scholarly journals Зміни антиоксидантно-прооксидантної системи та їх медикаментозна корекція при поєднанні сечокам’яної хвороби і пародонтиту

2018 ◽  
Author(s):  
Z. O. Bumbar ◽  
O. R. Pinyazhko
Keyword(s):  
High Efficiency ◽  
Periodontal Diseases ◽  
Antioxidant Protection ◽  
Biochemical Indicators ◽  
Treatment Regimens ◽  
Practical Research ◽  
Biochemical Studies ◽  
Drug Regimens ◽  
Oxidative Processes ◽  
Antioxidant Protection System

Introduction. The article presents the results of biochemical studies of enzymes, intermediate and final products of prooxidant-peroxidic processes in periodontal diseases against the background of urolithiasis in the dynamics of treatment and in the aspect of the presenting of comparison of two drug regimens: standard common and developed pathogenetic.The presented data represent a fragment of the scientific and practical research performed to improve the periodontal care in patients with urolithiasis.The aim of the study – to analyze the biochemical studies performed in patients with comorbid pathology after combined pharmacotherapy. The biomaterial was studied in 60 patients with inflammatory periodontal diseases on the background of urolithiasis. Two different pharmacotherapeutic regimens were used to treat patients.Research Methods. A series of biochemical studies was carried out to objectify the results. According to the obtained data, the application of the developed treatment regimen in patients with comorbid pathology provided normalization of the antioxidant protection system in catalase parameters from 1.99±0.14 at the beginning of treatment to 1.66±0.04 after treatment and superoxidedismutase from 1.40±0, 12 to 2.10±0.07, as well as a decrease in the levels of intermediate and final products of peroxidation.Results and Discussion. The analysis of the results of the observation showed high efficiency of combined pharmacotherapy.Conclusions. Thus, according to the resulted biochemical indicators, application of standard and developed treatment regimens ensured the normalization of the activity of the enzymatic level of the antioxidant system and reduced the intensity of the oxidative processes. An analysis of the results of the studies suggests a higher efficiency of the combined pharmacotherapy, since antioxidant protection indicators in patients treated under the developed scheme, normalized faster than when administered under the traditional generally accepted protocol.

scholarly journals ENHANCEMENT OF FRESHMEN’S ADAPTATION TO HIGH SCHOOL

2019 ◽  
Vol 19 (S1) ◽  
pp. 68-76
Author(s):  
A Nikulina
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Selenium Concentration ◽  
Antioxidant Protection ◽  
Short Term ◽  
Biochemical Indicators ◽  
Second Year ◽  
Antioxidant Protection System ◽  
Deficient Area

Aim. The article deals with studying the effect of a complex selenium-containing compound and physio disease-preventing means on the enhancement of biochemical indicators in freshmen living in a selenium-deficient area. Materials and methods. We conducted 12 longitudinal studies with the students of the first and second year studying at Chuvash Universities (n = 180). Selenium concentration in blood serum was established with the help of fluorometry performed according to Golubkina’s interpretation (Fluorat-02-2M). The activity of lipid peroxidation (c.u.) and antioxidant system (c.u.) was studied using induced chemiluminescence (Biochemiluminometer БХЛ-06). Results. The use of Selenes+ together with a disease-preventing photochrome session is accompanied by antioxidant, metabolic, and hemopoietic effects manifested in the increase of antioxidant activity and selenium concentration by 31.1 and 62.5 %, respectively, and the decrease of lipid peroxidation by 4.1–19.7 % compared to control values. The use of Selenes+ together with exercises contributes to less pronounced stress in the cardiovascular system both during the study and exam periods. Conclusion. Therefore, selenium correction of body adaptation with respect to a biogeochemical specifics of a region normalizes the balance between prooxidant and antioxidant elements of the antioxidant protection system and provides an accelerated shift from short-term to long-term adaptation.

LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION SYSTEM IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES

2019 ◽  
pp. 44-49
Author(s):  
A.O. Atykanov ◽  
G.U. Asymbekova ◽  
A.A. Masybaeva
Keyword(s):  
Lipid Peroxidation ◽  
Endometrial Hyperplasia ◽  
Uterine Cavity ◽  
Reproductive Age ◽  
Support Network ◽  
Antioxidant Protection ◽  
Women Of Reproductive Age ◽  
Atypical Form ◽  
Antioxidant Protection System ◽  
Quantitative Indicators

The paper presents quantitative indicators of lipid peroxidation (LP) products and antioxidant support network (ASN) in blood plasma in women with various histological forms of endometrial hyperplastic processes (EHPs). The goal of the paper is to assess the state of LP processes and ASN in women of reproductive age with various forms of EHPs. Materials and Methods. The trial enrolled 137 women of reproductive age: 112 women with endometrial hyperplasia (EH) and 25 women with uterine cavity synechia without EH. Conclusion. In case if EH progresses from a simple atypical form to adenocarcinoma, an increase in lipid peroxidation intensity and ASN inhibition is observed. Keywords: women, endometrial hyperplastic processes, endometrial hyperplasia, lipid peroxidation, antioxidant support network. В работе представлены количественные показатели содержания продуктов перекисного окисления липидов (ПОЛ) и системы антиоксидантной защиты (АОЗ) в плазме крови у женщин с различными гистологическими формами гиперпластического процесса эндометрия (ГПЭ). Цель исследования. Оценить состояние процессов ПОЛ и системы АОЗ при развитии различных форм ГПЭ у женщин репродуктивного возраста. Материалы и методы. Объектом исследования явились 137 женщин репродуктивного возраста: 112 женщин с гиперплазией эндометрия (ГЭ) и 25 женщин с синехиями полости матки без ГЭ. Выводы. При прогрессировании ГЭ от простой неатипичной до аденокарциномы происходит нарастание интенсивности липопереокисления и угнетения системы АОЗ. Ключевые слова: женщины, гиперпластические процессы эндометрия, гиперплазия эндометрия, перекисное окисление липидов, система антиоксидантной защиты.

scholarly journals The state of antioxidant protection system in cows under the influence of heavy metals

2020 ◽  
Vol 11 (2) ◽  
pp. 237-242
Author(s):  
L. G. Slivinska ◽  
A. R. Shcherbatyy ◽  
B. O. Lukashchuk ◽  
B. V. Gutyj
Keyword(s):  
Heavy Metals ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Malonic Dialdehyde ◽  
Protection System ◽  
Lipid Hydroperoxides ◽  
Technogenic Pollution ◽  
Antioxidant Protection ◽  
Diene Conjugates ◽  
Antioxidant Protection System

A highly relevant problem of modern veterinary science is the study of features and mechanisms of combined action of the most common heavy metals – cadmium and plumbum and their influence on the body of humans and animals in the regions of Ukraine under technogenic pollution. The purpose of the work was to study the influence of heavy metals on the state of the antioxidant protection system of cows, in particular on the content of lipid peroxidation products (malonic dialdehyde, lipid hydroperoxides and diene conjugates), and activity of antioxidant enzymes (glutathione peroxidase and superoxide dismutase), depending on the distance to the heaps of mines in the coal basin. The study objects were cows of black-and-white breed at the age of 3–7 years. It was established that this parameter in the place with the highest concentration of diene conjugates in the blood of cows was by 25.8 % higher compared to the place of low concentration and 12.1 % higher compared to the place with medium concentration. In the place with the highest content of lipid hydroperoxides in the blood of cows the parameter was 23.7 % higher compared to the cows from the place with the low content. The concentration of lipid hydroperoxides in the blood of cows from the place with the medium content was 16.7% higher compared to the cows from the place with the low content. The parameter from the place with the lowest content of lipid hydroperoxides in the blood of cows was 12.1% lower compared to the place with the highest content. The level of malonic dialdehyde in the blood of cows from the technogenic pollution zone in the place with the largest amount was higher by 36.2; 34.0 and 18.8 % – compared to places with medium and low levels, respectively. The activity of superoxide dismutase in the blood of cows in the place with its highest activity was 0.284 ± 0.0099 % block. reac/g Hb, and in the place with the lowest activity – 0.23 ± 0.0051 % block. reac/g Hb. The activity of glutathione peroxidase in the blood of cows in farms of the technogenic pollution zone depended on the distance to the mine. These researches will further develop effective methods of treating cows under the influence of heavy metals, in particular regarding the antioxidant system.

scholarly journals Results of clinical and additional examination methods in the treatment of localized periodontitis

2021 ◽  
Vol 27 (1-2) ◽  
pp. 46-62
Author(s):  
A.G. Oliynyk ◽  
Keyword(s):  
Periodontal Diseases ◽  
Effective Control ◽  
Duration Of Treatment ◽  
Treatment Regimens ◽  
Periodontal Tissues ◽  
Antiseptic Treatment ◽  
Before And After ◽  
Examination Methods ◽  
The Stability ◽  
Destructive Processes

Aim. The study aims at enhancing the therapeutic effect and reducing the duration of treatment by using a solution of titanium dioxide in ozonated distilled water for antiseptic treatment of periodontal tissues. Material and Methods. Treatment results of local inflammatory changes of periodontal tissues in 128 patients (73 female, 55 male aged 21-65 years) were analyzed and classified by the severity of periodontal disease as: gingivitis, primary and moderate periodontitis. Schemes of medical actions differed in pharmacotherapy. In order to ascertain the most effective approach, the results of conventional and developed treatment complexes were compared. Results and Discussion. Digital indicators of the periodontal tissues condition following treatment presented common positive dynamic in all patients. However, significantly better results were obtained by using the developed method. According to the dynamics of bleeding index values, the proposed treatment regimens allow achieving more effective control over the inflammatory process. Digital indicators of hygiene showed that a better effect was reached after the suggested method - the dynamics of reducing the depth of periodontal pockets demonstrated clearer and statistically better results. Changes in the pH of the gingival fluid in a severe inflammatory condition indicated a considerable improvement after using the suggested treating method. X-ray data demonstrated the stability of digital values in the observation groups before and after treatment, which was interpreted as a sufficient control of destructive processes. Conclusion. Mathematical analysis of the presented data demonstrates the benefits of the developed method for the treatment of periodontal diseases, especially in non-surgical treatment regimens. The performed research confirms greater effectiveness of the therapeutic method in initial lesions, and thus it proves the efficiency of complex control for preventive purposes

scholarly journals Pharmacoprophylaxis of liver diseases: creating a new hepatoprotector

2020 ◽  
Vol 17 ◽  
pp. 00061
Author(s):  
Svetlana Zykova ◽  
Sergey Shurov ◽  
Aleksey Savinkov ◽  
Nino Gugushvili ◽  
Vladimir Talismanov
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Toxic Effect ◽  
Alanine Aminotransferase ◽  
Liver Diseases ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Biochemical Indicators ◽  
Intact Group ◽  
Biochemical Studies

The article presents a study of the hepatoprotective activity of a tricyclic heterocycle, which refers to 5, 6, 7, 8-tetrahydroquinolines. The effect of 8, 8-dimethyl-5-p-tolyl-8, 9-dihydro-2H-pyrido [4, 3, 2-de] cinnolin-3 (7H) was studied on rats under the influence of the model of toxic hepatosis induced by carbon tetrachloride to find out the indicators of peroxidation and biochemical indicators. Biochemical studies have shown that modelling toxic fat hepatosis caused by the inception of carbon tetrachloride to rats increased the activity of alanine aminotransferase by 2.5 times more compared with the intact group, indicating the development of oxidative stress induced by the treatment of pyrido [4, 3, 2] Cinnol I that reduced the toxic effect of CTC by 79.9 %. Mexidol had a less pronounced hepatoprotective effect: the activity of Alanine aminotransferase on animals of the second group was lower by 29.2 % than on rats from the control group. Thus, a new compound with hepatoprotective activity has been developed and studied.

scholarly journals The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 111 ◽  
Author(s):  
Robert J. Aitken ◽  
Joel R. Drevet
Keyword(s):  
Oxidative Stress ◽  
Management Strategy ◽  
Reproductive Capacity ◽  
Ros Generation ◽  
Antioxidant Protection ◽  
Camp Generation ◽  
Continuous Generation ◽  
Rational Management ◽  
Oxidative Processes ◽  
Mammalian Spermatozoa

This article addresses the importance of oxidative processes in both the generation of functional gametes and the aetiology of defective sperm function. Functionally, sperm capacitation is recognized as a redox-regulated process, wherein a low level of reactive oxygen species (ROS) generation is intimately involved in driving such events as the stimulation of tyrosine phosphorylation, the facilitation of cholesterol efflux and the promotion of cAMP generation. However, the continuous generation of ROS ultimately creates problems for spermatozoa because their unique physical architecture and unusual biochemical composition means that they are vulnerable to oxidative stress. As a consequence, they are heavily dependent on the antioxidant protection afforded by the fluids in the male and female reproductive tracts and, during the precarious process of insemination, seminal plasma. If this antioxidant protection should be compromised for any reason, then the spermatozoa experience pathological oxidative damage. In addition, situations may prevail that cause the spermatozoa to become exposed to high levels of ROS emanating either from other cells in the immediate vicinity (particularly neutrophils) or from the spermatozoa themselves. The environmental and lifestyle factors that promote ROS generation by the spermatozoa are reviewed in this article, as are the techniques that might be used in a diagnostic context to identify patients whose reproductive capacity is under oxidative threat. Understanding the strengths and weaknesses of ROS-monitoring methodologies is critical if we are to effectively identify those patients for whom treatment with antioxidants might be considered a rational management strategy.

scholarly journals DYNAMICS OF BIOCHEMICAL INDICATORS OF BLOOD IN FRESH COWS ON THE BACKGROUND OF HEPATOPROTECTOR APPLICATION

2021 ◽  
Author(s):  
T.A. Sakhno ◽  
◽  
M.P Semenenko ◽  
V.N. Grin ◽  
◽  
...  
Keyword(s):  
High Efficiency ◽  
Biochemical Indicators ◽  
Hepatobiliary System ◽  
Hepatoprotective Drug

The influence of a new injectable hepatoprotective drug livasen in the prevention of hepatosis in highly productive fresh cows has been studied. The performed pharmacoprophylaxis has shown high efficiency in the correction of diseases of the hepatobiliary system and metabolic insufficiency.

scholarly journals Динаміка зміни показників системи ПОЛ-АОЗ, вуглеводного та ліпідного обміну в крові експериментальних щурів при переході гострого панкреатиту у хронічну форму

2012 ◽  
Vol 3 (2) ◽  
pp. 48-53
Author(s):  
V. A. Makarchuk ◽  
G. О. Ushakova
Keyword(s):  
Lipid Peroxidation ◽  
Male Rats ◽  
Antioxidant Protection ◽  
Main Duct ◽  
Experimental Animals ◽  
Pancreatic Tail ◽  
Carbohydrate And Lipid Metabolism ◽  
Antioxidant Protection System ◽  
Lipid Peroxidation Inhibition ◽  
Significant Intensification

In consequence of ligation of the main duct in pancreatic tail section of male rats the acute pancreatitis had developed but it gradually turned into a chronic form. In the blood of experimental animals processes of lipid peroxidation (LPO), the state of antioxidant protection system (AOP), carbohydrate and lipid metabolism were studied. In rats with chronic pancreatitis the significant intensification of lipid peroxidation, inhibition of antioxidant system, hyperglycaemia, and hyperlipidaemia were found.

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