scholarly journals Effect of thiazolidine derivatives on heart rate variability (hrv) and blood parameters of experimental animals under hypobaric hypoxia

2015 ◽  
Vol 17 (4) ◽  
Author(s):  
O. I. Antoniv ◽  
S. M. Kovalchuk ◽  
L. V. Panina ◽  
O. R. Pinyazhko

<p>Heart rate variability (HRV ) parameters and hematological indices in rats under hypobaric hypoxia during<br />treatment by a thiazolidine derivative substance Les-589 (potassium salt of 3-(5-phenylpropeniliden rhodamine-3-<br />yl)-propanoic acid) were studied. Hypobaric hypoxia was developed in altitude chamber for 1 hour under conditions<br />identical height of 6000 m above sea level, 45 minutes after injection of Les-589. Thiotriazolin was applied as a<br />reference drug.<br />After one day after exposure to hypoxia, according to blood parameters and hematological indices, adaptive<br />response develops by the type of insufficient adaptation. The effect of the prior administration of Les-589, similar to<br />the effect of a reference drug Thiotriazolin, in the time of post-hypoxic period developed reactions of an increased<br />activation, which indicates a favorable course of adaptation.<br />Considering the parameters of HRV was found that prior administration of Les-589 within studied terms of posthypoxic<br />period leads to earlier and more effective recovery of various links of regulatory systems, compared with<br />hypoxia. This is consistent with an estimated type of adaptation processes, based on hematological parameters<br />and indices.</p>

Author(s):  
G. Piccione ◽  
S. Casella ◽  
P. Pennisi ◽  
C. Giannetto ◽  
A. Costa ◽  
...  

Rectal temperature, heart and respiratory rates, and the course of some blood parameters were monitored in calves during perinatal and neonatal periods. The study was carried out on eight Limousine calves. From all subjects, rectal temperature, heart rate, and respiratory rate were measured. Blood samples were taken at the same hour (9am) from the external jugular vein, and then centrifuged and stored until analyses. By means of an UV spectrophotometer, the following blood parameters were assessed for each subject: total protein, total cholesterol, triglycerides, glucose, non-esterified fatty acids (NEFA), urea, creatinine, cholinesterase, lactate dehydrogenase (LDH), hydroxybutirate, glutamate pyruvate transaminases (GPT), glutamate oxalacetate transaminases (GOT), direct and total bilirubin, magnesium, iron, potassium, phosphorus, chloride and sodium. The results showed a significant effect of days of life (P<0.05) only on total cholesterol, creatinine and GOT during the first week of life and a significant effect of days of life on rectal temperature, heart rate, respiratory rate, total cholesterol, NEFA, creatinina, and GOT during the first month of life. A correlation among individual values for postnatal age (days of life) and heart rate in calves during the first month of life was observed. In conclusion, modifications of studied parameters could be attributed to functional development of calves in neonatal period and contribute to the knowledge of adaptation processes in calf during the first week and the first month of life resulting useful for the diagnosis and treatment of any neonatal diseases.


2021 ◽  
Author(s):  
S.E. Bebinov ◽  
O.N. Krivoshchekova ◽  
A.V. Nechaev

The research was carried out on two independent experimental groups of boys and girls. The first was observed in traffic conditions, the second during the period of auto-simulator training. The HRV indices were determined: HR - heart rate, IN - index of tension of regulatory systems, AMo - amplitude of the mode, LF/HF - index of vagosympathetic interaction. A pronounced sympathetic reaction of more prepared cadets to the training load with the subsequent restoration of the studied characteristics was revealed. Key words: heart rate variability, autonomic regulation, vagosympathetic interaction, driver training, level of preparedness.


2021 ◽  
Author(s):  
N.V. Mishchenko ◽  
S.V. Lyalyakin ◽  
L.A. Shirkin ◽  
E.S. Knyazeva ◽  
T.A. Trifonova

In the course of the study, the adaptive state of VlSU students was assessed by temporal, spectral, cardiointervalographic and integral indicators of heart rate variability. The characteristic of the state of the regulatory systems of students is given. The obtained results can serve as a certain addition to the understanding of the peculiarities of the process of adaptation of young students in the conditions of studying at higher school. Key words: heart rate variability (HRV), students, adaptation, regulatory systems, sympathetic and parasympathetic influence.


2020 ◽  
pp. 147-155
Author(s):  
V.A. Belyaeva ◽  

Students who attend a medical HEE often face strain in their adaptation mechanisms when preparing for exams; it can create substantial preconditions for functional deregulation in body systems. The articles outlines some results obtained via examining heart rate variability (HRV) in students of the 2nd and the 3rd year attending the North Ossetia State Medical Academy who had different metabolic status in a period prior to exams. Our research goal was to assess the state of the vegetative nervous system and regulatory systems in students with different metabolic status (BMI< 25; BMI=25–29.99; BMI=30–34.99.) who had to face excess stress during preparation to exams. Heart rate intervals were registered during five minutes in an examined person being at rest. HRV parameters were analyzed in time and frequency domains. We revealed that medical students had elevated activity of the sympathetic section in their vegetative nervous system (VNS) during a period prior to exams; in particular, it was apparent for the regulation system of the vasomotor center (PLF = 48.4%). Students’ bodies had apparent strain in their regulatory systems (SI=177.5 a.u.). Total activity of the regulatory system was significantly elevated (TP=2,293 msec2) due to central regulation levels. As students’ BMI grew, there was a decrease in activity of the parasympathetic component in vegetative regulation and heart rate management became more centralized (IC=3.2–4.5 a.u.). Students with Class 3 obesity had the maximum spectrum power of the superlow component in heart rate variability (PVLF=29.3%). HRV parameters analysis allows estimating whether adaptation processes in students’ bodies are adequate during preparation to exams; it can be done in screening mode and provides an opportunity to perform timely prevention activities.


2019 ◽  
Vol 10 (3) ◽  
pp. 63-69
Author(s):  
Valentin I. Nikolaev ◽  
Nataliya P. Denisenko ◽  
Anastasiya V. Brega ◽  
Marya D. Denisenko

Features of the heart rate variability at patients with acute disorder of cerebral circulation depending on localisation of ischemic damage and type of hemodynamics were studied in acute period of disease and in a condition of relative functional rest. Surveyed men and women (30–55 years old) were divided into 3 groups: patients with ischemic damage to the area of the left average brain artery, right average brain artery and with ischemia in vertebro-basilar department. According to indicators of the integral rheography of the body which was carried out in the acute period of a disease, patients of each group were divided into subgroups depending on hemodynamics type – with hyper dynamic, hypo dynamic and normo dynamic type of blood circulation. It was revealed that the highest activity of sympathetic link of regulation and also higher values of the index of tension and the index of vegetative balance characterized patients with ischemia in the area of right average brain artery and hyper dynamic type of blood circulation. The indicator of activity of regulatory systems characterized “overstrain of regulatory mechanisms” and also “exhaustion of mechanisms of regulation” at patients of this group in the acute period. However upon repeated examination 7 days later revealed the significant reduction of the values of the indicator of activity of regulatory systems. Similar indicators of the heart rate variability were found at patients with ischemic damage in the area of right average brain artery and normo dynamic type of blood circulation. Thus, it was detected that the greatest disorders of regulation of the cardiovascular system were characteristic of patients with ischemia in the area of right average brain artery both hyper dynamic and normo dynamic blood circulation types. Activation of parasympathetic and suppression of sympathetic link of regulation were noted in all patients on the seventh day of hospital stay regardless of localisation of ischemic damage and type of hemodynamics.


2021 ◽  
Vol 265 ◽  
pp. 06005
Author(s):  
Мarya Danacheva ◽  
Viktor Glebov ◽  
Vladimir Torshin ◽  
Vasily Shevtsov ◽  
Dilyara Efremova ◽  
...  

The presented empirical study assesses the state of the cardiovascular system of Moscow schoolchildren living in different environmental conditions. 233 practically healthy schoolchildren (109 boys and 124 girls aged 11.4 to 12.6 years) took part in the comprehensive study of HRV and the state of adaptive processes when living in different ecological conditions of the capital megapolis. On the basis of different ecological and social conditions the schoolchildren were divided into 4 compared groups. The comparative analysis of the obtained HRV data of schoolchildren of different groups showed differences in the adaptation processes and in the indices of the wave activity of the sympathetic and parasympathetic departments of the ANS.


2019 ◽  
Vol 47 (1) ◽  
pp. 60-66
Author(s):  
Zhang‐Jing Shi ◽  
Ming Cheng ◽  
Ying‐Cai Liu ◽  
Xin‐Rong Fan ◽  
Yi Zhang ◽  
...  

2016 ◽  
Vol 54 (1) ◽  
pp. 028-033
Author(s):  
N.A. Gorst ◽  
◽  
S.N. Lychagina ◽  
V.R. Gorst ◽  
L.V. Goryachkina ◽  
...  

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