Learning anatomy in late sixteenth-century Padua

2018 ◽  
Vol 56 (4) ◽  
pp. 381-402 ◽  
Author(s):  
Michael Stolberg

Based on the newly discovered, extensive manuscript notes of a virtually unknown German medical student by the name of Johann Konrad Zinn, who studied in Padua from 1593 to 1595, this paper offers a detailed account of what medical students could expect to learn about anatomy in late sixteenth-century Padua. It highlights the large number and wide range of anatomical demonstrations, most of which were private anatomies for a small circle of students and do not figure in Acta of the German Nation, the principal source historians have so far relied upon. While the large audience in the big, celebrated public anatomies made it difficult if not impossible for the students to see the details of the anatomical structures, the much more numerous private anatomies offered a view from close up. As Zinn’s notes show, the two leading Paduan anatomists, Hieronymus Fabricius Aquapendente and Giulio Casseri often focused on a specific part of the body, like the brain or the pregnant uterus, and, following the Galenic model, consistently linked the demonstration of the fabric of that part to a discussion of its action and uses. In this sense, the different kinds of valves in the body, including those in the veins, were shown and discussed, as a subsection on William Harvey underlines, and the vivisection of animals for a group of students even allowed them to see the beating heart and other organs in action. In retrospect, much of the anatomical knowledge that students acquired in late sixteenth-century Padua was of limited relevance for medical practice but the anatomists did their best to point out such clinical uses and even used anatomical demonstrations to show different kinds surgical interventions on the corpse.

2019 ◽  
Author(s):  
Leyla Tarhan ◽  
Talia Konkle

Humans observe a wide range of actions in their surroundings. How is the visual cortex organized to process this diverse input? Using functional neuroimaging, we measured brain responses while participants viewed short videos of everyday actions, then probed the structure in these responses using voxel-wise encoding modeling. Responses were well fit by feature spaces that capture the body parts involved in an action and the action’s targets (i.e. whether the action was directed at an object, another person, the actor, and space). Clustering analyses revealed five large-scale networks that summarized the voxel tuning: one related to social aspects of an action, and four related to the scale of the interaction envelope, ranging from fine-scale manipulations directed at objects, to large-scale whole-body movements directed at distant locations. We propose that these networks reveal the major representational joints in how actions are processed by visual regions of the brain.Significance StatementHow does the brain perceive other people’s actions? Prior work has established that much of the visual cortex is active when observing others’ actions. However, this activity reflects a wide range of processes, from identifying a movement’s direction to recognizing its social content. We investigated how these diverse processes are organized within the visual cortex. We found that five networks respond during action observation: one that is involved in processing actions’ social content, and four that are involved in processing agent-object interactions and the scale of the effect that these actions have on the world (its “interaction envelope”). Based on these findings, we propose that sociality and interaction envelope size are two of the major features that organize action perception in the visual cortex.


2021 ◽  
Vol 17 (2) ◽  
pp. 6-15
Author(s):  
L.A. Dziak ◽  
O.S. Tsurkalenko ◽  
K.V. Chekha ◽  
V.M. Suk

Coronavirus infection is a systemic pathology resulting in impairment of the nervous system. The involvement of the central nervous system in COVID-19 is diverse by clinical manifestations and main mechanisms. The mechanisms of interrelations between SARS-CoV-2 and the nervous system include a direct virus-induced lesion of the central nervous system, inflammatory-mediated impairment, thrombus burden, and impairment caused by hypoxia and homeostasis. Due to the multi-factor mechanisms (viral, immune, hypoxic, hypercoagulation), the SARS-CoV-2 infection can cause a wide range of neurological disorders involving both the central and peripheral nervous system and end organs. Dizziness, headache, altered level of consciousness, acute cerebrovascular diseases, hypogeusia, hyposmia, peripheral neuropathies, sleep disorders, delirium, neuralgia, myalgia are the most common signs. The structural and functional changes in various organs and systems and many neurological symptoms are determined to persist after COVID-19. Regardless of the numerous clinical reports about the neurological and psychiatric symptoms of COVID-19 as before it is difficult to determine if they are associated with the direct or indirect impact of viral infection or they are secondary to hypoxia, sepsis, cytokine reaction, and multiple organ failure. Penetrated the brain, COVID-19 can impact the other organs and systems and the body in general. Given the mechanisms of impairment, the survivors after COVID-19 with the infection penetrated the brain are more susceptible to more serious diseases such as Parkinson’s disease, cognitive decline, multiple sclerosis, and other autoimmune diseases. Given the multi-factor pathogenesis of COVID-19 resulting in long-term persistence of the clinical symptoms due to impaired neuroplasticity and neurogenesis followed by cholinergic deficiency, the usage of Neuroxon® 1000 mg a day with twice-day dosing for 30 days. Also, a long-term follow-up and control over the COVID-19 patients are recommended for the prophylaxis, timely determination, and correction of long-term complications.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Santosh Chandrasekaran ◽  
Matthew Fifer ◽  
Stephan Bickel ◽  
Luke Osborn ◽  
Jose Herrero ◽  
...  

AbstractAlmost 100 years ago experiments involving electrically stimulating and recording from the brain and the body launched new discoveries and debates on how electricity, movement, and thoughts are related. Decades later the development of brain-computer interface technology began, which now targets a wide range of applications. Potential uses include augmentative communication for locked-in patients and restoring sensorimotor function in those who are battling disease or have suffered traumatic injury. Technical and surgical challenges still surround the development of brain-computer technology, however, before it can be widely deployed. In this review we explore these challenges, historical perspectives, and the remarkable achievements of clinical study participants who have bravely forged new paths for future beneficiaries.


Author(s):  
Mónica Domínguez Torres

Since ancient times, pearls have been put to a wide range of uses—from decorative functions garnishing religious and secular objects, to medicinal applications for the cure of several maladies. During the sixteenth and seventeenth centuries, in particular, European scholars and aristocrats avidly collected and studied diverse specimens that became available thanks to new trade routes and markets. By means of these organic gems, scientists sought to understand nature’s mysteries while artists showed off their ingenuity and creative power. Especially appealing were large, irregular pearls, which were often transformed into expensive objects of virtue treasured over generations: an oddly formed pearl could become the body of a lion, a dragon, or a monster, whose heads, legs, and tails were recreated with gold, enamel, and other precious materials; or they could be transformed into a mermaid or a triton referencing thus the marine nature of the precious gem. They could even take the form of a caravel or a black captive, referring thus to the industry and commercial networks that made such treasures available to European patrons. Then as now, the labor cost of such desirable objects was concealed behind a veneer of beauty and opulence. In reality, by the turn of the sixteenth century, the pearl trade had become one of the most brutal forms of human exploitation. This chapter seeks to unveil the significance of objects usually deemed as innocuous decorative items.


2019 ◽  
Vol 116 (52) ◽  
pp. 26274-26279 ◽  
Author(s):  
Richard A. Andersen ◽  
Tyson Aflalo ◽  
Spencer Kellis

A dramatic example of translational monkey research is the development of neural prosthetics for assisting paralyzed patients. A neuroprosthesis consists of implanted electrodes that can record the intended movement of a paralyzed part of the body, a computer algorithm that decodes the intended movement, and an assistive device such as a robot limb or computer that is controlled by these intended movement signals. This type of neuroprosthetic system is also referred to as a brain–machine interface (BMI) since it interfaces the brain with an external machine. In this review, we will concentrate on BMIs in which microelectrode recording arrays are implanted in the posterior parietal cortex (PPC), a high-level cortical area in both humans and monkeys that represents intentions to move. This review will first discuss the basic science research performed in healthy monkeys that established PPC as a good source of intention signals. Next, it will describe the first PPC implants in human patients with tetraplegia from spinal cord injury. From these patients the goals of movements could be quickly decoded, and the rich number of action variables found in PPC indicates that it is an appropriate BMI site for a very wide range of neuroprosthetic applications. We will discuss research on learning to use BMIs in monkeys and humans and the advances that are still needed, requiring both monkey and human research to enable BMIs to be readily available in the clinic.


Author(s):  
Mariya S. Pravdivtseva ◽  
Oleg B. Shevelev ◽  
Vadim V. Yanshole ◽  
Mikhail P. Moshkin ◽  
Igor V. Koptyug ◽  
...  

AbstractThe impact of alcohol on the body can be investigated with NMR spectroscopy in vitro, which can detect a wide range of metabolites but preparing samples includes tissue biopsy. Blood sampling is less invasive, but blood metabolic content might not reflect the changes occurring in other tissues. Thus, this study aimed to investigate the liver, brain, and serum metabolism and evaluate the link between tissues and serum metabolic content. Two experimental groups with ten outbred rats each were provided intragastrically with water (control group) and 50% ethanol solution (alcohol group) for 28 days. 1H NMR spectroscopy in vitro was performed on the brain cortex, liver, and serum samples. Student’s t test with Holm–Bonferroni correction was used to investigate significant differences between groups. Partial least-squares discriminant analysis (PLS-DA) and two-way ANOVA were performed to compare liver and serum, brain and serum. In all, 38, 37, and 21 metabolites were identified in the liver, brain, and serum samples, respectively. Significant differences for three metabolites were found in the liver (alanine, proline, and glutathione, p < 0.002) and four in serum (lactate, betaine, acetate, and formic acid, p < 0.002) were detected between the control and alcohol groups. The contents of glucose, betaine, and isoleucine were correlated (r > 0.65) between serum and liver samples. PLS-DA determined separation between all tissues (p < 0.001) and between control and alcohol groups only for liver and serum (p < 0.001). Alcohol had a more substantial effect on liver and serum metabolism than on the brain.


Author(s):  
Sriram Sankar ◽  
Jithu Paulose ◽  
Nirmal Thomas

A cast is used to encase a limb or part of the body to stabilize and hold anatomical structures in place to allow healing of broken bones and ligament tears by promoting immobilization. Conventional orthopedic casts have been made out of Plaster of Paris or fiberglass since ages. The traditional plaster casts have a wide range of problems that have been long since evaded due to the lack of a better alternative. Ever since the advent of additive manufacturing, many remarkable things have been made possible by the technology of 3D printing. The Exoskeletal Immobilizer is a custom 3D printed orthopedic cast that is well ventilated, light weighted, aesthetically pleasing and anatomically accurate. Even though printing the immobilizer on spot takes a little longer than the conventional cast, its countless benefits make up for the waiting time. It is extremely logical and useful for the ones suffering from cerebral palsy, who are forced to wear casts for their entire life. This project is not just another profit making business idea but is the cornerstone that is being laid to serve the people better and lead humanity into the next phase of medical advancement. By integrating parts of physiotherapy, eastern medicine, orthopedics and latest technologies, the Immobilizer promises a speedy recovery. The possibility of performing ultrasound therapy, electrical stimulation therapy, chromotherapy, cryotherapy and acupuncture therapy during the immobilization period reduces the healing time at least by about 40% [4] and eases discomfort of the patients. The features imparted to the cast have been specially handpicked and researched to provide a safe overlap of post immobilization treatment and the immobilization period to facilitate faster healing. The Exoskeletal Immobilizer can not only heal the fracture or a tear faster but can also keep the patient comfortable during the treatment.


2019 ◽  
Vol 4 (4) ◽  

Millions of people are paralyzed or have suffered an amputation. Although these people can still see the object they may want to reach, for example a glass of wine, and can still process in their brains the specific commands to pursue this goal, the action cannot be completed due to, for example, a spinal cord injury or due to the fact that the arm has been amputated. Given that in most cases the brain of these persons is intact, the possibility of reading brain signals would allow the development of Neuroprosthetic devices, such as a robot arm that is driven by neural activity. These technological and scientific advances connect the amputee more intimately with their prosthetic limb, meaning we can now focus more on how the prosthesis is embodied. In other words, to what extent does the prosthetic limb feel like part of the biological body? Does your brain treat it as such? We have a good understanding of how our body is mapped in our brain. Both our motor cortex – the movement control centre, if you like – and the somatosensory cortex where we process a wide range of touch sensations are organisedsomatotopically. This means each area of our body corresponds to a specific area of the primary motor and sensory cortices. Importantly, this mapping does not disappear after the loss of a limb. This means we have an opportunity to connect prostheses, through muscles and peripheral nerves, to the parts of the brain that would have controlled and sensed the biological body part. But it may also allow us to measure embodiment, how successfully the brain accepts the prosthesis as part of the body. Ultimately this line of research, bringing together cognitive neuroscience and biomedical engineering, is not only important for designing better prostheses. It is a unique window for understanding how our brain creates and maintains the image of our bodies – mechanisms that apply equally to amputees and non-amputees.


2017 ◽  
Vol 12 (1-2) ◽  
pp. 86-118 ◽  
Author(s):  
Katharina A. Sabernig

Abstract In Tibetan medicine, ‘vulnerable parts’ (gnyan pa gnad) are bodily structures which should not be damaged. Most of these anatomical locations are important in terms of surgical care and the management of wounds. They are described in the primary classical text of the Tibetan medical tradition, the Four Treatises (Rgyud bzhi), and in far more detail in its respective commentaries. A list of these more than three hundred delicate spots is included in at least two sixteenth-century commentaries, but its origin remains unclear. With the help of the medical ‘scroll paintings’ (thang ka) accompanying the seventeenth-century Blue Beryl (Vaiḍūrya sngon po) commentary to the Four Treatises, we can identify the locations of many of these vulnerable anatomical structures. However, it is uncertain if these identifications have remained consistent over time. With increasing integration of Tibetan medical practices into the Chinese health care system, it became necessary to find and define new terms. A veritable revolution in Tibetan medical terminology has taken place over the past several decades. Through a careful examination of these ‘vulnerable parts’ of the body, including an exploration of three examples, this article examines the shift of anatomical designations and the coining of new terms for anatomical details in classical and modern publications. Correctly identifying the vulnerable parts matters a great deal, especially with regard to patient safety.


2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Włodzimierz Mrówczyński

This article presents a concept that wide expression of brain-derived neurotrophic factor (BDNF) and its receptors (TrkB) in the nervous tissue, evoked by regular endurance training (ET), can cause numerous motor and metabolic adaptations, which are beneficial for human health. The relationships between the training-evoked increase of endogenous BDNF and molecular and/or physiological adaptations in the nervous structures controlling both motor performance and homeostasis of the whole organism have been presented. Due to a very wide range of plastic changes that ET has exerted on various systems of the body, the improvement of motor skills and counteraction of the development of civilization diseases resulting from the posttraining increase of BDNF/TrkB levels have been discussed, as important for people, who undertake ET. Thus, this report presents the influence of endurance exercises on the (1) transformation of motoneuron properties, which are a final element of the motor pathways, (2) reduction of motor deficits evoked by Parkinson disease, and (3) prevention of the metabolic syndrome (MetS). This review suggests that the increase of posttraining levels of BDNF and its TrkB receptors causes simultaneous changes in the activity of the spinal cord, the substantia nigra, and the hypothalamic nuclei neurons, which are responsible for the alteration of the functional properties of motoneurons innervating the skeletal muscles, for the enhancement of dopamine release in the brain, and for the modulation of hormone levels involved in regulating the metabolic processes, responsively. Finally, training-evoked increase of the BDNF/TrkB leads to a change in a manner of regulation of skeletal muscles, causes a reduction of motor deficits observed in the Parkinson disease, and lowers weight, glucose level, and blood pressure, which accompany the MetS. Therefore, BDNF seems to be the molecular factor of pleiotropic activity, important in the modulation processes, underlying adaptations, which result from ET.


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