases ◽  
Hematologic Malignancy ◽  
Hematologic Malignancies ◽  
Residential Environment ◽  
Diagnosis And Treatment ◽  
Clinical Approach ◽  
Patient Factors ◽  
Definition Of ◽  
Antineoplastic Chemotherapy

The clinical approach to patients with hematologic malignancies and infection requires definition of several patient factors (immunologic competence [or defect], residential environment, and the syndrome), infection factors (its type, location, progress, and pathogen), and treatment factors (medical or surgical or both). Management of patients with hematologic malignancies and infection requires knowledge of general infectious diseases and factors pertaining to the hematologic malignancy, pathophysiology of the hematologic malignancy, types of antineoplastic chemotherapy used in treatment, and immunologic effects of both the malignancy and the associated chemotherapy, and complications and toxicities of both the malignancy and the associated chemotherapy. Diagnosis and treatment of specific infections are reviewed.

scholarly journals Mismatch Based Diagnosis of PV Fields Relying on Monitored String Currents

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Pierluigi Guerriero ◽  
Luigi Piegari ◽  
Renato Rizzo ◽  
Santolo Daliento
Keyword(s):  
Energy Production ◽  
Figure Of Merit ◽  
Diagnostic Method ◽  
Medium Size ◽  
Time Interval ◽  
Instantaneous Power ◽  
Maximum Value ◽  
The Difference ◽  
Definition Of ◽  
Day By Day

This paper presents a DC side oriented diagnostic method for photovoltaic fields which operates on string currents previously supplied by an appropriate monitoring system. The relevance of the work relies on the definition of an effective and reliable day-by-day target for the power that every string of the field should have produced. The procedure is carried out by comparing the instantaneous power produced by all solar strings having the same orientation and by attributing, as producible power for all of them, the maximum value. As figure of merit, the difference between the maximum allowed energy production (evaluated as the integral of the power during a defined time interval) and the energy actually produced by the strings is defined. Such a definition accounts for both weather and irradiance conditions, without needing additional sensors. The reliability of the approach was experimentally verified by analyzing the performance of two medium size solar fields that were monitored over a period of four years. Results allowed quantifying energy losses attributable to underperforming solar strings and precisely locating their position in the field.

scholarly journals Mapping the Pathways to StaphylococcalPathogenesis by Comparative Secretomics

2006 ◽  
Vol 70 (3) ◽  
pp. 755-788 ◽  
Author(s):  
M. J. J.B. Sibbald ◽  
A. K. Ziebandt ◽  
S. Engelmann ◽  
M. Hecker ◽  
A. de Jong ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Protein Transport ◽  
Cellular Protein ◽  
Clear Understanding ◽  
Gram Positive ◽  
Transport Pathways ◽  
Human Host ◽  
Extracellular Milieu ◽  
The Core ◽  
Definition Of

SUMMARY The gram-positive bacterium Staphylococcus aureus is a frequent component of the human microbial flora that can turn into a dangerous pathogen. As such, this organism is capable of infecting almost every tissue and organ system in the human body. It does so by actively exporting a variety of virulence factors to the cell surface and extracellular milieu. Upon reaching their respective destinations, these virulence factors have pivotal roles in the colonization and subversion of the human host. It is therefore of major importance to obtain a clear understanding of the protein transport pathways that are active in S. aureus. The present review aims to provide a state-of-the-art roadmap of staphylococcal secretomes, which include both protein transport pathways and the extracytoplasmic proteins of these organisms. Specifically, an overview is presented of the exported virulence factors, pathways for protein transport, signals for cellular protein retention or secretion, and the exoproteomes of different S. aureus isolates. The focus is on S. aureus, but comparisons with Staphylococcus epidermidis and other gram-positive bacteria, such as Bacillus subtilis, are included where appropriate. Importantly, the results of genomic and proteomic studies on S. aureus secretomes are integrated through a comparative “secretomics” approach, resulting in the first definition of the core and variant secretomes of this bacterium. While the core secretome seems to be largely employed for general housekeeping functions which are necessary to thrive in particular niches provided by the human host, the variant secretome seems to contain the “gadgets” that S. aureus needs to conquer these well-protected niches.

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