A Comparison of the Therapeutic and Cardiovascular Effects of a Single Nightly Dose of Prothiaden (Dothiepin, Dosulepin) and Lentizol (Sustained-Release Amitriptyline) in Depressed Elderly Patients

1981 ◽  
Vol 9 (2) ◽  
pp. 108-112 ◽  
Author(s):  
A U Khan
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Sustained Release ◽  
Rating Scale ◽  
Depression Scale ◽  
Comparative Trial ◽  
Check List ◽  
Night Time ◽  
Self Rating ◽  
Symptom Check List

This was a single-blind 4-week parallel group comparative trial in fifty depressed patients. Twenty-five patients received 50 mg of Lentizol, a sustained-release form of amitriptyline, and twenty-five received 75 mg of Prothiaden. Both groups took their drugs as a single night-time dose. Patient response was measured on a symptom check-list which was completed by the doctor and a self-rating depression scale. Tolerance was assessed by recording volunteered and observed side-effects and also by taking the pulse, blood pressure and an electrocardiogram before treatment and after 2 and 4 weeks. A statistically better response was seen with Prothiaden at each follow-up assessment (1, 2 and 4 weeks) compared to Lentizol as measured by both the symptom check-list and the self-rating scale. Less side-effects were also seen with Prothiaden. Minor changes were seen in the ECG records of two patients on Prothiaden and three on Lentizol. These changes were not associated with any clinical change in the patients' cardiovascular state. No consistent changes of any clinical significance were seen in the pulse and blood pressure recordings.

Beeinträchtigtes Erkennen emotionaler Gesichtsausdrücke durch psychiatrische Patientinnen bei Alexithymie

2013 ◽  
Vol 61 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Daniel Dittrich ◽  
Gregor Domes ◽  
Susi Loebel ◽  
Christoph Berger ◽  
Carsten Spitzer ◽  
...  
Keyword(s):  
Emotion Recognition ◽  
Emotional Expression ◽  
Depression Scale ◽  
Facial Emotion Recognition ◽  
Facial Emotion ◽  
Check List ◽  
Psychosomatische Erkrankungen ◽  
Psychiatrische Patienten ◽  
Symptom Check List ◽  
Tas 20

Die vorliegende Studie untersucht die Hypothese eines mit Alexithymie assoziierten Defizits beim Erkennen emotionaler Gesichtsaudrücke an einer klinischen Population. Darüber hinaus werden Hypothesen zur Bedeutung spezifischer Emotionsqualitäten sowie zu Gender-Unterschieden getestet. 68 ambulante und stationäre psychiatrische Patienten (44 Frauen und 24 Männer) wurden mit der Toronto-Alexithymie-Skala (TAS-20), der Montgomery-Åsberg Depression Scale (MADRS), der Symptom-Check-List (SCL-90-R) und der Emotional Expression Multimorph Task (EEMT) untersucht. Als Stimuli des Gesichtererkennungsparadigmas dienten Gesichtsausdrücke von Basisemotionen nach Ekman und Friesen, die zu Sequenzen mit sich graduell steigernder Ausdrucksstärke angeordnet waren. Mittels multipler Regressionsanalyse untersuchten wir die Assoziation von TAS-20 Punktzahl und facial emotion recognition (FER). Während sich für die Gesamtstichprobe und den männlichen Stichprobenteil kein signifikanter Zusammenhang zwischen TAS-20-Punktzahl und FER zeigte, sahen wir im weiblichen Stichprobenteil durch die TAS-20 Punktzahl eine signifikante Prädiktion der Gesamtfehlerzahl (β = .38, t = 2.055, p < 0.05) und den Fehlern im Erkennen der Emotionen Wut und Ekel (Wut: β = .40, t = 2.240, p < 0.05, Ekel: β = .41, t = 2.214, p < 0.05). Für wütende Gesichter betrug die Varianzaufklärung durch die TAS-20-Punktzahl 13.3 %, für angeekelte Gesichter 19.7 %. Kein Zusammenhang bestand zwischen der Zeit, nach der die Probanden die emotionalen Sequenzen stoppten, um ihre Bewertung abzugeben (Antwortlatenz) und Alexithymie. Die Ergebnisse der Arbeit unterstützen das Vorliegen eines mit Alexithymie assoziierten Defizits im Erkennen emotionaler Gesichtsausdrücke bei weiblchen Probanden in einer heterogenen, klinischen Stichprobe. Dieses Defizit könnte die Schwierigkeiten Hochalexithymer im Bereich sozialer Interaktionen zumindest teilweise begründen und so eine Prädisposition für psychische sowie psychosomatische Erkrankungen erklären.

scholarly journals Prevalence and Influencing Factors of Anxiety and Depression Symptoms Amongst Surgical Nurses During COVID-19 Pandemic: A Large-Scale Cross-Sectional Study

2020 ◽  
Author(s):  
Chun-Xia Ren ◽  
De-Cun Zhou ◽  
Yin-Guang Fan ◽  
Bao-Zhu Li ◽  
Wan-Fei Zhang ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Influencing Factors ◽  
Rating Scale ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Self Rating ◽  
Surgical Nurses

Abstract BackgroundThe outbreak of novel 2019 coronavirus disease (COVID-19) has imposed an enormous physical and psychological pressure on people across the world. This study focused on evaluating the prevalence and influencing factors of anxiety and depression symptoms in surgical nurses during the epidemic in China. MethodA cross-sectional, multicenter quantitative study was conducted in Anhui province (China) from March 3, 2020 to March 19, 2020, with a questionnaire package which consisted of general information questionnaire，Zung's self-rating anxiety scale (SAS), Zung's self-rating Depression Scale (SDS) and social support rating scale (SSRS). A total of 3600 surgical nurses participated in the survey by Wechat and QQ. Data were analysed using multiple linear regression models. ResultsA total of 3492 surgical nurses from 12tertiary hospitals and 12 secondary hospitals in one province of mainland China completed the survey. The prevalence rates of anxiety symptoms and depressive symptoms were 24.83% and 22.39%, respectively. The average level of anxiety and depression of surgical nurses were higher than that of the Chinese norm (P< 0.05).Levels of social support for surgical nurses were significantly negatively associated with the degree of anxiety (r = -0.630, P < 0.001) and depression (r = -0.578, P < 0.001). Fertility status (β = 1.469, P = 0.003), hospital (β = -0.611, P < 0.001), participation in care for COVID-19 patients (β = 2.229, P < 0.001), likelihood of being infected with COVID-19 (β = 1.146, P < 0.001), social support (β = -0.623, P < 0.001) were significantly influencing surgical nurses’ anxiety degree. Similarly, these characteristics were significantly associated with the odds of experiencing depression symptoms in surgical nurses. Divorce and widowed surgical nurses (β = -2.654, P < 0.001) were significantly more likely to experience depressive symptoms than single nurses. ConclusionIn this survey, we found that the surgical nurses had high anxiety and depression symptoms during the COVID-19 outbreak in China. The findings suggest that targeted psychological interventions to promote the mental health of surgical nurses with psychological problems need to be immediately implemented.

A Double-Blind Comparison of Prazepam with Diazepam, Chlorazepate Dipotassium and Placebo in Anxious Out-Patients

1979 ◽  
Vol 7 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Louis F Fabre ◽  
David M McLendon ◽  
Arthur Mallette
Keyword(s):  
Data Analysis ◽  
Side Effects ◽  
Rating Scale ◽  
Double Blind ◽  
Drug Study ◽  
Patient Reported ◽  
Symptom Check List ◽  
Blind Comparison ◽  
Lost To Follow Up ◽  
Age Range

This study compared prazepam with diazepam, chlorazepate dipotassium, and placebo in the treatment of anxious out-patients. Patients were screened for participation in the study to be sure they met the criteria for inclusion. Patients were excluded if they had complicating physical or mental problems. All patients signed an informed consent. Seventy-three patients entered the study, thirteen did not complete at least two weeks of treatment and were not used in the data analysis. Of these thirteen, ten did not return and were lost to follow-up, two entered the hospital for reasons unrelated to the drug study, and one patient on diazepam was terminated because of increased anxiety. Sixty patients were used in the data analysis, thirty-six males and twenty-four females with an age range of 21–61 years. Side-effects were minimal. Drowsiness was reported by two people in the placebo group, one taking chlorazepate dipotassium, three on prazepam and one on diazepam. One diazepam patient reported nausea and vomiting. Scores on the Zung Self-Rating Scale for Anxiety showed all three drug groups to be superior to placebo. The Hopkins Symptom Check-list found prazepam and diazepam to be superior to placebo and chlorazepate. No differences among the groups were found in the Hamilton Anxiety Scale. Prazepam may offer advantages over the other available benzodiazepines since it may be more readily absorbed than chlorazepate and has less side-effects than diazepam.

A Comparative Trial of Opipramol and Chlordiazepoxide in the Treatment of Anxiety

1973 ◽  
Vol 1 (3) ◽  
pp. 145-150 ◽  
Author(s):  
K Jepson ◽  
G Beaumont
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Rating Scale ◽  
Comparative Trial ◽  
Anxiety Score ◽  
Double Blind ◽  
Somatic Anxiety ◽  
Daily Dose ◽  
The Difference

A daily dose of 200 mg of opipramol (Insidon, Geigy) and 30 mg of chlordiazepoxide (Librium, Roche) were compared in a clinical trial in general practice. The trial was double blind and a stratified randomisation technique was employed. Twenty four patients received opipramol and twenty six chlordiazepoxide for four weeks. A total anxiety score and separate ‘psychic’ anxiety and ‘somatic’ anxiety scores were recorded, using a rating scale initially and after two and four weeks treatment. No overall difference in efficacy was found between the two drugs—opipramol producing a 76% improvement and chlordiazepoxide 64% by the end of the study. There was no difference in the relief of psychic anxiety. Although opipramol appeared to give more relief of somatic anxiety, the difference was not statistically significant. Again although opipramol relieved more individual symptoms than chlordiazepoxide, none of the differences were significant. 70% of patients on opipramol and 74% of those on chlordiazepoxide were classified ‘better’ globally by both doctor and patient by the end of the trial. The total number of side effects recorded was similar on both drugs although drowsiness occurred twice as frequently on chlordiazepoxide as it did on opipramol.

Alopecia areata: Viele Faktoren spielen eine Rolle

2019 ◽  
pp. 203-205
Author(s):  
Uwe Gieler
Keyword(s):  
Alopecia Areata ◽  
Dermatology Life Quality Index ◽  
Quality Index ◽  
Suicide Risk ◽  
Rating Scale ◽  
Life Quality ◽  
Depression Scale ◽  
Average Score ◽  
Self Rating ◽  
Life Quality Index

Alopecia areata (AA) is a nonscarring alopecia with an autoimmune etiology, unpredictable course, multiple presentations, and variable psychological distress. We conducted a cross-sectional study which included 126 patients with AA. A complete medical history was documented using the Severity Alopecia Tool (SALT) to assess the severity of the disease, and the following questionnaires were applied to the participants: the Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), Plutchik Suicide Risk Scale, and the Perceived Stress Scale (PSS-14) for adults. The Child Dermatology Life Quality Index (cDLQI) and the Birleson Depression Self-Rating Scale questionnaires were applied for children. Quality of life (QoL) disturbance was detected in 77.6% of adult participants, 65.9% of them had signs of depression or anxiety, and 12.8% were at risk of committing suicide. The PSS-14 average score for adults was 24.5. QoL disturbance was detected in 76.7% of children participants, and 6.3% of them showed signs of depression with the Birleson Depression Self-Rating Scale. We conclude that patients with AA could experience changes in their QoL and signs of depression, anxiety, and suicide risk, mainly in the adult population, during the course of the disease.

A Double-Blind Study of Trazodone and Mianserin in the Treatment of Depression in General Practice

1982 ◽  
Vol 10 (3) ◽  
pp. 147-156 ◽  
Author(s):  
H H Richards ◽  
R N Midha ◽  
S Miller
Keyword(s):  
General Practice ◽  
Side Effects ◽  
Therapeutic Effect ◽  
Rating Scale ◽  
Double Blind ◽  
Global Improvement ◽  
Hamilton Depression Rating Scale ◽  
Self Rating ◽  
Visual Analogue Scales ◽  
Analogue Scales

The antidepressant and anxiolytic efficacy of trazodone (100–200 mg daily), mianserin (60–120 mg daily) and diazepam (15–30 mg daily) was evaluated in ninety-three patients suffering from mild to moderate depression, with or without anxiety, over 6 weeks in a double-blind non-crossover general practice study. Efficacy was evaluated using the Hamilton Depression Rating Scale, Patient Self-Rating Visual Analogue scales, physician global assessments and the Zung Self-Rating Anxiety Scale. All three treatments significantly reduced symptoms of depression, as measured on the Hamilton Depression Rating Scale and the physician's assessment of Global Improvement. Trazodone was significantly superior to both mianserin and diazepam. As assessed using Visual Analogue Scales, trazodone was also shown to be significantly superior to diazepam in improving the patient's ability to concentrate and in reducing daytime tiredness. Although evidence of efficacy was found, there were no differences in activity between the treatment groups using the physician's assessment of Current Severity or on assessment of Therapeutic Effect. The treatments all caused a reduction in anxiety as assessed by the Zung Self-Rating Scale. The overall incidence of side-effects was similar between groups. For those side-effects considered to be significantly interfering with the patient's function, but not outweighing the therapeutic effect, a reduction of dosage was effective. Several patients complaining of drowsiness or lethargy as an unacceptable daytime side-effect were switched successfully from twice daily to night-time dosing. Significantly more patients with side-effects (outweighing therapeutic effect or in the presence of no improvement) were withdrawn from the mianserin group than from the trazodone or diazepam groups. Overall, the therapeutic efficacy in relation to the incidence of clinically significant side-effects, favoured trazodone for the treatment of general practice patients suffering from depression, with or without anxiety.

scholarly journals Family Dynamics and Grandparents' Anxiety and Depression in Intergenerational Rearing Families: A Correlational Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Chun-Yan Yang ◽  
Hong-Jiao Xu ◽  
Shan-Shan Liu ◽  
Yue-Jing Wu ◽  
Yun Long ◽  
...  
Keyword(s):  
Family Dynamics ◽  
Rating Scale ◽  
Depression Scale ◽  
General Information ◽  
Anxiety Scale ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Disease Concept ◽  
Self Rating ◽  
Scale Scores

Background: In China, intergenerational rearing is a ubiquitous phenomenon based on unique national conditions. This study aimed to explore family dynamics in intergenerational rearing families as well as their correlation with older household members' anxiety and depression.Methods: The elderly from intergenerational (n = 141) and non-intergenerational rearing families (n = 266) were investigated using the following scales: the general information questionnaire, Self-Rating Scale of Systemic Family Dynamics, Geriatric Depression Scale, and Self-Rating Anxiety Scale.Results: Scores from the four dimensions (family atmosphere, system logic, individuation, and the concept of disease) of the structure of family dynamics were computed. The comparison of these dimensions scores and the total scores of grandparents' anxiety and depression for the two groups were not statistically significant (p &gt; 0.05). In Pearson's correlation analysis, no significant correlation between the family atmosphere dimension and the total score of the grandparents' depression and anxiety scales was observed. The system logic aspect was negatively correlated with depression and anxiety scale scores. The individual dimension was positively correlated with the anxiety scale scores. The disease concept dimension was positively correlated with depression and anxiety scale scores. Hence, the results were statistically significant.Conclusion: There were no significant differences in terms of family dynamics and risk of anxiety and depression among grandparents between the two family types. The system logic, individuation, and disease concept dimensions were correlated with their anxiety and depression.

scholarly journals HYPERTENSION CONTROL AND DEPRESSION A STUDY IN SSPM MEDICAL COLLEGE & LIFETIME HOSPITAL PADAVE SINDHUDURG

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Sheetal Ratankumar Gatagat
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Antihypertensive Therapy ◽  
Depression Scale ◽  
Clinical Severity ◽  
Mean Blood Pressure ◽  
Adequate Treatment ◽  
Hypertensive Patients ◽  
Depressed Patients ◽  
Self Rating

Introduction:  Hypertension is a major public health issue worldwide, affecting millions of patients. Although control rates have improved during the past few years, the actual rate is still unacceptably low, and control rates in more vulnerable populations, like people living with diabetes mellitus, are even lower. Optimal BP control could prevent a high percentage of coronary heart disease events, and early BP control significantly reduces the risk of stroke and cardiovascular events Depression is usually not detected at primary levels, and patients do not typically receive adequate treatment, which may not only affect their quality of life, but may also interfere with the treatment and prognosis of other chronic diseases such as ischemic heart disease and stroke.  Material and Methods: 46 hypertensive patients undergoing antihypertensive therapy for longer than six months were included in the study. After a 5 min of rest period, measurement of BP was recorded in triplicate at 3 min intervals between measurements. Adherence to antihypertensive therapy was monitored. All patients completed the Zung Self-rating Depression Scale survey; depression was diagnosed if the patient scored >50 points (the maximum possible score using this scale was 80). The Zung Self-rating Depression Scale is said to be a sensitive measure of clinical severity in depressed patients. Results: Out of 46 patients there were 22 (47.8%) female and 24(52.2%) male. Patients who were depressed were 20 (43.5%) of which 8(40%) were male and 12 (60%) were female. Of the total 20 depressed patients 1 male having controlled hypertension while 19 (80%) were in the group of uncontrolled diabetes. In controlled hypertension group only 1 mild depression patient was observed while in uncontrolled group of the 19 patients 10 (50%) were having mild, 8 (40%) were having moderate and 1 (20%) were having severe depression according the Zung Self-rating Depression Scale. Mean blood pressure in depressed controlled BP group was 128/73 mmHg while in depressed uncontrolled group was 149/90 mmHg. Mean blood pressure in normal controlled BP group was 121/75mmHg while in depressed uncontrolled group was 146/95 mmHg. There was a significant correlation observed between depression and systolic and diastolic blood pressure value (P<0.001). Conclusion: Depression is common in patients having uncontrolled hypertension and screening of depression in hypertensive patients is simple and effective tool to control the hypertension. Keywords: Hypertension, Depression, controlled, uncontrolled.

scholarly journals Online Mental Health Survey for Addressing Psychosocial Conditions During the COVID-19 Pandemic in Indonesia: Instrument Evaluation

2021 ◽  
Author(s):  
Deni Sunjaya ◽  
Bambang Sumintono ◽  
Elvine Gunawan ◽  
Dewi Herawati ◽  
Teddy Hidayat
Keyword(s):  
Rating Scale ◽  
Virus Disease ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Online Assessment ◽  
Validity And Reliability ◽  
Post Traumatic Stress ◽  
Chi Square ◽  
Self Rating ◽  
Psychosocial Conditions

Abstract Background: Regular monitoring of the pandemic’s psychosocial impact could be conducted among the community but is limited through online media. This study aims to evaluate the self-rating questionnaire commonly used for online monitoring of the psychosocial implications of the corona virus disease 2019 (COVID-19) pandemic. Methods: The data was taken from the online assessment results of two groups, with a total of 765 participants. The instruments studied were: Self-Rating Questionnaire (SRQ-20), post-traumatic stress disorder (PTSD), and Center for Epidemiological Studies Depression Scale-10 (CESD-10), used in the online assessment. Data analysis used Rasch modeling and Winsteps applications. Validity and reliability were tested, data were fit with the model, rating scale, and item fit analysis.Results: All the scales for outfit mean square (MnSq) were very close to the ideal value of 1.0, and the Chi-square test was significant. Item reliability was greater than 0.67, item separation was greater than 3, and Cronbach’s alpha was greater than 0.60; all the instruments were considered very good. The raw variance explained by measures for the SRQ-20, PTSD, and CESD-10 was 30.7%, 41.6%, and 47.6%, respectively. The unexplained Eigen-value variances in the first contrast were 2.3, 1.6, and 2.0 for the SRQ-20, PTSD, and CESD-10, respectively. All items had positive point-measure correlations. Conclusions: The internal consistency of all the instruments was reliable. Data were fit to the model as the items were productive for measurement and had a reasonable prediction. All the scales are functionally one-dimensional.

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