Abstract P127: Ayurveda Improves Arterial Stiffness and Cardiometabolic Risk in Coronary Patients: A Prospective Pilot Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Robert DuBroff ◽  
Vasant Lad ◽  
Cristina Murray-Krezan
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Pilot Study ◽  
Arterial Stiffness ◽  
Systolic Blood Pressure ◽  
Cardiometabolic Risk ◽  
Medicinal Herbs ◽  
Cardiometabolic Risk Factors ◽  
Yoga Meditation

Introduction: Ayurveda is the ancient East Indian holistic approach to health that includes yoga, meditation, breathing exercises, medicinal herbs, and other practices. Although it has been practiced for nearly 5000 years there is little objective data regarding its efficacy in coronary disease. Hypothesis: Can the addition of Ayurveda to usual care improve markers and risk factors of cardiovascular disease? Methods: Twenty-six volunteers with a history of prior myocardial infarction, coronary bypass surgery, or coronary angioplasty/stent were recruited from the University of New Mexico cardiology clinics. Each patient underwent consultation with a single Ayurvedic specialist and received personalized instruction in daily yoga, meditation, breathing, medicinal herbs, and a caloric unrestricted Ayurvedic diet. Standardized measurements of arterial stiffness (pulse wave velocity) and cardiometabolic risk factors were obtained at baseline and after 90 days of therapy. Results: Nineteen patients, mean age 71.6 years, completed the study, six dropped out and one was lost to follow up. Among hypertensive patients (n=15), 60% (9 of 15) had either a >10 mm Hg drop in systolic blood pressure (n=4) or required a reduction in anti-hypertensive medications due to persistent systolic blood pressure < 110 mm Hg (n=5). Statistical analysis was performed using the paired student’s t test. Conclusion: This pilot study suggests that short term Ayurvedic therapy improves arterial stiffness and many cardiometabolic risk factors in patients with coronary artery disease. These findings support the need for a randomized controlled trial to further study the effects of Ayurveda on cardiovascular disease.

scholarly journals Association between Circulating Osteocalcin and Cardiometabolic Risk Factors following a 4-Week Leafy Green Vitamin K-Rich Diet

2020 ◽  
Vol 76 (5) ◽  
pp. 361-367
Author(s):  
Alexander Tacey ◽  
Marc Sim ◽  
Cassandra Smith ◽  
Mary N. Woessner ◽  
Elizabeth Byrnes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Plasma Glucose ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Cardiometabolic Health ◽  
Vitamin K1 ◽  
Low Responders ◽  
High Responders

<b><i>Background:</i></b> Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. <b><i>Materials and Methods:</i></b> Men (<i>n</i> = 20) and women (<i>n</i> = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed. <b><i>Results:</i></b> Following the HK diet, ucOC and ucOC/tOC were suppressed more (<i>p</i> &#x3c; 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (<i>p</i> &#x3e; 0.05). <b><i>Discussion/Conclusion:</i></b> Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.

scholarly journals Effects of Moderate Combined Resistance- and Aerobic-Exercise for 12 Weeks on Body Composition, Cardiometabolic Risk Factors, Blood Pressure, Arterial Stiffness, and Physical Functions, among Obese Older Men: A Pilot Study

2020 ◽  
Vol 17 (19) ◽  
pp. 7233
Author(s):  
Wonil Park ◽  
Won-Sang Jung ◽  
Kwangseok Hong ◽  
Yae-Young Kim ◽  
Sung-Woo Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Composition ◽  
Arterial Stiffness ◽  
Cardiometabolic Risk ◽  
Older Men ◽  
Cardiometabolic Risk Factors ◽  
Maximal Heart Rate ◽  
Combined Exercise ◽  
Physical Functions

We demonstrated the hypothesis that combined exercise improves body composition, cardiometabolic risk factors, blood pressure (BP), arterial stiffness, and physical functions, in obese older men. Older men (n = 20) were randomly assigned to combined exercise training (EXP; n = 10) or control groups (CON; n = 10). The combined exercise was comprised of elastic-band resistance training and walking/running on a treadmill and bicycle at 60–70% of maximal heart rate for 3 days/weeks. EXP showed significant decreases in body weight, body mass index, and %body fat (p < 0.05). The exercise program significantly reduced BP, mean arterial pressure, pulse pressure, and brachial-ankle pulse wave velocity. Furthermore, while the plasma levels of low-density lipoprotein cholesterol and epinephrine were significantly reduced in EXP, VO2 peak and grip strength were significantly enhanced (p < 0.05). In conclusion, it is indicated that 12-week regular combined exercise improves body composition, cardiometabolic risk factors, hemodynamics, and physical performance in obese older men.

scholarly journals Uric Acid Associates With Executive Function in Children and Adolescents With Hypertension

Hypertension ◽  
2021 ◽  
Author(s):  
Stella Stabouli ◽  
Katerina Chrysaidou ◽  
Athanasia Chainoglou ◽  
Dimos Gidaris ◽  
Vasilios Kotsis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Uric Acid ◽  
Systolic Blood Pressure ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Behavior Regulation ◽  
Executive Performance ◽  
High Uric Acid

Observational studies show that serum uric acid levels associate with cardiometabolic risk factors and subclinical target organ damage. The aim of the present study is to investigate the association of traditional cardiometabolic risk factors and uric acid with the executive performance in children and adolescents. Ninety-nine children and adolescents aged 5 to 18 years referred for assessment of primary hypertension were included. Traditional cardiometabolic risk factors, uric acid, and ambulatory blood pressure parameters were assessed. Executive performance was assessed by the validated Behavior Rating Inventory of Executive Function parent questionnaire. Serum uric acid correlated with cardiometabolic parameters, daytime and nighttime systolic blood pressure. High uric acid levels and ambulatory hypertension were associated with behavior regulation independently of other cardiometabolic risk factors or presence of metabolic syndrome. Participants with combined hypertension and high uric acid levels presented the lowest behavior regulation performance. Children with high uric acid had worse behavior regulation indices T scores with estimated marginal means 56.47 (95% CI, 51.68–61.27) compared with 49.22 (95% CI, 45.91–52.53) in those with low uric acid levels ( P =0.023, adjusted for age, sex, nighttime systolic blood pressure, daytime and nighttime heart rate). Mediation analysis showed that part of the effect of high uric acid levels on behavior regulation was mediated by nighttime systolic blood pressure. In conclusion, we found a positive association of serum uric acid with worse executive performance in children at risk for primary hypertension. Extending these cross-sectional findings with longitudinal studies may determine whether high uric acid levels increases the risk of cognitive decline in youth.

scholarly journals Fruit Intake and Changes of Cardio-Metabolic Risk Factors in People with Obesity

2021 ◽  
Vol 42 (5) ◽  
pp. 382-389
Author(s):  
Shiao Shih Liu ◽  
Ju Young Kim ◽  
Jung Ha Park ◽  
Sohye Kim ◽  
Kiheon Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Cardiometabolic Risk ◽  
Fasting Blood Glucose ◽  
Cardiometabolic Risk Factors ◽  
Abdominal Circumference ◽  
Fruit Intake ◽  
Lower Systolic Blood Pressure ◽  
Beneficial Effects

Background: This study aimed to explore the relationship between fruit intake, changes in fruit intake, and changes in cardiometabolic factors in people with obesity. Methods: A total of 21,270 subjects (8,718 men, 12,552 women) aged 40 years and over, from the Korean-based Genome and Epidemiology Study, were followed up for an average of 4.4 years. Fruit intake was assessed using a food frequency questionnaire at baseline and the second follow-up. The beta coefficient and confidence intervals for changes in cardiometabolic risk factors according to fruit consumption were calculated using a linear regression model. Results: In men, the abdominal circumference decreased with changes in fruit intake (P=0.029). Fruit intake and increased fruit intake in men were associated with a lower systolic blood pressure (P=0.012 and P=0.02, respectively) and lower triglyceride levels (P=0.002 and P<0.001, respectively). In women, abdominal circumference decreased with both fruit intake and increased fruit intake (P<0.001 and P=0.013, respectively). Systolic blood pressure and triglycerides tended to decrease only with fruit intake (P=0.048 and P<0.001, respectively). Unlike in men, fasting blood glucose tended to decrease in women with both fruit intake and increased fruit intake (P=0.011 and P=0.005, respectively). Conclusion: Fruit intake and increased fruit intake may have beneficial effects on cardiometabolic risk factors among individuals who are obese.

Abstract 463: Cardiometabolic Risk Factors and Vitamin D 25OH levels in Puerto Rican Adolescents

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Marta P Suarez-Rivera ◽  
Wilmarie Bruckman ◽  
Ana García ◽  
Melvin Bonilla-Felix
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Vitamin D ◽  
Puerto Rican ◽  
Cardiometabolic Risk ◽  
Statistical Significance ◽  
Cardiometabolic Risk Factors ◽  
Bivariate Analysis

Purpose: Overweight, obesity, hypertension (HTN), insulin resistance, and dyslipidemia have been recognized as cardiometabolic risk factors in adults. Early markers of cardiovascular disease in children are lacking. Low vitamin D (VITD) levels are associated with higher blood pressure, obesity and insulin resistance. We explored the association between traditional cardiometabolic risk factors and VITD levels with HTN status in adolescents. DESIGN METHODS: Cross-sectional pilot study in students from grades 9th - 12th in Puerto Rico. Fasting blood samples to estimate serum lipids, fasting glucose and vitamin D25OH levels were obtained, with anthropometric and blood pressure measurements. Variables described as mean [standard deviation (sd)] or frequencies and percentages as appropriate. Bivariate analysis using chi-square test; statistical significance was set at p<0.05. Results: 78 adolescents, mean age: 16 years were studied. Mean BMI: 23.8 (range 17-39); 19.2% (15/78) were overweight and 16.7% (13/78) were obese. Pre-HTN observed in 7.7% (6/78), with 1 HTN. Hypercholesterolemia (≥170 mg/dl): 16.9% 13/77), low HDL levels (≤ 40 mg/dl): 67.5% 23/77), and hypertriglyceridemia (≥ 110 mg/dl): 15.6% (12/77). VITD levels were low (< 30ng/dL) in 31% 24/77. Obese subjects were more likely to have insufficient VITD levels when compared with the non-obese, (61.5% vs 25%; p=0.02).At least 1 cardiometabolic risk factor was found in 69% (54/78); 33% (26/78) had 2 or more. Conclusion: Obesity is associated with low VITD levels and preHTN. Cardiometabolic risk factors are highly prevalent in our population. Interventions to prevent cardiovascular disease in Puerto Rican adolescents are required.

scholarly journals Cardiometabolic risk factors associated with brain age and accelerate brain ageing

2021 ◽  
Author(s):  
Dani Beck ◽  
Ann-Marie G. de Lange ◽  
Mads Lund Pedersen ◽  
Dag Alnaes ◽  
Ivan I. Maximov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Low Grade ◽  
Mean Cell Volume ◽  
Tissue Specific ◽  
Brain Ageing ◽  
Brain Age

The structure and integrity of the ageing brain is interchangeably linked to physical health, and cardiometabolic risk factors (CMRs) are associated with dementia and other brain disorders. In this mixed cross-sectional and longitudinal study (interval mean [standard deviation] = 19.7 [0.5] months), including 1062 datasets from 790 healthy individuals (mean (range) age = 46.7 (18-94) years, 54% women), we investigated CMRs and health indicators including anthropometric measures, lifestyle factors, and blood biomarkers in relation to brain structure using MRI-based morphometry and diffusion tensor imaging (DTI). We performed tissue specific brain age prediction using machine learning and performed Bayesian multilevel modelling to assess changes in each CMR over time, their respective association with brain age gap (BAG), and their interaction effects with time and age on the tissue-specific BAGs. The results showed credible associations between DTI-based BAG and blood levels of phosphate and mean cell volume (MCV), and between T1-based BAG and systolic blood pressure, smoking, pulse, and C-reactive protein (CRP), indicating older-appearing brains in people with higher cardiometabolic risk (smoking, higher blood pressure and pulse, low-grade inflammation). Longitudinal evidence supported interactions between both BAGs and waist-to-hip ratio (WHR), and between DTI-based BAG and systolic blood pressure and smoking, indicating accelerated ageing in people with higher cardiometabolic risk (smoking, higher blood pressure, and WHR). The results demonstrate that cardiometabolic risk factors are associated with brain ageing. While randomised controlled trials are needed to establish causality, our results indicate that public health initiatives and treatment strategies targeting modifiable cardiometabolic risk factors may also improve risk trajectories and delay brain ageing. Key words: T1 MRI, DTI, Brain age, Cardiometabolic risk

Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: is it related to cardiometabolic risk?

2020 ◽  
pp. 1-8
Author(s):  
Sanem Kayhan ◽  
Nazli Gulsoy Kirnap ◽  
Mercan Tastemur
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Uric Acid ◽  
Vitamin B12 ◽  
Cardiometabolic Risk ◽  
Vitamin B12 Deficiency ◽  
Left Ventricular ◽  
Cardiometabolic Risk Factors ◽  
B12 Deficiency ◽  
Deficiency Group

Abstract. Vitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel cardiovascular marker. In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p < 0.001; 80 vs 70 mmHg, p < 0.001; 14.2 vs 9.5, p < 0.001; 10.2 vs 4 mg/dl p < 0.001; 6.68 vs 4.8 mg/dl, p < 0.001 respectively). The prevalence of left ventricular hypertrophy was higher in vitamin B12 deficiency group (43.8%) than the control group (8.6%) (p < 0.001). In vitamin B12 deficiency group, a positive correlation was detected between MHR and SBP, CRP and uric acid (p < 0.001 r:0.34, p < 0.001 r:0.30, p < 0.001 r:0.5, respectively) and a significant negative correlation was detected between MHR and T-CHOL, LDL, HDL and B12 (p < 0.001 r: −0.39, p < 0.001 r: −0.34, p < 0.001 r: −0.57, p < 0.04 r: −0.17, respectively). MHR was high in vitamin B12 deficiency group, and correlated with the cardiometabolic risk factors in this group, which were SBP, CRP, uric acid and HDL. In conclusion, MRH, which can be easily calculated in clinical practice, can be a useful marker to assess cardiovascular risk in patients with vitamin B12 deficiency.

Association between maternal prepregnancy body mass index with offspring cardiometabolic risk factors: analysis of three Brazilian birth cohorts

2021 ◽  
pp. 1-7
Author(s):  
Mariane da Silva Dias ◽  
Alicia Matijasevich ◽  
Ana Maria B. Menezes ◽  
Fernando C. Barros ◽  
Fernando C. Wehrmeister ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Diastolic Blood Pressure ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Birth Cohorts ◽  
Prepregnancy Bmi ◽  
Prepregnancy Body Mass Index

Abstract Evidence suggests that maternal prepregnancy body mass index (BMI) is associated with offspring cardiometabolic risk factors. This study was aimed at assessing the association of maternal prepregnancy BMI with offspring cardiometabolic risk factors in adolescence and adulthood. We also evaluated whether offspring BMI was a mediator in this association. The study included mother–offspring pairs from three Pelotas birth cohorts. Offspring cardiometabolic risk factors were collected in the last follow-up of each cohort [mean age (in years) 30.2, 22.6, 10.9]. Blood pressure was measured using an automatic device, cholesterol by using an enzymatic colorimetric method, and glucose from fingertip blood, using a portable glucose meter. In a pooled analysis of the cohorts, multiple linear regression was used to control for confounding. Mediation analysis was conducted using G-computation formula. In the adjusted model, mean systolic blood pressure of offspring from overweight and obese mothers was on average 1.25 (95% CI: 0.45; 2.05) and 2.13 (95% CI: 0.66; 3.59) mmHg higher than that of offspring from normal-weight mothers; for diastolic blood pressure, the means were 0.80 (95% CI: 0.26; 1.34) and 2.60 (95% CI: 1.62; 3.59) mmHg higher, respectively. Non-HDL cholesterol was positively associated with maternal BMI, whereas blood glucose was not associated. Mediation analyses showed that offspring BMI explained completely the association of maternal prepregnancy BMI with offspring systolic and diastolic blood pressure, and non-HDL cholesterol. Our findings suggest that maternal prepregnancy BMI is positively associated with offspring blood pressure, and blood lipids, and this association is explained by offspring BMI.

scholarly journals Effects of Cranberry Juice Supplementation on Cardiovascular Disease Risk Factors in Adults with Elevated Blood Pressure: A Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2618
Author(s):  
Chesney K. Richter ◽  
Ann C. Skulas-Ray ◽  
Trent L. Gaugler ◽  
Stacey Meily ◽  
Kristina S. Petersen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Systolic Blood Pressure ◽  
Vascular Function ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Lipoprotein Profile ◽  
Cranberry Juice ◽  
Central Systolic Blood Pressure

Emerging cardiovascular disease (CVD) risk factors, including central vascular function and HDL efflux, may be modifiable with food-based interventions such as cranberry juice. A randomized, placebo-controlled, crossover trial was conducted in middle-aged adults with overweight/obesity (n = 40; mean BMI: 28.7 ± 0.8 kg/m2; mean age: 47 ± 2 years) and elevated brachial blood pressure (mean systolic/diastolic BP: 124 ± 2/81 ± 1 mm Hg). Study participants consumed 500 mL/d of cranberry juice (~16 fl oz; 27% cranberry juice) or a matched placebo juice in a randomized order (8-week supplementation periods; 8-week compliance break), with blood samples and vascular measurements obtained at study entry and following each supplementation period. There was no significant treatment effect of cranberry juice supplementation on the primary endpoint of central systolic blood pressure or central or brachial diastolic pressure. Cranberry juice significantly reduced 24-h diastolic ambulatory BP by ~2 mm Hg compared to the placebo (p = 0.05) during daytime hours. Cranberry juice supplementation did not alter LDL-C but significantly changed the composition of the lipoprotein profile compared to the placebo, increasing the concentration of large LDL-C particles (+29.5 vs. −6.7 nmol/L; p = 0.02) and LDL size (+0.073 vs. −0.068 nm; p = 0.001). There was no effect of treatment on ex vivo HDL efflux in the total population, but exploratory subgroup analyses identified an interaction between BMI and global HDL efflux (p = 0.02), with greater effect of cranberry juice in participants who were overweight. Exploratory analyses indicate that baseline C-reactive protein (CRP) values may moderate treatment effects. In this population of adults with elevated blood pressure, cranberry juice supplementation had no significant effect on central systolic blood pressure but did have modest effects on 24-hr diastolic ambulatory BP and the lipoprotein profile. Future studies are needed to verify these findings and the results of our exploratory analyses related to baseline health moderators.

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