scholarly journals Стан антиоксидантної системи експериментальних тварин при пошкодженні дванадцятипалої кишки за умов пострезекційної портальної гіпертензії

2018 ◽  
Author(s):  
M. S. Hnatjuk ◽  
L. V. Tatarchuk
Keyword(s):  
Portal Hypertension ◽  
Epithelial Cells ◽  
Antioxidant System ◽  
Liver Parenchyma ◽  
The State ◽  
Male Rats ◽  
Antioxidant Defence ◽  
Experimental Animals ◽  
Functional Changes ◽  
Smooth Myocytes

Introduction. The resections of large volumes of the liver leads to postresection portal hypertension that results in structural-functional changes in the organs of portal vena system. The features of remodeling structures of duodenum and state of the antioxidant system of organism in the conditions of postresection portal hypertension are not studied yet. The aim of the study – to learn the state of the antioxidant system for experimental animals at the structural-functional changes of duodenum in the conditions of postresection portal hypertension. Research Methods. The studies were performed on 39 white male rats, which were divided into 3 groups. The first group consisted of 15 intact experimental animals (control), 2nd – 12 animals, which eliminated 42 % of liver parenchyma, 3rd – 12 rats after resection of 58.1 % of liver parenchyma. One month after the beginning of the experiment, euthanasia of rats was performed by bloodletting under conditions of thiopental anesthesia. In the blood of experimental animals, indicators characterizing the state of oxidative protection were determined – the activity of superoxidedismutase, catalase and ceruloplasmin. Sections of the duodenum were fixed in a 10 % neutral formalin solution and, after passing through the ethyl alcohol of increasing concentration, were placed in paraffin. Histologic sections 5–7 мm thick after deparaffinization were stained with hematoxylin-eosin, for van Gizon, Mallory, Weigert, and toluidine blue. Gistostereometrically determined the relative volumes of damaged endothelial cells, epithelial cells, smooth myocytes. A correlation analysis was carried out between biochemical and histogeometric indices with the definition of the coefficient (r) of correlation. Quantitative values were processed statistically. Results and Discussion. It is set that in the conditions of the modelled experiment activity of superoxidedismutase at the resection of 42 % parenchyma of liver statistically for certain (р<0.001) diminished on 15.5 % and at removal of 58.1 % parenchima of liver – on 25 %; activity of catalase – accordingly on 22.2 and 38.8 % and activity of ceruloplasmin – on 15.3 and 21.3 %. Received and the analyzed indexes testify that at resection of considerable volumes (42; 58.1 %) parenchyma of liver antioxidant defence of organism gets worse substantially and depends on removal at volumes of liver. A relative volume of the damaged endotheliocytes is in 2 to the group of supervisions with high authenticity (р<0.001) grew in 8.4 times, epithelial cells – in 18.9 times, and smooth myocytes – in 12 times. After the resection of 58.1 % parenchyma of liver the investigated morphometric parameters increased accordingly in 15.8; 31.4 and 18.1 times. Correlation connections between the indexes of antioxidant defence and relative at volumes of the damaged endotheliocytes, epithelial cells and smooth myocytes in duodenum at resection 42 % parenchima of liver were opposite moderate and significance (r=–0.48ч–0.56) at resection 58.1 % of liver – significance (r=–0.72÷-0.83). Conclusions. The obtained results indicate that antioxidant protection of the organism plays an important role in the adaptive-compensatory processes of the duodenum after resection of different volumes of liver parenchyma. The degree of antioxidant defense of the organism depends on the removed volume of liver parenchyma and the number of damaged structures of the duodenum.

scholarly journals Особливості процесів ліпопероксидаціїв порожній кишціпри резекції різних об’ємів паренхіми печінки

2018 ◽  
Author(s):  
M. S. Hnatjuk ◽  
L. V. Tatarchuk
Keyword(s):  
Lipid Peroxidation ◽  
Endothelial Cells ◽  
Epithelial Cells ◽  
Liver Parenchyma ◽  
Relative Volume ◽  
Male Rats ◽  
Diene Conjugates ◽  
Experimental Animals ◽  
Peroxidation Processes ◽  
Smooth Myocytes

Introduction. Resections of large volumes of liver parenchyma are complicated by postresection portal hypertension, which leads to structural and functional changes in the organs of the basin portal hepatic vein. The features of the remodeling of the jejunum structures and the features of the processes of lipid peroxidation after resection of different volumes of liver parenchyma were not adequately investigated.The aim of the study – to learn the features of lipid peroxidation processes in the jejunum of experimental animals after resection of different volumes of liver parenchyma.Research Methods. The studies were performed on 36 white male rats, which were divided into 3 groups. The first group consisted of 12 intact experimental animals (control), 2nd – 12 animals, which removed the left side lobe of the liver, which was 31.5% of its parenchyma, 3rd – 12 rats after resection of the left and right lateral lobes, that is 58, 1% of liver parenchyma. One month after the beginning of the experiment, euthanasia of rats was performed by bloodletting under conditions of thiopental anesthesia. In quantitative evaluation of lipid peroxidation processes, the content of diene conjugates and active products of thiobarbituric acid in the wall jejunum homogenates were determined. Sections from the jejunum were fixed in a 10% neutral formalin solution, and after conducting, the ethyl alcohol of increasing concentration was placed in paraffin. Histologic sections 5–7 мm thick after deparaffinization were stained with hematoxylin-eosin, for van Gizon, Mallory, Weigert, and toluidine blue. Gistostereometrically there were determined the relative volumes of damaged endothelial cells, epithelial cells, smooth myocytes, relative volume of stroma in the muscle. A correlation analysis was carried out between biochemical and histostereometric indices with the definition of the coefficient (r) of correlation. Quantitative values were processedstatistically.Results and Discussion. It was established that in conditions of the simulated experiment one month after the resection of the liver the expressed processes of lipid peroxidation occurred in the intestine. Thus, after removal of 31.5% of the liver parenchyma, the content of diene conjugates increased in 1.9 times after resection of 58.1% of liver parenchyma – 3.4 times, the concentration of active products of tiobarbituric acid, respectively, in 2.1 and 6.7 times. The obtained and analyzed indicators testify that at removal of significant volumes of liver parenchyma processes of peroxide oxidation of lipids, which depend on the removed volume of a liver, are substantially increased. A relative volume of damaged epithelial cells of the mucous membrane of the jejunum in the 2nd group of observations increased in 2.6 times, endothelial cells – 2 times, smooth myocytes – 1.86 times, stroma in the muscle of the jejunum– 12.7%. After resection of 58.1% of liver parenchyma,the investigated morphometric parameters increased by 30.6; 19.0; 11.8 and 2.4 times. Correlation connections between the concentrationlipid peroxidation products and relative volumes of damaged endothelial cells, epithelial cells, smooth myocytes and stroma in the wall of the jejunum were positive and significant and intensified when 58.1% of liver parenchyma were removed and ranged from +0.53 to +0.84,Conclusions. Lipid peroxidation plays an important role in the adaptive-compensatory processes of the jejunumafter resection of different volumes of liver parenchyma. The degree of morphological changes in the jejunum correlates with the concentration oflipid peroxidation products and depends on the removed volume of liver parenchyma.

scholarly journals ПОРУШЕННЯ ВСМОКТУВАЛЬНОЇ ФУНКЦІЇ ТОНКОЇ КИШКИ ПРИ ПОСТРЕЗЕКЦІЙНІЙ ПОРТАЛЬНІЙ ГІПЕРТЕНЗІЇ

2018 ◽  
Author(s):  
M. S. Hnatiuk ◽  
L. V. Tatarchuk
Keyword(s):  
Small Intestine ◽  
Portal Hypertension ◽  
Epithelial Cells ◽  
Liver Parenchyma ◽  
Relative Volume ◽  
Male Rats ◽  
Morphometric Parameter ◽  
Lateral Part ◽  
Chemical Agent ◽  
Absorption Function

The liver resection is widely used in modern surgical clinics. Removal of large volumes of liver leads to postresection portal hypertension, which is complicated by bleeding from varicose veins of the esophagus, stomach, rectum, ascites, splenomegaly, secondary hypersplenism, parenchymal jaundice, and portosystemic encephalopathy. The widespread prevalence of this pathology, high mortality from its complications indicates that it is an important medical and social problem.The aim of the study – to learn the features of the suction function of the small intestine at postresection portal hypertension.Materials and Methods. The research was conducted on 45 laboratory-sexually mature white male rats, which were divided into 3 groups. The 1 group consisted of 15 intact virtually healthy animals, 2–15 rats after resection of the left lateral part – 31.5 % of liver parenchyma, 3–15 animals after removal of the right and left lateral parts of the liver (58.1 %). One month after the start of the experiment, the suction function of the small intestine was investigated for the D-xylose test. It is specified chemical agent is an inert carbohydrate which is absorbed by passive diffusion. D-xylose is not metabolized in the human body and animals, is excreted in the urine, fully and adequately reflects the suction function of the small intestine. From the small intestine made histological micropreparations. Morphometrically determined the height of the epitheliocytes of the mucousa of the intestine, the diameter of their nuclei, nuclearcytoplasmic relations in them, the relative volume of their damage. Quantitative indicators were processed statistically.Results and Discussion. It was found that one month after resection of 31.5 % of liver parenchyma, the content of D-xylose in urine decreased by only 5.1 %, indicating a slight disruption of the absorption function of the small intestine, and resection 58.1 % of the liver decreased of D-xylose in urine by 28.6 %. The latter figure testified to a marked violation of the suction function of the small intestine. One month after resection, 58.1 % of liver parenchyma decreased the height of epithelial cells by 19.4 % compared with the same control quantitative morphological parameters, and the diameter of their nuclei – only by 2.3 %. Non-uniform disproportionate changes in spatial characteristics of the nucleus and cytoplasm of the epithelial cells resulted in marked violations of nuclear-cytoplasmic relations in these cells. At the same time, the indicated morphometric parameter is statistically significantly (p <0.001) increased by 47.9 %, which indicated an alteration of structural cellular homeostasis. Relative volume of damaged endothelial cells a month after removal of 58.1 % of liver parenchyma increased 21.3 times. Significant correlation between the concentration of D-xylose in urine, nuclear-cytoplasmic ratios in epitheliocytes and the relative volume of damaged epithelial cells was found, which allowed to confirm the close relationship between structural changes in mucosa of the intestine and violation of the suction function in the simulated experimental conditions. Consequently, significant resection of the liver parenchyma leads to posresection portal hypertension, severe lesions of the mucosa of the intestine, which significantly impairs the suction function of the small intestine.Conclusions. Resection of 58.1 % of liver parenchyma leads to postresection portal hypertension and severe structural rearrangement of the epitheliocytes of the mucosa of the small intestine, which is confirmed by a disturbance in their cellular structural homeostasis and a significant increase in the relative volume of their damage, which was complicated by a significant violation of the suction function of the small intestine.

scholarly journals THE PECULIARITIES LOCAL IMMUNE REACTIONS IN ILEUM AT POSTRESECTION PORTAL HYPERTENSION

2018 ◽  
Vol 17 (2) ◽  
pp. 71-75
Author(s):  
L. V. Tatarchuk ◽  
M. S. Hnatyuk
Keyword(s):  
Portal Hypertension ◽  
Mast Cells ◽  
Cell Density ◽  
Structural Changes ◽  
White Male ◽  
Liver Parenchyma ◽  
Male Rats ◽  
Secretory Iga ◽  
Immune Homeostasis ◽  
Immune Reactions

In the experiment, in laboratory white male rats, local immune reactions were investigated in the ileum in conditions of postresection portal hypertension, which was modeled by removing 58.1% of liver parenchyma. It has been established that postresection portal hypertension leads to pronounced changes in local immune reactions in the ileum, characterized by a 29.6% reduction in secretory IgA, a plasmoncytes with IgA on 1 mm² on the mucosa by 32.5%, an uneven, disproportional increase in the number of plasmatic cells with IgM. IgG, IgE, respectively, by 77.0%, 4.1 and 5.1 times. The cell density of the infiltrate in the mucosa of the investigated organ increased by 37.0%, and the number of mast cells by 35.8%. The results obtained indicate that postresection portal hypertension leads to weakening, tension and instability of the local immune homeostasis of the ileum mucosa and marked structural changes in the wall of the investigated organ.

scholarly journals REMODELING PECULIARITIES OF ATRIAL ARTERY IN CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION

2021 ◽  
pp. 38-43
Author(s):  
М. S. Hnatjuk ◽  
N. M. Gdanska ◽  
L. V. Tatarchuk ◽  
Т. І. Gargula ◽  
О. В. Jasinovsky
Keyword(s):  
Endothelial Cells ◽  
Portal Hypertension ◽  
Left Atrium ◽  
Blood Supply ◽  
The Body ◽  
Male Rats ◽  
Outer Diameter ◽  
Functional Changes ◽  
The Media ◽  
The Right

It is known that structural and functional changes in the heart can be caused by various changes in hemodynamics, which include post resection portal hypertension. It should be noted that the structure of the atrial arteries in postresection portal hypertension has not been studied enough. The purpose of the study is to investigate the peculiarities of atrial artery remodeling in the conditions of post resection portal hypertension. Material and methods. The arteries of the atria of 34 male rats, which were divided into 2 groups, were studied by a complex of morphological methods. The group 1 consisted of 15 experimental intact animals; group 2 included 19 rats with post resection portal hypertension, which was simulated by removal of the left and right lateral lobes of the liver. Euthanasia of rats was performed by bloodletting under conditions of thiopental anesthesia one month after the start of the experiment. The outer and inner diameters of the atrial arteries of medium and small calibers, the thickness of the media and adventitial membrane, Wagenworth and Kernogan indices, the height of endothelial cells, the diameters of their nuclei, nuclear-cytoplasmic ratios in the studied endothelial cells, and relative volumes of damaged endotheliocytes were measured. Quantitative indicators were processed statistically. Results. It was established that in the conditions of post resection portal hypertension the arteries of small caliber of the atria changed more markedly. The outer diameter of these vessels of the left atrium increased by 4.2 %, the right - by 3.3 % (p <0.05), the thickness of the media and the adventitial membrane increased by 12.58 % and 45.7 % and respectively 11.8 % and 33.7 % (p <0.001, their lumen decreased by 13.5 % and 10.7 %, respectively) (p <0.001). The Wagenworth index of small caliber arteries increased markedly, and the Kernogan index decreased. Nuclear-cytoplasmic ratios in endotheliocytes of small arteries of the left atrium were changed by 7.6 %, and in the right - by 6.1 % (p<0.01), the relative volumes of damaged endotheliocytes respectively increased by 7.6 and 5, 2 times (p <0.001). Damage to a significant number of endothelial cells led to their dysfunction, blockade of NO synthase, decreased NO synthesis, activation of its degradation, which exacerbated spasm, narrowing of vessels and significantly impaired blood supply to the body and complicated by hypoxia.Histologically at post resection portal hypertension, there were pronounced vascular disorders, plethora, dilation of mainly venous vessels, perivasal edema and stroma edema, foci of dystrophic, necrobiotic, apoptotically altered endotheliocytes, stromal structures and cardiomyocytes. There was also swelling of endothelial cells, their dystrophy, necrobiosis, desquamation and proliferation. Conclusion. Post resection portal hypertension leads to severe remodeling of mainly small atrial arteries, which is characterized by thickening of their wall, narrowing of the lumen, changes in the Kernogan and Vaughanworth indices, endothelial cell damage, endothelial dysfunction, decreasing of organ blood supply, hypoxia, trophic disorders, dystrophic and necrobiolic changes of tissues and cells, infiltration, sclerosis.

scholarly journals MORPHOMETRIC ANALYSIS REMODELING VESSELS HEMOMICROCIRCULATORY BED OF JEJUNUM AT RESECTIONS OF LIVER

2018 ◽  
Vol 24 (1) ◽  
pp. 16-20
Author(s):  
M.S. Hnatjuk ◽  
L.V. Tatarchuk
Keyword(s):  
Portal Hypertension ◽  
Varicose Veins ◽  
Liver Parenchyma ◽  
Male Rats ◽  
Lateral Part ◽  
The Difference ◽  
The Right ◽  
Bed Expansion ◽  
Quantitative Indicators ◽  
Sexually Mature

Liver resection is widely used in modern surgical departments. Removal of large volumes of the liver leads to postresection portal hypertension, which is complicated by bleeding from varicose veins of the esophagus, stomach, rectum, ascites, splenomegaly with secondary hypersplenism, parenchymal jaundice and portosystemic encephalopathy. The widespread prevalence of this pathology, high mortality from its complications indicates that it is an important medical and social problem. The aim of the study is quantitative morphological study of the features of remodeling the vessels of the hemomicrocirculatory bad of the jejunum at resection of different volumes of the liver. The studies were conducted on 45 sexually mature male rats, which were divided into 3 groups. The first group consisted of 15 intact virtually animals, 2-15 rats after resection of the left lateral part – 31.5% of the parenchyma of the liver, 3-15 animals after resection of the right and left lateral parts of the liver (58.1%). Euthanasia of experimental animals was carried out by bloodletting in conditions of thiopental anesthesia 1 month after the beginning of the experiment. The hemomicrocirculatory bad of the jejunum was studied by injection of its vessels into the carcass-gelatinous mixture, which was injected through the abdominal aorta. From the jejunum, lightened and histologic preparates were prepared and morphometrically studied the vessels of the microhemocirculatory bed. Quantitative indicators were processed statistically, the difference between the comparative values was determined by the Student's criterion. It was established that the severity of structural transformation of the vessels of the microhemocirculatory bad of the jejunum depends on the volume of the removed parenchyma of the liver. The analysis of the obtained results revealed that one month after resection of 31.5% of liver parenchyma, the morphometric parameters of the vessels of the haemomicrocirculatory bad of the jejunum were insignificantly altered. It was determined that resection of 58.1% of liver parenchyma caused postresection portal hypertension and marked remodeling of blood vessels of the hemomicrocirculatory bad of the jejunum, which was characterized by narrowing of arterioles by 23.4%, precapillary arterioles by 22.8%, hemocapillaries by 22.9%%, decrease in the density of microvessels – by 22.4%, the expansion of the capillary venules – by 35.5% and venules – by 28.7%, venous plethora, hypoxia, dystrophy, necrobiosis of cells and tissues, infiltrative processes and sclerosis. Resection of 58.1% of liver parenchyma leads to postresection portal hypertension, pronounced narrowing of lumen of the vessels of the adnexa and exchange units hemomicrocirculatory bed, expansion of the postcapillary venules and venules, venous plethora, hypoxia, dystrophy and necrobiosis of cells and tissues, infiltrative and sclerotic processes in wall of the jejunum.

scholarly journals Alcohol Intoxication and Its Influence on the Course of Male Rats Spermatogenesis

2020 ◽  
Vol 7 (4) ◽  
pp. 46-52
Author(s):  
Nelia Dolynko ◽  
Tetiana Mykytyn ◽  
Natalia Bielova
Keyword(s):  
Functional Analysis ◽  
Epithelial Cells ◽  
Germ Cells ◽  
Sperm Count ◽  
Alcohol Intoxication ◽  
Sperm Concentration ◽  
Male Rats ◽  
Control Group ◽  
Stages Of Development ◽  
Experimental Animals

Morphometric and functional analysis of germ cells in histological micropreparations and ejaculate of male rats at the control group on the 7th, 14th, 21st and 28th days of alcoholization at experimental animals was performed. Prolonged use of ethanol has been shown to reduce resistance to spermatogenic epithelial cells, which are at different stages of development, manifested by inhibition of spermatogenesis with a decrease in sperm count and spermatids, and in ejaculate - a decrease in sperm concentration with increasing number of spermatozoa.

Research of enzyme activity changes in the antioxidant system and the state of NO-system in patients with colon cancer

2008 ◽  
Vol 21 (2) ◽  
pp. 255-258
Author(s):  
Sophia Kovalchuc ◽  
Andriy Revura ◽  
Bohdan Melekh ◽  
Oksana Khavrona ◽  
Yuriy Fedevych ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Enzyme Activity ◽  
Antioxidant System ◽  
The State

Effect of 1,3,6-trimethyl-5-hydroxyuracil succinate on the antioxidant system and free-radical processes in the liver of adult and old rats treated with carbon tetrachloride

2018 ◽  
pp. 55-59
Author(s):  
И.Д. Габдрахманова ◽  
В.А. Мышкин ◽  
Д.А. Еникеев ◽  
А.Р. Гимадиева
Keyword(s):  
Superoxide Dismutase ◽  
Free Radical ◽  
Carbon Tetrachloride ◽  
Antioxidant System ◽  
Complex Compound ◽  
Antiradical Activity ◽  
Conjugated Dienes ◽  
Experimental Animals ◽  
Old Rats ◽  
Radical Processes

Цель исследования: изучение влияния сукцината 1,3,6-триметил-5-гидроксиурацила на антиоксидантную систему и свободнорадикальные процессы в печени взрослых и старых крыс при воздействии тетрахлорметана. Методика. В эксперименте использованы половозрелые животные 12-месячного возраста со средней массой 250 г и старые животные 24-месячного возраста, средней массой 395 г по 30 особей в каждой возрастной группе. Токсическое поражение печени вызывали подкожным введением 50%-ного масляного раствора тетрахлорметана (ТХМ, 2 г/кг) в течение 4 сут. Одновременно с токсикантом опытным животным внутрибрюшинно вводили водный раствор коплексного соединения сукцинат-1,3,6-триметил-5-гидроксиурацила (2,5 мг/100 г) 3 раза в сут. в течение первых 4 сут. и в течение последующих 3 сут. 1 раз в сут. Контролем служили опытные животные, которым вводили физиологический раствор в том же объеме. Изучали окислительную модификацию белков, перекисное окисление липидов (по содержанию ТБК-реагирующих продуктов, уровню гидроперекисей липидов и содержанию диеновых конъюгатов). Состояние антиоксидантной системы оценивали по активности ферментов супероксиддисмутазы, каталазы и глутатионпероксидазы, определяемых биохимическими методами. Антирадикальную активность комплексного соединения и его составляющих субстанций исследовали в модельной системе «этилбензол-ледяная уксусная кислота» с вычислением константы К - скорости взаимодействия перекисных радикалов с молекулами изучаемого соединения в сравнении с эталонным антиоксидантом-ионолом с витамином Е. Результаты. Сукцинат + 1,3,6-триметил-5-гидрокси-урацила существенно снижает токсическое действие ТХМ на печень взрослых и старых крыс, устраняет дисбаланс в системах свободнорадикального окисления белков у старых крыс, статистически значимо улучшает показатели свободнорадикального окисления (СРО) липидов в печени взрослых и старых крыс: снижает уровень продуктов ПОЛ - гидроперекисей, диеновых конъюгатов, ТБК-реагирующих продуктов, а также улучшает работу антиоксидантной системы (АОС), повышая активность каталазы, супероксиддисмутазы и глутатионпероксидазы. Установлена высокая антирадикальная активность изучаемого препарата сопоставимая с активностью эталонного антиоксиданта ионола. Заключение. Сукцинат и его производные способны выступать как индивидуальные вещества с непосредственным антирадикальным механизмом действия, а не только как стимуляторы ферментативных систем антиоксидантной защиты. Aim. To study the effect of a complex compound, 1,3,6-trimethyl-5-hydroxyuracil succinate, on the antioxidant system and free radical processes induced by carbon tetrachloride in the liver of adult and old rats. Methods. The study used sexually mature animals aged 12 months and weighing 250 g and old animals aged 24 months weighing 395 g (total n= 60, 30 rats in each age group). Toxic damage of liver was induced by subcutaneous injections of a 50% oil solution of carbon tetrachloride (CTC) at 2 g/kg for 4 days. Together with the toxicant, experimental animals were injected with a water solution of a complex compound, succinate 1,3,6-trimethyl-5-hydroxyuracil, at a dose of 2.5 mg/100 g, i.p., 3 times per day for the first 4 days and once daily for the following 3 days. Experimental animals were used as controls, which were administered saline in the same volume. Oxidative modifications of proteins, lipid peroxidation (by levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, and conjugated dienes) were studied. Condition of the antioxidant system was evaluated by activities of superoxide dismutase, catalase, and glutathione peroxidase using biochemical methods. Antiradical activity of the complex compound and its components was studied in a model system of ethylbenzene-glacial acetic acid; the K7 constant of the rate of peroxide radical interaction with molecules of the studied compound was compared with the reference antioxidant ionol with vitamin E. Results. Succinate +1.3.6-trimethyl-5-hydroxyuracil, considerably reduced TXM hepatotoxicity in adult and old rats; removed the disbalance in free radical systems of protein oxidation in old rats; significantly improved indexes of free-radical oxidation (FRO) of hepatic lipids in adult and old rats; decreased levels of LP products, hydroperoxides, conjugated dienes, and TBARS, and enhanced performance of the antioxidant system (AOS) by increasing activities of catalase, superoxide dismutase, and glutathione peroxidase. The study demonstrated a high antiradical activity of the study drug comparable with the activity of the reference antioxidant, ionol. Сonclusion. Succinate and its derivatives can perform as individual substances with a direct antiradical mechanism of action rather than as stimulators of enzymic systems of antioxidant defence.

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