Hyaluronic Acid Stabilized Doxorubicin Nano-Precipitations for Osteosarcoma Treatment
2022 ◽
Vol 12
(3)
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pp. 500-505
Keyword(s):
Doxorubicin (Dox) is a wide-spectrum drug to treat different kinds of cancers. However, in clinical practice, Dox usually showed untargeted distributions to the other organs, which can cause serious side effects, such as cardiotoxity. Herein, the formulation of Dox into nanoparticles is critical to enhance its distribution to tumors. Herein, we used polysaccharide, hyaluronic acid, to stabilize the Dox to form nano-precipitations (PD NPs) for the therapy of osteosarcoma. The PD NPs showed enhanced drug accumulation to tumor cells and realized better anticancer effects than free drugs.
Keyword(s):
Keyword(s):
2020 ◽
Vol 27
(13)
◽
pp. 2118-2132
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2020 ◽
Vol 27
(28)
◽
pp. 4720-4740
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2019 ◽
Vol 14
(3)
◽
pp. 280-291
◽
Keyword(s):
Keyword(s):
1965 ◽
Vol 1
(3)
◽
pp. 68-70
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