Relationship of Cord Blood Adipokines to Atopy and Wheeze in the First Year of Life.

Author(s):  
M Kattan ◽  
CM Visness ◽  
GR Bloomberg ◽  
G O'Connor ◽  
RA Wood ◽  
...  
2009 ◽  
Vol 20 (3) ◽  
pp. 227-233 ◽  
Author(s):  
Hiromi Tadaki ◽  
Hirokazu Arakawa ◽  
Mikio Sugiyama ◽  
Kiyoshi Ozawa ◽  
Takahisa Mizuno ◽  
...  

PEDIATRICS ◽  
1982 ◽  
Vol 69 (5) ◽  
pp. 537-543
Author(s):  
Marie C. McCormick ◽  
Sam Shapiro ◽  
Barbara Starfield

A mother's expectations about the development of her infant have been found to be a strong determinant of child development, but little is known about the factors that may affect maternal assessment of development. In this study, the relationship of the mother's opinion of the development of her infant with several sociodemographic, antenatal, intrapartum, and infant health variables was examined for a large sample of 1-year-old infants for whom gross motor observations were also obtained at the time of the interview. Among those observed to be developing at an appropriate rate, 4.0% were perceived by their mothers as developing more slowly than the mothers considered normal; among infants developing more slowly, 28.6% were considered to be developing slowly by their mothers. In both groups, the major determinants of maternal opinion of slow development concerned the infant's health: low birth weight, congenital anomalies regardless of severity, hospitalization during the first year of life, and high ambulatory care use. These results indicate that maternal perception of infant development may not reflect the infant's level, but past or present illness, and raise questions about the influence of infant health on maternal-infant interactions and the effect of such interactions on subsequent development in the child.


Thorax ◽  
2018 ◽  
Vol 74 (2) ◽  
pp. 200-202 ◽  
Author(s):  
Hooman Mirzakhani ◽  
Amal A Al-Garawi ◽  
Vincent J Carey ◽  
Weiliang Qiu ◽  
Augusto A Litonjua ◽  
...  

Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways.


2014 ◽  
Vol 5 (3) ◽  
pp. 214-218 ◽  
Author(s):  
J. L. Kaar ◽  
J. T. Brinton ◽  
T. Crume ◽  
R. F. Hamman ◽  
D. H. Glueck ◽  
...  

Objective: To examine the association of cord blood leptin with body mass index (BMI) growth velocity from birth to 12 months of age among infants exposed and not exposed to over-nutrition in utero (defined as maternal overweight/obesity or presence of gestational diabetes). Methods: 185 infants enrolled in the Exploring Perinatal Outcomes among Children study (76 exposed and 109 not exposed) had leptin and insulin measured in cord blood. Longitudinal weight and length measures in the first 12 months of life (average 4 per participant) obtained from medical records were used to compute BMI growth rates. Mixed models were used to examine associations of cord blood leptin with growth. Results: Compared with unexposed infants, those exposed had significantly higher cord blood insulin (8.64 v. 6.97 uU/ml, P<0.01) and leptin levels (8.89 v. 5.92 ng/ml, P=0.05) as well as increased birth weights (3438.04 v. 3306.89 g, P=0.04). There was an inverse relationship between cord leptin levels and BMI growth from birth to 12 months of age (P=0.005); however, exposure to over-nutrition in utero did not significantly modify this association (P=0.59). Conclusion: We provide support of a possible operational feedback mechanism by which lower cord blood leptin levels are associated with faster infant growth in the first year of life. Our data do not tend to support the hypothesis that this mechanism is altered in infants exposed to over-nutrition in utero; however our sample is too small to provide sufficient evidence. Larger epidemiological studies are needed to elucidate the mechanisms responsible for increased propensity for obesity in exposed offspring.


2017 ◽  
Vol 23 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Annalisa Ruggeri ◽  
Fernanda Volt ◽  
Franco Locatelli ◽  
Gerard Michel ◽  
Cristina Diaz de Heredia ◽  
...  

Author(s):  
Iván Enrique Naranjo Logroño ◽  
Leslie Gricel Cuzco Macías ◽  
Alison Tamara Ruiz Chico ◽  
Anthony Alfonso Naranjo Coronel

Introduction: The human microbiome refers to the presence of microorganisms that live with its host. Objective: To analyze the relationship between the maternal perinatal microbiome and the development of the infant’s immune system, at the origins of the development of health and disease. Methodology: A non-systematic bibliographic review was carried out, including those controlled and randomized clinical trials focused on the relationship of the prenatal maternal microbiome and the infant’s immune system. And all those works whose approach was different from the topic raised were excluded. Discussion: 20 min after birth, the microbiome of newborns by vaginal delivery resembles the microbiota of their mother’s vagina, while those born by caesarean section house microbial communities that are usually found in human skin. The acquisition of the microbiome continues during the first years of life, with a microbiome of the baby’s gastrointestinal tract beginning to resemble that of an adult from the first year of life. Conclusion: Bacteria are microorganisms that have managed to colonize the vast majority of land surfaces, showing great adaptability. The human being is not indifferent, and hypotheses have been raised that affirm his participation in the development of health and the onset of the disease. Keywords: microbiota, inmune system, infant nutritional physiological phenomena. RESUMEN Introducción: El microbioma humano se refiere a la presencia de microorganismos que conviven con su hospedero. Objetivo: Analizar la relación existente entre el microbioma materno perinatal y el desarrollo del sistema inmune del lactante, en los orígenes del desarrollo de la salud y enfermedad. Metodología: Se realizó una revisión bibliográfica no sistemática, donde se incluyeron aquellos ensayos clínicos controlados y randomizados enfocados en la relación del microbioma materno prenatal y el sistema inmune del lactante. Y se excluyeron todos aquellos trabajos cuyo enfoque fue diferente al tema planteado. Resultados: Se encontraron 61 fuentes bibliográficas, de las cuales se incluyeron 53 artículos que contenían la información relacionada al tema y publicados en los últimos 11 años. Discusión: 20 min después del nacimiento, el microbioma de los recién nacidos por parto vaginal se asemeja a la microbiota de la vagina de su madre, mientras que los nacidos por cesárea albergan comunidades microbianas que generalmente se encuentran en la piel humana. La adquisición del microbioma continúa durante los primeros años de vida, con un el microbioma del tracto gastrointestinal del bebé comienza a parecerse al de un adulto desde el primer año de vida. Conclusiones: Las bacterias, son microorganismos que han logrado colonizar la gran mayoría de las superficies terrestres, mostrando una gran capacidad de adaptación. El ser humano, no es indiferente, y se han planteado hipótesis que aseveran su participación en el desarrollo de la salud e inicio de la enfermedad. Palabras clave: microbiota, sistema inmunológico, fenómenos fisiológicos nutricionales del lactante.


Author(s):  
Özge Yılmaz ◽  
Adem Yaşar ◽  
Pınar Ay ◽  
Arzu Çalışkan Polat ◽  
Ferhan Odabaşı Cingöz ◽  
...  

1996 ◽  
Vol 19 (3) ◽  
pp. 517-532 ◽  
Author(s):  
Jaroslava Dittrichová ◽  
Václav Břicháček ◽  
František Mandys ◽  
Karel Paul ◽  
Daniela Sobotková ◽  
...  

The present study aimed, first, to analyse in detail early sleep states in 21 preterm infants born before the 33rd week of gestational age and compare them with sleep states in 23 fullterm infants assessed at gestationally matched ages in the first six months. Second, to determine whether analyses of early sleep states in preterm infants may enable identification of infants with future developmental disabilities. In addition to evaluations of perinatal risk factors, neurological condition, psychological development, and social environment during the first year of life, examinations of psychological and neurological development and the assessment of the social environment at 3 and 9 years were carried out. Measures of perinatal status and sleep states up to the age of 40 weeks gestational age did not correlate with outcome measures at 3 and 9 years. However, the polygraphic measures of sleep states at 12 and 24 weeks corrected age, predicted the 3-year developmental outcomes. The complexity of these measures may contribute to their predictive validity for the outcomes at 3 years. Measures of the social environment at 3 and 9 years contributed significantly to the prediction of 9-year developmental outcomes. These results indicate that environmental factors may become more important with age. The detailed analysis of early sleep patterns may enable the early identification of infants who need special care and intervention.


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