Composition of the Otosclerotic Stapes: Electron Microprobe Analyses

1993 ◽  
Vol 102 (5) ◽  
pp. 353-358
Author(s):  
Gary D. Rosenberg ◽  
Laverne B. Tubergen
Keyword(s):  
Alkaline Phosphatase ◽  
Broad Spectrum ◽  
Confidence Level ◽  
Electron Probe ◽  
Energy Dispersive Spectrometer ◽  
Discriminant Analyses ◽  
The Difference ◽  
Level Of Significance ◽  
High Level ◽  
First Time

For the first time, otosclerotic stapes have been distinguished from unafflicted controls at a high level of significance by using a spectrum of elements measured by energy-dispersive spectrometer-electron probe microanalyses (EDS/EPMA). Discriminant analyses of the maximum concentration of 13 elements measured at several sites within each of 32 stapes differentiated otosclerotic from unafflicted individuals well above the 95% confidence level. Eight of the 9 control (unafflicted) and 21 of the 23 afflicted stapes were correctly classified. In descending order of contribution to the discriminant function, the elements are Zn > Cr > K > Ca > Si > Mn > Na > Al > Mg > P > Fe > S > Ti. Zinc and chromium account for much of the difference, but discriminant analyses excluding them still distinguish the two groups at the 95% confidence level. These results are consistent with previous reports of high levels of alkaline phosphatase, a zinc-containing enzyme, in afflicted stapes. But the broad spectrum of elements capable of distinguishing otosclerotic stapes warrants study of additional zinc-containing and other metal-containing or metal-activated moieties.

Quantitative indicators of air traffic controllers’ attitude to the danger of errors

2020 ◽  
pp. 68-78
Author(s):  
O. M. Reva ◽  
V. V. Kamyshin ◽  
S. P. Borsuk ◽  
V. A. Shulhin ◽  
A. V. Nevynitsyn
Keyword(s):  
Human Factor ◽  
Differential Method ◽  
Air Traffic ◽  
Professional Activity ◽  
Aviation Accidents ◽  
Air Traffic Controllers ◽  
The Difference ◽  
Level Of Significance ◽  
The Individual ◽  
High Level

The negative and persistent impact of the human factor on the statistics of aviation accidents and serious incidents makes proactive studies of the attitude of “front line” aviation operators (air traffic controllers, flight crewmembers) to dangerous actions or professional conditions as a key component of the current paradigm of ICAO safety concept. This “attitude” is determined through the indicators of the influence of the human factor on decision-making, which also include the systems of preferences of air traffic controllers on the indicators and characteristics of professional activity, illustrating both the individual perception of potential risks and dangers, and the peculiarities of generalized group thinking that have developed in a particular society. Preference systems are an ordered (ranked) series of n = 21 errors: from the most dangerous to the least dangerous and characterize only the danger preference of one error over another. The degree of this preference is determined only by the difference in the ranks of the errors and does not answer the question of how much time one error is more dangerous in relation to another. The differential method for identifying the comparative danger of errors, as well as the multistep technology for identifying and filtering out marginal opinions were applied. From the initial sample of m = 37 professional air traffic controllers, two subgroups mB=20 and mG=7 people were identified with statisti-cally significant at a high level of significance within the group consistency of opinions a = 1%. Nonpara-metric optimization of the corresponding group preference systems resulted in Kemeny’s medians, in which the related (middle) ranks were missing. Based on these medians, weighted coefficients of error hazards were determined by the mathematical prioritization method. It is substantiated that with the ac-cepted accuracy of calculations, the results obtained at the second iteration of this method are more ac-ceptable. The values of the error hazard coefficients, together with their ranks established in the preference systems, allow a more complete quantitative and qualitative analysis of the attitude of both individual air traffic controllers and their professional groups to hazardous actions or conditions.

scholarly journals The posterior cerebellum and inconsistent trait implications when learning the sequence of actions

2021 ◽  
Author(s):  
Min Pu ◽  
Qianying Ma ◽  
Elien Heleven ◽  
Naem Patemoshela Haihambo ◽  
Frank Van Overwalle
Keyword(s):  
Prefrontal Cortex ◽  
Social Cognition ◽  
Medial Prefrontal Cortex ◽  
Personality Trait ◽  
Confidence Level ◽  
Temporal Order ◽  
The Other ◽  
High Level ◽  
First Time ◽  
Temporal Sequences

Abstract It has been proposed that the cerebellum contributes to social cognition. Based on the view that cerebellar internal models create predictions on motions and actions, we hypothesize that the posterior cerebellum supports identifying temporal sequences of persons’ actions as well as detecting inconsistent actions that violate the implied trait. Participants were required to memorize the temporal order of a set of sentences that implied a personality trait. Importantly, the sentence sets were designed in such a way that the first half of each set involved actions that were consistent with the same trait, while the other half was either consistent or inconsistent with that trait. As expected, we found robust posterior cerebellar activation when memorizing the order of the actions, irrespective of trait consistency, but more crucially also for actions implying an inconsistent trait in comparison to consistent trait actions. We also found that the medial prefrontal cortex and posterior cerebellum were associated with confidence level in retrieving the sequences. This study supports the hypothesis that the posterior cerebellum identifies and predicts the low-level temporal order of actions and demonstrates for the first time that this area is also involved in the high-level prediction of trait implications of those actions.

scholarly journals Examining the Attacks After the 20th Scores in Volleyball According to Nationality and Positions

2018 ◽  
Vol 7 (6) ◽  
pp. 184
Author(s):  
Cengiz Akarcesme ◽  
Muhammed Sahin ◽  
Yaprak Kalemoğlu Varol ◽  
Filiz Fatma Colakoglu
Keyword(s):  
Study Data ◽  
Variance Analysis ◽  
Arithmetic Average ◽  
Video Recorder ◽  
Kolmogorov Smirnov ◽  
The Difference ◽  
Level Of Significance ◽  
Number Percentage ◽  
High Level ◽  
Post Hoc

The most efficient technique of scoring in volleyball is possible to be mentioned as attack. The numbers of efficient attacks performed after the 20th scores during the match are more important, and therefore this period should be managed more elaborately in terms of the technique and tactic. Therefore, it is considered that players’ presenting more productive performances with the drills related to the match after the trainings will be more efficient upon winning the match. The purpose of this study was to investigate the attacks performed after the 20th scores in 2017-2018 Volleyball Sultans League session according to the nationalities and positions. The study included totally 124 female players with natives (n=86) and foreigners (n=38) from 12 teams between 26 and 30 years old (28.25±1,62).  The numbers of the attacks performed after the 20th scores of 17.918 rallies in 496 sets (except from the 5th set) of 125 matches played by 12 teams during the session were evaluated. All matches were recorded with a video recorder by the researcher. The videos were analyzed by the experts in 3 repetitions. Attack errors, blocked attack, bad attacks, good attacks, numbers of attacks, coverage and totals numbers of attacks performed after the 20th scores during the match were recorded in numbers. Lilliefors Kolmogorov-Smirnov Test indicated whether the study data were appropriate for the normal distribution or not (p<.05). In data analysis, descriptive statistics such as number, percentage, arithmetic average and standard deviation were used; and Independent Samples T-Test and One-Way Variance Analysis (One-Way ANOVA) were used for determining the difference between dependent and independent variables. Tukey HSD Post-Hoc test was performed for finding among which groups there were differences between the units in one-way variance analysis (ANOVA). While interpreting the data, 0.01 and 0.05 were accepted as the level of significance. The research data were analyzed using SPSS 21 statistical software. As result of the findings obtained in the study, it was determined that there were significant differences in whole attacks performed by the players in terms of nationalities and positions (p<0.05). In conclusion, because the 20th scores are referred the critic period called as the golden scores, foreigners and opposite spiker’s that had high level conditional abilities for winning had more attacks.

scholarly journals Qualitative Analysis of Volatiles in Rabbiteye Blueberry Cultivars at Various Maturities Using Rapid Solid-phase Microextraction

2014 ◽  
Vol 139 (2) ◽  
pp. 167-177 ◽  
Author(s):  
John C. Beaulieu ◽  
Rebecca E. Stein-Chisholm ◽  
Deborah L. Boykin
Keyword(s):  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Value Added ◽  
Ripe Fruit ◽  
Vaccinium Ashei ◽  
Volatile Profiles ◽  
Level Of Significance ◽  
High Level ◽  
First Time ◽  
Chromatographic Mass

There are very few studies detailing the aroma, astringency, and flavor of rabbiteye blueberry [RAB (Vaccinium ashei)] fruit typically grown in the southeastern United States. The objectives were to investigate the rapid and qualitative solid-phase microextraction gas chromatographic–mass spectrometry volatile composition of several local RAB cultivars with an overall goal to build a database of possible flavor and aroma compounds. Volatile profiles were obtained in five Louisiana-grown RAB cultivars (Brightwell, Climax, Premier, Powder Blue, and Tifblue) assayed at four maturities. The method routinely captured 53 volatiles, including 12 aldehydes, six alcohols, 11 esters, four ketones, 17 terpenoids, one furan, and two aromatics. Of the 33 compounds considered important in blueberries, 17 were recovered in the RAB cultivars assessed. Herein, 10 compounds were recovered for the first time in blueberry (Vaccinium sp.) and five of those compounds were confirmed with standards [2-ethylfuran, (E)-2-pentenal, (Z)-dehydroxylinalool oxide, (E)-dehydroxylinalool oxide and 1,4-cineole]. In general, terpenoids and their subclass linalools were the most significant volatiles followed closely by esters, aldehydes, and then alcohols. Terpenoids and linalools displayed the greatest significant differences in ‘Powder Blue’ and ‘Premier’. Esters and aldehydes were the most significant compound classes based on cultivar effect per maturity in firm-ripe fruit. From the suite of 17 of the 33 important compounds in upright blueberry, 10 were recovered across the five cultivars at four maturities that displayed a high level of significance. These were linalool, methyl 3-methylbutanoate, 1,8-cineole, (E)-2-hexanal, (Z)-3-hexenal, (Z)-3-hexenyl acetate, limonene, hexyl acetate, hexanal, and α-terpineol. These data will be useful to evaluate aroma volatiles in RAB and changes in processed and value-added byproducts.

Variation in the fertility of ewes during the joining period and its modification by prior contact with rams

1975 ◽  
Vol 26 (3) ◽  
pp. 577 ◽  
Author(s):  
TW Knight ◽  
CM Oldham ◽  
DR Lindsay ◽  
JF Smith
Keyword(s):  
Breeding Season ◽  
Western Australia ◽  
Reproductive Performance ◽  
Low Fertility ◽  
The Third ◽  
Lower Fertility ◽  
The Difference ◽  
High Level ◽  
First Time ◽  
Embryonic Death

The reproductive performance of ewes mated for the first time in the first, second and third 2 weeks of joining was determined in 19,666 Merino ewes from 46 commercial flocks in the south of Western Australia. The percentage of ewes failing to lamb was higher for ewes mated in the first 2 weeks of joining than in ewes mated for the first time in the second 2 weeks (8.4%, P < 0.001). This difference was not associated with the age of the ewes, but it was related to the stage of the breeding season (19.2%, P < 0.001, in October–November; 4.1%, P < 0-01, in February–March). The difference resulted from the lower fertility of the ewes mated in the first period and was not associated with either an adverse ram/oestrous-ewe ratio or low fertility of the rams early in the joining period. The data on returns to service suggested that the low fertility of the ewes in the first 2 weeks of joining was associated with a low level of fertilization and/or a high level of early embryonic death. Placing vasectomized rams with the ewes for 2–4 weeks before joining reduced this difference in fertility between ewes mated in the first and the second 2 weeks of joining. The fertility of maiden ewes improved from the first to the third 2 weeks of joining. Older ewes were more fertile when mated in the second 2-week segment than in the first, but those mating for the first time in the third 2 weeks were least fertile of all.

High spatial resolution x-ray microanalysis of interfaces

1995 ◽  
Vol 53 ◽  
pp. 284-285
Author(s):  
J. R. Michael
Keyword(s):  
Spatial Resolution ◽  
Electron Probe ◽  
Solid Angle ◽  
Collection Efficiency ◽  
Spatial Scales ◽  
Energy Dispersive Spectrometer ◽  
X Rays ◽  
X Ray ◽  
Probe Size ◽  
Brightness Field

X-ray microanalysis in the analytical electron microscope (AEM) refers to a technique by which chemical composition can be determined on spatial scales of less than 10 nm. There are many factors that influence the quality of x-ray microanalysis. The minimum probe size with sufficient current for microanalysis that can be generated determines the ultimate spatial resolution of each individual microanalysis. However, it is also necessary to collect efficiently the x-rays generated. Modern high brightness field emission gun equipped AEMs can now generate probes that are less than 1 nm in diameter with high probe currents. Improving the x-ray collection solid angle of the solid state energy dispersive spectrometer (EDS) results in more efficient collection of x-ray generated by the interaction of the electron probe with the specimen, thus reducing the minimum detectability limit. The combination of decreased interaction volume due to smaller electron probe size and the increased collection efficiency due to larger solid angle of x-ray collection should enhance our ability to study interfacial segregation.

Difference of [Ca2+]i Movements in Platelets Stimulated by Thrombin and TRAP: the Involvement of αIIbβ3-Mediated TXA2 Synthesis

1998 ◽  
Vol 79 (06) ◽  
pp. 1184-1190 ◽  
Author(s):  
Yoshiaki Tomiyama ◽  
Shigenori Honda ◽  
Kayoko Senzaki ◽  
Akito Tanaka ◽  
Mitsuru Okubo ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Fibrinogen Binding ◽  
Adp Release ◽  
The Difference ◽  
Txa2 Receptor Antagonist ◽  
High Level ◽  
Inhibition Studies ◽  
Peak Increase ◽  
Second Peak ◽  
Assay Conditions

SummaryThis study investigated the difference of [Ca2+]i movement in platelets in response to thrombin and TRAP. The involvement of αIIbβ3 in this signaling was also studied. Stimulation of platelets with thrombin at 0.03 U/ml caused platelet aggregation and a two-peak increase in [Ca2+]i. The second peak of [Ca2+]i, but not the first peak was abolished by the inhibition of platelet aggregation with αIIbβ3 antagonists or by scavenging endogenous ADP with apyrase. A cyclooxygenase inhibitor, aspirin, and a TXA2 receptor antagonist, BM13505, also abolished the second peak of [Ca2+]i but not the first peak, although these regents did not inhibit aggregation. Under the same assay conditions, measurement of TXB2 demonstrated that αIIbβ3 antagonists and aspirin almost completely inhibited the production of TXB2. In contrast to thrombin-stimulation, TRAP caused only a single peak of [Ca2+]i even in the presence of platelet aggregation, and a high level of [Ca2+]i increase was needed for the induction of platelet aggregation. The inhibition of aggregation with αIIbβ3 antagonists had no effect on [Ca2+]i change and TXB2 production induced by TRAP. Inhibition studies using anti-GPIb antibodies suggested that GPIb may be involved in the thrombin response, but not in the TRAP. Our findings suggest that low dose thrombin causes a different [Ca2+]i response and TXA2 producing signal from TRAP. Endogenous ADP release and fibrinogen binding to αIIbβ3 are responsible for the synthesis of TXA2 which results in the induction of the second peak of [Ca2+]i in low thrombin- but not TRAP-stimulated platelets.

A Confrontation between Two Doctrines: The Birth of Struggle for Hegemony in Hebrew Children's Literature during the 1930s and 1940s

2008 ◽  
Vol 1 (2) ◽  
pp. 139-155 ◽  
Author(s):  
YAEL DARR
Keyword(s):  
Children's Literature ◽  
Educational System ◽  
Single Channel ◽  
Children’S Literature ◽  
The Political ◽  
Literary Creation ◽  
History Of ◽  
High Level ◽  
First Time ◽  
Literary Quality

This article describes a crucial and fundamental stage in the transformation of Hebrew children's literature, during the late 1930s and 1940s, from a single channel of expression to a multi-layered polyphony of models and voices. It claims that for the first time in the history of Hebrew children's literature there took place a doctrinal confrontation between two groups of taste-makers. The article outlines the pedagogical and ideological designs of traditionalist Zionist educators, and suggests how these were challenged by a group of prominent writers of adult poetry, members of the Modernist movement. These writers, it is argued, advocated autonomous literary creation, and insisted on a high level of literary quality. Their intervention not only dramatically changed the repertoire of Hebrew children's literature, but also the rules of literary discourse. The article suggests that, through the Modernists’ polemical efforts, Hebrew children's literature was able to free itself from its position as an apparatus controlled by the political-educational system and to become a dynamic and multi-layered field.

Paget’s disease: clinical update

2011 ◽  
Vol 152 (33) ◽  
pp. 1337-1346
Author(s):  
Judit Donáth ◽  
Gyula Poór
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Etiologic Role ◽  
Osteoblast Activity ◽  
Chronic Disorder ◽  
Abnormal Increase ◽  
Osteoclast Function ◽  
High Level

Paget’s disease is a chronic disorder of bone remodeling, characterized by an abnormal increase of osteoclast and, hence, osteoblast activity. The imbalance of bone turnover results in the formation of unhealthy and fragile bone. It also leads to impairment of adjacent joints and to a risk of various complications. Current research focuses on the elucidation of the etiologic role viral infection and predisposing genetic factors. Paget’s disease is commonly discovered by chance; its suspicion is raised either by high level of alkaline phosphatase or by the X-ray of the pathological bone. Bisphosphonates have proven to be effective in controlling disease activity because they inhibit osteoclast function. Their use is recommended when bone-derived serum alkaline phosphatase is high and/or when disease localizations are highly suspected for the development of complications. Orv. Hetil., 2011, 152, 1337–1346.

ATTITUDE TO OPEN ACCESS IN RUSSIAN SCHOLARLY COMMUNITY: 2018. SURVEY RESULTS AND ANALYSIS

2018 ◽  
Vol 1 (1) ◽  
pp. 6-21 ◽  
Author(s):  
I. K. Razumova ◽  
N. N. Litvinova ◽  
M. E. Shvartsman ◽  
A. Yu. Kuznetsov
Keyword(s):  
Open Access ◽  
Open Access Publishing ◽  
Scholarly Community ◽  
Research Areas ◽  
Survey Results ◽  
The Difference ◽  
Policies And Programs ◽  
The Uk ◽  
High Level ◽  
Access Policies

Introduction. The paper presents survey results on the awareness towards and practice of Open Access scholarly publishing among Russian academics.Materials and Methods. We employed methods of statistical analysis of survey results. Materials comprise results of data processing of Russian survey conducted in 2018 and published results of the latest international surveys. The survey comprised 1383 respondents from 182 organizations. We performed comparative studies of the responses from academics and research institutions as well as different research areas. The study compares results obtained in Russia with the recently published results of surveys conducted in the United Kingdom and Europe.Results. Our findings show that 95% of Russian respondents support open access, 94% agree to post their publications in open repositories and 75% have experience in open access publishing. We did not find any difference in the awareness and attitude towards open access among seven reference groups. Our analysis revealed the difference in the structure of open access publications of the authors from universities and research institutes. Discussion andConclusions. Results reveal a high level of awareness and support to open access and succeful practice in the open access publications in the Russian scholarly community. The results for Russia demonstrate close similarity with the results of the UK academics. The governmental open access policies and programs would foster the practical realization of the open access in Russia.

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