Management of the Bronchial Asthma Patients at Practice of Family Doctors

C. Clinical guideline is the result of an agreed decision of experts, adopted on the basis of a thorough analysis of literature data, as well as recommendations of foreign guideline GINA: Global Strategy For Asthma Management And Prevention. Updated 2019. The document provides an updated definition of bronchial asthma (BA), gives new approaches to the classification and diagnosis of the disease, proposes modern treatment regimens based on the results of multicenter international clinical trials, which justifies the high evidence for such therapeutic tactics. New principles for the distribution of patients to phenotypes, which should be taken into account when choosing treatment regimens, are presented, algorithms for initial and maintenance therapy, and new approaches to the treatment of exacerbations of the disease are presented. In previous publications of the manual (Asthma and Allergy, 2020, № 2, № 3), an updated definition and pathogenetic mechanisms of BA were presented, new approaches to the classification and diagnosis of the disease were outlined, and the definition and assessment of asthma control were given. The principles of assessing the severity of asthma, as well as the difference between severe and uncontrolled asthma are considered. Standards for the treatment of asthma patients according symptoms control and minimize risk are presented. The basic principles of asthma management and alternative correction strategies of treatment are considered. The third part of the manual presents a stepwise approach to the correction of therapy, immunotherapy with allergens, vaccination, indications for referral to a specialist consultation. The guideline is addressed to doctors at all levels of medical care – family doctors, general practitioners, pulmonologists, allergists, cardiologists, rehabilitologists. Key words: bronchial asthma, pathogenesis, classification, diagnosis, therapy

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MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v68i7.714 ◽

2013 ◽

Vol 68 (7) ◽

pp. 57-60

Author(s):

O. A. Sharavii ◽

S. V. Smirnova

Keyword(s):

Immune Response ◽

Chlamydia Trachomatis ◽

Blood Serum ◽

Bronchial Asthma ◽

Mycoplasma Hominis ◽

Acute Stage ◽

Control Group ◽

Clinical Markers ◽

Chlamydophila Psittaci ◽

Asthma Patients

Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results. We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum.

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Incresed IL-33 expression in atopic bronchial asthma patients with confirmed viral respiratory infection

10.26226/morressier.5acdc660d462b8029238e077 ◽

2018 ◽

Author(s):

Mariola Galitskaya

Keyword(s):

Bronchial Asthma ◽

Respiratory Infection ◽

Atopic Bronchial Asthma ◽

Asthma Patients ◽

Viral Respiratory Infection ◽

Viral Respiratory

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Comparison between Compliance of Fluticasone Propionate Diskhaler and of Fluticasone Propionate Diskus in Adult Bronchial Asthma Patients

Respiration ◽

10.1159/000095313 ◽

2006 ◽

Vol 73 (5) ◽

pp. 680-684 ◽

Cited By ~ 1

Author(s):

Takashi Hasegawa ◽

Eiichi Suzuki ◽

Katsuya Fujimori ◽

Takuro Sakagami ◽

Shinichi Toyabe ◽

...

Keyword(s):

Fluticasone Propionate ◽

Bronchial Asthma ◽

Asthma Patients

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Prevalence and Predictors of Metabolic Syndrome among Patients with Bronchial Asthma: A Cross Sectional Study

The Open Respiratory Medicine Journal ◽

10.2174/1874306402115010014 ◽

2021 ◽

Vol 15 (1) ◽

pp. 14-18

Author(s):

Abdellah H.K. Ali

Keyword(s):

Metabolic Syndrome ◽

Blood Sugar ◽

Bronchial Asthma ◽

Density Lipoprotein ◽

Patient Characteristics ◽

Cross Sectional Study ◽

Metabolic Abnormality ◽

Fasting Blood Sugar ◽

Cross Sectional ◽

Asthma Patients

Background: Recent studies have reported the epidemiological link between Metabolic Syndrome (MS) and asthma, but it has rarely been studied in Egypt. The study aimed to investigate the prevalence of MS and its predictors among asthma patients in Egypt. Methods: In total, 320 patients with bronchial asthma were included. The following were assessed: spirometric evaluation, anthropometric indices, blood pressure, fasting blood sugar and serum lipid profile. We analyzed the correlation between metabolic scores and patient characteristics. Predictors of MS were identified using logistic regression analysis. Results: The prevalence of MS was 57.5% in asthma patients. For asthma patients, low High-Density Lipoprotein (HDL) and abdominal obesity were the commonest metabolic abnormality. Waist circumference, Fasting Blood Sugar (FBS) and triglyceride correlated significantly with asthma (P ‹ 0.05). FBS and DBP were the best predictors of MS. Conclusion: MS is frequent in asthma patients in Egypt. Obesity and lipid abnormalities were the commonest metabolic abnormality. Screening of these patients for components of metabolic syndrome should be a part of routine workup.

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Periodontal clinical features of bronchial asthma patient using inhalation drugs

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol33no3.29739 ◽

2021 ◽

Vol 33 (3) ◽

pp. 217

Author(s):

Maria Efrinta Ginting ◽

Rosiliwati Wihardja ◽

Dyah Nindita Carolina

Keyword(s):

Periodontal Disease ◽

Clinical Features ◽

Bronchial Asthma ◽

Periodontal Pocket ◽

Periodontal Status ◽

Asthmatic Patients ◽

Gingival Bleeding ◽

Periodontal Index ◽

Asthma Patients ◽

One Year

Introduction: Bronchial asthma patients use inhalation drugs as therapy to achieve a controlled asthma state. Inhaled corticosteroids and β2 agonists are the medication that is being used in this case. Prolonged use of inhalation drugs will affect the health of periodontal tissue. The effect of these drugs can reduce the periodontal defense mechanism and increase the risk of periodontal disease. This study aims to determine the periodontal clinical features of bronchial asthma patients using inhalation drugs. Method: This research was a descriptive study. The sample of the study were 22 females and 8 males bronchial asthma patients at the Community Lung Health Center of Bandung (Balai Besar Kesehatan Paru Masyarakat Bandung/BBKPM Bandung) who had been using inhalation drugs for at least one year. The periodontal clinical feature was assessed by employing a Community Periodontal Index (CPI) modified with probing the gingival sulcus to assess the presence of gingival bleeding, periodontal pocket, and loss of clinical attachment where then a periodontal status was obtained. The periodontal status data were then processed using the periodontitis case definitions from the Centers for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) to determine periodontal disease in asthmatics patients. Results: Clinical features of gingival bleeding were found in 26 asthmatic patients (86.7%), periodontal pockets in 18 asthmatic patients (60%), and loss of clinical attachment in 27 asthmatic patients (90%). Based on the CDC/AAP case definition, 23 asthmatic patients (76.7%) had periodontitis. Bronchial asthma patients who used inhalation drugs had a risk of periodontitis.Conclusion: Bronchial asthma patients who used inhalation drugs for at least one year had gingival bleeding and loss of clinical attachment and periodontal pocket.

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Opistorchis felineus invasion influence on immunity in bronchial asthma

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2010-3-85-90 ◽

2010 ◽

Vol 9 (3) ◽

pp. 85-90

Author(s):

L. M. Ogorodova ◽

M. B. Freidin ◽

A. E. Sazonov ◽

O. S. Fyodorova ◽

I. A. Deyev ◽

...

Keyword(s):

Experimental Study ◽

Immune Response ◽

Bronchial Asthma ◽

Cell Cultures ◽

Molecular Mechanisms ◽

Opisthorchis Felineus ◽

Genes Expression ◽

Asthma Patients ◽

Human Immune Response ◽

Human Immune

To investigate the molecular mechanisms of human immune response modification by Opisthorchis felineus antigens in bronchial asthma. The experimental study was performed with cell cultures from patients with bronchial asthma, patients with opisthorchiasis, and patients with BA and opisthorchiasis co-occurred. A proposed down-regulation of immune response by higher level of IL10 and TGFB genes expression in patients with opisthorchiasis was revealed.

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The Utility of Serum IL-1β and CRP Together with Fractional Exhaled Nitric Oxide in the Diagnosis of Asthma in Adults

NeuroQuantology ◽

10.14704/nq.2021.19.8.nq21122 ◽

2021 ◽

Vol 19 (8) ◽

pp. 119-124

Author(s):

Hayder Abdul-Amir Makki Al-Hindy ◽

Ali Jihad Hemid Al-Athari ◽

Mazin J. Mousa ◽

Safa Jihad Hameed ◽

Suhad Hafidh Obeed

Keyword(s):

Nitric Oxide ◽

Sensitivity And Specificity ◽

Bronchial Asthma ◽

High Sensitivity ◽

Exhaled Nitric Oxide ◽

Fractional Exhaled Nitric Oxide ◽

Asthmatic Patients ◽

Significant Difference ◽

Asthma Patients ◽

Hs Crp

Background: Bronchial asthma (BrA), recognized lately as an umbrella, covers various subtypes rather than only one disease. Asthma is a chronic inflammation of the airways, in which cytokines could play a crucial role in its pathogenesis. Hence, labors to progress noninvasive markers for asthma had centered through this era. Presently, the fractional exhaled nitric oxide (FeNO), serum C-reactive protein (CRP), and interleukin levels are emerging analytical biomarkers in this field. FeNO is a noninvasive and practical tool even in mild asthma. This study aimed to evaluate the utility of serum IL-1β and CRP together with fractional exhaled nitric oxide in the diagnosis of adult bronchial asthma. Method: The study was a case control, including 150-patients and 100-healthy controls. FeNO tests, measurements of plasma levels IL-1β and HS-CRP had undertaken for all the participants. The statistical data had examined by SPSS (V/27) for Windows. Descriptive data of the variables had compatibly used. A significance lower than or identical to 0.05 had intended. ROC curve examination of FeNO tests, IL-1β, and HS-CRP, to predict asthma from healthy control had applied. Results: there was a significant difference in the FeNo test, HS-CRP levels, and BMI, while no significant difference in all other variables between the groups. The FeNo results correlate positively, though not significantly, with the levels of IL-1β in asthmatic patients (> 0.05). There was a nonsignificant negative correlation between the FeNo results with the level of HSCRP. The accuracy, sensitivity, and specificity of the IL-1β to distinguish asthma were 68.6% and 58% at 95% CI [0.41-0.745], respectively, which was not significant (p>0.05). However, ROC analysis of HS-CRP revealed predictability for asthma patients (p-0.000), with higher accuracy, sensitivity, and specificity: 89.9%, and 68.1% at 95% CI [0.820-0.979], respectively. The FeNo tests revealed highly significant (0.000), high sensitivity, and specific (91% for both) with high 95% CI [0.938-1.000] predictability for asthma. Conclusion: The utility of circulating HS-CRP is more valuable than IL-1β when combined with fractional exhaled nitric oxide in the diagnosis of asthma. Novel biomarkers could improve the precision of this field.

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The role of physical rehabilitation in the treatment of bronchial asthma patients

10.1183/13993003.congress-2021.pa311 ◽

2021 ◽

Author(s):

Mykola Ostrovskyy ◽

Kostiantyn Shvets ◽

Kseniia Ostrovska ◽

Iryna Savelikhina ◽

Oleksandr Varunkiv ◽

...

Keyword(s):

Bronchial Asthma ◽

Physical Rehabilitation ◽

Asthma Patients

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Identifying the Clinical Pattern of Eosinophilic and Non-Eosinophilic Asthma subtype in adult patients with Bronchial Asthma

QJM ◽

10.1093/qjmed/hcab100.063 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Maged Mohammed Refaat ◽

Dina Sayed Sheha ◽

Riham Hazem Raaft ◽

Maged Mohamed Refaat ◽

Heba Eid Farhat Abo Alia ◽

...

Keyword(s):

Bronchial Asthma ◽

Skin Prick Testing ◽

Nasal Endoscopy ◽

Asthma Control Test ◽

Eosinophilic Asthma ◽

Total Ige ◽

Common Chronic Disease ◽

Sputum Eosinophilia ◽

Asthma Patients ◽

The Mean

Abstract Background Context:- Asthma is a heterogenous disease with various phenotypes, it is the most common chronic disease characterized by airway limitation due to bronchospasm and airway inflammation associated with excessive mucus secretion from agitated mucus gland that occur due to air way hyper responiveness. Purpose of the study Comparison between eosinophilic and non-eosinophilic asthma patients. Patients and Methods 100 bronchial asthma patients of age ≥ 18 years old divided into2 groups according to blood eosinophilia. All patients were subjected to: history. Total Asthma Control Test. Spirometry. Sputum eosinophil count. IgE levels 6-Skin prick testing (SPT). Nasal endoscopy. Results the mean age of all patients was (35.4 ± 12.8) years, majority (61%) of patients were males,; the mean ACT score was (18.7 ± 2); 39% of cases have obstructive pattern by spirometry, 39% of cases had abnormal nasal endoscopy, SPT had significant relation with asthma, there is significant correlation between total IGE,sputum eosinophilia with eosinophilic asthma. Conclusion Blood eosinophils had the highest accuracy in the identification of sputum eosinophilia in asthma. Total IgE values and sutum eosinophilia were markedly increased in patients with eosinophilic asthma more than patients with non-eosinophilic asthma.

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