Electrospun poly(vinyl alcohol) nanofibrous membranes containing Coptidis Rhizoma extracts for potential biomedical applications

2018 ◽  
Vol 89 (17) ◽  
pp. 3506-3518 ◽  
Author(s):  
Jin Jeong ◽  
Seungsin Lee
Keyword(s):  
Antibacterial Activity ◽  
Vinyl Alcohol ◽  
Drug Carrier ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Antibacterial Activity ◽  
Coptidis Rhizoma ◽  
Nanofibrous Membranes

Coptidis Rhizoma is a medicinal plant that is well known for its high antibacterial activity against various pathogens and its anti-inflammatory, antioxidant, and hemostatic effects. Here, nanofibrous membranes containing 10, 20, and 30 wt% of Coptidis Rhizoma extracts were fabricated by electrospinning using poly(vinyl alcohol) as the drug carrier and thermally treated to increase their aqueous stability. The antibacterial properties and release characteristics of Coptidis Rhizoma nanofibrous membranes were investigated. Coptidis Rhizoma-loaded nanocomposite fibers exhibited a high drug-loading efficiency ranging from 92% to 97%. The release profile from the nanofibrous membranes of Coptidis Rhizoma showed an initial fast release followed by a gradual release for 48 h. High antibacterial activity of the Coptidis Rhizoma-loaded nanofibrous membranes was exhibited against both Staphylococcus aureus and Staphylococcus epidermidis. These results demonstrate that poly(vinyl alcohol) nanofibrous membranes containing Coptidis Rhizoma extracts have considerable potential to be effective antimicrobial wound dressings based on natural substances.

scholarly journals Antibacterial Activity and Drug Loading of Moxifloxacin-Loaded Poly(Vinyl Alcohol)/Chitosan Electrospun Nanofibers

2021 ◽  
Vol 8 ◽  
Author(s):  
Qi Liu ◽  
Wen-Chong Ouyang ◽  
Xiu-Hong Zhou ◽  
Tao Jin ◽  
Zheng-Wei Wu
Keyword(s):  
Antibacterial Activity ◽  
Vinyl Alcohol ◽  
Composite Nanofibers ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Electrospun Nanofibers ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Blank Group

In this study, nanofibers with different ratios of poly(vinyl alcohol) and chitosan incorporated with moxifloxacin hydrochloride (MH/PVA/CS) were fabricated through the blending electrospinning, and the morphological features were tested using scanning electron microscopy (SEM). Further characterization of the new nanofiber was accomplished by Thermogravimetric analysis (TG), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity of the MH-loaded nanofibers at different drug loading were tested and compared with the blank group. Experimental results show that the MH/PVA/CS nanofibers exhibited the good antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa due to the MH incorporation. Compared with blank nanofibers, MH/PVA/CS nanofibers have significantly better antibacterial properties, and different proportions of PVA and CS have a certain effect on the antibacterial activity of nanofibers. The conclusions in this paper show that MH/PVA/CS composite nanofibers may have great potential in antibacterial materials.

scholarly journals The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 96
Author(s):  
John Jackson ◽  
Helen Burt ◽  
Dirk Lange ◽  
In Whang ◽  
Robin Evans ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Silver Nitrate ◽  
Vinyl Alcohol ◽  
Unmet Need ◽  
Chemical Characterization ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Burn Wound

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.

Functionalized Bacterial Cellulose Microparticles for Drug Delivery in Biomedical Applications

2019 ◽  
Vol 25 (34) ◽  
pp. 3692-3701 ◽  
Author(s):  
Hanif Ullah ◽  
Munair Badshah ◽  
Alexandra Correia ◽  
Fazli Wahid ◽  
Hélder A. Santos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Drug Release ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Amorphous State ◽  
Spherical Shape

Background: Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. Objective: In the current work, we tested the feasibility of BC as a drug carrier in microparticulate form for potential pharmaceutical and biomedical applications. Method : For this purpose, drug-loaded BC microparticles were prepared by simple grinding and injection moulding method through regeneration. Model drugs, i.e., cloxacillin (CLX) and cefuroxime (CEF) sodium salts were loaded in these microparticles to assess their drug loading and release properties. The prepared microparticles were evaluated in terms of particle shapes, drug loading efficiency, physical state of the loaded drug, drug release behaviour and antibacterial properties. Results: The BC microparticles were converted to partially amorphous state after regeneration. Moreover, the loaded drug was transformed into the amorphous state. The results of scanning electron microscopy (SEM) showed that microparticles had almost spherical shape with a size of ca. 350-400 μm. The microparticles treated with higher drug concentration (3%) exhibited higher drug loading. Keeping drug concertation constant, i.e., 1%, the regenerated BC (RBC) microparticles showed higher drug loading (i.e., 37.57±0.22% for CEF and 33.36±3.03% for CLX) as compared to as-synthesized BC (ABC) microparticles (i.e., 9.46±1.30% for CEF and 9.84±1.26% for CLX). All formulations showed immediate drug release, wherein more than 85% drug was released in the initial 30 min. Moreover, such microparticles exhibited good antibacterial activity with larger zones of inhibition for drug loaded RBC microparticles as compared to corresponding ABC microparticles. Conclusion : Drug loaded BC microparticles with immediate release behaviour and antibacterial activity were fabricated. Such functionalized microparticles may find potential biomedical and pharmaceutical applications.

scholarly journals Hybrid levan–Ag/AgCl nanoparticles produced by UV-irradiation: properties, antibacterial efficiency and application in bioactive poly(vinyl alcohol) films

RSC Advances ◽  
2021 ◽  
Vol 11 (62) ◽  
pp. 38990-39003
Author(s):  
Anissa Haddar ◽  
Emna Ben Ayed ◽  
Assaad Sila ◽  
Jean-Luc Putaux ◽  
Ali Bougatef ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Uv Irradiation ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Antibacterial Efficiency ◽  
High Antibacterial Activity ◽  
Agcl Nanoparticles

Hybrid Ag/AgCl nanoparticles with high antibacterial activity were synthesised using bacterial levan.

scholarly journals Synthesis, Physical, Mechanical and Antibacterial Properties of Nanocomposites Based on Poly(vinyl alcohol)/Graphene Oxide–Silver Nanoparticles

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 723 ◽  
Author(s):  
Mónica Cobos ◽  
Iker De-La-Pinta ◽  
Guillermo Quindós ◽  
María Jesús Fernández ◽  
María Dolores Fernández
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Coming Out ◽  
Vinyl Alcohol ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Nanocomposite Films ◽  
Poly Vinyl Alcohol ◽  
Dependent Manner ◽  
Bacterial Cells

The design of new materials with antimicrobial properties has emerged in response to the need for preventing and controlling the growth of pathogenic microorganisms without the use of antibiotics. In this study, partially reduced graphene oxide decorated with silver nanoparticles (GO–AgNPs) was incorporated as a reinforcing filler with antibacterial properties to poly(vinyl alcohol) (PVA) for preparation of poly(vinyl alcohol)/graphene oxide-silver nanoparticles nanocomposites (PVA/GO–AgNPs). AgNPs, spherical in shape and with an average size of 3.1 nm, were uniformly anchored on the partially reduced GO surface. PVA/GO–AgNPs nanocomposites showed exfoliated structures with improved thermal stability, tensile properties and water resistance compared to neat PVA. The glass transition and crystallization temperatures of the polymer matrix increased with the incorporation of the hybrid. The nanocomposites displayed antibacterial activity against Staphylococcus aureus and Escherichia coli in a filler content- and time-dependent manner. S. aureus showed higher susceptibility to PVA/GO–AgNPs films than E. coli. Inhibitory activity was higher when bacterial cells were in contact with nanocomposite films than when in contact with leachates coming out of the films. GO–AgNPs based PVA nanocomposites could find application as wound dressings for wound healing and infection prevention.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Bicomponent multifilament yarns of recycled poly(ethylene terephthalate) and nano-titanium dioxide for antibacterial carpet

2021 ◽  
pp. 152808372110117
Author(s):  
Sommai Pivsa-Art ◽  
Komson Sunyikhan ◽  
Weraporn Pivsa-Art
Keyword(s):  
Antibacterial Activity ◽  
Titanium Dioxide ◽  
Ethylene Terephthalate ◽  
Antibacterial Properties ◽  
Nano Structure ◽  
Elongation At Break ◽  
High Antibacterial Activity ◽  
Poly Ethylene Terephthalate ◽  
Poly Ethylene ◽  
Multifilament Yarns

Recycled poly(ethylene terephthalate) (RPET) multifilament yarns are used in carpet manufacturing as a way to reduce plastic waste. The conventional RPET carpet is however susceptible to bacterial accumulation. As a result, this research experimentally doped RPET with nano-structure titanium dioxide (nano-TiO2) to produce RPET/nano-TiO2 bicomponent multifilament yarns with antibacterial property. The experimental multifilament yarn structure consisted of two parts: neat RPET core and RPET/nano-TiO2 shell. The nano-TiO2 content in the shell was varied between 1 and 3 wt% and the core/shell (C/S) ratios between 90/10, 70/30, and 50/50 w/w. The effects of C/S ratio and nano-TiO2 content on the mechanical and antibacterial properties of bicomponent multifilament yarns were determined. The experimental results indicated that the C/S ratio had no effect on the tenacity and elongation at break. Meanwhile, the tenacity and elongation at break of bicomponent fibers increased with nano-TiO2 content in the shell. The TiO2-doped RPET bicomponent yarns effectively inhibited the growth of Escherichia coli and Staphylococcus aureus. The 90/10 bicomponent multifilament fiber with 3 wt% TiO2 achieved the highest antibacterial activity. The very high antibacterial activity was attributable to greater deposition of nano-TiO2 particles near and on the shell surface.

scholarly journals Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating Agrimonia eupatoria L. Extract

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 83
Author(s):  
Cláudia Mouro ◽  
Colum P. Dunne ◽  
Isabel C. Gouveia
Keyword(s):  
Composite Material ◽  
Vinyl Alcohol ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Coating Layer ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Microbial Invasion ◽  
Layer Composite ◽  
Medicinal Plant Extracts

Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced therapeutic dressings, such as electrospun membranes containing antimicrobial agents. Among the most used antimicrobial agents, medicinal plant extracts demonstrate considerable potential for clinical use, due primarily to their efficacy allied to relatively low incidence of adverse side-effects. In this context, the present work aimed to develop a unique dual-layer composite material with enhanced antibacterial activity derived from a coating layer of Poly(vinyl alcohol) (PVA) and Chitosan (CS) containing Agrimonia eupatoria L. (AG). This novel material has properties that facilitate it being electrospun above a conventional cotton gauze bandage pre-treated with 2,2,6,6-tetramethylpiperidinyl-1-oxy free radical (TEMPO). The produced dual-layer composite material demonstrated features attractive in production of wound dressings, specifically, wettability, porosity, and swelling capacity. Moreover, antibacterial assays showed that AG-incorporated into PVA_CS’s coating layer could effectively inhibit Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth. Equally important, the cytotoxic profile of the dual-layer material in normal human dermal fibroblast (NHDF) cells demonstrated biocompatibility. In summary, these data provide initial confidence that the TEMPO-oxidized cotton/PVA_CS dressing material containing AG extract demonstrates adequate mechanical attributes for use as a wound dressing and represents a promising approach to prevention of bacterial wound contamination.

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