The Qumran Psalms Scroll Debate and Ben Sira: Considering the Evidence of Textual Reuse in Sir 43:11–19

2016 ◽  
Vol 23 (1) ◽  
pp. 27-50
Author(s):  
Lindsey A. Askin
Keyword(s):  
Textual Reuse ◽  
Ben Sira ◽  
Close Proximity ◽  
Shed Light

This study explores whether Ben Sira’s textual use of the Psalms may shed light on the Qumran Psalms Scroll debate. It is proposed that Ben Sira’s quotations of Psalms 104, 147, and 148 in Sir 43:11–19 could point us to which Psalter Ben Sira may have used, since these three psalms are found in close proximity to each other in 11QPsa and 4QPsd. Doing so will allow us to better gauge Ben Sira’s relationship to 11QPsa. Issues such as the 364-day calendar, Sir 51:13–30, and pluriformity are considered. This article finds that the debate is still open as to which Psalter Ben Sira used, either proposal equally remaining possible at this stage, needing more analysis from the rest of Ben Sira’s text. Remarkably the examples and analysis do not yield anything yet to positively disqualify the 11QPsa-Psalter from being used by Ben Sira.

Four qsur between the Wadis Islan and Samalus, Cyrenaica

2008 ◽  
Vol 39 ◽  
pp. 117-130 ◽  
Author(s):  
Paul Bennett ◽  
Ahmed Buzaian ◽  
Abdelgader al-Muzeini ◽  
Faraj Abdulkareem ◽  
Fathalla Khalifa ◽  
...  
Keyword(s):  
Roman Period ◽  
The South ◽  
South Side ◽  
Direct Route ◽  
Close Proximity ◽  
Form Part ◽  
Shed Light

AbstractThis brief paper has been prepared to shed light on four qsur located in close proximity to one another on three different sites overlooking an important Haj and caravan route between Soluq in northwestern Cyrenaica and Tamimi to the east, on the Gulf of Bomba. Massively built in mudbrick and faced with stone, each qasr was positioned to dominate an adjacent cultivated wadi crossed by the caravan route. The qsur, with many constructional details in common but in various states of dilapidation, were built on the site of previous settlements and have yet to be conclusively dated. Two possible construction dates are suggested. The buildings may have been constructed in the later Roman period to form part of a system of defence similar to the limes Tripolitanus in that they were built not only to protect the settlements and roadway that they undoubtedly served but as frontier outposts (and defence ‘in depth’) for the cities of the Pentapolis on the south side of the Gebel Akhdar. It is equally possible that the qsur may be of post-Roman date, being built not only for a local defensive purpose, but to provide security and hospitality for those travelling the most direct route between Soluq and Tamimi, south of the Gebel.

scholarly journals His-FLAG Tag as a Fusion Partner of Glycosylated Human Interferon-Gamma and Its Mutant: Gain or Loss?

2017 ◽  
Vol 2017 ◽  
pp. 1-12
Author(s):  
Elena Krachmarova ◽  
Milena Tileva ◽  
Elena Lilkova ◽  
Peicho Petkov ◽  
Klaus Maskos ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Biological Properties ◽  
Expression Vectors ◽  
Human Interferon ◽  
Fusion Partner ◽  
E Coli ◽  
Binding Domains ◽  
Close Proximity ◽  
Dynamics Simulations ◽  
Shed Light

In order to obtain glycosylated human interferon-gamma (hIFNγ) and its highly prone to aggregation mutant K88Q, a secretory expression in insect cells was employed. To facilitate recombinant proteins purification, detection, and stability the baculovirus expression vectors were constructed to bear N-terminal His6-FLAG tag. Although the obtained proteins were glycosylated, we found that their biological activity was 100 times lower than expected. Our attempts to recover the biological properties of both proteins by tag removal failed due to enterokinase resistance of the tag. Surprisingly, the tag was easily cleaved when the proteins were expressed inE. colicells and the tag-free proteins showed fully restored activity. To shed light on this phenomenon we performed molecular dynamics simulations. The latter showed that the tags interact with the receptor binding domains and the flexible C-termini of the fusion proteins thus suppressing their complex formation with the hIFNγreceptor. We hypothesize that in the case of glycosylated proteins the tag/C-terminal interaction positions the FLAG peptide in close proximity to the glycans thus sterically impeding the enterokinase access to its recognition site.

scholarly journals Nesting fidelity and molecular evidence for natal homing in the freshwater turtle, Graptemys kohnii

2005 ◽  
Vol 272 (1570) ◽  
pp. 1345-1350 ◽  
Author(s):  
Steven Freedberg ◽  
Michael A Ewert ◽  
Benjamin J Ridenhour ◽  
Maurine Neiman ◽  
Craig E Nelson
Keyword(s):  
Isolation By Distance ◽  
Sea Turtle ◽  
Mantel Test ◽  
Freshwater Turtle ◽  
Molecular Evidence ◽  
Freshwater Turtles ◽  
Nesting Ecology ◽  
Natal Homing ◽  
Close Proximity ◽  
Shed Light

Numerous studies of sea turtle nesting ecology have revealed that females exhibit natal homing, whereby they imprint on the nesting area from which they hatch and subsequently return there to nest as adults. Because freshwater turtles comprise the majority of reptiles known to display environmental sex determination (ESD), the study of natal homing in this group may shed light on recent evolutionary models of sex allocation that are predicated on natal homing in reptiles with ESD. We examined natal homing in Graptemys kohnii , a freshwater turtle with ESD, using mitochondrial sequencing, microsatellite genotyping and mark and recapture of 290 nesting females. Females showed high fidelity to nesting areas, even after being transplanted several kilometres away. A Mantel test revealed significant genetic isolation by distance with respect to nesting locations ( r =0.147; p <0.05), suggesting that related females nest in close proximity to one another. The patterns of fidelity and genotype distributions are consistent with homing at a scale that may affect population sex ratios.

scholarly journals In silico analysis of interaction of compounds, containing photoactivatable groups,with human CYP7 enzymes

2020 ◽  
Vol 64 (5) ◽  
pp. 558-566
Author(s):  
Ya. U. Dzichenka ◽  
M. S. Horetski ◽  
Ya. V. Faletrov ◽  
A. V. Yantsevich ◽  
V. M. Shkumatov ◽  
...  
Keyword(s):  
In Silico ◽  
Binding Mode ◽  
Amino Acid Residues ◽  
Structural Peculiarities ◽  
Close Proximity ◽  
Mechanism Of Interaction ◽  
Covalent Adducts ◽  
Steroid Hydroxylases ◽  
Shed Light

In silico analysis of “protein-ligand” complexes of human CYP7 enzymes with modified borondipyrrome-tene (BODIPY) and steroids, containing photo-activated crosslinking groups, wasperformed in order to identify structural peculiarities of their interaction. It was found that BODIPY molecules and DHEA derivative with diazirine group are able to bind tightly with human steroid-hydroxylases. Binding affinity is comparable with corresponding values for essential ligands of the enzymes. Binding mode of the modified steroid corresponds to the binding mode of essential CYP7 ligands, so formation of hydroxylated products is possible. It was found that presence of both diazirine and NBD groups in a molecule significantly increases affinity of the compound in case of CYP7A1 and, especially, CYP7B1. Amino acid residues, located in a close proximity with photo-activated groups were detected, that can form covalent adducts with them. The obtained results can shed light on the mechanism of interaction of the compounds with recombinant human CYP7 enzymes in vitro. The results can also be used for the identification of modified amino acids of the proteins that are formed under photoactivation of the compounds in vitro.

scholarly journals Intergroup contact and its effects on discriminatory attitudes Evidence from India

2021 ◽  
Author(s):  
Shreya Bhattacharya
Keyword(s):  
Survey Data ◽  
Administrative Data ◽  
Intergroup Contact ◽  
Social Groups ◽  
Contact Hypothesis ◽  
Positive Effects ◽  
Close Proximity ◽  
Original Survey ◽  
Shed Light

The contact hypothesis posits that having diverse neighbours may reduce one’s intergroup prejudice. This hypothesis is difficult to test as individuals self-select into neighbourhoods. Using a slum relocation programme in India that randomly assigned neighbours, I examine the effects of exposure to other-caste neighbours on trust and attitudes towards members of other castes. Combining administrative data on housing assignment with original survey data on attitudes, I find evidence corroborating the contact hypothesis. Exposure to more neighbours of other castes increases inter-caste trust, support for inter-caste marriage, and the belief that caste injustice is growing. I explore the role of friendships in facilitating these favourable attitudes. The findings shed light on the positive effects of exposure to diverse social groups through close proximity in neighbourhoods.

scholarly journals Nipple Aspirate Fluid at a Glance

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 159
Author(s):  
Susana I. S. Patuleia ◽  
Karijn P. M. Suijkerbuijk ◽  
Elsken van der Wall ◽  
Paul J. van Diest ◽  
Cathy B. Moelans
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Imaging Techniques ◽  
Nipple Aspirate Fluid ◽  
Close Proximity ◽  
Breast Magnetic Resonance ◽  
Clinical Potential ◽  
Promising Source ◽  
Shed Light ◽  
Rule Out

Nipple aspirate fluid (NAF) is an intraductal mammary fluid that, because of its close proximity to and origin from the tissue from which breast cancer originates, is a promising source of biomarkers for early breast cancer detection. NAF can be non-invasively acquired via the nipple by aspiration using a suction device; using oxytocin nasal spray helps increase yield and tolerability. The aspiration procedure is generally experienced as more tolerable than the currently used breast imaging techniques mammography and breast magnetic resonance imaging. Future applications of NAF-derived biomarkers include their use as a tool in the detection of breast carcinogenesis at its earliest stage (before a tumor mass can be seen by imaging), or as a supporting diagnostic tool for imaging, such as when imaging is less reliable (to rule out false positives from imaging) or when imaging is not advisable (such as during pregnancy and breastfeeding). Ongoing clinical studies using NAF samples will likely shed light on NAF’s content and clinical potential. Here, we present a narrative review and perspectives of NAF research at a glance.

Active Listening in a Bat Cocktail Party: Adaptive Echolocation and Flight Behaviors of Big Brown Bats, Eptesicus fuscus, Foraging in a Cluttered Acoustic Environment

2015 ◽  
Vol 86 (1) ◽  
pp. 6-16 ◽  
Author(s):  
Michaela Warnecke ◽  
Chen Chiu ◽  
Jonathan Engelberg ◽  
Cynthia F. Moss
Keyword(s):  
Dynamic Environment ◽  
Video Data ◽  
Active Listening ◽  
Open Spaces ◽  
Acoustic Environment ◽  
Cluttered Environments ◽  
Multichannel Audio ◽  
Big Brown Bats ◽  
Close Proximity ◽  
Shed Light

In their natural environment, big brown bats forage for small insects in open spaces, as well as in vegetation and in the presence of acoustic clutter. While searching and hunting for prey, bats experience sonar interference, not only from densely cluttered environments, but also from calls of conspecifics foraging in close proximity. Previous work has shown that when two bats compete for a single prey item in a relatively open environment, one of the bats may go silent for extended periods of time, which can serve to minimize sonar interference between conspecifics. Additionally, pairs of big brown bats have been shown to adjust frequency characteristics of their vocalizations to avoid acoustic interference in echo processing. In this study, we extended previous work by examining how the presence of conspecifics and environmental clutter influence the bat's echolocation behavior. By recording multichannel audio and video data of bats engaged in insect capture in open and cluttered spaces, we quantified the bats' vocal and flight behaviors. Big brown bats flew individually and in pairs in an open and cluttered room, and the results of this study shed light on the different strategies that this species employs to negotiate a complex and dynamic environment.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Experiments with a scanning tunneling microscope (STM) mounted in a scanning electron microscope (SEM)

1986 ◽  
Vol 44 ◽  
pp. 636-639
Author(s):  
Oliver C. Wells ◽  
Mark E. Welland
Keyword(s):  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Mechanical Stability ◽  
Tunneling Current ◽  
Feedback System ◽  
Scanning Tunneling ◽  
Surface Profiling ◽  
Close Proximity ◽  
Metal Tip ◽  
Scanning Electron

Scanning tunneling microscopes (STM) exist in two versions. In both of these, a pointed metal tip is scanned in close proximity to the specimen surface by means of three piezos. The distance of the tip from the sample is controlled by a feedback system to give a constant tunneling current between the tip and the sample. In the low-end STM, the system has a mechanical stability and a noise level to give a vertical resolution of between 0.1 nm and 1.0 nm. The atomic resolution STM can show individual atoms on the surface of the specimen.A low-end STM has been put into the specimen chamber of a scanning electron microscope (SEM). The first objective was to investigate technological problems such as surface profiling. The second objective was for exploratory studies. This second objective has already been achieved by showing that the STM can be used to study trapping sites in SiO2.

Ultrastructure and Senescence in an Achloroplastic Mutant of Hordeum vulgare L. cv. Dyan

1992 ◽  
Vol 50 (1) ◽  
pp. 844-845
Author(s):  
R.H.M. Cross ◽  
C.E.J. Botha ◽  
A.K. Cowan ◽  
B.J. Hartley
Keyword(s):  
Cell Wall ◽  
Hordeum Vulgare ◽  
Leaf Tissue ◽  
Ultrastructural Changes ◽  
Hordeum Vulgare L ◽  
Mesophyll Cells ◽  
Lethal Mutant ◽  
Cytoplasmic Matrix ◽  
Close Proximity ◽  
Pinocytotic Vesicles

Senescence is an ordered degenerative process leading to death of individual cells, organs and organisms. The detection of a conditional lethal mutant (achloroplastic) of Hordeum vulgare has enabled us to investigate ultrastructural changes occurring in leaf tissue during foliar senescence.Examination of the tonoplast structure in six and 14 day-old mutant tissue revealed a progressive degeneration and disappearance of the membrane, apparently starting by day six in the vicinity of the mitochondria associated with the degenerating proplastid (Fig. 1.) where neither of the plastid membrane leaflets is evident (arrows, Fig. 1.). At this stage there was evidence that the mitochondrial membranes were undergoing retrogressive changes, coupled with disorganization of cristae (Fig. 2.). Proplastids (P) lack definitive prolamellar bodies. The cytoplasmic matrix is largely agranular, with few endoplasmic reticulum (ER) cisternae or polyribosomal aggregates. Interestingly, large numbers of actively-budding dictysomes, associated with pinocytotic vesicles, were observed in close proximity to the plasmalemma of mesophyll cells (Fig. 3.). By day 14 however, mesophyll cells showed almost complete breakdown of subcellular organelle structure (Fig. 4.), and further evidence for the breakdown of the tonoplast. The final stage of senescence is characterized by the solubilization of the cell wall due to expression and activity of polygalacturonase and/or cellulose. The presence of dictyosomes with associated pinocytotic vesicles formed from the mature face, in close proximity to both the plasmalemma and the cell wall, would appear to support the model proposed by Christopherson for the secretion of cellulase. This pathway of synthesis is typical for secretory glycoproteins.

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