Bag-1 Expression in Hyperplastic and Neoplastic Prostate Tissue: Is There Any Relationship with BCL-Related Proteins and Androgen Receptor Status?

2005 ◽  
Vol 91 (6) ◽  
pp. 539-545 ◽  
Author(s):  
Önder Bozdoğan ◽  
Pınar Atasoy ◽  
Nazan Bozdoğan ◽  
Selim Erekul ◽  
Ertan Batislam ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Chromogranin A ◽  
Prostate Tissue ◽  
Low Grade ◽  
Positive Correlation ◽  
Histological Score ◽  
Significant Difference ◽  
Related Proteins ◽  
The Relationship ◽  
Early Carcinogenesis

Aims and Background To evaluate the function and distribution of BAG-1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL-related proteins (BCL-2 and BAX), androgen receptor (AR) expression and chromogranin A. Methods Twenty-eight prostatic adenocarcinomas and 16 prostate hyperplasias were included in this retrospective study. BAG-1, BCL-2, BAX, androgen receptor and chromogranin A immunostaining was performed by means of standard avidin-biotin peroxidase methods. The M30 antibody was used to identify preapoptotic and apoptotic cells. The immunohistochemical histological score (HSCORE) semi-quantative system was used to evaluate immunohistochemical staining. Results Statistical analysis showed a significant difference in HSCOREs of BAX, M30 and AR between the carcinoma and hyperplasia groups. Carcinomas expressed higher HSCOREs of these markers than hyperplasias. There were significant differences in nuclear and cytoplasmic BAG-1 positivity between high and low-grade carcinomas. BAG-1 expression was higher in low-grade carcinomas. In the carcinoma group there was a positive correlation (Pearson) between BCL-2 and cytoplasmic/nuclear BAG-1. In the hyperplasia group there was a negative correlation between BAX and BCL-2, and between AR and M30. We also detected a positive correlation between AR and nuclear/cytoplasmic BAG-1 and between nuclear and cytoplasmic BAG-1 in hyperplasias. BAG-1 showed the same specific basal cell localization as BCL-2 in hyperplastic and normal glands. Conclusions The BAG-1 protein showed a distinct distribution pattern in hyperplastic and neoplastic prostate. BAG-1 in association with BCL-2 inhibits apoptosis and may prolong the life of neoplastic cells and give them a chance to gain new oncogenic features in early carcinogenesis.

scholarly journals The Expressions of Wnt/β-catenin Pathway-Related Components in Brainstem Gliomas

2013 ◽  
Vol 40 (3) ◽  
pp. 355-360 ◽  
Author(s):  
Wenhao Wu ◽  
Yongji Tian ◽  
Hong Wan ◽  
Yongmei Song ◽  
Junhua Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Clinicopathological Characteristics ◽  
Current Treatment ◽  
Brainstem Glioma ◽  
Low Grade ◽  
Normal Brain ◽  
Ki 67 ◽  
Significant Difference ◽  
The Relationship ◽  
Brain Tissues

Background:The overall prognosis of brainstem gliomas is very poor, and the current treatment cannot significantly prolong the overall survival of these patients; therefore, studying the molecular biological mechanisms of the occurrence and development of brainstem gliomas has important significance for their treatment. The Wnt/β-catenin signaling pathway is closely associated with the occurrence and development of tumors, but its relationship with brainstem gliomas remains unclear.Methods:This study used Western blot and immunohistochemistry methods to detect the expressions of Wnt/β-catenin signaling pathway-related components such as Wnt-1, Wnt-2, β-catenin and C-myc in six cases of normal brain tissues and 24 cases of brainstem gliomas and analyzed the relationship between their expressions and clinicopathological characteristics.Results:Wnt-1 had no obvious expression in normal brain tissues and did not show any significant difference between high- and low-grade brainstem gliomas; the expressions of Wnt-2, β-catenin and C-myc in high-grade brainstem gliomas were significantly higher than that in low-grade brainstem gliomas and normal brain tissues and were positively correlated with the expression of Ki-67. Moreover, the expressions of Wnt-2 and C-myc were significantly associated with the prognosis of brainstem glioma patients; additionally, there was a trend toward increased β-catenin expression with shorter survival, but there was no statistical difference.Conclusions:Wnt/β-catenin signaling pathway might be abnormally activated and plays an important role in the occurrence and development of brainstem gliomas. Wnt-2, β-catenin and C-myc may be potential targets for brainstem glioma treatment.

The Influence of Rainfall on Growth of Rubber Trees in Marginal Area of Northeast Thailand

2013 ◽  
Vol 844 ◽  
pp. 7-10
Author(s):  
Niramol Sangchanda ◽  
Supat Isarangkool Na Ayutthaya ◽  
Somyot Meetha ◽  
Patcharin Songsri
Keyword(s):  
Rubber Tree ◽  
Soil Surface ◽  
Tree Planting ◽  
Annual Rainfall ◽  
Tree Plantations ◽  
Northeast Thailand ◽  
Positive Correlation ◽  
Significant Difference ◽  
Khon Kaen ◽  
The Relationship

Rubber trees grow predominately in the southern and eastern areas of Thailand, where there is the majority of rainfall. However, the rubber tree plantations extend to north and northeastern areas, with lower annual rainfall. The aim of this study was to evaluate the effect of rainfall on growth of rubber tree in northeastern areas of Thailand. The outcome of this work should be helped to indicate the optimum area for rubber tree planting in northeast. The study was undertaken using rubber tree clone RRIM600 by comparing the girth at 150 cm at the soil surface, planted in areas of differing rainfall: in Nongkhai, Chaiyaphum, Khon Kaen, Roiet and Buriram provinces. The sample of 50 trees was selected in 3 plantations per province (150 trees per province). The results found that there was no significant difference in girth of the rubber trees in all areas. However, the rubber trees planted in Nongkhai, where had highest rainfall, had highest growth. Moreover, the relationship between rainfall and growth exhibited a positive correlation, demonstrating that higher rainfall increased the girth of rubber trees.

scholarly journals Is There a Relation Between Shoulder Dysfunction and Core Instability?

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0017
Author(s):  
Zeynep Hazar ◽  
Naime Ulug ◽  
Inci Yuksel
Keyword(s):  
Healthy Volunteers ◽  
Impingement Syndrome ◽  
Core Stability ◽  
Strong Positive Correlation ◽  
Shoulder Impingement Syndrome ◽  
Shoulder Impingement ◽  
Positive Correlation ◽  
Shoulder Dysfunction ◽  
Significant Difference ◽  
The Relationship

Objectives: Little is known about the relationship between core stability and shoulder dysfunction in shoulder impingement syndrome. The purpose of this study was to analyze the difference between healthy volunteers and patients with shoulder dysfunction in regard to core stability measures. Secondary purpose was to explore the relationship between measures of core stability and measures of shoulder dysfunction. Methods: 15 patients with shoulder impingement syndrome (mean age: 32.2±4.2 years) and 15 healthy volunteers (mean age: 33.8±6.2 years) participated in this study. Sorenson test, front plank and side bridge exercise was performed to assess anterior, lateral and posterior core endurance, respectively. Simple shoulder test (SSS) and seated medicine ball throw test was used to evaluate the functions of the shoulder joints. Mann-Whitney U test was used for comparison of variables between groups. Analyses of relationships between variables were examined with Spearman correlation test. Results: There was a statistically significant difference between patients with shoulder impingement syndrome and healthy controls in core stability and function (p<0.05). A strong positive correlation was found between shoulder functional test (SSS) and lateral bridge test (r= .874, p < .05). Additionally, a modest positive correlation was found between the SSS and the Sorenson test at (r= .695, p < .05), and a weak positive correlation was found between the SSS and the front plank test at (r= .365, p < .05). Conclusion: Core stability and functional deficiency was found in patients with subacromial impingement syndrome. According to this study, greater shoulder dysfunction is correlated with greater stability deficiency. Therapists should consider incorporating core strengthening as an integral component of rehabilitation program in patients with shoulder dysfunction.

scholarly journals Loneliness & Depression among Old Aged People

2016 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Farhat Jabin
Keyword(s):  
Sampling Technique ◽  
Positive Correlation ◽  
Purposive Sampling ◽  
Empirical Verification ◽  
Aged People ◽  
Loneliness Scale ◽  
Significant Difference ◽  
Depression Level ◽  
The Relationship

In the present research an attempt was made to study the relationship between loneliness and depression among old aged people. The study was carried on by formulating hypotheses that (a)-There would be significant difference between loneliness and depression level of old aged people (b)-There would be positive correlation between loneliness and depression. For empirical verification of these two hypotheses a study was conducted on 60 old aged people of Patna and its neighboring places, by employing incidental-cum-purposive sampling technique. Their age ranged from 60 to 75 years. The UCLA Loneliness Scale was used for measuring loneliness. In order to check the level of depression in old aged people, Hindi adaptation of Beck’s Depression Inventory was applied. For the analysis of the obtained scores t-ratio and co-efficient of correlation were computed. The result confirmed all the hypotheses. The findings on the whole indicated that there is significant difference between loneliness and depression level of old aged people. Positive correlation between loneliness and depression level was also observed by the researcher. The findings of the present research reveal that loneliness plays an important role in determining depression among old aged people. Depression level can be reduced by reducing loneliness among old aged people.

scholarly journals Near binocular visual function after SMILE surgery for myopia

2020 ◽  
Author(s):  
XIAOQIN CHEN ◽  
Yan Wang ◽  
Lihua Li
Keyword(s):  
Binocular Vision ◽  
Visual Function ◽  
Repeated Measures ◽  
Pearson Correlation ◽  
Visual Fatigue ◽  
Positive Correlation ◽  
Small Incision ◽  
Significant Difference ◽  
The Relationship ◽  
Vision Function

Abstract Purpose: To analyze the changes of near binocular vision function after small incision lenticule extraction and association with asthenopia. Methods: This was a retrospective study．Twenty-five myopic patients who underwent small incision lenticular extraction (SMILE) surgery from Tianjin Eye Hospital were included in this study．The values of parameters of near binocular vision function were measured at preoperative, 1 week, 1 month and 3 months postoperatively including near heterophoria, near point convergence (NPC), horizontal base-in fusional reserves (BIFR) and base-out fusional reserves (BOFR). The patients were grouped by the preoperative symptoms scores. The comparisons among different follow-up periods were conducted by the repeated measures analysis of variance. The Pearson correlation coefficient (r) was used to evaluate the linear fit of the relationship between variables. Multiple linear regressions were used to analyze the relationship between asthenopia and parameters of binocular and accommodative function. Results: The NPC significantly increased at 1 week and 1 month after SMILE and then get back to the level of preoperatively in 3 months postoperatively. Near heterophoria significantly decreased at 1 week after SMILE and then remained stable in 3 months postoperatively. In the regression analysis, there was no significant association between the values of the fatigue questionnaire at different stages after SMILE operation and the parameters of near binocular visual function (P>0.05). However, there was significant positive correlation among each visit with the preoperative visual fatigue questionnaire（P<0.05). There was no significant difference in the parameters of binocular visual function between the normal group and the fatigue group. For the visual fatigue group, there was positive correlation between the score of visual fatigue questionnaire 1 week after SMILE surgery and the difference in near horizontal phoria between 1w postoperative and that preoperative (r=0.523, P=0.046), and significant negative correlation with the recovery point of BOFR at 1 week (r=-0.581, P=0.023). Conclusion: SMILE surgery wouldn’t influence the binocular vision in the short term. Since there was no significant association between binocular vision function and visual fatigue, factors of asthenopia in the early period of SMILE surgery should be further studied.

scholarly journals Influence of lipopolysaccharides on autophagy and inflammation in pancreatic islet cells of mice fed by high-fat diet

2018 ◽  
Vol 16 ◽  
pp. 1721727X1775418
Author(s):  
Hongwei Jiang ◽  
Yujin Ma ◽  
Liujun Fu ◽  
Jie Wang ◽  
Linlei Wang ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
High Fat Diet ◽  
Islet Cells ◽  
Low Grade ◽  
Pancreatic Islet Cells ◽  
High Fat ◽  
Significant Difference ◽  
Gsk 3Β ◽  
Related Proteins ◽  
Low Grade Inflammation

The aim of this study was to confirm whether chronic low-grade inflammation could induce autophagy and damage in islet cells. The high-fat diet (HF) and low-dose lipopolysaccharides (LPS) were used to simulate chronic inflammation. Islet function was observed, the expression of autophagy-related proteins and the activity of glucose synthase kinase 3β (GSK-3β) were detected, and the role of autophagy in islet injury induced by inflammation was explored. Higher blood glucose was observed in HF group and LPS group compared with control (C) group, and there was no significant difference between LPS group and LiCl group. The apoptotic pancreatic islet cells in the LPS group were higher than in the HF and C groups, and the in the LiCl group they were higher than in the C group and lower than in the LPS group. Compared with the C group, LC3II/I ratio in the HF group was increased ( P < 0.05), in LPS and LiCl groups it was lower than in the HF group, and in LiCl group it was higher than in the LPS group. There was no significant difference between HF group and C group with regard to the ratio of p-GSK-3β/GSK-3β, but in the LiCl group it was higher than in the LPS group. The results demonstrated that low-grade inflammation might cause autophagy flux impaired through activation of GSK-3β, and induced islet cells damage. LiCl could play a role in protecting islet cells through autophagy enhancement.

scholarly journals Personality and Leadership as Antecedents of Organizational Citizenship Behaviour: A Study of Mining Company in Goa

2014 ◽  
Vol 13 (2) ◽  
pp. 1-38
Author(s):  
Sonam J Gondlekar
Keyword(s):  
Organizational Citizenship ◽  
Demographic Variables ◽  
Personality Factors ◽  
Job Status ◽  
Mining Company ◽  
Positive Correlation ◽  
Significant Difference ◽  
Neo Five Factor Inventory ◽  
Organizational Tenure ◽  
The Relationship

This study investigates the relationship between personality factors, leadership and organizational citizenship behaviour (OCB), predict changes in OCB by personality and leadership, and analyze the influence of demographic variables (organizational tenure, educational qualifications, age, designation, gender and job status) on OCB, personality, leadership and their dimensions. The sample consisted of 203 employees from three units of Sesa Goa Ltd., a leading mining company in Goa. Three reliable and valid tools were employed for the assessment-Organizational Citizenship Behaviour, NEO Five Factor Inventory and Leadership Effectiveness scale. Results of correlation analysis indicated positive correlation between leadership (all dimensions) and OCB. Of five personality factors, extraversion, agreeableness and conscientiousness showed positive correlation while neuroticism was found to be negatively correlated with OCB. Furthermore, result of regression analysis unveiled that 18% variance in OCB is contributed by leadership and 11% by personality. Unit wise differences were also evident in OCB. An incidental analysis using One Way ANOVA and t test revealed significant influence of organizational tenure and educational level on OCB. No significant difference was noticed on leadership and any of its dimensions. This study provides guidelines to aid managers better understand how to enhance OCB.

scholarly journals Renal cell carcinoma: a systematic review and meta-analysis on expression of androgen receptor

2018 ◽  
Vol 5 (11) ◽  
pp. 2820-2826
Author(s):  
Hossein Abdi ◽  
Hamid Reza Mozaffari ◽  
Mehrdad Payandeh ◽  
Edris Sadeghi
Keyword(s):  
Androgen Receptor ◽  
Web Of Science ◽  
Meta Analysis ◽  
Tumor Grade ◽  
Cochrane Library ◽  
Low Grade ◽  
Version 2.0 ◽  
Role Of It ◽  
The Relationship

Background: Chromosome Xq11-12 is the place that the androgen receptor (AR) sequence appears. Herein, the prevalence of this biomarker and its relation with pT stage and tumor grade was reported. Methods: Four online sites (PubMed, Scopus, Web of Science, and Cochrane Library) have been searched up to Sep 2018 systematically. Meta-Analysis software version 2.0 (CMA 2.0) and STATA 14.0 statistical software were utilized. Publication bias did not exist. Results: From the initial 1141 articles identified from the systematically searches. At last, nine of them remained for analysis. The meta-analysis included 1447 patients that 345 of them had AR expression. AR expression significantly correlated with low tumor grade and low tumor pT stage. Conclusion: AR expression was 28.2%, and it had the relationship with tumor low grade and low pT stage. Additional studies required to figure out the role of it on RCC patients.

scholarly journals Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Yating Yang ◽  
Yulong Zhang ◽  
Juan Wang ◽  
Xiaoshuai Ning ◽  
Yelei Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sex Differences ◽  
Chronic Schizophrenia ◽  
Model Assessment ◽  
Bdnf Level ◽  
Positive Correlation ◽  
Female Patients ◽  
Significant Difference ◽  
The Relationship ◽  
Serum Bdnf

Background: Previous research has indicated that there are significant sex differences in serum BDNF levels and metabolic indicators in patients with schizophrenia. Studies have found that BDNF is involved in blood sugar regulation. Homeostasis model assessment of insulin resistance (HOMA-IR) is currently a sensitive indicator for measuring insulin resistance. Our study aims to explore the sex differences in the relationship between serum BDNF levels and HOMA-IR in patients with chronic schizophrenia (CS).Methods: A total of 332 patients with CS were enrolled in this study. General information of all participants was collected. Haematological indicators were collected, and the Positive and Negative Syndrome Scale (PANSS) was used to evaluate psychiatric symptoms. Sex differences in serum BDNF levels, HOMA-IR index and other metabolic indexes were investigated. Then, linear regression analysis was used to analyse the relationship between the HOMA-IR index and BDNF levels in male and female patients.Results: The HOMA-IR index of female patients was significantly higher than that of males, but there was no significant difference in serum BDNF levels between male patients and female patients. There was a positive correlation between BDNF level and HOMA-IR index, and this relationship only existed in female patients.Conclusion: The results show that there are significant sex differences in HOMA-IR in patients with CS. In addition, only in female patients was there a positive correlation between the HOMA-IR index and BDNF level, which suggests that sex factors should be taken into account in evaluating the relationship between BDNF and blood glucose in patients with CS.

scholarly journals ON THE ASSOCIATION OF IRANIAN EFL TEACHER’S IDENTITY STYLE, RELIGIOUS IDENTITY, AND IDENTITY COMMITMENT

2021 ◽  
pp. 1-6
Author(s):  
MOHAMMAD ALIAKBARI ◽  
FIAN GHASEMI
Keyword(s):  
Language Learning ◽  
Religious Identity ◽  
English Language ◽  
Significant Positive Correlation ◽  
Test Analysis ◽  
Positive Correlation ◽  
Identity Style ◽  
Identity Commitment ◽  
Significant Difference ◽  
The Relationship

The purpose of the present study was to investigate the relationship among EFL teacher’s identity style, religious identity, and identity commitment. The data was collected from 88 EFL teachers teaching at different English language learning institutes in Ilam province- Iran. Two questionnaires were used, including Dollinger’s (2001) Brief Religiosity Scale (BRS-6) and Berzonsky’s (1992) Identity Style Inventory, the revised version (ISI3). Results suggested that EFL teacher’s identity style and their commitment were positively correlated (r = 0.350). There was also a significant positive correlation between EFL teacher’s religious identity and their commitment (r = 0.312). A significant positive correlation was also found between EFL teacher’s identity style and religious identity (r = 0.367).  The results of one-way ANOVA indicated that there was a statistically significant difference in identity style scores, identity commitment scores, and religiosity scores for four groups. The results of independent t-test analysis indicated that there was no significant difference in identity style, identity commitment, and the religiosity scores of the two groups of participants. Finally, the implications and limitations of the study were also discussed.

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